Julkaisulista

Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.

2025

Maaliskuu

Vitamin D levels, assessment of evidence for an association between vitamin D deficiency and atherosclerosis: a two-way Mendelian randomization study

Liu C, Huang X, Huang Y, Jin H.

medRxiv 2025.03.19.25324287; doi: https://doi.org/10.1101/2025.03.19.25324287

Multi-level Regulatory Roles of Lactate Metabolism Gene Network in Oral Cancer: Machine Learning Insights

Liu Z, Shen X.

medRxiv 2025.03.19.25324051; doi: https://doi.org/10.1101/2025.03.19.25324051

Gout drives metabolic dysfunction-associated steatotic liver disease through gut microbiota and inflammatory mediators

Liu S, Li F, Cai Y, Sun L, Ren L, Yin M, Cui H, Pan Y, Gang X, Wang G.

Sci Rep. 2025 Mar 19;15(1):9395. doi: 10.1038/s41598-025-94118-7.

A Mendelian randomization study to reveal gut-disc axis: causal associations between gut microbiota with intervertebral disc diseases

Ge Y, Yang H, Fu Y, Zhou J, Cheng Z, Fan X, Yu Y.

Eur Spine J. 2025 Mar 19. doi: 10.1007/s00586-025-08795-z.

Genome-wide association study of dry eye disease reveals shared heritability with systemic comorbidities

Gorman BR, Huang JJ, Barr PB, Halladay CW, Nealon CL, Chatzinakos C, Francis M, Jiang C, VA Million Veteran Program, Greenberg PB, Wu W-C, Pyarajan S, Choquet H, Bigdeli TB, Iyengar SK, Peachey NS, Galor A.

medRxiv 2025.03.18.25324218; doi: https://doi.org/10.1101/2025.03.18.25324218

Mendelian Randomization Analysis Identifies Causal Effects of Multi-Site Chronic Pain on Obstructive Sleep Apnea

Wang Z, Chen L, Kang R, Li Z, Fan J, Peng Y, He Y, Zhao X.

Nat Sci Sleep. 2025 Mar 18;17:463-473. doi: 10.2147/NSS.S487056.

Assessing Causality Between Plasma Brain-Derived Neurotrophic Factor With Major Depression Disorder: A Bidirectional Mendelian Randomization Study

Chen M, Huang HZ, Liu YH, Li Q, Fu LY, Hou CL.

Brain Behav. 2025 Mar;15(3):e70425. doi: 10.1002/brb3.70425.

Obesity- and age-dependent genetic regulation of the plasma proteome in children and adolescents

Thielemann R, Stinson SE, Huang Y, Holm LA, Gräf JF, Rohde PD, Møller PL, Illeris Poggi AI, Vølund Anderson L, Fonvig CE, Thiele M, Krag A, Rasmussen S, Holm J-C, Hansen T.

medRxiv 2025.03.18.25324169; doi: https://doi.org/10.1101/2025.03.18.25324169

The Role of the Major Histocompatibility Complex Region on Chromosome 6 in Skin Atrophy: A Mendelian Randomization Study

Zhao C, Fan Z, Zhang R, Sun Y, Li WY.

J Cosmet Dermatol. 2025 Mar;24(3):e70040. doi: 10.1111/jocd.70040.

Impact of Glucagon-like Peptide-1 Receptor Agonists on Mental Illness: Evidence from a Mendelian Randomization Study

Xiang L, Peng Y.

Int J Mol Sci. 2025 Mar 18;26(6):2741. doi: 10.3390/ijms26062741.

Exploring the causal effects of physical activity, diet, and nutrition on hypertension and hyperlipidemia: a multivariable Mendelian randomization analysis

Qian H, Liu Y, Choi H, Lee S.

BMC Cardiovasc Disord. 2025 Mar 18;25(1):196. doi: 10.1186/s12872-025-04539-5.

Risk factors for non-responsiveness to 5-aminosalicylic acid in patients with ulcerative colitis identified using retrospective clinical study and Mendelian randomization

Ye ZN, Liu XT, Gu YM, Mao SX, Liang DH, Zhan K, Lei HQ, Huang SG.

Sci Rep. 2025 Mar 17;15(1):9182. doi: 10.1038/s41598-025-89620-x.

Shared genetic investigation of asthma and blood eosinophils in relation to chronic rhinosinusitis

Li X, Li J, Xue S, Gao Y, Wan L, Wang C, Zhang Y, Zhang L.

Allergy Asthma Clin Immunol. 2025 Mar 17;21(1):11. doi: 10.1186/s13223-025-00956-5.

Trans-ancestry genome-wide association meta-analysis of gallstone disease

Lim J, Vujkovic M, Levin MG, Lorenz K, Voight BF, Zhang DY, Dudek MF, Pahl MC, Pippin JA, Su C, Manduchi E, Wells AD, Grant SFA, Abramowitz S, Damrauer SM, Mukherjee S, Yang G, Kaplan DE, Rader DJ.

medRxiv 2025.03.16.25324077; doi: https://doi.org/10.1101/2025.03.16.25324077

Genetic insights into idiopathic pulmonary fibrosis: a multi-omics approach to identify potential therapeutic targets

Wen Z, Liang W, Yang Z, Liu J, Yang J, Xu R, Lin K, Pan J, Chen Z.

J Transl Med. 2025 Mar 16;23(1):337. doi: 10.1186/s12967-025-06368-8.

DNA Methylation-Regulated ZDHHC13 Promotes the Progression of Parkinson's Disease

Liao J, Bei L, Nie P, Liu P, Zhang Y.

Mol Neurobiol. 2025 Mar 15. doi: 10.1007/s12035-025-04829-1.

The Causal Relationship Between Gut and Skin Microbiota and Chronic Obstructive Pulmonary Disease:A Bidirectional Two-Sample Mendelian Randomization Analysis

Luo Z, Liao G, Meng M, Huang X, Liu X, Wen W, Yue T, Yu W, Wang C, Jiang Y.

Int J Chron Obstruct Pulmon Dis. 2025 Mar 15;20:709-722. doi: 10.2147/COPD.S494289.

Thyroid function and multiple sclerosis: a two-sample mendelian randomization study and mediation analysis

Ren Y, Wang X, Wang W, Wang Z.

Sci Rep. 2025 Mar 15;15(1):9022. doi: 10.1038/s41598-025-89888-z.

Circulating branched-chain amino acids and risk of psychiatric disorders: A two-sample Mendelian randomization study

Gao X, Zhang W, Wang F.

J Psychosom Res. 2025 Mar 15;192:112101. doi: 10.1016/j.jpsychores.2025.112101.

Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease

Li Y, Li D, Lin J, Zhou L, Yang W, Yin X, Xu C, Cao Z, Wang Y.

Cardiovasc Diabetol. 2025 Mar 14;24(1):120. doi: 10.1186/s12933-025-02670-3.

Association between 91 circulating inflammatory proteins and the risk of glaucoma: A Mendelian randomization study

Xu W, Fan Q, Meng Y, Nie Z, Sawut A, Xie S, Chen C.

Sci Rep. 2025 Mar 14;15(1):8876. doi: 10.1038/s41598-025-92153-y.

Self-reported myopia and age-related cataract: a two-sample Mendelian randomization study

Liu H, Wang F, Wei J.

Sci Rep. 2025 Mar 14;15(1):8839. doi: 10.1038/s41598-025-93564-7.

Association between dietary intakes and pregnancy complications: a two-sample Mendelian randomization analysis

Zhao Z, Chang T, Liu X, Zhang X, Liu X, Zhang Y, Chen J, Zhang Y, Lu M.

BMC Pregnancy Childbirth. 2025 Mar 14;25(1):286. doi: 10.1186/s12884-025-07385-7.

Novel Parkinson's Disease Genetic Risk Factors Within and Across European Populations

The Global Parkinson's Genetics Program (GP2), Leonard HL.

medRxiv 2025.03.14.24319455; doi: https://doi.org/10.1101/2025.03.14.24319455

Genomic and proteomic signatures highlight diverse pathways between obesity and type-2 diabetes

Åsa Johansson, Pascal Mutie, Torgny Karlsson

Researchsquare, 13 March 2025, doi: 10.21203/rs.3.rs-6079296/v1

Ischemic Stroke May Increase the Risk of Crohn's Disease and Ulcerative Colitis: Evidence from a Bidirectional Mendelian Randomization Study

Luo X, Yao L, Chen Y, Song Y.

World Neurosurg. 2025 Apr;196:123718. doi: 10.1016/j.wneu.2025.123718.

Exploring Causal Relationships Between Gut Microbiota, Inflammatory Cytokines, and Inflammatory Dermatoses: A Mendelian Randomization Study

Huang Z, Lu T, Lin J, Ding Q, Li X, Lin L.

Clin Cosmet Investig Dermatol. 2025 Mar 13;18:579-592. doi: 10.2147/CCID.S496091.

Is metabolic syndrome a risk factor for skin cancer? A UKBiobank Observational and two Sample Mendelian randomization Study

Black EAM, Allemani C, Dudding T.

Cancer Epidemiol Biomarkers Prev. 2025 Mar 13. doi: 10.1158/1055-9965.EPI-24-1388.

Causal effect of the 25-Hydroxyvitamin D concentration on ocular diseases: A Mendelian randomization study

Luo X, Ruan Z, Liu L.

Sci Rep. 2025 Mar 13;15(1):8701. doi: 10.1038/s41598-025-93613-1.

Causal associations between 26 musculoskeletal disorders and gut microbiota: a Mendelian randomization analysis with Bayesian validation

Wang Y, Sun Y, Liao H.

World J Microbiol Biotechnol. 2025 Mar 13;41(3):106. doi: 10.1007/s11274-025-04318-6.

Unraveling the Molecular Nexus Between Ankylosing Spondylitis and IgA Nephropathy: Insights from Mendelian Randomization and Bioinformatics Analysis

Shao N, Tan K, Chen P, Luo Q.

Nephron. 2025 Mar 12:1-22. doi: 10.1159/000544970.

Placental weight as a predictor of future health: Insights from a large-scale genome-wide association study

Zhang Q, Xu T, Yu S, Wu S, Yang Y, Wu H, Zhang J.

Placenta. 2025 Mar 12;164:10-20. doi: 10.1016/j.placenta.2025.03.006.

Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease

Ao L, van Heemst D, Jukema JW, Rensen PCN, Willems van Dijk K, Noordam R.

J Lipid Res. 2025 Apr;66(4):100778. doi: 10.1016/j.jlr.2025.100778.

Integrated genetic analysis and single cell-RNA sequencing for brain image-derived phenotypes and Parkinson's disease

Pan L, Yang L, Ding W, Hu Y, Yang W, Wang J, Zhang Z, Fan K, Sun Z, Liang Y, Lin X, Chen J, Zhang Y.

Prog Neuropsychopharmacol Biol Psychiatry. 2025 Mar 11;138:111317. doi: 10.1016/j.pnpbp.2025.111317.

Investigation of Potential Targets for Bupleuri Radix in the Treatment of Subacute Thyroiditis

Lei X, Lv L, Ma Y, Zhang C, Li L, Huang Y.

Int J Endocrinol. 2025 Mar 11;2025:7460422. doi: 10.1155/ije/7460422.

Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses

Pujol Gualdo N, Džigurski J, Rukins V, Pajuste FD, Wolford BN, Võsa M, Golob M, Haug L, Alver M, Läll K, Peters M, Brumpton BM; Estonian Biobank Research Team; Palta P, Mägi R, Laisk T.

Nat Med. 2025 Mar 11. doi: 10.1038/s41591-025-03543-8.

Autoimmune thyroid disease is a risk factor for mood disorders, a Mendelian randomization study

Liu J, Li Z.

J Affect Disord. 2025 Mar 11;379:204-212. doi: 10.1016/j.jad.2025.03.033.

Association between allergic rhinitis, nasal polyps, chronic sinusitis and chronic respiratory diseases: a mendelian randomization study

Ren F, Zhang L, Zhao D, Zhang J.

BMC Pulm Med. 2025 Mar 11;25(1):109. doi: 10.1186/s12890-025-03523-1.

Exploration of Circadian Clock-Related Genes in the Pathogenesis of Psoriatic Arthritis to Identify Potential Therapeutic Targets From Multi-Omics Insight: A Mendelian Randomization Study

Liu A, Huoshen W, Wang Y, Yi S, Qin Z.

Int J Rheum Dis. 2025 Mar;28(3):e70158. doi: 10.1111/1756-185X.70158.

Bidirectional Mendelian Randomization Study Identifies No Genetic Link Between Psoriasis and Diabetes

Li J, Li M, Kong S, Zhong C, Sun D, Zhang L.

J Diabetes Res. 2025 Mar 10;2025:9917071. doi: 10.1155/jdr/9917071.

Proteome-Wide Mendelian Randomization Identifies Candidate Causal Proteins for Cardiovascular Diseases

Li C, De Jay N, Zhang SS, Fang X, Sharma S, Catalano KA, Sridharan V, Wang Z, Zhao L, Szustakowski JD, Chang CP, Maranville JC, Holzinger ER, Kvikstad EM.

Adv Genet (Hoboken). 2025 Mar 10;6(2):2500003. doi: 10.1002/ggn2.202500003.

Causal associations between atrial fibrillation and esophageal cancer: a two-sample Mendelian randomization study

Lei J, Yang L, Wang G, Liu Q, Guo G.

Transl Cancer Res. 2025 Mar 30;14(3):1849-1856. doi: 10.21037/tcr-24-2107.

Identification of potential drug targets for pelvic organ prolapse using a proteome-wide Mendelian randomization approach

Xie Z, Feng Y, He Y, Lin Y, Wang X.

Sci Rep. 2025 Mar 10;15(1):8291. doi: 10.1038/s41598-025-92800-4.

Integrated Single-Cell Transcriptome and eQTL Analyses Reveal the Role of PZP in Aging and Chronic Kidney Disease

Huang X, Zhu C, Lv S, Wang Y, Wang J, Yuan S, Yang Y, Ding X, Zhang X.

J Gene Med. 2025 Mar;27(3):e70015. doi: 10.1002/jgm.70015.

Causal relationship between Baff-R expression and normal pressure hydrocephalus: insights from Mendelian randomization analysis

Wang W, Ma L, Liu M, Zhao Y, Ye W, Li X.