Publications

Noah Cook, Youjie Zeng, Chenyu Yang, Zhiwen Jiang, Ting-Chen Wang, Yann Le Guen, Karly Cody, Matthew Johnson, Rui Zhang, Victoria C. Merritt, Richard L. Hauger, the VA Million Veteran Program, FinnGen, Mary Ellen Koran, Elizabeth C. Mormino, Brian Gordon, Alex DeCasien, Shea Andrews, Logan Dumitrescu, Derek Archer, Timothy J. Hohman, Cyril Pottier, Carlos Cruchaga, Richard Sherva, Mark Logue, Valerio Napolioni, Michael D. Greicius, Michael E. Belloy

medRxiv 2026.05.05.26352461; doi: https://doi.org/10.64898/2026.05.05.26352461

Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts

Joensuu L, Lukander V, Herranen P, Tynkkynen NP, Kujala U, Lopéz-Bueno R, Nordeidet AN, Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Ollikainen M; FinnGen; Sillanpää E.

Scand J Med Sci Sports. 2026 May;36(5):e70291. doi: 10.1111/sms.70291.

[Study on the causal relationship between serum albumin and carpal tunnel syndrome and the mediating role of leptin]

Zheng JX, Zhong SW, Yang Y, Peng ZH, He YN, Zhu SH, Huang FYX, Wang Z.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2026 Apr 20;44(4):241-246. doi: 10.3760/cma.j.cn121094-20250704-00267.

Genetic evidence for associations between food intake and prostatic diseases: a Mendelian randomization study

Chen X, Ren C, Xie L, Liu X.

Can J Urol. 2026 Apr 15;33(2):339-348. doi: 10.32604/cju.2025.069578.

Machine Learning-Based Prediction of Drug-Induced QTc Changes in a Large Finnish Biobank Cohort

Langén V, Winstén A, Teppo K, Pohjonen T, Laukkanen J, Mannermaa A, Niiranen TJ, Palmu J.

Clin Transl Sci. 2026 May;19(5):e70577. doi: 10.1111/cts.70577.

Causal effect of gut Streptococcus abundance on maternal genitourinary infection during pregnancy: a two-sample Mendelian randomization study

Wu R, Batu B, Badarch J, Tsagaankhuu S, Jiang X, Chen J, Boldbaatar D.

3 Biotech. 2026 May;16(5):185. doi: 10.1007/s13205-026-04819-7.

Gender-specific Causal Relationship between Sex Hormones and Carpal Tunnel Syndrome: A Mendelian Randomisation Study

Zeng X, Li Z, Luo B, Zheng R, Wei D, Lao S.

Niger Postgrad Med J. 2026 May 1;33(3):341-352. doi: 10.4103/npmj.npmj_125_25

Causal relationship between circulating immune cells, cytokines and different types of autoimmune liver diseases: A univariable and multivariable Mendelian randomization study

Li C, Zhai Q, Wu H, Du C, Yuan J, Peng J, You Y, Li J, Zhong T.

Medicine (Baltimore). 2026 Apr 24;105(17):e48439. doi: 10.1097/MD.0000000000048439.

DNA methylation-regulated ZDHHC5 and PPT1 in the pathogenesis of osteoporosis

Wang C, Zhu Y, Ruan Z.

Medicine (Baltimore). 2026 Apr 24;105(17):e48429. doi: 10.1097/MD.0000000000048429.

Multi-Omics Mendelian Randomization and Clinical Validation Implicate NLRP6 as a Candidate Autophagy-Related Gene in Systemic Lupus Erythematosus

Nie D, Yin J, Tu W, Huang K, Wan J, Yu Y, Wang B, Chen Y, Lin S, Zeng Z.

Genes (Basel). 2026 Apr 16;17(4):466. doi: 10.3390/genes17040466.

Directionally opposing effects of a shared immune genetic signature on atopic dermatitis and glioblastoma: integrative insights from single-cell and clustered Mendelian randomization analyses

Xiaomei Chen, Hua Ye, Jizhen Yang, Tao Qu

medRxiv 2026.05.01.26352272; doi: https://doi.org/10.64898/2026.05.01.26352272

Integrative Mendelian randomization reveals the mediating role of immune cell traits in the causal pathway from gene expression to neonatal bacterial sepsis

Liang J, Wei R, Yi W, Chen J, Li D, Xiao L, Lai Q, Fang Q, Lü J, Wei Y, Yuan J, Gan J.

Medicine (Baltimore). 2026 Apr 24;105(17):e48476. doi: 10.1097/MD.0000000000048476.

Genetically Predicted t(6)A (a tRNA-Derived Adenosine Modification) and Risk of Bullous Pemphigoid: A Two-Sample Mendelian Randomization Study

Yan L, Chen D, Yu D, Shen X.

Clin Cosmet Investig Dermatol. 2026 Apr 27;19:564082. doi: 10.2147/CCID.S564082.

Population-based genome-wide association study of plasma complex lipid species

Landstra EN, Imtiaz MA, Talevi V, Eichelmann F, Schulze MB, Aziz NA, Breteler MMB.

Nat Commun. 2026 May 2;17(1):3984. doi: 10.1038/s41467-026-72542-1.

Identifying THBS3 as a potentially viable therapeutic target for gastric cancer: Intergration of Mendelian randomization and cell experiments validation study

Wang YY, Xing YT, Guo KY, Zhu ZT.

Int J Biol Macromol. 2026 Apr 29;364:152278. doi: 10.1016/j.ijbiomac.2026.152278.

The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications

Yakov A. Tsepilov, Daniel Suveges, Daniel Considine, Szymon Szyszkowski, Xiangyu Jack Ge, Irene Lopez Santiago, Polina Rusina, Tobi Alegbe, Vivien W. Ho, Kirill Tsukanov, Juan Maria Roldan-Romero, Ines A. Smit, Helena Cornu, Laura Harris, Kaur Alasoo, Alexander Predeus, Samuel Lessard, Clement Chatelain, Shameer Khader, Stephanie Yang, Anna O'Carroll, Yury S. Aulchenko, Daniel Seaton, Annalisa Buniello, Ewan Birney, Eric B. Fauman, Mark I. McCarthy, David G. Hulcoop, Gosia Trynka, Ellen M. McDonagh, David Ochoa

bioRxiv 2026.04.28.721048; doi: https://doi.org/10.64898/2026.04.28.721048

Focus on M2-TAMs and gastric cancer: a Mendelian randomization and bioinformatics analysis

Min G, Tang H, Min G, Li Y.

Mol Genet Genomics. 2026 May 2;301(1):105. doi: 10.1007/s00438-026-02422-2.

Huhtikuu

Genetic Evidence Links Gestational Diabetes Mellitus to Increased ER-Negative Breast Cancer Risk Through a Mendelian Randomization Analysis

Peng W, Huang Z, Zhang M.

Int J Endocrinol. 2026 Apr 28;2026:7371037. doi: 10.1155/ije/7371037

The causal relationship in hypertensive encephalopathy: mechanistic analysis of five specific circulating cytokines

Zhang P, Huang Y, Li H, Zhang C, Chen Z.

Open Med (Wars). 2026 Apr 24;21(1):20261412. doi: 10.1515/med-2026-1412.

Identification of key biomarkers for myocardial infarction by multi-omics analysis and machine learning

Wu J, Yang Y, Huang J, Li X, Ma Q, Chen H, Wang Y, Lama E, Qiu Z, Zhou Z.

Front Immunol. 2026 Apr 13;17:1711521. doi: 10.3389/fimmu.2026.1711521

preSCRIPT: Large-scale prescription search and annotation engine for pharmacogenomic studies

Maria Pieczarka, Paweł Pieńkowski, Paula Konowalska, Sylwia Grubarek, Jacek Hajto, Dzesika Hoinkis, Marcin Piechota, Małgorzata Borczyk, Michał Korostyński

medRxiv 2026.04.28.26351989; doi: https://doi.org/10.64898/2026.04.28.26351989

Exploring the causal effect of genetically predicted blood and cerebrospinal fluid metabolites and metabolic pathways on intracranial aneurysm

Ding L, Cao W, Zhou Z, Mei Z, Chen B, Lu X, Chen W.

J Int Med Res. 2026 Apr;54(4):3000605261442755. doi: 10.1177/03000605261442755

Causal associations between plasma metabolites and head and neck cancer: a bidirectional Mendelian randomization study

Pan Z, Wang X, Xu Z, Lu M, Zhang X, Xiao L.

Braz J Otorhinolaryngol. 2026 Apr 28;92(4):101812. doi: 10.1016/j.bjorl.2026.101812

A shared MHC immunogenetic signal links aging, rheumatoid arthritis, and herpes zoster through high inflammatory burden–compensatory immune tolerance dysregulation

Xin Yao, Manli Wan

medRxiv 2026.04.28.26351835; doi: https://doi.org/10.64898/2026.04.28.26351835

Exploring Risk Drugs and Mechanisms in Dystonia: Insights from Pharmacovigilance and Proteogenomics

Chen Z, Yao J, Lin J, Sun H, Li J, Zhang W, Meng H, Hou S.

Curr Neuropharmacol. 2026 Apr 13. doi: 10.2174/011570159X448484260107125041

Causal role of EPA on ischemic heart disease, triglyceride rich lipoproteins and related traits: A two-sample Mendelian randomization analysis

Rehana Rasul, Mary Schooling, Ghada Soliman, Joy Shi, Zach Shahn

medRxiv 2026.04.27.26351885; doi: https://doi.org/10.64898/2026.04.27.26351885

The causality between gut microbiota and ectopic pregnancy based on genome-wide association: A Mendelian randomization study

Zhang N, Wang Z, Yang F, Liu T, Ji D.

Afr J Reprod Health. 2026 Apr 28;30(8):66-75. doi: 10.29063/ajrh2026/v30i8.7

The effects of micronutrients on the risk of upper gastrointestinal diseases: a two-sample Mendelian randomization study

Zhang X, Cheng Y, Ding R, Gu J.

Eur J Nutr. 2026 Apr 28;65(4):122. doi: 10.1007/s00394-026-03966-0.

Identification of key genes as diagnostic biomarkers for lung adenocarcinoma using bioinformatics and machine learning

Liu Z, Luo C, Zhao H, Li L, Ma X, Wang J, Qiu S, Wang T, Li M, Li G, Li H, Li G.

Discov Oncol. 2026 Apr 27. doi: 10.1007/s12672-026-05031-y

Genome-wide association study identifies protective genetic factors in active blood donors against multiple diseases

Clancy J, Toivonen J, Lauronen J, Partanen J; Blood Service Biobank; FinnGen; Arvas M, Ritari J.

Eur J Hum Genet. 2026 Apr 27. doi: 10.1038/s41431-026-02100-2.

Mapping the genetic landscape of eight common cardiovascular diseases

Cato Romero, Douglas P Wightman, Sean Jurgens, Eva van Walree, Marre Corver, Poeya Haydarlou, Marijn Schipper, Connie Bezzina, Danielle Posthuma, Sophie van der Sluis

medRxiv 2026.04.26.26351760; doi: https://doi.org/10.64898/2026.04.26.26351760

Causal relationships of inflammatory cytokines and serum metabolites with colorectal carcinoma: A Mendelian randomization study

Feng S, Xiao X, Zhou M, Huang Z, Zhong B.

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2026 Jan 28;51(1):118-128. doi: 10.11817/j.issn.1672-7347.2026.250494.

Shared Risk Genes and Casual Relationships across Sex Hormone Related Traits and Alzheimer’s Disease

Chenyu Yang, Noah Cook, Youjie Zeng, Sathesh K. Sivasankaran, FinnGen, Alex DeCasien, Shea J Andrews, Michael E. Belloy

medRxiv 2026.04.23.26351626; doi: https://doi.org/10.64898/2026.04.23.26351626

Causal association between systemic diseases and periodontitis: a twoway two-sample Mendelian randomization study

Sun L, Zheng Q, Hou Y, Lou H.

Quintessence Int. 2026 Apr 24;0(0):0. doi: 10.3290/j.qi.b6990697

SNPic: SNP Topic Modeling for Interpretable Clustering of Complex phenotypes

Zhang Leyi, Christof Seiler, Doug Speed, Raphael Micheroli, Caroline Ospelt

bioRxiv 2026.04.22.720106; doi: https://doi.org/10.64898/2026.04.22.720106

Narcolepsy is associated with cardiovascular burden

Reyhane Eghtedarian, Hele Haapaniemi, Markus Ramste, FinnGen, Hanna M. Ollila

medRxiv 2026.04.22.26351468; doi: https://doi.org/10.64898/2026.04.22.26351468

Cross-sectional assessment of telephone- and computer-administered instruments in detection of cognitive impairment

Aaltonen A, Saari TT, Urjansson M, Palviainen T, Paajanen TI, FinnGen, Palotie A, Runz H, Kaprio J, Julkunen V, Vuoksimaa E.

J Clin Exp Neuropsychol. 2026 Apr 24:1-12. doi: 10.1080/13803395.2026.2661625.

Exploring the regulatory mechanisms of antidiabetic drugs on osteoporosis and Bone mineral density

Jing YL, Zhu XY, Gong SA, Sun T, Lin XY.

Exp Gerontol. 2026 Apr 21:113142. doi: 10.1016/j.exger.2026.113142

DNA Methylation Regulates CDK5R1 and NRBP1 to Exert Effects on Alcohol Dependence: Insights From Mendelian Randomization

Deng F, Peng J, Lai S, Zhang G, Li M, Huang Y, Yuan M, Yao G, Zhang P, Lu L.

Addict Biol. 2026 May;31(5):e70162. doi: 10.1111/adb.70162.

Multi-ancestral GWAS with the VA Million Veteran Program enables functional interpretation of rheumatoid arthritis alleles

Saori Sakaue, Doris Yang, Harrison Zhang, Daniel Posner, Zachary Rodriguez, Zoe Love, Jing Cui, Ashley Budu-Aggrey, Yuk-Lam Ho, Lauren Costa, Paul Monach, Sicong Huang, Kazuyoshi Ishigaki, Connor Melley, Vidisha Tanukonda, Rahul Sangar, Monika Maripuri, Sara Morini Sweet, Vidul Panickan, Gregory McDermott, Jennifer S. Hanberg, Thomas Riley, Vincent Laufer, Yukinori Okada, Ian Scott, S. Louis Bridges, Joshua Baker, VA Million Veteran Program, Peter W. Wilson, J. Michael Gaziano, Chuan Hong, Anurag Verma, Kelly Cho, Jennifer E. Huffman, Tianxi Cai, Soumya Raychaudhuri, Katherine P. Liao

medRxiv 2026.04.22.26351423; doi: https://doi.org/10.64898/2026.04.22.26351423

Interpretable Machine Learning for Sepsis Risk Prediction in Elderly ICU Patients With Heart Failure: Integrating Genetic Evidence and Clinical Data

Lin Wang, Yiping Hu, Yu Xiong, Yang Yu, Chunxiang Zhang

Research Square, 23 April 2026, [https://doi.org/10.21203/rs.3.rs-9185668/v1]

Identification of LRP8 as a potential therapeutic target for irritable bowel syndrome from the proteomes of plasma and cerebrospinal fluid in a Mendelian randomization study

Zhuo Y, Zhao L, Li D, Ding Y, Liu N, Wang Y, Liu J, Shen C, Zhang S.

Rev Esp Enferm Dig. 2026 Apr 23. doi: 10.17235/reed.2026.11686/2025.

Systematic elucidation of the cross-omics regulatory network in chronic rhinosinusitis: the LAT-IL23R metabolic axis

Ou Z, Gao C.

Braz J Otorhinolaryngol. 2026 Apr 22;92(4):101819. doi: 10.1016/j.bjorl.2026.101819

Pan-cancer polygenic risk score associates with cancer susceptibility following kidney transplantation

Ritari J, Hyvärinen K, Jahnukainen K, Partanen J, Helanterä I, Jahnukainen T.