Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

Huhtikuu

Causal relationship between atherosclerosis and inflammatory bowel disease risk: a two-sample Mendelian randomization study
Guo W, Peng N, Du S.
Thromb J. 2025 Apr 23;23(1):39. doi: 10.1186/s12959-025-00722-y.
Elucidating Cellular Senescence-related Genes in Benign Prostatic Hyperplasia through Mendelian Randomization and Single-cell RNA Sequencing
Wang Y, Zhou L, Liu J, Zhou Q, Xiong W, Wang L.
J Gerontol A Biol Sci Med Sci. 2025 Apr 23:glaf073. doi: 10.1093/gerona/glaf073.
Integrated multi-omics insight into the molecular networks of oxidative stress in triggering multiple sclerosis
Xu Y, Zhang X, Zhang Y, Ma H, Zhou Z, Qin H, Liu H, Han X.
Neurobiol Dis. 2025 Jun 15;210:106929. doi: 10.1016/j.nbd.2025.106929.
Potential association between allergic disease and risk of Alzheimer’s disease: insight from genetic analysis
Jin T, Huang W, Cheng Y, Cao Z, Guo S, Li C.
BMC Neurol. 2025 Apr 23;25(1):173. doi: 10.1186/s12883-025-04192-7.
DNA methylation and 28 year incidence of two neuropathy phenotypes in type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications cohort study
Zhou J, Mychaleckyj JC, Onengut-Gumuscu S, Orchard TJ, Costacou T, Miller RG.
Diabetologia. 2025 Jul;68(7):1423-1439. doi: 10.1007/s00125-025-06427-1.
Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration
Yao H, Chen J, Wang Y, Li Y, Tang P, Liang M, Jiang Q.
BMC Pregnancy Childbirth. 2025 Apr 23;25(1):479. doi: 10.1186/s12884-025-07608-x.
Multiomic insight into the involvement of cell aging related genes in the pathogenesis of endometriosis
Chen L, Yi Y, Nie J.
Sci Rep. 2025 Apr 23;15(1):14103. doi: 10.1038/s41598-025-96711-2.
Combining GWAS Summary Data and Proteomics Identified Potential Drug Targets in Dementia
Zhao Y, Fei L, Duan Y.
Mol Neurobiol. 2025 Apr 23. doi: 10.1007/s12035-025-04967-6.
Sleep deprivation impacts the immunological milieu of epididymis leading to low sperm quality in rats
Li Z, Gong S, Yu Z, Luo Y, Zhao Y, Xue E, Lu H, Xiang D, Sun F.
Commun Biol. 2025 Apr 22;8(1):644. doi: 10.1038/s42003-025-08091-y.
Association between age at diabetes diagnosis and the development and progression of diabetic retinopathy
Li H, Wang B, Liu C.
Sci Rep. 2025 Apr 22;15(1):13827. doi: 10.1038/s41598-025-98840-0.
Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobanks
Levin MG, Koyama S, Woerner J, Zhang DY, Rodriguez A, Nandi T, Truong B, Abramowitz SA, Gupta H, Kamineni H, Hornsby W, Li Z, Cohron T, Huffman JE, Ellinor P, Kim D, Liao KP, Madduri RK, Voight BF, Verma A, Damrauer SM, Natarajan P.
medRxiv [Preprint]. 2025 Apr 22:2025.04.18.25326074. doi: 10.1101/2025.04.18.25326074.
Elevated VRK2 expression promotes the onset and progression of bronchiectasis
Zheng S, Huang Y, Hong K, Tang J, Wu X, Qing C, Jiang Y, Lu W, Bao C, Luo J & Kong J.
The Egyptian Journal of Bronchology (2025) 19:36 https://doi.org/10.1186/s43168-025-00390-6
Exploring the comorbidity association and biological mechanisms of chronic rhinosinusitis and chronic obstructive pulmonary disease
Liu S, Yang J, Lin Y, Zhang L, Luo W.
Sci Rep. 2025 Apr 22;15(1):13855. doi: 10.1038/s41598-025-98175-w.
Exploring the effect of SGLT2 inhibitors on the risk of primary open-angle glaucoma using Mendelian randomization analysis
Guo Y, Zhao J, Hou S, Chen Z.
Sci Rep. 2025 Apr 22;15(1):13946. doi: 10.1038/s41598-025-98997-8.
Psoriasis vulgaris and circulating metabolic biomarkers: a mendelian randomization analysis
Bi D, Shi J, Hu Y, Tey JT, Yao D, Hua S, Zhu X, Liu J, Guo S.
Arch Dermatol Res. 2025 Apr 22;317(1):733. doi: 10.1007/s00403-025-04232-9.
Identification of mitochondrial-related causal genes for major depression disorder via integrating multi-omics
Li H, Liu Q, Shan Q, Xu H, Wang J, Liu L, Wang Y.
J Affect Disord. 2025 Apr 22;382:540-548. doi: 10.1016/j.jad.2025.04.124.
KZFP-mediated variable DNA methylation of a primate-specific transposon is linked to type I diabetes in humans
Derakhshan M, Issarapu P, Prentice AM, Kuebel JA, Moore SE, Bernstein RM, Sesay AK, Jammeh M, Waterland RA, Hellenthal G, Imbeault M, Silver MJ.
medRxiv 2025.04.22.25326054; doi: https://doi.org/10.1101/2025.04.22.25326054
The genetic associations of lipidome on bladder cancer: a Mendelian randomization study
Jin J, Wang W, Zhao K, Xu G, Peng C, Chen J, Li Y, Pan S.
Discov Oncol. 2025 Apr 22;16(1):586. doi: 10.1007/s12672-025-02389-3.
Dissecting the Genetic Architecture of Intracranial Aneurysms
Adkar SS, Lynch J, Choi RB, Roychowdhury T, Judy RL, Paruchuri K, Go DC, Bamezai S, Cabot J, Sorondo S, Levin MG, Milewicz DM, Willer CJ, Natarajan P, Pyarajan S, Chang KM, Damrauer S, Tsao P, Skirboll S, Leeper NJ, Klarin D.
Circ Genom Precis Med. 2025 Jun;18(3):e004626. doi: 10.1161/CIRCGEN.123.004626.
Association of the gut microbiome with diabetic nephropathy and the mediated effect of metabolites: friend or enemy?
Yu Y, Yang X, Deng J, Yin Y, Wu Y, Yu R.
Int Urol Nephrol. 2025 Apr 21. doi: 10.1007/s11255-025-04519-w.
An expanded view of disease continuum centered on rheumatoid arthritis: from single to systemic perspectives
Zheng M.
Front Med. 2025 Apr 21. doi: 10.1007/s11684-025-1135-5.
Exploring Hepatocellular Carcinoma Etiology through Multi-omics Bioinformatics
Yimin Chen, Zhiwen Wang, Wenjie Li, Jiahui Yang, Zheyu Chen
Researchsquare, 21 April 2025, doi: 10.21203/rs.3.rs-6188338/v1
Genetic Association Between High-Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization Analysis
Wu Y, Xia H, Du F, Zhang J, Jiang X, Tang J, Li Z.
Health Sci Rep. 2025 Apr 21;8(4):e70704. doi: 10.1002/hsr2.70704.
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer
Dai H, Yu Z, Zhao Y, Jiang K, Hang Z, Huang X, Ma H, Wang L, Li Z, Wu M, Fan J, Luo W, Qin C, Zhou W, Nie J.
Biol Direct. 2025 Apr 21;20(1):56. doi: 10.1186/s13062-025-00650-x.
Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study
Ohseto H, Ishikuro M, Obara T, Narita A, Takahashi I, Shinoda G, Noda A, Murakami K, Orui M, Iwama N, Kikuya M, Metoki H, Sugawara J, Tamiya G, Kuriyama S.
Sci Rep. 2025 Apr 21;15(1):13743. doi: 10.1038/s41598-025-97291-x.
Unraveling the Causal Links Between Immune Traits and Hepatocellular Carcinoma: Insights From a Bi-Directional Mendelian Randomization Study
Li J, Wang G, Xiang X, Wang J.
Turk J Gastroenterol. 2025 Apr 21. doi: 10.5152/tjg.2025.24558.
Exploring the role of gut microbiota in intervertebral disc degeneration: insights from bidirectional Mendelian randomization analysis
Xiao J, Zhou X, Xia T, Zhang W, Xing X, Zhang Y, Xiong L.
Eur Spine J. 2025 Jun;34(6):2092-2105. doi: 10.1007/s00586-025-08794-0.
COVID-19 Predisposition Inherently Increases Cardiovascular Risk Before SARS-CoV-2 Infection
Zheng M.
Cardiovasc Toxicol. 2025 Jun;25(6):821-829. doi: 10.1007/s12012-025-09996-0.
Association between growth factors and Sjögren syndrome: A two-sample Mendelian randomization study
Cao Z, Zhu Z, Qu H.
Medicine (Baltimore). 2025 Apr 18;104(16):e42210. doi: 10.1097/MD.0000000000042210.
Novel insights into immune-gut microbiota interactions in colorectal cancer: a Mendelian randomization study
Liu Z, Zhou X, Kuang L, Chen Q, Zhao J, Yin H, Zhou Z, Liu X, Liu D, Wu S, Wu L.
Infect Agent Cancer. 2025 Apr 18;20(1):27. doi: 10.1186/s13027-025-00653-3.
Interference between rheumatoid arthritis and autoimmune thyroid diseases: A bidirectional Mendelian randomization
Yin Y, Liao M, Yu Y, Hu G, Yang X, Guo C, Yu R.
Medicine (Baltimore). 2025 Apr 18;104(16):e42188. doi: 10.1097/MD.0000000000042188.
A genome-wide association study identifies novel genetic variants associated with neck or shoulder pain in the UK biobank (N = 430,193)
Tao Y, Pan Q, Cai T, Lu ZH, Haque M, Dottorini T, Colvin LA, Smith BH, Meng W.
Pain Rep. 2025 Apr 18;10(3):e1267. doi: 10.1097/PR9.0000000000001267.
Association between gynecological cancers and female infertility: insights from bidirectional Mendelian randomization analysis
Li J, Zeng Y, Zhang D.
BMC Womens Health. 2025 Apr 18;25(1):191. doi: 10.1186/s12905-025-03729-9.
Association of FGF21 with Metabolic and Cardiovascular Diseases: A Mendelian Randomization Analysis
He Q, Li Y, Yu R, Lin M.
Exp Clin Endocrinol Diabetes. 2025 Apr 17. doi: 10.1055/a-2549-6889.
Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis
Zeng J, Qiu Y, Yang C, Fan X, Zhou X, Zhang C, Zhu S, Long Y, Hashimoto K, Chang L, Wei Y.
Mol Psychiatry. 2025 Apr 17. doi: 10.1038/s41380-025-03003-2.
The role of the hippocampus and SLC39A8 in chronic musculoskeletal pain-induced dementia: a Mendelian randomization study
Du K, Zuo YL, Zhang ZM, Li A, Zuo QH, Zhang CY, Guo R, Ping C, Du WS, Li SM.
Sci Rep. 2025 Apr 16;15(1):13211. doi: 10.1038/s41598-025-97428-y.
Exploring the Potential Relationship Between Sleep Patterns and Thyroid Cancer Risk
Wang M, Zhu Y.
Bratislava Medical Journal (2025) 126:1444–1454 https://doi.org/10.1007/s44411-025-00149-x
Evaluation of the Association Between Postpartum Hemorrhage and Antidepressant Use: A Mendelian Randomization Study
Chen Z, Lv Q, Lin S, Lin W, Zhuang W.
Drugs Real World Outcomes. 2025 Apr 16. doi: 10.1007/s40801-025-00490-1.
Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study
Pan X, Guo Z, Zheng Y, Su C, Chen J.
Hereditas. 2025 Apr 16;162(1):63. doi: 10.1186/s41065-025-00383-x.
Elucidating the role of lipid metabolism dysregulation in the transition from oral lichen planus to oral squamous cell carcinoma
Yao M, Lu Y, Liu T, Lu H, Shang H, Dong B, Zhang JA.
J Transl Med. 2025 Apr 16;23(1):448. doi: 10.1186/s12967-025-06431-4.
Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications
Cheng C, Liu Y, Sun L, Fan J, Sun X, Zheng JS, Zheng L, Zhu Y, Zhou D.
Cardiovasc Diabetol. 2025 Apr 16;24(1):166. doi: 10.1186/s12933-025-02718-4.
Novel insight of critical genes involved in breast cancer brain metastasis: evidence from a cross-tissue transcriptome association study and validation through external clinical cohorts
Liu J, Guan X, Gao S, Quan L, Dou M, Yue J, Shi M, Yuan P.
BMC Cancer. 2025 Apr 16;25(1):707. doi: 10.1186/s12885-025-14095-y.
Sleep and schizophrenia polygenic scores in non-affective and affective psychotic disorders
Cederlöf E, Holm M, Kämpe A, Ahola-Olli A, Kantojärvi K, Lähteenvuo M, Ahti J, Hietala J, Häkkinen K, Isometsä E, Tuulio-Henriksson A, Kampman O, Lahdensuo K, Lönnqvist J, Tiihonen J, Turunen H, Wegelius A, Veijola J, Kieseppä T, Palotie A, Paunio T.
Psychol Med. 2025 Apr 15;55:e117. doi: 10.1017/S0033291725000844.
The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study
Hui J, Tang K, Zhou Y, Cui X, Han Q.
Sci Rep. 2025 Apr 15;15(1):12928. doi: 10.1038/s41598-025-97722-9.
Celiac Disease Increases the Risk of Multiple Sclerosis: Evidence from Mendelian Randomization and the Role of CCL19
Lim S, Wu J, Kim YW, Lim SW, Shin J, Shin HJ, Kim SR, Kim DW.
Exp Neurobiol. 2025 Apr 15. doi: 10.5607/en25009.
Causal relationship between gut microbiota and pyogenic arthritis: a two-sample Mendelian randomization study
Li JA, Zhou CH, Xiao HD, Guo HB, Liang JY, Zhang Y.
J Med Microbiol. 2025 Apr;74(4). doi: 10.1099/jmm.0.002004.
Investigating Correlation Between Gut Microbiota and Rheumatoid Arthritis Subtypes by Mendelian Randomization
Wu J, Peng Y, Tian R, Yu H, Hu H, Huang Q, Xu Y, Liu L, Pan H.
Pathogens. 2025 Apr 15;14(4):385. doi: 10.3390/pathogens14040385.
Plasma L-aspartic acid predicts the risk of gastric cancer and modifies the primary prevention effect: a multistage metabolomic profiling and Mendelian randomization study
Wang M, Yin Z, Xu H, Liu Z, Huang S, Wu W, Zhang Y, Zhou T, You W, Pan K, Li W.
Cancer Biol Med. 2025 Apr 15:j.issn.2095-3941.2024.0523. doi: 10.20892/j.issn.2095-3941.2024.0523.
Causal Impact of Immune Phenotypes on Herpes Zoster and Postherpetic Neuralgia: Insights from Mendelian Randomization Analysis
Yan Z, Shen D, Qiu X, Ai B, Xiong C.
Clin Cosmet Investig Dermatol. 2025 Apr 15;18:919-928. doi: 10.2147/CCID.S502861.
Genomic structural equation modeling elucidates the shared genetic architecture of allergic disorders
Ruan J, Yi X.
J Transl Med. 2025 Apr 15;23(1):445. doi: 10.1186/s12967-025-06465-8.