Below you will find all the published and preprint scientific papers using FinnGen data.

2024

September

Lipids, lipid-lowering drugs and lateral epicondylitis of the humerus: a drug-targeted Mendelian randomization study
Liu MM, Chen X, Bao XH, Huang BH.
Front Genet. 2024 Sep 2;15:1437712. doi: 10.3389/fgene.2024.1437712.
Effects of rheumatoid arthritis on ventricular structure and function: a Mendelian randomization study
Hao Liu, Di Luo, Wei Yan, Jinsong Li, Dezhi Yan
Researchsquare, 02 September 2024, doi: 10.21203/rs.3.rs-4713343/v1
Causal associations between gut microbiota and premature rupture of membranes: a two-sample Mendelian randomization study
Zhang L, Li Q, Huang J, Zou Q, Zou H, Zhang X, Su Y, Li C.
Front Immunol. 2024 Sep 2;15:1440232. doi: 10.3389/fimmu.2024.1440232.
Whole -genome survival analysis of 144 286 people from the UK Biobank identifies novel loci associated with blood pressure
Saluja S, Darlay R, Lennon R, Keavney BD, Cordell HJ.
J Hypertens. 2024 Sep 1;42(9):1647-1652. doi: 10.1097/HJH.0000000000003801.
Risk of Parkinson's disease and depression severity in different populations: A two-sample Mendelian randomization analysis
Qin Y, Li J, Quan W, Song J, Xu J, Chen J.
Brain Behav. 2024 Sep;14(9):e3642. doi: 10.1002/brb3.3642.

August

Parkinson's disease and the risk of gastrointestinal cancers: a two-sample Mendelian randomization study
Liu Z, Cui L.
J Gastrointest Oncol. 2024 Aug 31;15(4):1475-1486. doi: 10.21037/jgo-24-106.
Elucidating the causal nexus between antibody-mediated immunity and autoimmune diseases: Insights from bidirectional mendelian randomization, gene expression profiling, and drug sensitivity analysis
Chen J, Wei C, Huang S, Wu S, He R, Chen T, Qin X, Wei W, Qin B, Wu S, Zhu J, Huang C, Feng S, Zhou Z, Zhang B, Xue J, Mo S, Zhou C, Qin Y, Zhan X, Liu C.
Int Immunopharmacol. 2024 Aug 30;142(Pt A):113027. doi: 10.1016/j.intimp.2024.113027.
Specific blood metabolite associations with Gout: a Mendelian randomization study
Zeng H, Lai J, Liu Z, Liu W, Zhang Y.
Eur J Clin Nutr. 2024 Aug 30. doi: 10.1038/s41430-024-01497-7.
Health condition and socioeconomic status mediate the causal effect of reproductive traits on nonalcoholic fatty liver disease: evidence from Mendelian randomization study
Wang Q, Wang L, Hao R, Zhang L, Wang W, Xia L.
Front Endocrinol (Lausanne). 2024 Aug 30;15:1419964. doi: 10.3389/fendo.2024.1419964.
Causal Effects of Kidney Function and Chronic Kidney Disease on Alzheimer's Disease by Analyzing Large-Scale Genome-Wide Association Study Datasets
Zhao H, Yuan H, Wang E.
J Alzheimers Dis. 2024 Aug 30. doi: 10.3233/JAD-240807.
Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study
Li Y, Miao Y, Feng Q, Zhu W, Chen Y, Kang Q, Wang Z, Lu F, Zhang Q.
Front Endocrinol (Lausanne). 2024 Aug 30;15:1401531. doi: 10.3389/fendo.2024.1401531.
Causal relationships between gut microbiota, plasma metabolites, and HIV infection: insights from Mendelian randomization and mediation analysis
Hu J, Hu J, Han D.
Virol J. 2024 Aug 30;21(1):204. doi: 10.1186/s12985-024-02480-1.
A study on the causal relationship between the gut microbiome and herpes zoster using Mendelian randomization
Meng Z, Wang T, Liao Y, Li X.
Front Med (Lausanne). 2024 Aug 30;11:1442750. doi: 10.3389/fmed.2024.1442750.
Genetic analysis from multiple cohorts implies causality between 2200 druggable genes, telomere length, and leukemia
Yun Z, Liu Z, Shen Y, Sun Z, Zhao H, Du X, Lv L, Zhang Y, Hou L.
Comput Biol Med. 2024 Aug 30;181:109064. doi: 10.1016/j.compbiomed.2024.109064.
Repurposing antihypertensive drugs for pain disorders: a drug-target mendelian randomization study
Du K, Li A, Zhang CY, Li SM, Chen P.
Front Pharmacol. 2024 Aug 29;15:1448319. doi: 10.3389/fphar.2024.1448319.
Obesity mediates the relationship between depression and infertility: insights from the NHANES 2013-2018 cross-sectional study and a Mendelian randomization study
Xu T, Zhuang Y, Cao H, Yang J.
Front Endocrinol (Lausanne). 2024 Aug 29;15:1465105. doi: 10.3389/fendo.2024.1465105.
Postpartum depression and autoimmune disease: a bidirectional Mendelian randomization study
Yu W, Su B, Wang C, Xia Q, Sun Y.
Front Psychiatry. 2024 Aug 29;15:1425623. doi: 10.3389/fpsyt.2024.1425623.
Exploring causal correlations between plasma proteins and peripheral neuropathy: a Mendelian randomization
Song M, Chen F, Li X, Chen L.
Front Neurol. 2024 Aug 29;15:1431669. doi: 10.3389/fneur.2024.1431669.
Primary biliary cholangitis has causal effects on systemic rheumatic diseases: a Mendelian randomization study
Zhang HP, Zhou Z, Chen K, Xiong LF, Wu J, Jin L.
BMC Gastroenterol. 2024 Aug 29;24(1):294. doi: 10.1186/s12876-024-03319-3.
The Causal Relationship Between Physical Activity and Skin Cancer Risk: An Univariable Mendelian Randomization Study
Fu X, Zeng F, Li L, Liu G, Zhong Q, Chen S.
Clin Cosmet Investig Dermatol. 2024 Aug 28;17:1963-1972. doi: 10.2147/CCID.S472443.
Causal association between frailty and chronic obstructive pulmonary disease: insights from bidirectional Mendelian randomization and mediation analysis
Zewen Cheng, Jian Wu, Chun Xu, Xiaokun Yan
Researchsquare, 28 August 2024, doi:10.21203/rs.3.rs-4869762/v1
Exploring causal effects of sarcopenia on risk and progression of Parkinson disease by Mendelian randomization
Wang T, Geng J, Zeng X, Han R, Huh YE, Peng J.
NPJ Parkinsons Dis. 2024 Aug 28;10(1):164. doi: 10.1038/s41531-024-00782-3.
Multivariable Mendelian Randomization Analysis Reveals the Protective Effect of Restless Legs Syndrome against Lower Limb Venous Diseases and Pulmonary Embolism
Zhang R-Y, Wen C, Geng R-L, Su J-H, Liu X-H, Lai Z-Y, Tao E-X, Li F-J.
medRxiv 2024.08.27.24312632; doi: https://doi.org/10.1101/2024.08.27.24312632
Inflammatory factors and risk of lung adenocarcinoma: a Mendelian randomization study mediated by blood metabolites
Ding Z, Chen J, Li B, Ji X.
Front Endocrinol (Lausanne). 2024 Aug 27;15:1446863. doi: 10.3389/fendo.2024.1446863.
Quantifying variant contributions in cystic kidney disease using national-scale whole genome sequencing
Sadeghi-Alavijeh O, Chan MM, Doctor GT, Voinescu CD, Stuckey A, Kousathanas A, Ho AT, Stanescu HC, Bockenhauer D, Sandford RN, Levine AP, Gale DP.
J Clin Invest. 2024 Aug 27:e181467. doi: 10.1172/JCI181467.
Associations Between Gut Microbiota and Alcohol Abuse: A Mendelian Randomisation and Bioinformatics Study
Wang X, Pan L, Gu J, Gu L, Lou M, Liu Y.
J Mol Neurosci. 2024 Aug 26;74(3):80. doi: 10.1007/s12031-024-02259-7.
Therapeutically targeting the classical complement pathway with antisense oligonucleotides in Alzheimer’s disease
Wang Y, Wu T, Gogineni A, Tsai M-C, Kielpinski L, Mahajan A, Pandey S, Schachner L, Tran JC, Wu C, Schauer S, Biever A, Boesen S, Li M, Munk A, Meilandt WJ, Elstrott J, Easton A, Gylling HM, Hanson JE.
bioRxiv 2024.08.23.609240; doi: https://doi.org/10.1101/2024.08.23.609240
Causal associations of obstructive sleep apnea with Chronic Respiratory Diseases: a Mendelian Randomization study
Hong PY, Liu D, Liu A, Su X, Zhang XB, Zeng YM.
BMC Pulm Med. 2024 Aug 26;24(1):409. doi: 10.1186/s12890-024-03228-x.
Primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome: a Mendelian randomization study
Wang H, Chen G, Gong Q, Wu J, Chen P.
Front Immunol. 2024 Aug 26;15:1403429. doi: 10.3389/fimmu.2024.1403429.
Causal Effect of Tobacco Exposure on Acute Respiratory Distress Syndrome: A Mendelian Randomization Study
Yunfeng Wang, Zhihui Cheng, Dongwei Xu, Kan Shen, Jun Li, Shenghua Yan, Maofeng Zhou, Yingchao Qi, Hua Yu, Hui Ni, Lijun Liao, Yuling Li, Xingqi Deng
Researchsquare, 26 August 2024, doi: 10.21203/rs.3.rs-4806401/v1
A Two-Sample Mendelian Randomization Study of Neuroticism and Sleep Bruxism
Strausz T, Strausz S, Jones SE, Palotie T, Lobbezoo F, Ahlberg J, Ollila HM.
J Dent Res. 2024 Aug 26:220345241264749. doi: 10.1177/00220345241264749.
Elucidating the relationship between coffee consumption and obsessive-compulsive disorder: A Mendelian randomization study
Jiawei Wang, Minyan Feng, Zhiguo Li, Weifan Li
Researchsquare, 26 August 2024, doi: 10.21203/rs.3.rs-4724718/v1
Investigating the causal relationship between major depressive disorder and benign prostatic hyperplasia: a bidirectional Mendelian randomisation study
Zheng G, Xiao S, Cheng Y, Huang J, Luo C, Peng L, Zeng T.
Psychogeriatrics. 2024 Aug 26. doi: 10.1111/psyg.13180.
Metabolic factors are not the direct mediators of the association between type 2 diabetes and osteoporosis
Yang Q, Wang X, Liu Y, Liu J, Zhu D.
Front Endocrinol (Lausanne). 2024 Jul 25;15:1404747. doi: 10.3389/fendo.2024.1404747.
Causal associations of osteoporosis with stroke: a bidirectional Mendelian randomization study
Fan Z, Zhao J, Chen J, Hu W, Ma J, Ma X.
Osteoporos Int. 2024 Aug 24. doi: 10.1007/s00198-024-07235-w.
Causal association between blood leukocyte counts and vascular dementia: a two-sample bidirectional Mendelian randomization study
Liu S, Zhang C, Zhang Y, Wu Z, Wu P, Tian S, Zhang M, Lang L, Li L, Wang R, Liu H, Zhang J, Mao X, Li S.
Sci Rep. 2024 Aug 23;14(1):19582. doi: 10.1038/s41598-024-70446-y.
Causal relationships between gut microbiome and obstructive sleep apnea: a bi-directional Mendelian randomization
Liu L, He G, Yu R, Lin B, Lin L, Wei R, Zhu Z, Xu Y.
Front Microbiol. 2024 Aug 23;15:1410624. doi: 10.3389/fmicb.2024.1410624.
Relationship of Hypothyroidism with Alopecia Areata and Androgenetic Alopecia: Insights from a Two-Sample Mendelian Randomization Study
Zhang G, Huang X, Li H, Gong H, Zhou Y, Liu F.
Clin Cosmet Investig Dermatol. 2024 Aug 22;17:1865-1874. doi: 10.2147/CCID.S474168.
Causal relationship between genetically predicted antibody-Mediated Immune Responses and female infertility
Mo W, Zhang J, Peng X, Wang Y.
J Reprod Immunol. 2024 Aug 22;166:104319. doi: 10.1016/j.jri.2024.104319.
Deciphering the causal association and underlying transcriptional mechanisms between telomere length and abdominal aortic aneurysm
Zhang J, Xia X, He S.
Front Immunol. 2024 Aug 21;15:1438838. doi: 10.3389/fimmu.2024.1438838.
Association between gynecologic cancer and Alzheimer’s disease: a bidirectional mendelian randomization study
Cao D, Zhang S, Zhang Y, Shao M, Yang Q, Wang P.
BMC Cancer. 2024 Aug 21;24(1):1032. doi: 10.1186/s12885-024-12787-5.
Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories
Gezsi A, Van der Auwera S, Mäkinen H, Eszlari N, Hullam G, Nagy T, Bonk S, González-Colom R, Gonda X, Garvert L, Paajanen T, Gal Z, Kirchner K, Millinghoffer A, Schmidt CO, Bolgar B, Roca J, Cano I, Kuokkanen M, Antal P, Juhasz G.
Nat Commun. 2024 Aug 21;15(1):7190. doi: 10.1038/s41467-024-51467-7.
Causal Insights into Plasma Lipidome and Allergic Rhinitis: Implications from a Bidirectional Two-Sample Mendelian Randomization Analysis
Haoxiang Yang, Yaxin Luo, Qiang Liu
Researchsquare, 20 August 2024, doi: 10.21203/rs.3.rs-4617768/v1
The Causal Effect of Intrapancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study
Yamazaki H, Heni M, Wagner R, Fukuhara S, Grossman SR, Han S, Wu L, Streicher SA, Huang BZ.
Am J Gastroenterol. 2024 Dec 1;119(12):2540-2544. doi: 10.14309/ajg.0000000000003048.
Exploring the causal relationship between asthma in the metabolic syndrome: a Mendelian randomization study
Ru X, Huang L, Su Z, Ye C, Guo Y.
J Asthma. 2024 Aug 20:1-38. doi: 10.1080/02770903.2024.2394143.
Multiple sclerosis and abnormal spermatozoa: A bidirectional two-sample mendelian randomization study
Li B, Zhang L, Li Q, Zhang J, Wang W, Quan J.
PLoS One. 2024 Aug 20;19(8):e0308815. doi: 10.1371/journal.pone.0308815.
Body Mass Index and Risk of Female Reproductive System Tumors Subtypes: A Meta-Analysis Using Mendelian Randomization
Jiang XY, Zheng L, Xiong M, Wang SL, Jin QQ, Yang YT, Fang YX, Hong L, Mei J, Zhou SG.
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241277699. doi: 10.1177/15330338241277699.
Genetic Susceptibility of Thrombin Measurement Levels and the Risk of Colon Adenocarcinoma: A Mendelian Randomization Study
Liu Y, Zhou J.
Br J Hosp Med (Lond). 2024 Aug 30;85(8):1-13. doi: 10.12968/hmed.2024.0220.
The causal effect of gut microbiota on hepatic encephalopathy: a mendelian randomization analysis
Wu JL, Chen JW, Huang MS, Deng XY, Deng JJ, Lau TY, Cao SY, Ran HY, Jiang ZB, Luo JY.
BMC Med Genomics. 2024 Aug 19;17(1):216. doi: 10.1186/s12920-024-01939-y.
Causal Effects of Smoking, Alcohol Consumption, and Coffee Intake on Hepatobiliary and Pancreatic Diseases: A Mendelian Randomization Study
Zhao B, Xue J, Zhang H.
Clin Res Hepatol Gastroenterol. 2024 Aug 19:102450. doi: 10.1016/j.clinre.2024.102450.