Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

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Assessing Causality Between Plasma Brain-Derived Neurotrophic Factor With Major Depression Disorder: A Bidirectional Mendelian Randomization Study
Chen M, Huang HZ, Liu YH, Li Q, Fu LY, Hou CL.
Brain Behav. 2025 Mar;15(3):e70425. doi: 10.1002/brb3.70425.
Mendelian Randomization Analysis Identifies Causal Effects of Multi-Site Chronic Pain on Obstructive Sleep Apnea
Wang Z, Chen L, Kang R, Li Z, Fan J, Peng Y, He Y, Zhao X.
Nat Sci Sleep. 2025 Mar 18;17:463-473. doi: 10.2147/NSS.S487056.
Obesity- and age-dependent genetic regulation of the plasma proteome in children and adolescents
Thielemann R, Stinson SE, Huang Y, Holm LA, Gräf JF, Rohde PD, Møller PL, Illeris Poggi AI, Vølund Anderson L, Fonvig CE, Thiele M, Krag A, Rasmussen S, Holm J-C, Hansen T.
medRxiv 2025.03.18.25324169; doi: https://doi.org/10.1101/2025.03.18.25324169
Shared genetic investigation of asthma and blood eosinophils in relation to chronic rhinosinusitis
Li X, Li J, Xue S, Gao Y, Wan L, Wang C, Zhang Y, Zhang L.
Allergy Asthma Clin Immunol. 2025 Mar 17;21(1):11. doi: 10.1186/s13223-025-00956-5.
Risk factors for non-responsiveness to 5-aminosalicylic acid in patients with ulcerative colitis identified using retrospective clinical study and Mendelian randomization
Ye ZN, Liu XT, Gu YM, Mao SX, Liang DH, Zhan K, Lei HQ, Huang SG.
Sci Rep. 2025 Mar 17;15(1):9182. doi: 10.1038/s41598-025-89620-x.
Genetic insights into idiopathic pulmonary fibrosis: a multi-omics approach to identify potential therapeutic targets
Wen Z, Liang W, Yang Z, Liu J, Yang J, Xu R, Lin K, Pan J, Chen Z.
J Transl Med. 2025 Mar 16;23(1):337. doi: 10.1186/s12967-025-06368-8.
Trans-ancestry genome-wide association meta-analysis of gallstone disease
Lim J, Vujkovic M, Levin MG, Lorenz K, Voight BF, Zhang DY, Dudek MF, Pahl MC, Pippin JA, Su C, Manduchi E, Wells AD, Grant SFA, Abramowitz S, Damrauer SM, Mukherjee S, Yang G, Kaplan DE, Rader DJ.
medRxiv 2025.03.16.25324077; doi: https://doi.org/10.1101/2025.03.16.25324077
The Causal Relationship Between Gut and Skin Microbiota and Chronic Obstructive Pulmonary Disease:A Bidirectional Two-Sample Mendelian Randomization Analysis
Luo Z, Liao G, Meng M, Huang X, Liu X, Wen W, Yue T, Yu W, Wang C, Jiang Y.
Int J Chron Obstruct Pulmon Dis. 2025 Mar 15;20:709-722. doi: 10.2147/COPD.S494289.
Thyroid function and multiple sclerosis: a two-sample mendelian randomization study and mediation analysis
Ren Y, Wang X, Wang W, Wang Z.
Sci Rep. 2025 Mar 15;15(1):9022. doi: 10.1038/s41598-025-89888-z.
Circulating branched-chain amino acids and risk of psychiatric disorders: A two-sample Mendelian randomization study
Gao X, Zhang W, Wang F.
J Psychosom Res. 2025 Mar 15;192:112101. doi: 10.1016/j.jpsychores.2025.112101.
DNA Methylation-Regulated ZDHHC13 Promotes the Progression of Parkinson's Disease
Liao J, Bei L, Nie P, Liu P, Zhang Y.
Mol Neurobiol. 2025 Mar 15. doi: 10.1007/s12035-025-04829-1.
Association between 91 circulating inflammatory proteins and the risk of glaucoma: A Mendelian randomization study
Xu W, Fan Q, Meng Y, Nie Z, Sawut A, Xie S, Chen C.
Sci Rep. 2025 Mar 14;15(1):8876. doi: 10.1038/s41598-025-92153-y.
Self-reported myopia and age-related cataract: a two-sample Mendelian randomization study
Liu H, Wang F, Wei J.
Sci Rep. 2025 Mar 14;15(1):8839. doi: 10.1038/s41598-025-93564-7.
Association between dietary intakes and pregnancy complications: a two-sample Mendelian randomization analysis
Zhao Z, Chang T, Liu X, Zhang X, Liu X, Zhang Y, Chen J, Zhang Y, Lu M.
BMC Pregnancy Childbirth. 2025 Mar 14;25(1):286. doi: 10.1186/s12884-025-07385-7.
Novel Parkinson's Disease Genetic Risk Factors Within and Across European Populations
The Global Parkinson's Genetics Program (GP2), Leonard HL.
medRxiv 2025.03.14.24319455; doi: https://doi.org/10.1101/2025.03.14.24319455
Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease
Li Y, Li D, Lin J, Zhou L, Yang W, Yin X, Xu C, Cao Z, Wang Y.
Cardiovasc Diabetol. 2025 Mar 14;24(1):120. doi: 10.1186/s12933-025-02670-3.
Causal effect of the 25-Hydroxyvitamin D concentration on ocular diseases: A Mendelian randomization study
Luo X, Ruan Z, Liu L.
Sci Rep. 2025 Mar 13;15(1):8701. doi: 10.1038/s41598-025-93613-1.
Causal associations between 26 musculoskeletal disorders and gut microbiota: a Mendelian randomization analysis with Bayesian validation
Wang Y, Sun Y, Liao H.
World J Microbiol Biotechnol. 2025 Mar 13;41(3):106. doi: 10.1007/s11274-025-04318-6.
Ischemic Stroke May Increase the Risk of Crohn's Disease and Ulcerative Colitis: Evidence from a Bidirectional Mendelian Randomization Study
Luo X, Yao L, Chen Y, Song Y.
World Neurosurg. 2025 Apr;196:123718. doi: 10.1016/j.wneu.2025.123718.
Exploring Causal Relationships Between Gut Microbiota, Inflammatory Cytokines, and Inflammatory Dermatoses: A Mendelian Randomization Study
Huang Z, Lu T, Lin J, Ding Q, Li X, Lin L.
Clin Cosmet Investig Dermatol. 2025 Mar 13;18:579-592. doi: 10.2147/CCID.S496091.
Genomic and proteomic signatures highlight diverse pathways between obesity and type-2 diabetes
Åsa Johansson, Pascal Mutie, Torgny Karlsson
Researchsquare, 13 March 2025, doi: 10.21203/rs.3.rs-6079296/v1
Is metabolic syndrome a risk factor for skin cancer? A UKBiobank Observational and two Sample Mendelian randomization Study
Black EAM, Allemani C, Dudding T.
Cancer Epidemiol Biomarkers Prev. 2025 Mar 13. doi: 10.1158/1055-9965.EPI-24-1388.
Unraveling the Molecular Nexus Between Ankylosing Spondylitis and IgA Nephropathy: Insights from Mendelian Randomization and Bioinformatics Analysis
Shao N, Tan K, Chen P, Luo Q.
Nephron. 2025 Mar 12:1-22. doi: 10.1159/000544970.
Placental weight as a predictor of future health: Insights from a large-scale genome-wide association study
Zhang Q, Xu T, Yu S, Wu S, Yang Y, Wu H, Zhang J.
Placenta. 2025 Mar 12;164:10-20. doi: 10.1016/j.placenta.2025.03.006.
Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease
Ao L, van Heemst D, Jukema JW, Rensen PCN, Willems van Dijk K, Noordam R.
J Lipid Res. 2025 Apr;66(4):100778. doi: 10.1016/j.jlr.2025.100778.
Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses
Pujol Gualdo N, Džigurski J, Rukins V, Pajuste FD, Wolford BN, Võsa M, Golob M, Haug L, Alver M, Läll K, Peters M, Brumpton BM; Estonian Biobank Research Team; Palta P, Mägi R, Laisk T.
Nat Med. 2025 Mar 11. doi: 10.1038/s41591-025-03543-8.
Autoimmune thyroid disease is a risk factor for mood disorders, a Mendelian randomization study
Liu J, Li Z.
J Affect Disord. 2025 Mar 11;379:204-212. doi: 10.1016/j.jad.2025.03.033.
Association between allergic rhinitis, nasal polyps, chronic sinusitis and chronic respiratory diseases: a mendelian randomization study
Ren F, Zhang L, Zhao D, Zhang J.
BMC Pulm Med. 2025 Mar 11;25(1):109. doi: 10.1186/s12890-025-03523-1.
Integrated genetic analysis and single cell-RNA sequencing for brain image-derived phenotypes and Parkinson's disease
Pan L, Yang L, Ding W, Hu Y, Yang W, Wang J, Zhang Z, Fan K, Sun Z, Liang Y, Lin X, Chen J, Zhang Y.
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Mar 11;138:111317. doi: 10.1016/j.pnpbp.2025.111317.
Investigation of Potential Targets for Bupleuri Radix in the Treatment of Subacute Thyroiditis
Lei X, Lv L, Ma Y, Zhang C, Li L, Huang Y.
Int J Endocrinol. 2025 Mar 11;2025:7460422. doi: 10.1155/ije/7460422.
Bidirectional Mendelian Randomization Study Identifies No Genetic Link Between Psoriasis and Diabetes
Li J, Li M, Kong S, Zhong C, Sun D, Zhang L.
J Diabetes Res. 2025 Mar 10;2025:9917071. doi: 10.1155/jdr/9917071.
Proteome-Wide Mendelian Randomization Identifies Candidate Causal Proteins for Cardiovascular Diseases
Li C, De Jay N, Zhang SS, Fang X, Sharma S, Catalano KA, Sridharan V, Wang Z, Zhao L, Szustakowski JD, Chang CP, Maranville JC, Holzinger ER, Kvikstad EM.
Adv Genet (Hoboken). 2025 Mar 10;6(2):2500003. doi: 10.1002/ggn2.202500003.
Causal associations between atrial fibrillation and esophageal cancer: a two-sample Mendelian randomization study
Lei J, Yang L, Wang G, Liu Q, Guo G.
Transl Cancer Res. 2025 Mar 30;14(3):1849-1856. doi: 10.21037/tcr-24-2107.
Identification of potential drug targets for pelvic organ prolapse using a proteome-wide Mendelian randomization approach
Xie Z, Feng Y, He Y, Lin Y, Wang X.
Sci Rep. 2025 Mar 10;15(1):8291. doi: 10.1038/s41598-025-92800-4.
Exploration of Circadian Clock-Related Genes in the Pathogenesis of Psoriatic Arthritis to Identify Potential Therapeutic Targets From Multi-Omics Insight: A Mendelian Randomization Study
Liu A, Huoshen W, Wang Y, Yi S, Qin Z.
Int J Rheum Dis. 2025 Mar;28(3):e70158. doi: 10.1111/1756-185X.70158.
Integrated Single-Cell Transcriptome and eQTL Analyses Reveal the Role of PZP in Aging and Chronic Kidney Disease
Huang X, Zhu C, Lv S, Wang Y, Wang J, Yuan S, Yang Y, Ding X, Zhang X.
J Gene Med. 2025 Mar;27(3):e70015. doi: 10.1002/jgm.70015.
Association between leukocyte telomere length and renal cell carcinoma: insight from Mendelian randomization study
Chen XB, Wang L, Zhu PY.
Discov Oncol. 2025 Mar 8;16(1):285. doi: 10.1007/s12672-025-02027-y.
Causal relationship between Baff-R expression and normal pressure hydrocephalus: insights from Mendelian randomization analysis
Wang W, Ma L, Liu M, Zhao Y, Ye W, Li X.
BMC Neurol. 2025 Mar 8;25(1):98. doi: 10.1186/s12883-025-04098-4.
Causal role of mitochondrial proteins in aortic aneurysms: Evidence from Mendelian randomization, transcriptomic analysis, and experimental validation
Abodulikemu A, Li L, Juaiti M.
Medicine (Baltimore). 2025 Mar 7;104(10):e41757. doi: 10.1097/MD.0000000000041757.
Comprehensive causal analysis between autoimmune diseases and glioma: A Mendelian randomization study
Deng N, Agila R, He Q, You C, Zheng S.
Medicine (Baltimore). 2025 Mar 7;104(10):e41815. doi: 10.1097/MD.0000000000041815.
The associations between circulating amino acids and arterial aneurysms and dissection: A bidirectional Mendelian randomization study
Li X, Ma Y, Jiang Q, Zhan H, Sun X.
Int J Cardiol Cardiovasc Risk Prev. 2025 Mar 7;25:200388. doi: 10.1016/j.ijcrp.2025.200388.
Positive causal association between diabetes and osteomyelitis, mediated by glycosylated hemoglobin and BMI: Evidence from a Mendelian randomization study
Zhang K, Geng M, Zhang P.
Medicine (Baltimore). 2025 Mar 7;104(10):e41688. doi: 10.1097/MD.0000000000041688.
Bidirectional causal relationships between the skin microbiome and psoriasis: Insights from Mendelian randomization analysis
Xu S, Yang K, Qiu J, Zhong J, Xian D.
Medicine (Baltimore). 2025 Mar 7;104(10):e41736. doi: 10.1097/MD.0000000000041736.
Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson’s disease treatment through network pharmacology and transcriptomics
Xu QH, Wang YL, Wang C, Jiang SS, Zhang BR, Tian J.
Sci Rep. 2025 Mar 6;15(1):7847. doi: 10.1038/s41598-025-91344-x.
Cardiovascular diseases and risk of dementia in the general population
Luo J, Rasmussen IJ, Nordestgaard BG, Tybjærg-Hansen A, Thomassen JQ, Frikke-Schmidt R.
Eur J Prev Cardiol. 2025 Mar 6:zwaf129. doi: 10.1093/eurjpc/zwaf129.
Multi-omics study on autophagic dysfunction molecular network in the pathogenesis of rheumatoid arthritis
Jiang P, Zhao Y, Jia Y, Ma H, Guo Y, Yan W, Xi X.
J Transl Med. 2025 Mar 5;23(1):274. doi: 10.1186/s12967-025-06288-7.
Genetic drivers and clinical consequences of mosaic chromosomal alterations in 1 million individuals
Zhao K, Pershad Y, Poisner HM, Ma X, Quade K, Vlasschaert C, Mack T, Khankari NK, von Beck K, Brogan J, Kishtagari A, Corty R, Li Y, Xu Y, Reiner AP, Scheet P, Auer P, Bick AG.
medRxiv 2025.03.05.25323443; doi: https://doi.org/10.1101/2025.03.05.25323443
Snapshot of disease continuum centered on Alzheimer's disease: Exploring modifiable risk factors
Zheng M.
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Mar 5;138:111316. doi: 10.1016/j.pnpbp.2025.111316.
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture
Zhang G, Zheng J, Zhou Y, Zhou M, Zhang J, Liu Y, Geng Y, Wang W, Xin M, Yang B, Zhang L, Huang L.
BMC Oral Health. 2025 Mar 5;25(1):340. doi: 10.1186/s12903-025-05735-7.
The relationship between amino acids and gastroesophageal reflux disease: evidence from a mendelian randomization analysis combined with a meta-analysis
Shen J, Guo Y, Cao R.
Front Immunol. 2025 Mar 4;16:1420132. doi: 10.3389/fimmu.2025.1420132.