Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

Heinäkuu

Borzoi-informed fine mapping improves causal variant prioritization in complex trait GWAS
Srivastava D, Korsakova A, Wang Q, Ruiz L, Yuan H, Kelley DR.
bioRxiv 2025.07.09.663936; doi: https://doi.org/10.1101/2025.07.09.663936
Immune cells mediate the association between the plasma lipidome and pancreatic cancer: a Mendelian randomization analysis
Chunhong Ma, Dandan Liu, Changchun Ye, Zilu Chen, Ranran Kong, Jianzhong Li, Xuejun Sun, Zhengshui Xu
Sci Rep 15, 24451 (2025). https://doi.org/10.1038/s41598-025-05898-x
The Causal Relationship Between Atrial Fibrillation and Work and Sleep
Wu X, Liu F, Jin L, Huo M, Chen J, Song R, Shi X, Gao H.
Int Heart J. 2025 Jul 9. doi: 10.1536/ihj.24-660.
Dissecting the pleiotropic genetic architecture linking telomere biology to chronic respiratory diseases and lung function
Zhang P, Zheng L, Qiao J, Fan Y, Chang S, Ning Y, Yang Y, Liu M, Hao X, Gao J, Feng Y.
medRxiv 2025.07.09.25331189; doi: https://doi.org/10.1101/2025.07.09.25331189
Low-density lipoprotein cholesterol mediates the causal association between systemic lupus erythematosus and asthma: a mediation mendelian randomization study
Hui Yin, Tongxia Wang, Lin Liu, Zhi Hu
BMC Rheumatol 9, 85 (2025). https://doi.org/10.1186/s41927-025-00539-2
The role of mitochondria-related proteins in inflammation and autoimmune diseases: a causal analysis using Mendelian randomization and colocalization
Hong Y.
Health Inf Sci Syst. 2025 Jul 8;13(1):42. doi: 10.1007/s13755-025-00358-2.
Exploring the role of inflammation, immunity, and metabolism in colorectal cancer via mendelian randomization approach
Li Zhou, Mingjing Liao, Leilei Zhang, Tingting Peng, Chengyun Han, Qiang Zeng, Xuanrong Huan, Anya Dai, Zhongyan Gao, Jie Li, Jia Tang, Jie Chen, Yuan Li, Jiwang Zhang
Sci Rep 15, 24466 (2025). https://doi.org/10.1038/s41598-025-10318-1
The host genes influencing Clostridioides difficile infection and the potential role of intestinal Lactobacillus acidophilus: a Mendelian randomization and animal model study
Yuxin Sun, Wenzhen Zhou, Senlin Ma, Qiuxin Lu, Yinuo Yuan, Yanchao Zheng, Yifan Yang, Kangshuai Zhou, Qingjiang Chen, Gonghao Sun, Zhaoming Shang, Junwei Qian, Xiaofei Jiang, Mingquan Chen
Front. Cell. Infect. Microbiol., 08 July 2025 Sec. Intestinal Microbiome Volume 15 - 2025 | https://doi.org/10.3389/fcimb.2025.1607476
Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental Validation
Chen Y, Guo C, Liang X, Chi X, Zhang Z, Chang Z, Zhang Y.
Cell Mol Neurobiol. 2025 Jul 7;45(1):66. doi: 10.1007/s10571-025-01583-9.
A Causal Inference Study of Circulating Metabolites Mediating the Effect of Obesity-Related Indicators on the Incidence of Anxiety Disorders
Qin C, Gai W.
Brain Behav. 2025 Jul;15(7):e70653. doi: 10.1002/brb3.70653.
Differential association of platelet indices in NAFLD/NASH: a Mendelian randomized study
Huang H, Bai Y, Zhao Y, Sun X.
Eur J Gastroenterol Hepatol. 2025 Jul 7. doi: 10.1097/MEG.0000000000003029.
Recessive FANCM cancer syndrome with high cancer risks, chemotherapy toxicity, chromosome fragility and gonadal failure
Nynäs E, Sulkava S, Nurmi AK, Suvanto M, Aittomäki K; FinnGen; Nevanlinna H.
Genet Med. 2025 Jul 7:101521. doi: 10.1016/j.gim.2025.101521.
Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation
Liao W, Jiang Y, Zhang J, Wu Y, Yu X, Chen S, Liu H, Xiu L, Zhong G.
Microbiol. 2025 Jul 7;16:1621167. doi: 10.3389/fmicb.2025.1621167.
Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis
Chen J, Zhuo X, Ling Y, Zhu Y, Li Y, Shen X, Zhuo Y, Tan H, Li Z.
Transl Vis Sci Technol. 2025 Jul 1;14(7):6. doi: 10.1167/tvst.14.7.6.
Dual Functions and Therapeutic Potential of FZD6 in Biliary Atresia
Xinying Wang, Hongkun Lai, Ledong Tan, Ying Wen, Yanlu Tong, Lin Huang, Jiachi Liao, Yingyi Xu, Le Li, Ming Fu, Zefeng Lin
Dig Dis Sci (2025). https://doi.org/10.1007/s10620-025-09154-0
Multi-Omics Analysis and Validation of Cell Senescence-Related Genes Associated with Non-Alcoholic Fatty Liver Disease
Gong J, Qin Z, Xiao Y, Li J, Wang Q, Lei L, Li J.
J Inflamm Res. 2025 Jul 5;18:8821-8833. doi: 10.2147/JIR.S525168.
Genetic evidence for causal links between diet, gut microbiota, and hepatobiliary cancer: a Mendelian randomization study
Runze Huang, Xin Jin, Qinyu Liu, Xuanci Bai, Yibin Wu, Yixiu Wang, Xigan He, Ziting Jiang, Lu Wang, Weiping Zhu
AMB Expr 15, 100 (2025). https://doi.org/10.1186/s13568-025-01910-9
Causal association between cathepsins and asthma: a Mendelian randomization study
Qiu F, Shao W, Qin X, Xu R, Liu Y, Lu H.
Sci Rep. 2025 Jul 4;15(1):23984. doi: 10.1038/s41598-025-08457-6.
Genome-Wide Association Study of COVID-19 Breakthrough Infections and Genetic Overlap with Other Diseases: A Study of the UK Biobank
Feng Y, Wong KC, Tsui WK, Zhang R, Xiang Y, So HC.
Int J Mol Sci. 2025 Jul 4;26(13):6441. doi: 10.3390/ijms26136441.
Cathepsin H increases the risk of diabetic retinopathy: evidence from Mendelian randomization and bioinformatic analysis
Xiudao Song, Jin Ma, Ting Zou, Rong Xin Lu, Wei Ji, Fei Huang, Meiqi Yin
Diabetol Metab Syndr 17, 255 (2025). https://doi.org/10.1186/s13098-025-01829-y
Migraine and cochlear disease: A 2-sample bidirectional Mendelian randomized study
Zhong C, Wang LH, Dong Y, Zhang HP, Ji L, Guo Y.
Medicine (Baltimore). 2025 Jul 4;104(27):e42418. doi: 10.1097/MD.0000000000042418.
Multi-omics analysis identifies SNP-associated immune-related signatures by integrating Mendelian randomization and machine learning in hepatocellular carcinoma
Qingyan Kou, Zhichao Wu, Wenbin Zhao, Zhenyuan Liu, Shengxian Qiao, Qiang Mu, Xu Zhang
Sci Rep 15, 23930 (2025). https://doi.org/10.1038/s41598-025-09010-1
Sedentary behaviors, physical activity, and risk of allergic rhinitis and asthma: evidence from cohort and Mendelian randomization studies
Xiaoyu Wang, Yaya Gao, Lin Lou, Wenjie Yang, Wei Xu, Yu Zhao, Jianjun Ren
BMC Pulm Med 25, 320 (2025). https://doi.org/10.1186/s12890-025-03779-7
Genome-wide Association Study Identifies SORCS3 as a Novel Susceptibility Locus for Panic Disorder in the FinnGen Study
Naamanka J, Tasanko E, Trontti K, Novak B, Kinnunen V, Suvisaari J, Paunio T, Vaht M, Zhou W, Kurki M, Reinhart J, Boschet-Lange J, Pittig R, Pittig A, Misiewicz Z, Mattheisen M, Meier S, Binder EB, Metspalu A, Daly M, Turck CW, Erhardt-Lehmann A, Hartiala J, Hovatta I.
medRxiv 2025.07.03.25330813; doi: https://doi.org/10.1101/2025.07.03.25330813
Identification of key genes as diagnostic biomarkers for IBD using bioinformatics and machine learning
Li T, Jing H, Gao X, Zhang T, Yao H, Zhang X, Zhang M.
J Transl Med. 2025 Jul 3;23(1):738. doi: 10.1186/s12967-025-06531-1.
Association between keloid and mental disorders: perspective from genetic evidence
Ying Zhan, Yanan Tong, Xiaodan Wu, Zhiguo Wang, Guoxu Zhang
Ann Gen Psychiatry 24, 42 (2025). https://doi.org/10.1186/s12991-025-00579-5
Etiological basis for chronic pain genetic variation in brain and dorsal root ganglia cell types
Toikumo S, Parisien M, Leone MJ, Srinivasan C, Yu H, Arendt-Tranholm A, Franco-Enzástiga U, Hofstetter C, Curatolo M, Luo W, Pfenning AR, Seal RP, Kember RL, Price TJ, Diatchenko L, Waxman SG, Kranzler HR.
medRxiv 2025.07.03.25330832; doi: https://doi.org/10.1101/2025.07.03.25330832
Mendelian Randomization Analysis Reveals Causal Associations Between Autoimmune Diseases and Female Infertility Risk
Wang J, Long H, Su M, Cao Y, Zhou R, Li X, Li J, Tang Y, Tang J, Wang S, Tang L, Chen R, Deng D, Tang L.
Reprod Toxicol. 2025 Jul 2:108984. doi: 10.1016/j.reprotox.2025.108984.
Genetic susceptibility to cerebral palsy involves complement system-mediated neuronal development and plasticity pathway
Huang Kun, Qi Zhou, Hao Wu, Dejiang Yang, Chongyu Xiong, Xiaowei Zhang
Sci Rep 15, 23088 (2025). https://doi.org/10.1038/s41598-025-07178-0
Investigating the potential role of EIF2S2 in OSCC progression through comprehensive bioinformatics analysis and experimental validation
Zhiwen Shao, Tao Dong, Ke Yun, Zhaohui Wang, Yu Wen, Zongli Zhang, Tao Jia
Eur J Med Res 30, 562 (2025). https://doi.org/10.1186/s40001-025-02830-x
Functional determinants and evolutionary consequences of pleiotropy in complex and Mendelian traits
Guanglei Chen, Yaxian Jin, Cancan Chu, Yuhao Zheng, Changfu Yang, Yunzhi Chen, Xing Zhu
Sci Rep 15, 21633 (2025). https://doi.org/10.1038/s41598-025-05290-9
Linking obstructive sleep apnea with pulmonary hypertension via pooled prevalence and causal association: A systematic review, meta-analysis and Mendelian randomization
Du D, Qin J, Hu X, Xu D, Gao L, Wu Y, Chen M, Chen Z, Luo F, Shen Y.
Heart Lung. 2025 Jul 2;74:82-89. doi: 10.1016/j.hrtlng.2025.06.009.
Autism spectrum disorders and childhood caries: a comprehensive Mendelian randomization study
Qiufang Jin, Zexiu He, Dongfang Xu, Ruihua Lin, Tongtong Zhang, Bingjian Lv, Yuliang Zhao
BMC Pediatr 25, 484 (2025). https://doi.org/10.1186/s12887-025-05839-7
Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis
Nan Li, Chuan He
Sci Rep 15, 23618 (2025). https://doi.org/10.1038/s41598-025-07962-y
Detecting a potential causal relationship between plasma metabolites and myocardial infarction using bidirectional and two-step Mendelian randomization
Yang M, Wang M, Li J, Li M, Liu X, Li Y, Xue Y.
Sci Rep. 2025 Jul 2;15(1):23008. doi: 10.1038/s41598-025-04687-w.
Exploring the Causal Relationship Between Antidepressant Use and Lung Cancer Risk: A Mendelian Randomization Analysis
Yang C, Xu W.
Clin Respir J. 2025 Jul;19(7):e70102. doi: 10.1111/crj.70102.
Real-world data and Mendelian randomization analysis in assessing adverse reactions of rilonacept
Lihong Liu, Zhenfei Chi, Zhe Zhang
Int J Clin Pharm 47, 1365–1374 (2025). https://doi.org/10.1007/s11096-025-01932-0
Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis
Li Y, Wang Y, Chen S, Liu L.
Sci Rep. 2025 Jul 1;15(1):21499. doi: 10.1038/s41598-025-08633-8.
Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for stroke
Xueling Zhao, Menghao He, Desheng Zhou, Zhong Li, Lijuan Liu, Renyi Yang, Xinhua Zhu, Cuilan Gong, Siyang Yan
BMC Neurol 25, 255 (2025). https://doi.org/10.1186/s12883-025-04239-9
The mediating factors between systemic lupus erythematosus and prostate cancer risk: a two-step Mendelian randomization and transcriptome analysis
Siwen Zhong, Wei Li, Xingliang Yang, Jun Qiao, Quliang Zhong, Yuan Tian, Peng Chen, Yuewei Tao, Fa Sun, Tao Li
Discov Onc 16, 1199 (2025). https://doi.org/10.1007/s12672-025-03046-5
Frailty and the Risk of Delirium: A Mendelian Randomization Study
Yu M, Li B.
Crit Care Nurs Q. 2025 Jul-Sep 01;48(3):316-324. doi: 10.1097/CNQ.0000000000000565.
Genetic evidence suggests a causal relationship linking thyroid function to prospective memory and dementia and Parkinson’s disease
Yang Wang, Yanying Liu,Huimin Yang, Zhuang Mo, Haiyan Liu, Qi Yu
Sci Rep 15, 21633 (2025). https://doi.org/10.1038/s41598-025-05290-9
Genetic prediction of immune cells, inflammatory proteins, and metabolite-mediated association between gut microbiota and COPD: a Mendelian randomization study
Guanglei Chen, Yaxian Jin, Cancan Chu, Yuhao Zheng, Changfu Yang, Yunzhi Chen, Xing Zhu
Sci Rep 15, 21633 (2025). https://doi.org/10.1038/s41598-025-05290-9
Loss of CFHR5 function reduces the risk for age-related macular degeneration
Reeve MP, Loomis S, Nissilä E, Soare TW, Rausch T, Zheng Z, Della Briotta Parolo P, Ben-Isvy D, Aho E, Cesetti E, Okunuki Y, McLaughlin H, Mäkelä J; FinnGen; Kurki M, Talkowski ME, Korbel JO, Connor K, Meri S, Daly MJ, Runz H.
Nat Commun. 2025 Jul 1;16(1):5766. doi: 10.1038/s41467-025-61193-3.
Investigating the potential of oxidative stress-related gene as predictive markers in idiopathic pulmonary fibrosis
Wang Y, Zhang Z, Zhang H, Xu L, Huang S, Wen Y, Zhuang Z, Li X, Lu J, Li X.
Sci Rep. 2025 Jul 1;15(1):21228. doi: 10.1038/s41598-025-02579-7.
Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants
Franz Förster, David Emmert, Katrin Horn, Janne Pott, Johannes Frasnelli, Mohammed Aslam Imtiaz, Konstantinos Melas, Valentina Talevi, Honglei Chen, Christoph Engel, Michele Filosi, Myriam Fornage, Martin Gögele, Markus Löffler, Cristian Pattaro, Peter Pramstaller, Srishti Shrestha, N. Ahmad Aziz, Monique M. B. Breteler, Kerstin Wirkner, Markus Scholz, Christian Fuchsberger
Nat Commun 16, 5434 (2025). https://doi.org/10.1038/s41467-025-61330-y
The role of immune cells in cirrhosis: evidence from a two-sample Mendelian randomization study
Chen Y, Wang K, Liu Y, Zeng H, Long H, Kang J, Wang S, He J.
Sci Rep. 2025 Jul 1;15(1):20737. doi: 10.1038/s41598-025-07325-7.
Mendelian randomization study reveals causal association between skin microbiome and skin cancers
Yong He, Liming Li, Yuancheng Li, Xiaoke Wang, Leqi Qian, Jiajia Yang, Mingjun Jiang
Sci Rep 15, 21590 (2025). https://doi.org/10.1038/s41598-025-07265-2
Association of air pollution, lifestyle factors, and metabolic syndrome: a Mendelian randomization study
Sijie Gu, Fulei Chen, Teng Li, Huanyu Hu, Mulatibieke Keerman, Qiang Niu, Heng Guo, Shuxia Guo, Jia He
Researchsquare, 01 July 2025, doi: 10.21203/rs.3.rs-6966151/v1
Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study
Kuang X, Wu B, Hu D, Matsika J, Cheng C, Xiao J, Cai Z, Li M, Chen J, Zhou W, Liu B.
Discov Oncol. 2025 Jul 1;16(1):1226. doi: 10.1007/s12672-025-03010-3.