På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2025

Juli

The role of immune cells in cirrhosis: evidence from a two-sample Mendelian randomization study
Chen Y, Wang K, Liu Y, Zeng H, Long H, Kang J, Wang S, He J.
Sci Rep. 2025 Jul 1;15(1):20737. doi: 10.1038/s41598-025-07325-7.
Mendelian randomization study reveals causal association between skin microbiome and skin cancers
Yong He, Liming Li, Yuancheng Li, Xiaoke Wang, Leqi Qian, Jiajia Yang, Mingjun Jiang
Sci Rep 15, 21590 (2025). https://doi.org/10.1038/s41598-025-07265-2
Association of air pollution, lifestyle factors, and metabolic syndrome: a Mendelian randomization study
Sijie Gu, Fulei Chen, Teng Li, Huanyu Hu, Mulatibieke Keerman, Qiang Niu, Heng Guo, Shuxia Guo, Jia He
Researchsquare, 01 July 2025, doi: 10.21203/rs.3.rs-6966151/v1
Loss of CFHR5 function reduces the risk for age-related macular degeneration
Reeve MP, Loomis S, Nissilä E, Soare TW, Rausch T, Zheng Z, Della Briotta Parolo P, Ben-Isvy D, Aho E, Cesetti E, Okunuki Y, McLaughlin H, Mäkelä J; FinnGen; Kurki M, Talkowski ME, Korbel JO, Connor K, Meri S, Daly MJ, Runz H.
Nat Commun. 2025 Jul 1;16(1):5766. doi: 10.1038/s41467-025-61193-3.
Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study
Kuang X, Wu B, Hu D, Matsika J, Cheng C, Xiao J, Cai Z, Li M, Chen J, Zhou W, Liu B.
Discov Oncol. 2025 Jul 1;16(1):1226. doi: 10.1007/s12672-025-03010-3.
Exploring the role of immune cell traits and circulating inflammatory cytokines in the development of diabetic neuropathy
Guo N, Li Q, Wang H, Li P.
Cytokine. 2025 Jul 1;194:156985. doi: 10.1016/j.cyto.2025.156985.
Causal association of antibody-mediated immune responses to infectious disease agents with lung cancer: a Mendelian randomization study
Guicai Liang, Lyubo Wang, Zhiqiang Wang, Tao Li, Lei Jiang, Yuncheng Bai, Lei Yang, Yi Feng, Yan Li, Meng Yang, Jiling Chang, Haiyue Yang, Xilong Zhou, Lincan Duan, Chunlei Ge
Discov Onc 16, 1234 (2025). https://doi.org/10.1007/s12672-025-02997-z
Gut microbiota constituents may affect hypertrophic scarring risk through interaction with specific immune cells in a two-step, two-sample Mendelian randomization study
Jiaqi Lou, Ziyi Xiang, Xiaoyu Zhu, Jiliang Li, Guoying Jin, Shengyong Cui, Neng Huang, Pei Xu, Sida Xu, Youfen Fan, Xin Le
Sci Rep 15, 20656 (2025). https://doi.org/10.1038/s41598-025-07455-y
Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis
Li Y, Wang Y, Chen S, Liu L.
Sci Rep. 2025 Jul 1;15(1):21499. doi: 10.1038/s41598-025-08633-8.
Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for stroke
Xueling Zhao, Menghao He, Desheng Zhou, Zhong Li, Lijuan Liu, Renyi Yang, Xinhua Zhu, Cuilan Gong, Siyang Yan
BMC Neurol 25, 255 (2025). https://doi.org/10.1186/s12883-025-04239-9
The mediating factors between systemic lupus erythematosus and prostate cancer risk: a two-step Mendelian randomization and transcriptome analysis
Siwen Zhong, Wei Li, Xingliang Yang, Jun Qiao, Quliang Zhong, Yuan Tian, Peng Chen, Yuewei Tao, Fa Sun, Tao Li
Discov Onc 16, 1199 (2025). https://doi.org/10.1007/s12672-025-03046-5

Juni

Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signatures
Kim MS, Song M, Kim H, Park S, Shim I, Lim S, Kim B, Chen X, Sui Y, Cho SMJ, Koyama S, Yun J-S, Natarajan P, Ellinor PT, Fahed AC, Won H-H.
medRxiv 2025.06.30.25330607; doi: https://doi.org/10.1101/2025.06.30.25330607
Investigation of potential toxicity associated with long-term amitriptyline exposure: Evidence from genomics
Liu J, Li Z, Deng Z, Wang Y, Deng F.
Ecotoxicol Environ Saf. 2025 Jun 30;302:118587. doi: 10.1016/j.ecoenv.2025.118587.
The causal and mediated relationships between major depressive disorder (MDD), post-traumatic stress disorder (PTSD), anxiety disorders and premature mortality: Evidence from genome-wide association study
Wu C, Tong S, You Y, Li Y, Cai R, Fang J, Fang X, Zhang X.
J Affect Disord. 2025 Jun 30:119781. doi: 10.1016/j.jad.2025.119781.
Single-cell multi-omic integration analysis prioritizes druggable genes and reveals cell-type-specific causal effects in glioblastomagenesis
Huang Y-F, Huang K-L.
medRxiv 2025.06.28.25330486; doi: https://doi.org/10.1101/2025.06.28.25330486
Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves' Ophthalmopathy: A Mendelian Randomization Study
Li Y, Chen L, Lin S, An W, Miao L, Wan M, Zhang B.
Transl Vis Sci Technol. 2025 Jun 2;14(6):34. doi: 10.1167/tvst.14.6.34.
Genome-wide Cross-multi-trait Analysis into Shared Genetic Architecture of Coronary Artery Disease and Aortic Aneurysms
Virkkala J, FINNGEN, Kettunen J, Kaikkonen MU.
medRxiv 2025.06.27.25330395; doi: https://doi.org/10.1101/2025.06.27.25330395
Identification of Potential Therapeutic Targets for Coronary Atherosclerosis from an Inflammatory Perspective Through Integrated Proteomics and Single-Cell Omics
Wang H, Xie F, Wang M, Ji J, Song Y, Dai Y, Wang L, Kang Z, Cao L.
Int J Mol Sci. 2025 Jun 27;26(13):6201. doi: 10.3390/ijms26136201.
Glatiramer Acetate Reduces Risk of Cardiovascular Disease and Myocardial Infarction
Lehrer S, Rheinstein PH.
In Vivo. 2025 Jul-Aug;39(4):2066-2072. doi: 10.21873/invivo.14001.
Uncovering the Molecular Landscape of Physical Activity: Proteomic Insights from the UK Biobank
Qian H, Wu C, Yang Y, Li B, Rosenzweig A, Wang M.
medRxiv 2025.06.27.25330418; doi: https://doi.org/10.1101/2025.06.27.25330418
Association between gut microbiota and disorders of lipoprotein metabolism: a two sample Mendelian randomization study
Du Q, Chen Y, Kou C, Wei J, Xu R, Cao Y, Yu L, Kou X.
Nutr Metab Cardiovasc Dis. 2025 Jun 27:104212. doi: 10.1016/j.numecd.2025.104212.
Genetic mapping of lifespan and mitochondrial stress response in C. elegans
Li X, Li W, Gao AW, Zhu Y, Katsyuba E, Overmyer KA, Li TY, Wang Z, Legon L, Plantade L, Mouchiroud L, Cornaglia M, Li H, Houtkooper RH, Coon JJ, Auwerx J.
bioRxiv 2025.06.26.661693; doi: https://doi.org/10.1101/2025.06.26.661693
The influence of 179 lipid metabolism on head and neck cancer is mediated by 91 inflammatory factors
Hua S, Lang T, Liu R.
Community Dent Health. 2025 Jun;42(2):17-26. doi: 10.1177/0265539X251343832
Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization
Li H, Yue F, Gu X, Guan H, Chen K, Zhang J, Ji H, He J.
Eur Arch Psychiatry Clin Neurosci. 2025 Jun 26. doi: 10.1007/s00406-025-02048-2.
Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression
Xiong Y, Krebs K, Jermy B, Karlsson R, Pasman JA, Nguyen TD, Gong T, Kowalec K, Rück C, Sigström R, Jonsson L, Clements CC, Hörbeck E, Andersson E, Bäckman J; FinnGen; Estonian Biobank Research Team; Ganna A, German J, Sullivan PF, Landén M, Lehto K, Lu Y.
Mol Psychiatry. 2025 Jun 26. doi: 10.1038/s41380-025-03084-z.
Genetic associations between Serotonin Receptor 1F (HTR1F) regulatory variation and sleep apnea in non-obese individuals: Insights from GWAS and eQTL analyses
Strausz S, Broberg M, Jones SE, Koskela J, Kiiskinen T, FinnGen; Estonian Biobank Research Team; Palotie A, Palotie T, Bachour A, Saxena R, Ripatti S, Abner E, Ollila HM.
Eur Respir J. 2025 Jun 26:2401778. doi: 10.1183/13993003.01778-2024.
Genetic associations between serotonin receptor 1F (HTR1F) regulatory variation and sleep apnoea in non-obese individuals: insights from GWAS and eQTL analyses
Strausz S, Broberg M, Jones SE, Koskela J, Kiiskinen T; FinnGen; Estonian Biobank Research Team; Palotie A, Palotie T, Bachour A, Saxena R, Ripatti S, Abner E, Ollila HM.
Eur Respir J. 2025 Sep 17;66(3):2401778. doi: 10.1183/13993003.01778-2024. Print 2025 Sep.
Bayesian-weighted Mendelian randomization reveals sleep apnea syndrome mediates the BMI-chronic pain link
Shi W, Luo J, Yang L, Chen D, Zhang Y, Peng J, Ruetzler K, Sun M, Jin H.
J Thorac Dis. 2025 Jun 30;17(6):4091-4103. doi: 10.21037/jtd-2025-827.
Homocysteine and risk of interstitial lung disease: A mendelian randomization approach to causal inference
Li S, Hu X, Hu X, Liu H, Meng S.
Sarcoidosis Vasc Diffuse Lung Dis. 2025 Jun 25;42(2):16386.
The Casual Associations Between Brain Functional Networks and Fibromyalgia: A Large-Scale Genetic Correlation and Mendelian Randomization Study
Hu Y, Yang G, Deng Z, Yang S, Li Y, Xiao W, Lu B, Zhu X.
Bioengineering (Basel). 2025 Jun 25;12(7):692. doi: 10.3390/bioengineering12070692.
Causal relationship between varicose veins and hydrocele: A bidirectional two-sample Mendelian randomization study
Guo C, Qu Y, Liu H.
SAGE Open Med. 2025 Jun 25;13:20503121251338670. doi: 10.1177/20503121251338670.
Uncovering Putative Causal Non-Coding RNAs in Acute and Chronic Myeloid Leukemia: A Genome-Wide Mendelian Randomization Study
Jung S, Kim JW, Han B.
Cancer Res Treat. 2025 Jun 25. doi: 10.4143/crt.2025.377.
Assessing the Causal Effect of Pulse Pressure on Migraine Risk: A Mendelian Randomization Study
Xu H, Qin X, Feng Z, You S.
J Pain Res. 2025 Jun 25;18:3159-3170. doi: 10.2147/JPR.S512795.
Identification of novel therapeutic targets for cognitive performance and associations with brain health
Lu-Yang Zhang, Yu-Xin Liu, Yun-Hui Chu, Yun-Fan You, Luo-Qi Zhou, Sheng Yang, Ming-Hao Dong, Hang Zhang, Xiao-Wei Pang, Lian Chen, Li-Fang Zhu, Jun Xiao, Ke Shang, Wei Wang, Chuan Qin, Dai-Shi Tian
Transl Psychiatry 15, 214 (2025). https://doi.org/10.1038/s41398-025-03437-w
Mendelian Randomization of Serum Micronutrients in relation to Lower Back Pain and Sciatica protection: focus on Vitamin A
Yan Gu, Dalong Liu, Tianyang Chen, Zihao Zhang, Zhaoliang Chen, Tianqi Gao, Chenglong Ai, Xiangyang Leng
Researchsquare, 24 June 2025, doi: 10.21203/rs.3.rs-6809845/v1
Causal Associations Between Socioeconomic Status, Intelligence, Cognition and Atrial Fibrillation: Evidence From Mendelian Randomization
Kaisaier W, Ye M, Wu Z, Liu C, He J, Lip GYH, Chen Y, Zhu W.
JACC Asia. 2025 Jun 2:S2772-3747(25)00265-0. doi: 10.1016/j.jacasi.2025.04.008.
Multi-population GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish
Wolford BN, Zhao QY, Wu KH, Yu X, Richter CE, Bhatta L, Brumpton BM, Desch KC, Thibord F, Klarin D, Johnson AD, Tregouet DA, Damrauer SM, Smith NL, Lo Faro V, Tsuo K, Daly M, Neale B, Zhou W, Willer CJ, Shavit JA, Surakka I.
Blood Adv. 2025 Jun 24:bloodadvances.2024015790. doi: 10.1182/bloodadvances.2024015790.
Causal Associations Between 141 Gut Microbiota Taxa and 14 Rheumatic Diseases: A Mendelian Randomization Study
Hu Y, He H, Zhang Y, Lyu H, Zeng C, Wei J, Lei G.
Int J Rheum Dis. 2025 Jun;28(6):e70334. doi: 10.1111/1756-185X.70334.
Mendelian Randomization Analyses Support Causal Relationship between Brain Imaging-derived Phenotypes and Risk of Low Back Pain
Xie XY, Lin JW, Fang JY, Chen ZC, Li PC, Huang XY, Guo MY, Lin LL, Cao MH.
Brain Res Bull. 2025 Jun 24:111440. doi: 10.1016/j.brainresbull.2025.111440.
Metformin reduces the risk of frailty: evidence from a Mendelian randomization study
Tong Chen, Yan-Lan Liu, Hui-Na Qiu, Chen-Ying Lin, Fan Wu, Jing-Bo Li, Jing-Na Lin
Diabetol Metab Syndr 17, 239 (2025). https://doi.org/10.1186/s13098-025-01825-2
Endometriosis and Ovarian Cancer: Insights from NHANES and Mendelian Randomization Analysis
Dong Liu, Yuke Wu, Kunyan Zhou
Reprod. Sci. 32, 2283–2294 (2025). https://doi.org/10.1007/s43032-025-01910-x
PARK7 is a Key Regulator of Oxidative Stress - Related Breast Cancer Risk: A Multi-Omics Study
Wang T, Yao Y, Zhang M, Luan H, Chang X, Liu L, Sun C.
J Cancer. 2025 Jun 23;16(9):2877-2889. doi: 10.7150/jca.111796.
Barrier genes are associated with preterm birth
Chen KR, Chu SK, Kuo PL.
Front Med (Lausanne). 2025 Jun 23;12:1580877. doi: 10.3389/fmed.2025.1580877.
From Hypothyroidism to Coronary Heart Disease: Unraveling the Lipid Profile Link: A Mendelian Randomization Study
Li J, Long S, Liu B, Hong S, Yu S, Li Y, Wu D, Xiao H.
J Endocr Soc. 2025 Jun 23;9(9):bvaf108. doi: 10.1210/jendso/bvaf108.
Dissecting the Genetic Relationship Between Severe Mental Disorders and Autoimmune Diseases
Wiström ED, Fuhrer J, Shadrin A, Fominykh V, O’Connell KS, Jaholkowski P, Steen NE, Stinson SE, Parekh P, Frei O, Rødevand L, Parker N, Haavik J, Djurovic S, Dale AM, Andreassen OA, Smeland OB.
medRxiv 2025.06.22.25330080; doi: https://doi.org/10.1101/2025.06.22.25330080
A Mendelian randomization analysis reveals the role of the skin microbiota in systemic lupus erythematosus
Yangqi Yin, Jingting Zhao, Zhongbin Tao, Jie Wang
Clin Rheumatol 44, 3191–3199 (2025). https://doi.org/10.1007/s10067-025-07556-z
Decoding coffee's chlorogenic acid: genetic-network pharmacology insights on kidney stones
Hou X, Meng H, Ying D, Tian R, Guo X, Li B, Chen Y.
Urolithiasis. 2025 Jun 21;53(1):124. doi: 10.1007/s00240-025-01776-3. PMID: 40542847.
Identifying potential pathogenic oxidative stress-related genes in depression through multi-omics summary-data-based Mendelian randomization analysis
Cheng J, Liu Z, Zhu R, Liu Q, Han H, Liu N, Shi J, Han S, Ma N.
J Affect Disord. 2025 Jun 20;388:119734. doi: 10.1016/j.jad.2025.119734.
Multi-omics Mendelian randomization study on the causality between non-ionizing radiation and facial aging
He ZC, Shang YX, Xu XP, Jia CY, Wang YP.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2025 Jun 20;41(6):594-603. Chinese. doi: 10.3760/cma.j.cn501225-20240830-00320.
Evidence from Mendelian randomization analysis combined with meta-analysis for the causal validation of the relationship between 35 blood and urine metabolites and lumbar disc herniation
Yang J, Xu W, Chen D, Yang H, Zhou Z.
Medicine (Baltimore). 2025 Jun 20;104(25):e42749. doi: 10.1097/MD.0000000000042749.