Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2020

Syyskuu

An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study
Yuan S, Larsson SC.
Diabetologia. 2020 Nov;63(11):2359-2371. doi: 10.1007/s00125-020-05253-x.
Sleep duration and risk of overall and 22 site-specific cancers: A Mendelian randomization study
Titova OE, Michaëlsson K, Vithayathil M, Mason AM, Kar S, Burgess S, Larsson SC.
Int J Cancer. 2021 Feb 15;148(4):914-920. doi: 10.1002/ijc.33286.

Elokuu

Assessing the efficacy and safety of angiotensinogen inhibition using human genetics
Bovijn J, Censin JC, Lindgren CM, Holmes MV.
medRxiv 2020.08.13.20174094; doi: https://doi.org/10.1101/2020.08.13.20174094.

Heinäkuu

A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling
Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V; FinnGen Study, Trégouët DA, Morange PE, Civelek M, Ben-Shlomo Y, Schlaeger T, Chen MH, Johnson AD.
Am J Hum Genet. 2020 Aug 6;107(2):211-221. doi: 10.1016/j.ajhg.2020.06.008.

Toukokuu

Mendelian randomization analysis to characterize causal association between coronary artery disease and COVID-19
Wu L, Zhu J, Wu C.
medRxiv 2020.05.29.20117309; doi: https://doi.org/10.1101/2020.05.29.20117309
Body mass index and carpal tunnel syndrome: a Mendelian randomization study
Daghlas I, Varady N.
medRxiv 19011536; doi: https://doi.org/10.1101/19011536
Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohort
Ritari J, Hyvärinen K, Clancy J; FinnGen, Partanen J, Koskela S.
NAR Genom Bioinform. 2020 May 6;2(2):lqaa030. doi: 10.1093/nargab/lqaa030.
Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma
Tanigawa Y, Wainberg M, Karjalainen J, Kiiskinen T, Venkataraman G, Lemmelä S, Turunen JA, Graham RR, Havulinna AS, Perola M, Palotie A; FinnGen, Daly MJ, Rivas MA.
PLoS Genet. 2020 May 5;16(5):e1008682. doi: 10.1371/journal.pgen.1008682.

Huhtikuu

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Emdin CA, Haas ME, Khera AV, Aragam K, Chaffin M, Klarin D, Hindy G, Jiang L, Wei WQ, Feng Q, Karjalainen J, Havulinna A, Kiiskinen T, Bick A, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gupta N, Danesh J, Saleheen D, Chang KM, Vujkovic M, Voight B, Damrauer S, Lynch J, Kaplan D, Serper M, Tsao P; Million Veteran Program, Mercader J, Hanis C, Daly M, Denny J, Gabriel S, Kathiresan S.
PLoS Genet. 2020 Apr 13;16(4):e1008629. doi: 10.1371/journal.pgen.1008629.
Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration
Han X, Gharahkhani P, Mitchell P, Liew G, Hewitt AW, MacGregor S.
J Hum Genet. 2020 Aug;65(8):657-665. doi: 10.1038/s10038-020-0750-x.
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers
Mars N, Koskela JT, Ripatti P, Kiiskinen TTJ, Havulinna AS, Lindbohm JV, Ahola-Olli A, Kurki M, Karjalainen J, Palta P; FinnGen, Neale BM, Daly M, Salomaa V, Palotie A, Widén E, Ripatti S.
Nat Med. 2020 Apr;26(4):549-557. doi: 10.1038/s41591-020-0800-0.

Maaliskuu

Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan
Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y; FinnGen, Daly MJ, Kamatani Y, Okada Y.
Nat Med. 2020 Apr;26(4):542-548. doi: 10.1038/s41591-020-0785-8.
Polygenic Hyperlipidemias and Coronary Artery Disease Risk
Ripatti P, Rämö JT, Mars NJ, Fu Y, Lin J, Söderlund S, Benner C, Surakka I, Kiiskinen T, Havulinna AS, Palta P, Freimer NB, Widén E, Salomaa V, Tukiainen T, Pirinen M, Palotie A, Taskinen MR, Ripatti S; FinnGen†.
Circ Genom Precis Med. 2020 Apr;13(2):e002725. doi: 10.1161/CIRCGEN.119.002725.

Tammikuu

Genomic prediction of alcohol-related morbidity and mortality
Kiiskinen T, Mars NJ, Palviainen T, Koskela J, Rämö JT, Ripatti P, Ruotsalainen S; FinnGen, GSCAN Consortium, Palotie A, Madden PAF, Rose RJ, Kaprio J, Salomaa V, Mäkelä P, Havulinna AS, Ripatti S.
Transl Psychiatry. 2020 Jan 21;10(1):23. doi: 10.1038/s41398-019-0676-2.
2019

Lokakuu

Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and wildtype transthyretin amyloidoses
De Lillo A, De Angelis F, Di Girolamo M, Luigetti M, Frusconi S, Manfellotto D, Fuciarelli M, Polimanti R.
Hum Genet. 2019 Dec;138(11-12):1331-1340. doi: 10.1007/s00439-019-02078-6.
CCR5-del32 is not deleterious in the homozygous state in humans
Gudbjartsson D, Sulem P, Stefansson K, Mars N, Karjalainen J, Ripatti S, Palotie A, Daly M.
bioRxiv 788117; doi: https://doi.org/10.1101/788117.

Syyskuu

Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Tabassum R, Rämö JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Söderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M; FinnGen Project, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S.
Nat Commun. 2019 Sep 24;10(1):4329. doi: 10.1038/s41467-019-11954-8.

Heinäkuu

Exome sequencing of Finnish isolates enhances rare-variant association power
Locke AE, Steinberg KM, Chiang CWK, Service SK, Havulinna AS, Stell L, Pirinen M, Abel HJ, Chiang CC, Fulton RS, Jackson AU, Kang CJ, Kanchi KL, Koboldt DC, Larson DE, Nelson J, Nicholas TJ, Pietilä A, Ramensky V, Ray D, Scott LJ, Stringham HM, Vangipurapu J, Welch R, Yajnik P, Yin X, Eriksson JG, Ala-Korpela M, Järvelin MR, Männikkö M, Laivuori H; FinnGen Project, Dutcher SK, Stitziel NO, Wilson RK, Hall IM, Sabatti C, Palotie A, Salomaa V, Laakso M, Ripatti S, Boehnke M, Freimer NB.
Nature. 2019 Aug;572(7769):323-328. doi: 10.1038/s41586-019-1457-z.

Toukokuu

The validity of heart failure diagnoses in the Finnish Hospital Discharge Register
Vuori MA, Laukkanen JA, Pietilä A, Havulinna AS, Kähönen M, Salomaa V, Niiranen TJ; FinnGen investigators.
Scand J Public Health. 2020 Feb;48(1):20-28. doi: 10.1177/1403494819847051.