Below you will find all the published and preprint scientific papers using FinnGen data.

2021

February

A genetically-informed study disentangling the relationships between tobacco smoking, cannabis use, alcohol consumption, substance use disorders and respiratory infections, including COVID-19
Rosoff DB, Yoo J, Lohoff FW.
medRxiv 2021.02.11.21251581; doi: https://doi.org/10.1101/2021.02.11.21251581.
Genome-wide association study reveals genetic risk factors for trigeminal neuralgia
Hale AT, He J, Akinnusotu O, Sale RL, Wang J, Bastarache L, Gamazon ER.
medRxiv 2021.02.08.21251349; doi: https://doi.org/10.1101/2021.02.08.21251349.

January

Genetics of 35 blood and urine biomarkers in the UK Biobank
Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP, Qian J, Shcherbina A; FinnGen, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA.
Nat Genet. 2021 Feb;53(2):185-194. doi: 10.1038/s41588-020-00757-z.
Genetically proxied interleukin-6 receptor inhibition: opposing associations with COVID-19 and pneumonia
Larsson SC, Burgess S, Gill D.
Eur Respir J. 2021 Jan 14;57(1):2003545. doi: 10.1183/13993003.03545-2020.
Sleep apnoea is a risk factor for severe COVID-19
Strausz S, Kiiskinen T, Broberg M, Ruotsalainen S, Koskela J, Bachour A; FinnGen, Palotie A, Palotie T, Ripatti S, Ollila HM.
BMJ Open Respir Res. 2021 Jan;8(1):e000845. doi: 10.1136/bmjresp-2020-000845.
The associations of plasma phospholipid arachidonic acid with cardiovascular diseases: A Mendelian randomization study
Zhang T, Zhao JV, Schooling CM.
EBioMedicine. 2021 Jan;63:103189. doi: 10.1016/j.ebiom.2020.103189.
Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study
Luo J, le Cessie S, van Heemst D, Noordam R.
J Am Coll Cardiol. 2021 Jan 5;77(1):45-54. doi: 10.1016/j.jacc.2020.10.048.
2020

December

HeartBioPortal2.0: new developments and updates for genetic ancestry and cardiometabolic quantitative traits in diverse human populations
Khomtchouk BB, Nelson CS, Vand KA, Palmisano S, Grossman RL.
Database (Oxford). 2020 Dec 31;2020:baaa115. doi: 10.1093/database/baaa115.
Investigating Causal Relations Between Sleep-Related Traits and Risk of Type 2 Diabetes Mellitus: A Mendelian Randomization Study
Gao X, Sun H, Zhang Y, Liu L, Wang J, Wang T.
Front Genet. 2020 Dec 15;11:607865. doi: 10.3389/fgene.2020.607865.
The role of polygenic risk and susceptibility genes in breast cancer over the course of life
Mars N, Widén E, Kerminen S, Meretoja T, Pirinen M, Della Briotta Parolo P, Palta P; FinnGen, Palotie A, Kaprio J, Joensuu H, Daly M, Ripatti S.
Nat Commun. 2020 Dec 14;11(1):6383. doi: 10.1038/s41467-020-19966-5.
Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study
Rosoff DB, Davey Smith G, Mehta N, Clarke TK, Lohoff FW.
PLoS Med. 2020 Dec 4;17(12):e1003410. doi: 10.1371/journal.pmed.1003410.
Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study
Larsson SC, Mason AM, Kar S, Vithayathil M, Carter P, Baron JA, Michaëlsson K, Burgess S.
BMC Med. 2020 Dec 2;18(1):370. doi: 10.1186/s12916-020-01839-9.

November

Findings and insights from the genetic investigation of age of first reported occurrence for complex disorders in the UK Biobank and FinnGen
Feng Y-CA, Ge T, Cordioli M, FinnGen, Ganna A, Smoller JW, Neale BM.
medRxiv 2020.11.20.20234302; doi: https://doi.org/10.1101/2020.11.20.20234302.
Overall and abdominal obesity in relation to venous thromboembolism
Yuan S, Bruzelius M, Xiong Y, Håkansson N, Åkesson A, Larsson SC.
J Thromb Haemost. 2021 Feb;19(2):460-469. doi: 10.1111/jth.15168.
Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Hypertension: A Mendelian Randomization Study
van Oort S, Beulens JWJ, van Ballegooijen AJ, Grobbee DE, Larsson SC.
Hypertension. 2020 Dec;76(6):1971-1979. doi: 10.1161/HYPERTENSIONAHA.120.15761.

October

An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease
Ruotsalainen SE, Partanen JJ, Cichonska A, Lin J, Benner C, Surakka I; FinnGen, Reeve MP, Palta P, Salmi M, Jalkanen S, Ahola-Olli A, Palotie A, Salomaa V, Daly MJ, Pirinen M, Ripatti S, Koskela J.
Eur J Hum Genet. 2021 Feb;29(2):309-324. doi: 10.1038/s41431-020-00730-8.
Validation of Psoriasis Diagnoses Recorded in Finnish Biobanks
Haverinen S, Vihervaara A, Löyttyniemi E, Peltonen S, Koulu L, Tasanen K, Huilaja L; FinnGen investigators.
Acta Derm Venereol. 2020 Oct 21;100(17):adv00297. doi: 10.2340/00015555-3656.
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
Bao EL, Nandakumar SK, Liao X, Bick AG, Karjalainen J, Tabaka M, Gan OI, Havulinna AS, Kiiskinen TTJ, Lareau CA, de Lapuente Portilla AL, Li B, Emdin C, Codd V, Nelson CP, Walker CJ, Churchhouse C, de la Chapelle A, Klein DE, Nilsson B, Wilson PWF, Cho K, Pyarajan S, Gaziano JM, Samani NJ; FinnGen; 23andMe Research Team, Regev A, Palotie A, Neale BM, Dick JE, Natarajan P, O'Donnell CJ, Daly MJ, Milyavsky M, Kathiresan S, Sankaran VG.
Nature. 2020 Oct;586(7831):769-775. doi: 10.1038/s41586-020-2786-7.

September

Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks
Fritsche LG, Patil S, Beesley LJ, VandeHaar P, Salvatore M, Ma Y, Peng RB, Taliun D, Zhou X, Mukherjee B.
Am J Hum Genet. 2020 Nov 5;107(5):815-836. doi: 10.1016/j.ajhg.2020.08.025.
PhenomeXcan: Mapping the genome to the phenome through the transcriptome
Pividori M, Rajagopal PS, Barbeira A, Liang Y, Melia O, Bastarache L, Park Y, Consortium G, Wen X, Im HK.
Sci Adv. 2020 Sep 10;6(37):eaba2083. doi: 10.1126/sciadv.aba2083.
An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study
Yuan S, Larsson SC.
Diabetologia. 2020 Nov;63(11):2359-2371. doi: 10.1007/s00125-020-05253-x.
Sleep duration and risk of overall and 22 site-specific cancers: A Mendelian randomization study
Titova OE, Michaëlsson K, Vithayathil M, Mason AM, Kar S, Burgess S, Larsson SC.
Int J Cancer. 2021 Feb 15;148(4):914-920. doi: 10.1002/ijc.33286.

August

Assessing the efficacy and safety of angiotensinogen inhibition using human genetics
Bovijn J, Censin JC, Lindgren CM, Holmes MV.
medRxiv 2020.08.13.20174094; doi: https://doi.org/10.1101/2020.08.13.20174094.

July

A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling
Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V; FinnGen Study, Trégouët DA, Morange PE, Civelek M, Ben-Shlomo Y, Schlaeger T, Chen MH, Johnson AD.
Am J Hum Genet. 2020 Aug 6;107(2):211-221. doi: 10.1016/j.ajhg.2020.06.008.

May

Mendelian randomization analysis to characterize causal association between coronary artery disease and COVID-19
Wu L, Zhu J, Wu C.
medRxiv 2020.05.29.20117309; doi: https://doi.org/10.1101/2020.05.29.20117309
Body mass index and carpal tunnel syndrome: a Mendelian randomization study
Daghlas I, Varady N.
medRxiv 19011536; doi: https://doi.org/10.1101/19011536
Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohort
Ritari J, Hyvärinen K, Clancy J; FinnGen, Partanen J, Koskela S.
NAR Genom Bioinform. 2020 May 6;2(2):lqaa030. doi: 10.1093/nargab/lqaa030.
Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma
Tanigawa Y, Wainberg M, Karjalainen J, Kiiskinen T, Venkataraman G, Lemmelä S, Turunen JA, Graham RR, Havulinna AS, Perola M, Palotie A; FinnGen, Daly MJ, Rivas MA.
PLoS Genet. 2020 May 5;16(5):e1008682. doi: 10.1371/journal.pgen.1008682.

April

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Emdin CA, Haas ME, Khera AV, Aragam K, Chaffin M, Klarin D, Hindy G, Jiang L, Wei WQ, Feng Q, Karjalainen J, Havulinna A, Kiiskinen T, Bick A, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gupta N, Danesh J, Saleheen D, Chang KM, Vujkovic M, Voight B, Damrauer S, Lynch J, Kaplan D, Serper M, Tsao P; Million Veteran Program, Mercader J, Hanis C, Daly M, Denny J, Gabriel S, Kathiresan S.
PLoS Genet. 2020 Apr 13;16(4):e1008629. doi: 10.1371/journal.pgen.1008629.
Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration
Han X, Gharahkhani P, Mitchell P, Liew G, Hewitt AW, MacGregor S.
J Hum Genet. 2020 Aug;65(8):657-665. doi: 10.1038/s10038-020-0750-x.
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers
Mars N, Koskela JT, Ripatti P, Kiiskinen TTJ, Havulinna AS, Lindbohm JV, Ahola-Olli A, Kurki M, Karjalainen J, Palta P; FinnGen, Neale BM, Daly M, Salomaa V, Palotie A, Widén E, Ripatti S.
Nat Med. 2020 Apr;26(4):549-557. doi: 10.1038/s41591-020-0800-0.

March

Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan
Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y; FinnGen, Daly MJ, Kamatani Y, Okada Y.
Nat Med. 2020 Apr;26(4):542-548. doi: 10.1038/s41591-020-0785-8.
Polygenic Hyperlipidemias and Coronary Artery Disease Risk
Ripatti P, Rämö JT, Mars NJ, Fu Y, Lin J, Söderlund S, Benner C, Surakka I, Kiiskinen T, Havulinna AS, Palta P, Freimer NB, Widén E, Salomaa V, Tukiainen T, Pirinen M, Palotie A, Taskinen MR, Ripatti S; FinnGen†.
Circ Genom Precis Med. 2020 Apr;13(2):e002725. doi: 10.1161/CIRCGEN.119.002725.

January

Genomic prediction of alcohol-related morbidity and mortality
Kiiskinen T, Mars NJ, Palviainen T, Koskela J, Rämö JT, Ripatti P, Ruotsalainen S; FinnGen, GSCAN Consortium, Palotie A, Madden PAF, Rose RJ, Kaprio J, Salomaa V, Mäkelä P, Havulinna AS, Ripatti S.
Transl Psychiatry. 2020 Jan 21;10(1):23. doi: 10.1038/s41398-019-0676-2.
2019

October

Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and wildtype transthyretin amyloidoses
De Lillo A, De Angelis F, Di Girolamo M, Luigetti M, Frusconi S, Manfellotto D, Fuciarelli M, Polimanti R.
Hum Genet. 2019 Dec;138(11-12):1331-1340. doi: 10.1007/s00439-019-02078-6.
CCR5-del32 is not deleterious in the homozygous state in humans
Gudbjartsson D, Sulem P, Stefansson K, Mars N, Karjalainen J, Ripatti S, Palotie A, Daly M.
bioRxiv 788117; doi: https://doi.org/10.1101/788117.

September

Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Tabassum R, Rämö JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Söderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M; FinnGen Project, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S.
Nat Commun. 2019 Sep 24;10(1):4329. doi: 10.1038/s41467-019-11954-8.

July

Exome sequencing of Finnish isolates enhances rare-variant association power
Locke AE, Steinberg KM, Chiang CWK, Service SK, Havulinna AS, Stell L, Pirinen M, Abel HJ, Chiang CC, Fulton RS, Jackson AU, Kang CJ, Kanchi KL, Koboldt DC, Larson DE, Nelson J, Nicholas TJ, Pietilä A, Ramensky V, Ray D, Scott LJ, Stringham HM, Vangipurapu J, Welch R, Yajnik P, Yin X, Eriksson JG, Ala-Korpela M, Järvelin MR, Männikkö M, Laivuori H; FinnGen Project, Dutcher SK, Stitziel NO, Wilson RK, Hall IM, Sabatti C, Palotie A, Salomaa V, Laakso M, Ripatti S, Boehnke M, Freimer NB.
Nature. 2019 Aug;572(7769):323-328. doi: 10.1038/s41586-019-1457-z.

May

The validity of heart failure diagnoses in the Finnish Hospital Discharge Register
Vuori MA, Laukkanen JA, Pietilä A, Havulinna AS, Kähönen M, Salomaa V, Niiranen TJ; FinnGen investigators.
Scand J Public Health. 2020 Feb;48(1):20-28. doi: 10.1177/1403494819847051.