Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

Elokuu

Multi-omics insights into Palmitoylation-mediated brain network remodeling and glioblastoma risk
Tan S, You J, Wang H, Zhao L, Li S, Tang X, Liu H.
Discov Oncol. 2025 Aug 8;16(1):1507. doi: 10.1007/s12672-025-03369-3.
Statins and hemorrhagic stroke: New insight from a Mendelian randomization study
Gu X, Du X, Yao Z, Gu S.
Medicine (Baltimore). 2025 Aug 8;104(32):e43838. doi: 10.1097/MD.0000000000043838.
Genetic Association of CANT1 Gene with Scoliosis: An Integrative Study Involving Methylation, Immune Factors, and Metabolites
Xiao Zhang, Wenbo Gu, Yanrong Tian, Hongyang Zhao, Donghui Cao, Tenyao Niu, Xusheng Li, Haifeng Yuan
J Mol Neurosci75, 100 (2025). https://doi.org/10.1007/s12031-025-02383-y
Genetic evidence for causal effects of inflammatory protein factors on breast cancer
Liu X, Xu X, Ye P, Jiang Z, Tian L, Yin Y, Feng L.
Discov Oncol. 2025 Aug 7;16(1):1490. doi: 10.1007/s12672-025-03370-w.
Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis
Wenhao Tian, Zixin Wu, Wen Yang, Hongyang Wang, Qiyu Feng
BMC Gastroenterol 25, 564 (2025). https://doi.org/10.1186/s12876-025-04162-w
Mendelian Randomization Analysis Reveals Iron as a Potential Contributor to Male Infertility
Gu Y, Zhuo H.
World J Mens Health . 2025 Aug 7. doi: 10.5534/wjmh.250072.
Targeting Monocyte Dysregulation in Ovarian Cancer: Insights from Single-Cell Genomics and Mendelian Randomization
Li Ou, Hao Lin, Bo Ding, Yang Shen
Researchsquare, 07 August 2025, doi: 10.21203/rs.3.rs-6944323/v1
Unraveling Genetic Causality Between Type 2 Diabetes Mellitus and Hemiplegia Based on Mendelian Randomization
Li Y, Zhang Z, Jin W, Yuan Y, Cen X, Tan J, Wu X.
J Multidiscip Healthc. 2025 Aug 7;18:4893-4901. doi: 10.2147/JMDH.S543296.
Exploring the Association Between Multidimensional Dietary Patterns and Non-Scarring Hair Loss Using Mendelian Randomization
Pan L, Moog P, Li C, Steinbacher L, Knoedler S, Kükrek H, Dornseifer U, Machens HG, Jiang J.
Nutrients. 2025 Aug 7;17(15):2569. doi: 10.3390/nu17152569.
Premature ovarian insufficiency as a consequence of immunological abnormalities and dyslipidemia: a Mendelian randomization study
Shao F, Li Y.
Gynecol Endocrinol. 2025 Dec;41(1):2541647. doi: 10.1080/09513590.2025.2541647.
HDL cholesterol as a mediator of the relationship between breastfeeding and coronary atherosclerosis from a two-step Mendelian randomization analysis
Zhang B, Yang B, Xiu W, Xue D, Zheng Y, Wei J, Dai Y.
Sci Rep. 2025 Aug 6;15(1):28739. doi: 10.1038/s41598-025-12369-w.
Genetic Evidence for Causal Relationships Between Circulating Cathepsin Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study
Duan C, Zhang A, Tian S.
Chronic Obstr Pulm Dis. 2025 Aug 6. doi: 10.15326/jcopdf.2025.0626.
Blood cell perturbation responses mediate the causal relationship between the gut microbiota and asthma: a bidirectional Mendelian randomization study
Junjie Bi, Liqun Zhao, Xue Liu, Jingjing Zhang, Wei Zhang
BMC Med Genomics 18, 127 (2025). https://doi.org/10.1186/s12920-025-02196-3
Unravelling Osteoporosis: Key Genes and Potential Therapies
Fu H, Wu Y, Lv H, Qiu LA, Hu W, Wu H, Qian J, Liang X, Wang X, Xu G.
J Cell Mol Med. 2025 Aug;29(15):e70759. doi: 10.1111/jcmm.70759.
Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty
Mak JKL, Qin C, Krüger M, Kuukka A; FinnGen; Hägg S, Lin J, Jylhävä J.
Nat Aging. 2025 Aug 5. doi: 10.1038/s43587-025-00925-y.
Integrative GWAS and Mendelian randomization study of rheumatoid arthritis based on the 2019 UK Biobank questionnaire
Cai T, Pan Q, Tao Y, Nangia C, Rajendrakumar AL, Dottorini T, Haque M, Palmer C, Meng W
Clin Rheumatol 44, 3835–3845 (2025). https://doi.org/10.1007/s10067-025-07590-x
Refining the generation, interpretation and application of multi-organ, multi-omics biological aging clocks
Wen J.
Nat Aging 5, 1897–1913 (2025). https://doi.org/10.1038/s43587-025-00928-9
Causal relationships between immune cell traits and HER2 subtypes in breast cancer: a Mendelian randomization study
Gu F, Hu C, Li C.
Discov Oncol. 2025 Aug 5;16(1):1475. doi: 10.1007/s12672-025-03358-6.
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling
Foote IF, Flint JP, Fürtjes AE, Mullin DS, Fisk JD, Karakach TK, Rutenberg A, Martin NG, Lupton MK, Llewellyn DJ, Ranson JM, Cox SR, Luciano M, Rockwood K, Grotzinger AD.
Nat Genet . 2025 Aug;57(8):1848-1859. doi: 10.1038/s41588-025-02269-0
Exploring the Causal Relationship Between Inflammatory Bowel Disease and Bell's Palsy Based on Inflammatory Proteins: A Mendelian Randomization Study
Fan D, Wu W, Dai J, Chen Y, Lian Q, Zhao C, Que B, Qiu R.
Brain Behav. 2025 Aug;15(8):e70715. doi: 10.1002/brb3.70715.
Exploring the causal relationship between 16 eye diseases and stroke and their subtypes from a genome-wide perspective
Su B, Sun Y, Yu W, Wang C, Xia Q, Zhu Y.
Sci Rep. 2025 Aug 4;15(1):28357. doi: 10.1038/s41598-025-98225-3.
Integrated Omics and Multi-Cohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer
Ma S, Ge Y, Lu Z, Zhang J, Zhang Q, Peng Y, Xi Z, Peng H, Xu MY, Xiong Z, Gao Y, Wang Y, Li L, Zhang C, Chao Z, Li T, Zhang R, Zhang Q, Horne DA, Wang B, Gao X, Zhang X, Tian J, Li J, Jin M, Wei GH, Wang Z.
Cancer Res. 2025 Aug 4. doi: 10.1158/0008-5472.CAN-24-5018.
ZDHHC4 Influences Obsessive-Compulsive Disorder Risk Through Imaging-Derived Phenotypes: A Mendelian Randomization Study
Huang Y, Luo H, Huang J, Hou X.
J Mol Neurosci. 2025 Aug 2;75(3):98. doi: 10.1007/s12031-025-02391-y.
Causal relationship between white matter structural connectivity and epilepsy
Zhang N, Huang R, Dong X.
Epilepsy Behav. 2025 Aug 2;171:110642. doi: 10.1016/j.yebeh.2025.110642.
Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas
Li, Y., Lin, L., Zhang, W.
Discov Onc 16, 1457 (2025). https://doi.org/10.1007/s12672-025-03318-0
Exploring the impact of physical activity and micronutrients on diabetic nephropathy: a subtype-specific genetic correlation and Mendelian randomization study
Li F, Dang L, Wang Y, Cao J.
Nutr Metab (Lond). 2025 Aug 1;22(1):87. doi: 10.1186/s12986-025-00980-7.
Causal association between inflammatory cytokines and osteonecrosis: A bidirectional 2-sample Mendelian randomization study
You W, Lin Z, Lin Y, Liu M, Ye R, Zeng R.
Medicine (Baltimore). 2025 Aug 1;104(31):e43671. doi: 10.1097/MD.0000000000043671.
Exploring causal pathways between hypertension, lipid levels, and gout: Insights from Mendelian randomization and NHANES observations
Li M, Nie Q, Lv K, Liu J, Jiang Z.
Medicine (Baltimore). 2025 Aug 1;104(31):e43638. doi: 10.1097/MD.0000000000043638.
Exploring causal relationships between brain imaging-derived phenotypes and ovarian cancer risk: a bidirectional Mendelian randomization
Liu, T., Tuo, X., Zhao, H
J Ovarian Res 18, 173 (2025). https://doi.org/10.1186/s13048-025-01733-z
Revealing the causal relationship between cathepsin and inflammatory disease of wrist through Mendelian randomization
Qu Y, Gong Q, Huang X, Zhao W.
Medicine (Baltimore). 2025 Aug 1;104(31):e43461. doi: 10.1097/MD.0000000000043461.
Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases
Wang J-H, Dong S-S, Wang H-A, Liu S-S, Ma X, Zhu R-J, Shi W, Wu H, Yu K, Zhang T-P, Wang C-R, Guo Y, Yang T-L.
Cardiovasc Diabetol . 2025 Aug 1;24(1):312. doi: 10.1186/s12933-025-02847-w
Integrative analysis reveals novel inflammatory and metabolic pathways in glioblastoma development: A large-scale mediation Mendelian randomization study
Yang X, Lin X.
Medicine (Baltimore). 2025 Aug 1;104(31):e43636. doi: 10.1097/MD.0000000000043636.

Heinäkuu

A Proteomic Profile of the Ocular Phenome: Systemic Signatures, Predictive Value, and Causal Insights Across 131 Ocular Diseases and Traits
Liu D, Liu H, Chen X, Zhang X, Zhang J, Wu J, Chen L, Wang N.
medRxiv 2025.07.31.25332495; doi: https://doi.org/10.1101/2025.07.31.25332495
Multi-omics analysis unveiled fibroblast-mediated pathogenesis in male genital lichen sclerosus
Lin, L., Liu, Y., Wang, X.
Cell Biosci 15, 113 (2025). https://doi.org/10.1186/s13578-025-01453-3
Metabolism-Mediated FGF5 Association with Stroke: Based on Mendelian Randomization and Bioinformatics Analysis
Xu C, Xu Y, Gao L, Wang M, Wang G, Wang G.
J Multidiscip Healthc. 2025 Jul 31;18:4481-4495. doi: 10.2147/JMDH.S529168.
Long-term cardiovascular risk in women with hypertensive disorders of pregnancy: Insights from polygenic risk scores
Kivioja A, Tyrmi J, Toivonen E, Huhtala H; FinnGen; Jääskeläinen T, Kettunen J, Saarela T, Laivuori H.
Acta Obstet Gynecol Scand. 2025 Jul 31. doi: 10.1111/aogs.70021.
Potential Causal Relationship Between Plasma and Cerebrospinal Fluid Metabolites and Meningioma: Two-Sample Mendelian Randomization Study
Du G, Xu D, Zhao H, Yan Z, Wang J.
https://www.dovepress.com/potential-causal-relationship-between-plasma-and-cerebrospinal-fluid-m-peer-reviewed-fulltext-article-JMDH
The Palmitoyltransferases ZDHHC6 and ABHD17A Modulate Type 2 Diabetes Risk via Genetic Causality and Molecular Interactions
Jiashu Li, Taoyuan Hao, Zhenzhen He, Modan Zhu, Wanting Du, Xianbo Huang, Qiuxian Li, Xinyuan Liu, Yan Su, Weiping Teng, Zhongyan Shan
Researchsquare, 31 July 2025, doi: 10.21203/rs.3.rs-6697832/v1
Estimating effects of serum vitamin B12 levels on psychiatric disorders and cognitive impairment: a Mendelian randomization study
Lu T, Paterson AD.
Commun Med (Lond) . 2025 Jul 30;5(1):316. doi: 10.1038/s43856-025-01043-x
Mind the gap: characterizing bias due to population mismatch in two-sample Mendelian randomization
Li J, Morrison J.
medRxiv 2025.07.30.25332465; doi: https://doi.org/10.1101/2025.07.30.25332465
Shikonin as a therapeutic agent in renal cell carcinoma: insights from TEK-related causal association with glaucoma
Jia R, Liang Y, Zou B, Li X, Chen T, Zhang C, Bian J, Guo R.
Front Pharmacol. 2025 Jul 30;16:1580704. doi: 10.3389/fphar.2025.1580704.
Exploring the liver-brain axes: insights from a bidirectional Mendelian randomization study on brain cortical structure and liver cancers
Zhu Q, Li Z, Cai C, Li D.
Discov Oncol. 2025 Jul 30;16(1):1446. doi: 10.1007/s12672-025-03276-7.
Causal relationships between gut microbiota and urothelial carcinoma mediated by inflammatory cytokines and blood cell traits identified through Mendelian randomization analysis.
Wu, X., Zou, W. & Liu, Z
Discov Onc 16, 1440 (2025). https://doi.org/10.1007/s12672-025-03219-2
Oxidative Stress Links Thyroid Autoimmunity to Cancer: Peroxiredoxin 2 Protection via Genomic and Single-Cell Insights
Kang J, Wang S, Ni X.
Cancer Biother Radiopharm. 2025 Jul 30. doi: 10.1177/10849785251360744.
Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study
Lu C, Wang M, Li J, Xian H, Huang Z, Wang Y, Xie S, Zhang W, Yu Y, Zheng H, Li D, Zheng Y, Liu H, Zhao C.
Hematology. 2025 Dec;30(1):2538327. doi: 10.1080/16078454.2025.2538327.
Systemic evaluation of the effects of monomeric GLP-1R-based agonists on MASLD and its complications
Cai, Y., Xie, S., Xu, L
Diabetol Metab Syndr 17, 300 (2025). https://doi.org/10.1186/s13098-025-01870-x
Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components
Omdahl AR, Weinstock JS, Keener R, Chhetri SB, Arvanitis M, Battle A.
Am J Hum Genet. 2025 Sep 4;112(9):2178-2197. doi: 10.1016/j.ajhg.2025.07.003. Epub 2025 Jul 28.
The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study
Detian Jiang, Yuxin Chang, Xiaowen Zhen, Xin Zhao
Nutr Metab (Lond) 22, 86 (2025). https://doi.org/10.1186/s12986-025-00979-0
DLK1 downregulation serves as a potential biomarker for disease severity and a therapeutic target in bronchiectasis
Yanping Liu, Shaochu Zheng, Shihao Yang, Yuting Huang, Jinling Tang, Haizhu Huang, Kangkang Hong, Jing Luo, Jinliang Kong
Researchsquare, 29 July 2025, doi: 10.21203/rs.3.rs-7090713/v1
Unraveling the link between inflammatory bowel disease and perianal abscess: insights from bidirectional and multivariable Mendelian randomization study
Zhu H, Pan J.
BMC Gastroenterol. 2025 Jul 29;25(1):538. doi: 10.1186/s12876-025-04137-x.