Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

Kesäkuu

Causal association of cholesterol metabolism-related proteins with hepatocellular carcinoma and dysfunction-associated steatotic liver disease: a mendelian randomization study
Tian D, Jiang S, Liu Y, Zheng H, Zhang L, Xu Y, Lu X.
Discov Oncol. 2025 Jun 2;16(1):987. doi: 10.1007/s12672-025-02321-9.
NFKB1-targeted metabolites as novel therapeutic approaches for erectile dysfunction: evidence from gut microbiota network pharmacology and machine learning
Xiang B, An J, Li D.
Sex Med. 2025 Jun 2;13(3):qfaf039. doi: 10.1093/sexmed/qfaf039.
Global burden of maternal hypertensive disorders (1990-2045): trends, regional disparities, and causal links to occupational exposures
Xiong J, Chen S, Wang H, Yang X, Chen X, You B, Yu R.
BMC Pregnancy Childbirth. 2025 Jun 2;25(1):641. doi: 10.1186/s12884-025-07766-y.
Refining the generation, interpretation, and application of multi-organ, multi-omics biological aging clocks
Wen J.
medRxiv 2025.02.06.25321803; doi: https://doi.org/10.1101/2025.02.06.25321803
Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG
Chen J, Zhuo X, Li Y, Zhu Y, Li Z, Shen X, Zhuo Y, Tan H, Lei L.
Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):7. doi: 10.1167/iovs.66.6.7.
Exploring the genetic basis between inflammatory bowel disease and venous thromboembolism
Wu Y, Shang C.
Thromb J. 2025 Jun 2;23(1):56. doi: 10.1186/s12959-025-00745-5.
Whole-genome sequencing study of 488,888 individuals identifies rare variants and genes associated with glaucoma
Gao XR, Kizhatil K.
medRxiv 2025.06.02.25328820; doi: https://doi.org/10.1101/2025.06.02.25328820
Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders
Gilchrist L, Mutz J, Hysi P, Legido-Quigley C, Kõks S, Lewis CM, Proitsi P.
BMC Med. 2025 Jun 2;23(1):326. doi: 10.1186/s12916-025-04129-4.
Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study
Chen J, Zhao J, Zhang Z, Zhu X, Zuo J, Nie Z, Fu Y, Wang H, Tang M, Fu S.
Front Pharmacol. 2025 Jun 2;16:1568780. doi: 10.3389/fphar.2025.1568780.
Atlas of Proteomic signatures of brain structure and its links to brain disorders
Ren P, Hou XH, Li Z, You J, Li Y, Zhang W, Gong W, Zhang B, Wu B, Wang L, Shen C, Zhao Y, Ma Q, Kang J, Jiang Y, Roberts N, Xu F, He Y, Yu JT, Wang M, Cheng W.
Nat Commun. 2025 Jun 2;16(1):5092. doi: 10.1038/s41467-025-60185-7.
Association between chronic kidney disease and colorectal cancer: evidence from meta-analysis and Mendelian randomization
Qian S, Gong Y, Chen Y.
Discov Oncol. 2025 Jun 1;16(1):974. doi: 10.1007/s12672-025-02785-9.
Genetic analysis of the correlation between GLP1 action and metabolic liver disease: Insights from Mendelian randomization analysis
Ma Z, Wang B, Li D, Chen X.
J Diabetes Investig. 2025 Jun 1. doi: 10.1111/jdi.70087.
A two-sample Mendelian randomization study on the association between temporomandibular disorder and insomnia
Yuan W, Cheng Y, Cui Y, Gao D.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2025 Jun 1;43(3):354-361. Chinese. doi: 10.7518/hxkq.2025.2024255.

Toukokuu

Unravelling the Shared Genetic Architecture between Suicidality and Subcortical Brain Volume: A Genome-Wide Association Study
Defo J, Ramesar R.
Acta Neuropsychiatr. 2025 Mar 31:1-31. doi: 10.1017/neu.2025.12.
Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization
Ling S, Xie D, Huang L, Huang S, Tian C, Huang L, Chen R, Qin L, Qin X.
Hereditas. 2025 May 31;162(1):92. doi: 10.1186/s41065-025-00457-w.
Unveiling the role of lipid metabolism in haemorrhagic disorders: genetic insights and therapeutic perspectives
Wei J, Yang Z, Wu X, Zheng N, Wu D.
Thromb J. 2025 May 31;23(1):55. doi: 10.1186/s12959-025-00731-x.
Causal relationship between immune cells and post-viral fatigue syndrome: a Mendelian randomization study
Wang Z, Bai Z, Sun Y.
Virol J. 2025 May 30;22(1):171. doi: 10.1186/s12985-025-02809-4.
Causal assessment of the relationship between diet, lifestyle, and stroke: A two-sample Mendelian randomization study
Jareebi MA.
Medicine (Baltimore). 2025 May 30;104(22):e42563. doi: 10.1097/MD.0000000000042563.
Lung development genes, adult lung function and cardiovascular comorbidities
Portas L, Talaei M, Dean C, Aung N, Hind MD, Pozarickij A, Walters RG; China Kadoorie Biobank Collaborative Group; Burney PG, Petersen S, Minelli C, Shaheen SO.
Thorax. 2025 May 30:thorax-2024-222474. doi: 10.1136/thorax-2024-222474.
Cross-Trait Cross-Genome Cross-Organ Analysis of Gastrointestinal Disorders and Depression
Wang C, Lv G, Chen E, Xue Y, Zhou B, Yang M, Zhong Y.
Dig Dis Sci. 2025 May 30. doi: 10.1007/s10620-025-09083-y.
Analysis of the correlation between inflammatory cytokines and glioblastoma: A Mendelian randomization study
Xuan F, Lv T, Zheng L, Yu S, Ding M.
Medicine (Baltimore). 2025 May 30;104(22):e42137. doi: 10.1097/MD.0000000000042137.
Causal association between periodontitis and oral cancer: a two-sample Mendelian randomization study
Xiao T, Hu G, Li T, Zhu X, Wang H, Zhu Z.
Discov Oncol. 2025 May 30;16(1):964. doi: 10.1007/s12672-025-02528-w.
Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization study
Huang X, Zhao JV.
BMC Med. 2025 May 30;23(1):321. doi: 10.1186/s12916-025-04127-6.
Identifying causal genes for prostatitis through drug-targeted Mendelian randomization
Yan K, Tao Y, Chen B, Zhang D, Li Z, Li C, Zhang P.
Sci Rep. 2025 May 30;15(1):19069. doi: 10.1038/s41598-025-03510-w.
Causal association between uterine fibroids and cardiovascular disease: A Mendelian randomization study
Yao M, Zhao S, Zhang D, Cui Y, Wang Y, Jiang L.
Medicine (Baltimore). 2025 May 30;104(22):e42627. doi: 10.1097/MD.0000000000042627.
Identification of novel therapeutic targets for atrial fibrillation through Mendelian randomization analysis of druggable genes
Ding Y, Chen R, Zheng Z, Xu S, Liu M, Hou C, Li S.
Exp Gerontol. 2025 May 30:112797. doi: 10.1016/j.exger.2025.112797.
A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors
Chen F, Zhou Y, Mao X, Lin R, Huang H.
Discov Oncol. 2025 May 30;16(1):961. doi: 10.1007/s12672-025-02761-3.
Dietary factors and postmenopausal bleeding: A Mendelian randomization investigation
Ren J, Yang W, Tian T.
Medicine (Baltimore). 2025 May 30;104(22):e41650. doi: 10.1097/MD.0000000000041650.
Unveiling the Intricate Causal Nexus Between 91 Circulating Inflammatory Proteins and Perianal Abscess Through a Comprehensive Bidirectional Two-Sample Mendelian Randomization Analysis
Wang Z, Chen T, Shi H, Zhang X, Yang W.
Health Sci Rep. 2025 May 29;8(6):e70803. doi: 10.1002/hsr2.70803.
From infection to tumor: genetic evidence of viral antibody immune response' role in urologic cancer development
Wang C, Zhang Q, Li Q, Wang Y, Chen X.
Discov Oncol. 2025 May 29;16(1):947. doi: 10.1007/s12672-025-02768-w.
Multi-Omics Mendelian Randomization Identifies Therapeutic Targets for Sjögren’s Disease with Clinical and Bayesian Validation
He J, Li K, Guo Z, Zhou X, Tang X.
J Inflamm Res. 2025;18:16685-16698 https://doi.org/10.2147/JIR.S543644
The Mediating Role of Plasma Inflammatory Proteins in Gut Microbiota-Driven Valvular Heart Disease: A Mendelian Randomization Study
Zhao J, Wang Y, Lv C, Peng J, Lu S, Shen L.
Cell Biochem Biophys. 2025 May 28. doi: 10.1007/s12013-025-01780-9.
Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study
Wang N, Wang T, Tang M, Zu B, Chen J.
BMC Pregnancy Childbirth. 2025 May 28;25(1):622. doi: 10.1186/s12884-025-07754-2.
Decoding the impact of glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist on cardiometabolic health: inflammatory mediators at the focus
Cheng F, Niu X, Wang Y, Yang F, Yang K, Li W.
Diabetol Metab Syndr. 2025 May 28;17(1):175. doi: 10.1186/s13098-025-01744-2.
Association of glucagon-like peptide-1 receptor agonists and seven common mental disorders: A drug target and mediation Mendelian randomization
Zhang Z, Li S, Dai X, Li C, Sun P, Qu J, Jiang H, Pan B.
J Affect Disord. 2025 May 28:119509. doi: 10.1016/j.jad.2025.119509.
Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts
Joensuu L, Koivunen K, Tynkkynen NP, Palviainen T, Kaprio J; FinnGen Consortium; Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Sillanpää E.
Br J Sports Med. 2025 May 27;59(11):783-790. doi: 10.1136/bjsports-2024-109491.
Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability
Drouard G, Hagenbeek FA, Ollikainen M, Zheng Z, Wang X; FinnGen; Ripatti S, Pirinen M, Kaprio J.
J Proteome Res. 2025 May 27. doi: 10.1021/acs.jproteome.4c00971.
Sleep disturbances as risk factors for neurodegeneration later in life
Simmonds E, Levine KS, Han J, Iwaki H, Koretsky MJ, Kuznetsov N, Faghri F, Warly Solsberg C, Schuh A, Jones L, Bandres-Ciga S, Blauwendraat C, Singleton A, Escott-Price V, Leonard HL, Nalls MA.
npj Dement. 1, 6 (2025). https://doi.org/10.1038/s44400-025-00008-0
Higher body mass index is a causal risk factor for skin infections: a Mendelian randomisation study using UK Biobank and FinnGen
Hopkins R, de Villiers E, Weedon MN, Shields BM, Dennis JM, McGovern AP, Green HD.
medRxiv 2025.05.27.25328427; doi: https://doi.org/10.1101/2025.05.27.25328427
Variant-specific priors clarify colocalisation analysis
Pullin JM, Wallace C.
PLoS Genet. 2025 May 27;21(5):e1011697. doi: 10.1371/journal.pgen.1011697.
Variant-specific priors clarify colocalisation analysis
Pullin JM, Wallace C.
PLoS Genet. 2025 May 27;21(5):e1011697. doi: 10.1371/journal.pgen.1011697.
Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics
Lobato-Moreno S, Yildiz U, Claringbould A, Servaas NH, Vlachou EP, Arnold C, Bauersachs HG, Campos-Fornés V, Kim M, Berest I, Prummel KD, Noh KM, Marttinen M, Zaugg JB.
Nat Methods. 2025 Jun;22(6):1213-1225. doi: 10.1038/s41592-025-02700-8.
Contextualizing molecular and structural aging across human organs
Shu J, Guo Y, Chirinos J, Fan Z, Yang Y, Li Y, Yang X, Beeche C, Su B, Horng I, Zheng R, Paschou P, Wang L-S, O’Brien JM, Gur R, Lin J, Witschey W, Rader DJ, Rosenzweig A, Zhao B.
medRxiv 2025.05.26.25328375; doi: https://doi.org/10.1101/2025.05.26.25328375
Screening of biobank SNP-array genotyping data to detect Lynch syndrome predisposing MLH1 copy number variants
Ala-Kulju K, Carpén O, Lappalainen M, Pehrsson M.
Fam Cancer. 2025 May 26;24(2):47. doi: 10.1007/s10689-025-00476-6.
Metabolomics insights into the causal associations between antihypertensive drugs and myocarditis
Hu X, Hu T, Ye Y, Chen X, Abulikemu S, Yu J, Zhao Y, Wang J, Peng Y.
Int Immunopharmacol. 2025 May 26;159:114946. doi: 10.1016/j.intimp.2025.114946.
Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses
Li X, Yang CH, Zhou M, Yin MY.
Thromb J. 2025 May 26;23(1):54. doi: 10.1186/s12959-025-00733-9.
Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk
MULTI consortium; Anagnostakis F, Ko S, Saadatinia M, Wang J, Davatzikos C, Wen J.
Nat Commun. 2025 May 26;16(1):4871. doi: 10.1038/s41467-025-59964-z.
Association of lipid-lowering drugs with venous thromboembolism outcomes: a phenome-wide association study and a drug-target Mendelian randomization study
Lingyu Z, Wanting Z, Ying G, Qianqian J, Chunfang W.
J Thromb Thrombolysis. 2025 May 26. doi: 10.1007/s11239-025-03108-z.
Causal relationship between citrate and gestational diabetes mellitus: a two-sample Mendelian randomization analysis
He Y, Gan Y, Mao J, Shi Q.
J Matern Fetal Neonatal Med. 2025 Dec;38(1):2509160. doi: 10.1080/14767058.2025.2509160.
Susceptibility genes for allergic conjunctivitis revealed by cross-tissue transcriptome-wide association study
Xu Q, Li Y, Zhang X.
Exp Eye Res. 2025 May 24;257:110444. doi: 10.1016/j.exer.2025.110444.