Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

Marraskuu

TLR1-Regulated Ferroptosis Gene Decreases the Occurrence of Restless Legs Syndrome
Chen Q, Men X.
Brain Behav. 2025 Nov;15(11):e71038. doi: 10.1002/brb3.71038.
Exploring the causal associations between obesity indicators and male reproductive diseases: new evidence from Mendelian randomization
Huijuan Wei, Haoting Chen, Yifei Lin & Haibin Lu
Basic Clin. Androl. 35, 43 (2025). https://doi.org/10.1186/s12610-024-00242-1
Plasma proteins and osteosarcoma risk: causal evidence from Mendelian randomization
Ma H, Liao J, He Z, Liu M, Wei F, Wei Q, Luo Q.
Discov Oncol. 2025 Nov 11;16(1):2090. doi: 10.1007/s12672-025-03932-y.
Molecular mechanisms and genetic predisposition to osteoarthritis and osteosarcoma through Mendelian inheritance patterns
Hao Fei, Wen Huang, Yueyuan Chen & Shuo Yang
Discov Onc 16, 2093 (2025). https://doi.org/10.1007/s12672-025-03917-x
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
Olav B. Smeland, Gleda Kutrolli, Shahram Bahrami, Vera Fominykh, Nadine Parker, Julian Fuhrer, Guy F. L. Hindley, Linn Rødevand, Piotr Jaholkowski, Markos Tesfaye, Pravesh Parekh, Torbjørn Elvsåshagen, Andrew D. Grotzinger, Nils Eiel Steen, Dennis van der Meer, Kevin S. O’Connell, Srdjan Djurovic, Anders M. Dale, Alexey A. Shadrin, Oleksandr Frei & Ole A. Andreassen
Nat Neurosci 28, 2439–2450 (2025). https://doi.org/10.1038/s41593-025-02090-2
Plasma proteins and osteosarcoma risk: causal evidence from Mendelian randomization
Ma H, Liao J, He Z, Liu M, Wei F, Wei Q, Luo Q.
Discov Oncol. 2025 Nov 11;16(1):2090. doi: 10.1007/s12672-025-03932-y.
The associations between diet-induced inflammation and health outcomes: a population-based phenome-wide association study
Weiwei Chen, Ke Liu, Xinzhe Jing, Yu Qian, Bin Liu, Ying Chen, Jiayu Li, Xiaohui Sun, Yingying Mao & Ding Ye
npj Sci Food 9, 223 (2025). https://doi.org/10.1038/s41538-025-00583-9
The role and prognostic value of mitochondria-related gene PARK7 in breast cancer
Yu S, Zhou Y, Zhang S, He F, Jiang L, Lv X, Gu X, Xie X.
Breast Cancer Res. 2025 Nov 11;27(1):200. doi: 10.1186/s13058-025-02153-z.
Causal Influences of Micronutrients on Anxiety: Insights From an Observational and Mendelian Randomization Analysis
Fang X, Zhao Q, Liu P, Baranova A, Cao H, Zhang X, Zhang F.
Food Sci Nutr. 2025 Nov 5;13(11):e71166. doi: 10.1002/fsn3.71166. eCollection 2025 Nov.
Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease
Albarrán-Juárez J, Markov A, Jensen AL, Møller PL, Uryga AK, Djordjevic D, Hansen J, Jensen LF, Sharysh D, Pyke C, Moreno J, Borghetti G, Bachmann J, Herum K, Røge LM, Traylor M, Nyberg M, Nyegaard M, Bentzon JF.
iScience. 2025 Oct 4;28(11):113698. doi: 10.1016/j.isci.2025.113698. eCollection 2025 Nov 21.
Impact of Immune Cells on IgA Vasculitis via Metabolites and Inflammatory Cytokines
Ming Xie, Nian Zhou, Qian Liang, Zhong Lin & Yanbing Yao
J Clin Immunol 45, 157 (2025). https://doi.org/10.1007/s10875-025-01946-3
Causal relationship between multiple modifiable risk factors and gestational diabetes mellitus: a two-sample Mendelian randomization study
Liao CC, Lee CI, Li JM.
Can J Diabetes. 2025 Nov 8:S1499-2671(25)00394-6. doi: 10.1016/j.jcjd.2025.10.178. Online ahead of print.
Mitochondrial-related pathogenic genes in varicose veins: A multi-omics Mendelian randomization study
Tan X, Liu Z, Chen K, Li D, Xia J, Niu C, Li H, Huang J.
Phlebology. 2025 Nov 10:2683555251398726. doi: 10.1177/02683555251398726. Online ahead of print.
Elucidation and application of the neuroimmune axis between depression and autoimmune diseases: A genome wide and cohort study
Fu Sun , Shirong Hui , Bin Gong, Jinhua Gu , Peng Huang
PLOS ONE 20(11): e0336109. https://doi.org/10.1371/journal.pone.0336109
131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma
Saarentaus EC, Fischer-Rasmussen K, Sliz E, Bizaki-Vallaskangas A; FinnGen; Laitinen T, Toppila-Salmi S, Kankaanranta H, Kettunen J, Bønnelykke K, Palotie A, Mäkitie A.
Nat Commun. 2025 Nov 10;16(1):9879. doi: 10.1038/s41467-025-64847-4.
Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for gout
Wei-quan Liao, Hui-ying Chen, Yu-ying Li, Li-juan Xiao, Zai-xing Qiu, Sha-sha Hu, Si-hui He, Lan Luo, Jing-jing Xie & Jian-yong Zhang
Naunyn-Schmiedeberg's Arch Pharmacol (2025). https://doi.org/10.1007/s00210-025-04787-4
FINEMAP-miss: Fine-mapping genome-wide association studies with missing genotype information
Kartau J, Pirinen M.
Bioinformatics. 2025 Dec 1;41(12):btaf616. doi: 10.1093/bioinformatics/btaf616.
Role of Transitional %B cells in Mediating the Effect of Phosphatidylinositol (16:0_18:1) on Aortic Dissection
Ma L, Tang L, Jin L, Li J, Li H, Chen L, Qiu Z.
Am J Hypertens. 2025 Nov 6:hpaf223. doi: 10.1093/ajh/hpaf223. Online ahead of print.
Mendelian randomization analysis of gut microbiota and chronic kidney disease: Implications for herbal interventions
Hu X, Wang L, Lin C, Zhu Z, Yang S, Wang S, Wang Y, Jin H, Lv Y, Wang D, Zhang X, Ren K.
Medicine (Baltimore). 2025 Nov 7;104(45):e45730. doi: 10.1097/MD.0000000000045730.
Rotator cuff injury and myocardial infarction: Findings of NHANES 2011 to 2018 and Mendelian randomization study
Wang Z, Dang J, Xu L, Yang X, Jia C.
Medicine (Baltimore). 2025 Nov 7;104(45):e45840. doi: 10.1097/MD.0000000000045840.
Causal associations between food intakes and autoimmune skin diseases: A 2-sample Mendelian randomization study
Xiao T, Lu H, Pan S, Hong X, Chen A, Zhang X, Hu Y, Ni C, Shen S.
Medicine (Baltimore). 2025 Nov 7;104(45):e45732. doi: 10.1097/MD.0000000000045732.
Immune cells and the risk of acne vulgaris: A Mendelian randomization study
Yang X, Wu W, Yang J.
Medicine (Baltimore). 2025 Nov 7;104(45):e45608. doi: 10.1097/MD.0000000000045608.
Association between frailty and gout in middle-aged and older adults: A nationwide cross-sectional and Mendelian randomization study
Sun Y, Liu W, Li D, Cen Z, Shen Y, Zhao T, Lu Z, Liu X, Xie X.
Medicine (Baltimore). 2025 Nov 7;104(45):e45794. doi: 10.1097/MD.0000000000045794.
The influence of mitochondrial biological function on sudden sensorineural hearing loss: Exploring potential mechanisms and associations through Mendelian randomization analysis
Chen J, Hao C, Tang X, Yao H, Su S.
Medicine (Baltimore). 2025 Nov 7;104(45):e45151. doi: 10.1097/MD.0000000000045151.
Causal association between 3 adiposity indices and 5 infectious diseases: A Mendelian randomization study
Chen X, Yin J, Chen C, Xiang T.
Medicine (Baltimore). 2025 Nov 7;104(45):e45775. doi: 10.1097/MD.0000000000045775.
Causal association between sepsis and acute respiratory distress syndrome: Evidence from a 2-sample Mendelian randomization study
Zhang P, Tian W, Tian Y, Yu N, Liu C, Ma S, Li X, Zhou X, Lu H.
Medicine (Baltimore). 2025 Nov 7;104(45):e45574. doi: 10.1097/MD.0000000000045574.
Plasma Protein Profile Associated With a Family History of Early-Onset Coronary Heart Disease
Wahrenberg A, Lind L, Åberg N, Häbel H, Ström M, Mälarstig A, Magnusson PKE, Halkola RK, Bergström G, Engström G, Hagström E, Jernberg T, Söderberg S, Östgren CJ, Svensson P.
Circ Genom Precis Med. 2025 Nov 7:e005220. doi: 10.1161/CIRCGEN.124.005220. Online ahead of print.
Identification and validation of plasma protein biomarkers as therapeutic targets in acute myeloid leukemia: an integrative multi-omics studyIdentification and validation of plasma protein biomarkers as therapeutic targets in acute myeloid leukemia: an integrative multi-omics study
Hu L, Luo Q, Liao Y, Zhai Z, Ding Y, Fei Y.
Front Immunol. 2025 Oct 22;16:1659811. doi: 10.3389/fimmu.2025.1659811. eCollection 2025.
Genetic risk factors and clinical manifestations of systemic lupus erythematosus: Large-scale analysis of genetic predisposition and disease subtypes
Reid S, Sandling JK, Pucholt P, Sayadi A, Frodlund M, Lerang K, Gunnarsson I, Jönsen A, Syvänen A-C, Molberg Ø, Rantapää-Dahlqvist S, Rudin A, Sjöwall C, Svenungsson E, Bengtsson AA, Rönnblom L, Leonard D.
J Intern Med. 7.11.2025; 1–14 https://doi.org/10.1111/joim.70040
Causal effects of telomere length on ovarian tumor risk: Insights from genetic evidence
Lang T, Liang X, Yang Y.
J Chromatogr B Analyt Technol Biomed Life Sci. 2025 Nov 5;1268:124845. doi: 10.1016/j.jchromb.2025.124845. Online ahead of print.
Inflammatory cytokines mediate the common genetic and immunological background between rheumatoid arthritis and osteoporosis
Jianguo Zhou, Xiaoyan Dou, Xize Wu, Yue Li, Shixuan Wang & Jian Kang
Clin Rheumatol (2025). https://doi.org/10.1007/s10067-025-07693-5
Genetic risk factors and clinical manifestations of systemic lupus erythematosus: Large-scale analysis of genetic predisposition and disease subtypes
Reid S, Sandling JK, Pucholt P, Sayadi A, Frodlund M, Lerang K, Gunnarsson I, Jönsen A, Syvänen AC, Molberg Ø, Rantapää-Dahlqvist S, Rudin A, Sjöwall C, Svenungsson E, Bengtsson AA, Rönnblom L, Leonard D.
J Intern Med. 2025 Nov 7. doi: 10.1111/joim.70040. Online ahead of print.
Systematic comparison of colocalization methods using protein quantitative trait loci
Hwang S, Pullin J, Wallace C, Whittaker J, Stephen Burgess S
bioRxiv 2025.11.07.686776; doi: https://doi.org/10.1101/2025.11.07.686776
Multi-omics-based decoding of circulating biomarkers in amyotrophic lateral sclerosis and risks in environmental toxins
Lei Xu, Bin Huang, Yaqiu Zhou, Xiaolin Liao, Ting Chen & Hongping He
BMC Pharmacol Toxicol 26, 186 (2025). https://doi.org/10.1186/s40360-025-01024-9
Proteome-wide Mendelian randomization and colocalization analysis uncovers druggable targets for lung cancer across multiple phenotypes and complications
Chen Y, Dai X, Zhang P, Yao L, Wang Q, Qin Z, Gao T, Zhang J.
Discov Oncol. 2025 Nov 6;16(1):2048. doi: 10.1007/s12672-025-03910-4.
Validity of telephone-administered word list learning measures for assessment of episodic memory in aging and Alzheimer's disease
Saari TT, Aaltonen A, Lohi K, Palviainen T, Schwarz C, Urjansson M, Palotie A, Runz H, Julkunen V, Kaprio J, Vuoksimaa E; FinnGen.
Neuropsychology. 2025 Nov 6. doi: 10.1037/neu0001019. Online ahead of print.
Deciphering the Role of VIM, STX8, and MIF in Pneumoconiosis Susceptibility: A Mendelian Randomization Analysis of the Lung-Gut Axis and Multi-Omics Insights from European and East Asian Populations
Zhang CW, Wan BB, Zhang YK, Xiong T, Li YS, Su XS, Liu G, Wei YY, Sun YY, Zhang JF, Yu X, Shi YW.
Biomed Environ Sci. 2025 Oct 20;38(10):1270-1286. doi: 10.3967/bes2025.028.
Blood metabolites mediate gut microbiota effects on depression: A Mendelian randomization study
Zhang YW, Zhao SS, Li XY, Liu HZ.
J Affect Disord. 2025 Nov 4;394(Pt B):120478. doi: 10.1016/j.jad.2025.120478. Online ahead of print.
Mendelian Randomization and Bioinformatics Analysis Reveal the Potential Protective Role of Metformin in Primary Liver Cancer
Ma Y, Qi J, Chen Z, Zhang Y, Liu K, Suo J, Chen B, Bu Y.
Food Sci Nutr. 2025 Nov 2;13(11):e71156. doi: 10.1002/fsn3.71156. eCollection 2025 Nov.
Causal relationships between modifiable risk factors and heart failure: A comprehensive Mendelian randomization study
Fu Y, He Y, Wu W.
Medicine (Baltimore). 2025 Oct 17;104(42):e45084. doi: 10.1097/MD.0000000000045084.
Causal effects of 731 immune cells on post-traumatic stress disorder: A Mendelian randomization study
Tan J, Bai S, Hu G, Yin Y, Guo C, Liu L.
Medicine (Baltimore). 2025 Oct 17;104(42):e45131. doi: 10.1097/MD.0000000000045131.
Causal relationship between albumin, total protein, and colorectal cancer risk: A 2-sample Mendelian randomization study
Chen J, Zhong X, Wang F, Kuang Y, Chen J.
Medicine (Baltimore). 2025 Oct 17;104(42):e45229. doi: 10.1097/MD.0000000000045229.
Inflammation related proteins and PLCG1 may contribute to papillary thyroid carcinoma risk through a potential regulatory axis
Wang SQ, Yang M, Rao DW, Su YJ, Cheng RC.
Discov Oncol. 2025 Nov 4;16(1):2033. doi: 10.1007/s12672-025-03864-7.
Rheumatoid arthritis and cardiovascular disease associations in the UK Biobank
Salatzki J, Condurache DG, D'Angelo S, Salih AM, Szabo L, Mahmood A, Curtis EM, Petersen SE, Altmann A, Frey N, André F, Harvey NC, Raisi-Estabragh Z.
BMC Med. 2025 Nov 3;23(1):605. doi: 10.1186/s12916-025-04431-1.
Dietary intake and periodontal health: Evidence from a Mendelian randomization analysis
Yan F, Feng Y, Dai X, Li H.
J Int Med Res. 2025 Nov;53(11):3000605251389392. doi: 10.1177/03000605251389392. Epub 2025 Nov 4.
Mendelian Randomization Analysis Reveals No Causal Genetic Link Between Dentofacial Anomalies and Dental Caries
Wang X, Fan Q, Ma B, Yu J, Yuan G.
Oral Health Prev Dent. 2025 Nov 4;23:651-663. doi: 10.3290/j.ohpd.c_2319.
Genetic associations with educational fields
Cheesman R, Anapaz V, van Alten S, Abdellaoui A, Porneso R, Ebeltoft JC, Ayorech Z, Demange PA, Eilertsen EM, Fauske A, Havdahl A, Lahtinen H, Lyngstad TH, Qin Q; FinnGen; Ganna A, Ystrom E.
Nat Genet. 2025 Nov 4. doi: 10.1038/s41588-025-02391-z. Online ahead of print.
Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population
Enzan N, Miyazawa K, Koyama S, Kurosawa R, Ieki H, Yoshida H, Takechi F, Fukuyama M, Osako R, Tomizuka K, Liu X, Ozaki K, Onouchi Y, BioBank Japan Project, Matsuda K, Momozawa Y, Aburatani H, Kamatani Y, Yamaguchi T, Hiroshi A, Node K, Ellinor PT, Levin MG, Damrauer SM, Voight BF, Joseph J, Sun YV, Terao C, Ninomiya T, Komuro I, Ito K.
Nat Commun 16, 9680 (2025). https://doi.org/10.1038/s41467-025-64659-6
Genetic evidence of the causal relationship between genetically predicted nutrients and psoriatic arthritis
Zhao J, Wu J, Zhou H, Han J, Xu Y, Zhang L.
Clin Rheumatol. 2025 Nov 3. doi: 10.1007/s10067-025-07664-w. Online ahead of print.
One-carbon metabolism and risk of PCOS: insights from Mendelian randomization
Yifan Zhao, Gaochen Zhang, Jiexue Pan & Hefeng Huang
J Ovarian Res 18, 235 (2025). https://doi.org/10.1186/s13048-025-01795-z