Publications

Below you will find all the published and preprint scientific papers using FinnGen data.

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

Yosuke Tanigawa, Michael Wainberg, Juha Karjalainen, Tuomo Kiiskinen, Guhan Venkataraman, Susanna Lemmelä, Joni A. Turunen, Robert Graham, Aki S. Havulinna, Markus Perola, Aarno Palotie, FinnGen,  Mark J. Daly, Manuel A. Rivas

Plos Genetics 2020, May 5: https://doi.org/10.1371/journal.pgen.1008682

 

Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancers 

Nina J. Mars, Jukka T. Koskela, Pietari Ripatti, Tuomo T.J. Kiiskinen, Aki S. Havulinna, Joni V. Lindbohm, Ari Ahola-Olli, Mitja Kurki, Juha Karjalainen, Priit Palta, FinnGen, Benjamin M Neale, Mark Daly, Veikko Salomaa, Aarno Palotie, Elisabeth Widén, Samuli Ripatti

Nat Med 2020 April 7: https://www.nature.com/articles/s41591-020-0800-0

 

Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan

Saori SakaueMasahiro KanaiJuha KarjalainenMasato AkiyamaMitja KurkiNana MatobaAtsushi TakahashiMakoto HirataMichiaki KuboKoichi MatsudaYoshinori MurakamiFinnGenMark J. DalyYoichiro Kamatani Yukinori Okada

Nat Med 2020 March 23. https://doi.org/10.1038/s41591-020-0785-8

 

Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality 

Tuomo KiiskinenNina J. MarsTeemu Palviainen Jukka Koskela Pietari Ripatti Joel T. RämöSanni RuotsalainenFinnGen, GSCAN Consortium Aarno PalotiePamela A.F. MaddenRichard J. Rose, Jaakko KaprioVeikko Salomaa Pia Mäkelä, Aki S. HavulinnaSamuli Ripatti

Transl Psychiatry 2020 Jan 21;10(1):23. http://dx.doi.org/10.1038/s41398-019-0676-2


 

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

Preprint

Erik L Bao, Satish Nandakumar, Xiaotian Liao, Alexander Bick, Juha Karjalainen, Marcin Tabaka, Olga I. Gan, Aki Havulinna, Tuomo Kiiskinen, Caleb A. Lareau, Aitzkoa L. de Lapuente Portilla, Bo Li, Connor Emdin, Veryan Codd, Christopher P. Nelson, Pradeep Natarajan, Claire Churchhouse, 23andMe Research Team, Björn Nilsson, Peter W.F. Wilson, Kelly Cho, Saiju Pyarajan, J. Michael Gaziano, Nilesh J. Samani, Million Veteran Program, Aviv Regev, Aarno Palotie, Benjamin M. Neale, John E. Dick, Christopher J. O’Donnell, Mark J. Daly, Michael Milyavsky, Sekar Kathiresan, Vijay G. Sankaran

https://www.biorxiv.org/content/10.1101/790626v1.full

 

Genetic architecture of human plasma lipidome and its link to cardiovascular disease 

Tabassum R, Rämö JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Söderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M; FinnGen Project, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S.

Nat Commun. 2019 Sep 24;10(1):4329. doi: 10.1038/s41467-019-11954-8 

 

Exome sequencing of Finnish isolates enhances rare-variant association power 

Adam E. Locke, Karyn Meltz Steinberg, Charleston W. K. Chiang, Susan K. Service, Aki S. Havulinna, Laurel Stell, Matti Pirinen, Haley J. Abel, Colby C. Chiang, Robert S. Fulton, Anne U. Jackson, Chul Joo Kang, Krishna L. Kanchi, Daniel C. Koboldt, David E. Larson, Joanne Nelson, Thomas J. Nicholas, Arto Pietilä, Vasily Ramensky, Debashree Ray, Laura J. Scott, Heather M. Stringham, Jagadish Vangipurapu, Ryan Welch, Pranav Yajnik, Xianyong Yin, Johan G. Eriksson, Mika Ala-Korpela, Marjo-Riitta Järvelin, Minna Männikkö, Hannele Laivuori, Susan K. Dutcher, Nathan O. Stitziel, Richard K. Wilson, Ira M. Hall, Chiara Sabatti, Aarno Palotie, Veikko Salomaa, Markku Laakso, Samuli Ripatti, Michael Boehnke, Nelson B. Freimer. 

Nature, 2019. dot: 10.1038/s41586-019-1457-z

 

The validity of heart failure diagnoses in the Finnish Hospital Discharge Register.

Vuori MA, Laukkanen JA, Pietilä A, Havulinna AS, Kähönen M, Salomaa V, Niiranen TJ; FinnGen investigators.

Scand J Public Health. 2019 May 9:1403494819847051. doi: 10.1177/1403494819847051.