Below you will find all the published and preprint scientific papers using FinnGen data.

2026

April

Temporal shifts in polygenic traits track major epidemics in Western Eurasia
Flavio De Angelis, Lars Fehren-Schmitz, Carlos Eduardo G. Amorim
bioRxiv 2026.04.07.717059; doi: https://doi.org/10.64898/2026.04.07.717059
Antidiabetic drug effects on gastrointestinal health: convergent evidence from a longitudinal cohort and Mendelian randomization study
Li X, Chen J, Wang L, Jiang F, Ruan X, Yuan S, Zheng J, Gill D, Larsson SC, Mantzoros CS, Li X.
J Adv Res. 2026 Apr 6:S2090-1232(26)00293-6. doi: 10.1016/j.jare.2026.04.014.
Comparative genomic analysis reveals shared and distinct mechanisms of nasal polyps and chronic rhinosinusitis
Shuai Yuan, John C McVey, Katherine Hartmann, Sarah Abramowitz, Jakob Woerner, Gabrielle Shakt, Renae Judy, Jennifer E. Douglas, Benjamin F. Voight, Michael A. Kohanski, Noam A Cohen, Michael Levin, Scott M. Damrauer
medRxiv 2026.04.07.26350325; doi: https://doi.org/10.64898/2026.04.07.26350325
Circulating Plasma Proteins Influence the Risk of Aortic Dissection via Blood Pressure: A Network Mendelian Randomization and Multi-Omics Study
Li Z, Liu J, Fan X, Shi L, Shi H, Li C, Duan C, Zhang C, Wu Q, Shao Y.
J Inflamm Res. 2026 Mar 31;19:600596. doi: 10.2147/JIR.S600596.
Interplay between genetically predicted gut microbiota and chronic apical periodontitis: a Mendelian randomization analysis
Zhu L, Xie Y, Yang X.
J Oral Microbiol. 2026 Mar 31;18(1):2650930. doi: 10.1080/20002297.2026.2650930.
Genetic architecture of lumbar spinal stenosis
Salo V, Määttä J, Takala J, Heikkilä A; FinnGen; Reimann E, Mägi R; Estonian Biobank Research Team; Reis K, Elhanas AG, Reigo A, Palta P, Esko T, Leinonen V, Karppinen J, Sliz E, Kettunen J.
Nat Commun. 2026 Apr 6. doi: 10.1038/s41467-026-70935-w.
The effect of SGLT2 inhibition on immune cells and transplant rejection/failure: A drug-targeted mendelian randomization study
Xiao H, Zeng X, Pang Q, Chen H, Lai S.
Transpl Immunol. 2026 Apr 4:102385. doi: 10.1016/j.trim.2026.102385.
Genetic pharmacoepidemiology of JAK inhibitors in chronic immune-mediated skin diseases: implications for precision therapy and medication safety
Zhang Y, Qu Y, Luo Q, Liang B, Jiang Q, Zhu X, Wu J, Bao W.
Front Pharmacol. 2026 Mar 19;17:1738089. doi: 10.3389/fphar.2026.1738089.
Genetic liability to endometriosis and pregnancy outcomes: a two-sample Mendelian randomization study with maternal-fetal effect decomposition
Jonas Vibert, Tuck Seng Cheng, Maria Christine Magnus, Elisabeth Aiton, Zoltán Kutalik, David Baud, Deborah A. Lawlor, Maria Carolina Borges, Nicola Pluchino
medRxiv 2026.04.05.26350188; doi: https://doi.org/10.64898/2026.04.05.26350188
Mendelian randomization and clinical retrospective radiomics study reveal causal relationships between brain imaging-derived phenotypes and epilepsy risk
Wu H, Ou C, Yang Y, Zhou C, Cao X, Tan Y.
Brain Imaging Behav. 2026 Apr 6;20(2):69. doi: 10.1007/s11682-026-01145-7.
Genetic evidence for causal roles of circulating proteins on breast cancer susceptibility
Chen H, Liu Q, Zhao H, Cheng X.
iScience. 2026 Mar 7;29(4):115286. doi: 10.1016/j.isci.2026.115286.
Triglyceride-glucose index, plasma metabolome and aortic stenosis: a Mendelian randomization analysis
Yan Z, Wang Y, Dai X, Chang Q.
J Cardiothorac Surg. 2026 Apr 6. doi: 10.1186/s13019-026-03976-3.
Hyperthyroidism drives gout risk: A Mendelian randomization observational study
Pan Y, Zhou S, Luo D.
Medicine (Baltimore). 2026 Apr 3;105(14):e48283. doi: 10.1097/MD.0000000000048283.
Protective Causal Effects of CCL19, CCL23, and IL17A on Achilles Tendinitis: Insights from Bidirectional Mendelian Randomization and Metabolite-Mediated Pathway Analysis
Wei L, Wang W, Chen X, Dong S, Su H, Zhen P, Nie X, Hua Q.
Orthop Res Rev. 2026 Jan 13;18:574286. doi: 10.2147/ORR.S574286.
Single-Cell Genetic Architecture Identifies GSTM1 as a Novel Therapeutic Target for Reversing T-Cell Ferroptosis in NSCLC
Shouyong Xiao, Siyun Wu, Xianfeng Shao, Ming Chao, Quibo Huang, Guangjian Li, Lianhua Ye
Research Square, 02 April 2026, PREPRINT [https://doi.org/10.21203/rs.3.rs-9010841/v1]
Metabolic-Renal Disease Genetics Architecture Revealed by Genomic Structural Equation Modeling
Ding K, Xiang L, Jiang W, Lei M, Gao Y.
J Mol Endocrinol. 2026 Mar 25:JME-25-0171. doi: 10.1530/JME-25-0171.
The gut microbiota and plasma metabolites on functional dyspepsia: a study integrating Mendelian randomization and experimental validation
Hu X, Zhang X, Yang C, Chen L, Yang R, Wang C, Wu S, Ma L, Jiang W, Deng P, Su X, Wei W.
Front Med (Lausanne). 2026 Mar 16;13:1793831. doi: 10.3389/fmed.2026.1793831.

March

Intercellular communication is a heritable dimension of human tissue architecture
Chen Yang, Xianyang Zhang, Jun Chen
bioRxiv 2026.03.29.715138; doi: https://doi.org/10.64898/2026.03.29.715138
A Risk Factor Atlas for Allergy-Related Airway Diseases: Evidence From Multi-Biobank Genetic Study
Guo T, Luo P, Jia G, Liu D, Xie H.
Allergy Asthma Immunol Res. 2026 Mar;18(2):224-241. doi: 10.4168/aair.2026.18.2.224.
Association of Obstructive Sleep Apnea With Risk of Myocardial Infarction: A Multivariable Mendelian Randomization and Mediation Analysis
Yifan Zhang, Xiaoli Zhu, Yulan Chen, Ayiguzaili Maimaitimin, Zeyu Liang, Rehanguli Maihemutijiang, Nayiman Nihimaiti
medRxiv 2026.03.29.26349673; doi: https://doi.org/10.64898/2026.03.29.26349673
Causal Associations of Cerebrospinal Fluid and Circulating Metabolites With Malignant Brain Neoplasms: A Mendelian Randomization Analysis
Zhang X, Wu Z, Tan J, Hu M, Pan F, Tao T.
Brain Behav. 2026 Apr;16(4):e71319. doi: 10.1002/brb3.71319.
Multivariate genome-wide association study dissects shared biology and disorder-specific loci across internalizing spectrum in millions of ancestrally diverse participants
Dan Qiu, Zhongzheng Mao, Jun He, Ziang Xu, Chang Liu, David Davtian, Qianyu Chen, Sefayet Karaca, 23andMe Research Team, Brenda Cabrera-Mendoza, Renato Polimanti
medRxiv 2026.03.27.26348717; doi: https://doi.org/10.64898medRxiv 2026.03.27.26348717; doi: https://doi.org/10.64898/2026.03.27.26348717
Computational and Experimental Biology Reveals Dihydroartemisinin's Efficacy Against Steroid-Induced Osteonecrosis of the Femoral Head Adjusting Ferroptosis via CCL17-PRDX6
Li Y, Wang Y, Feng X, Zhang L, Wang Q, Liu X, Ma T, Zhang P, Du Y, Qin M, Ma J.
Drug Des Devel Ther. 2026 Mar 23;20:574294. doi: 10.2147/DDDT.S574294.
Investigating the Inflammatory Link Between Vitamin D and Hidradenitis Suppurativa: A Systematic Review and Causal Inference Analysis
Spiteri J, Grech L, Mintoff D, Pace NP.
Int J Mol Sci. 2026 Mar 23;27(6):2895. doi: 10.3390/ijms27062895.
Can Dietary Fibre Intake Reduce the Risk of Mental and Behavioral Disorders Due to Use of Tobacco in Smokers?
Xueting Qi, Hui Qi, Na li, Tong Wang, Weijing Wang, Xin Song, Baibing Mi, Dongfeng Zhang
medRxiv 2026.03.26.26349460; doi: https://doi.org/10.64898/2026.03.26.26349460
Human Genetic Analysis Reveals Circulating Alpha-1 Antitrypsin Level as a Protective Factor in Sepsis
Dandan Tan, Ping Zhang, Thomas M. Zheng, Kevin Y.H. Liang, Chen-Yang Su, Yiheng Chen, Tianyuan Lu, J Brent Richards, Amanda Y. Chong, Patrick R. Lawler, Fergus Halmailton, Alexander J. Mentzer, Julian C. Knight, Guillaume Butler-Laporte
medRxiv 2026.03.25.26349312; doi: https://doi.org/10.64898/2026.03.25.26349312
Blood donor biobank pipeline to collect genome-based samples for research
Honkanen J, Timonen VA, Koski JR, Juvila J, Arvas M; Blood Service Biobank, FinnGen; Hartwall L, Kilpivaara O, Rodosthenous RS, Wartiovaara-Kautto U, Vuorela A, Daly M, Palotie A, Pitkänen E, Partanen J.
Sci Rep. 2026 Mar 26;16(1):10202. doi: 10.1038/s41598-026-37772-9.
Causal Effect of Multi-cohort Circulating Proteome on the Risk of Aortic Aneurysm: A Mendelian Randomization Study
Ding M, Li Y, Yao S, Wang K.
Ann Vasc Surg. 2026 Mar 25:S0890-5096(26)00169-X. doi: 10.1016/j.avsg.2026.03.008
Risk assessment of secondary primary malignancies: results from two large prospective European cohorts
Yin J, Rixiati Y, Xu Y, Yang P, Sheng C, Wang Z.
NPJ Precis Oncol. 2026 Mar 27. doi: 10.1038/s41698-026-01380-7.
Incorporating phenotype heterogeneity in disease GWAS improves power while maintaining specificity
Jasper Hof, Chao Ning, Liam Quinn, Doug Speed
medRxiv 2026.03.26.26349370; doi: https://doi.org/10.64898/2026.03.26.26349370
CCS-mediated mechanistic link between gestational diabetes mellitus and carpal tunnel syndrome: a multi-omics MR framework
Chen R, Zhang Y, Meng X, Ren X, Lv T, Sun Y, Chen T.
Front Immunol. 2026 Mar 11;17:1766134. doi: 10.3389/fimmu.2026.1766134
Integrative Multi-Omics and Experimental Analyses Identify TAPBP as a Key Mediator Linking Genetic Susceptibility to Melanocyte Dysfunction in Vitiligo
Shi J, Guo M, Fu L, He J, Hu Y.
Clin Cosmet Investig Dermatol. 2026 Jan 23;19:577486. doi: 10.2147/CCID.S577486.
Mendelian randomization implicates circulating plasma proteins in gout risk and identifies candidate therapeutic targets
Zhang H, Dang Z, Yu P, Chen G, Zhang Y, Wang T, Yu T, Zhang Y, Shang Z.
Int J Immunopathol Pharmacol. 2026 Jan-Dec;40:3946320261428859. doi: 10.1177/03946320261428859.
Adiposity, Not Galectin-3, Is the Independent Causal Driver of Periodontitis: A Multivariable Mendelian Randomization Study
Canxu Meng
Research Square, 26 March 2026, PREPRINT [https://doi.org/10.21203/rs.3.rs-9116792/v1]
Identification of Potential Therapeutic Targets for Xihuang Pill in Breast Cancer: A Mendelian Randomization and Experimental Study
Tang Y, Yang Z, Ye Z, Su H, Zhu R, Meng X, Zheng Q.
Breast Cancer (Dove Med Press). 2026 Feb 6;18:572244. doi: 10.2147/BCTT.S572244.
Proposing an Optimized Prediction Model for Pancreatic Cancer Based on Mendelian Randomization Analysis of Fibrinogen Levels and Urinary Protein Excretion Rate
Wu Q, Sun M, Lin Y, Lin S, Lin T, Han X, Han X.
Clin Med Insights Oncol. 2026 Mar 17;20:11795549251392490. doi: 10.1177/11795549251392490
Disentangling the Shared and Differential Genetic Architecture Between COVID-19 and Other Respiratory Disorders: A Multi-Omics Genome-Wide Analysis
Xiao Xue, Yu-Ping Lin, Yaning Feng, Hon-Cheong So
medRxiv 2026.03.21.26348591; doi: https://doi.org/10.64898/2026.03.21.26348591
Cross-omic dissection reveals locus-specific heterogeneity and antagonistic pleiotropy between Alzheimer’s disease and type 2 diabetes
Emmanuel O Adewuyi, Asa Auta, Olayinka S Okoh, Kaja Selmer, Kristina Gervin, Dale R Nyholt, Gavin Pereira
medRxiv 2026.03.23.26349030; doi: https://doi.org/10.64898/2026.03.23.26349030
Integrative genomics reveal genetic links of chronic cough with risk factors and brain regional volumes
Lin Z, Huang J, He L, Xie S, Shu G, Chen G, Lin W, Zhong X, Li S, Chung KF, Chen R.
ERJ Open Res. 2026 Mar 23;12(2):00844-2025. doi: 10.1183/23120541.00844-2025
A genome-wide CRISPR Screening identifies targets that drive Tolerogenic Dendritic Cells
Xiaoguang Li, Liang Chen, Tiankai Han, Megha Suresh, Fedik Rahimov, Chao Gao, Jing Wang, Renze Ma, Joshua D Stender, Kanstantsin Katlinski
bioRxiv 2026.03.23.713621; doi: https://doi.org/10.64898/2026.03.23.713621
Causal links between gut microbiota, metabolites, and diffuse large B-cell lymphoma: Evidence from a Mendelian randomization study
Feng G, Zhong G, Wang C, Kong R, Wang J, Zhou X.
Adv Clin Exp Med. 2026 Mar 25. doi: 10.17219/acem/208704.
Evolution of the genetic architecture of uterine disorders
Eulalie Liorzou, Hanna Julienne, Maëlle Daunesse, Guillaume Laval, Hugues Aschard, Camille Berthelot
bioRxiv 2026.03.24.713926; doi: https://doi.org/10.64898/2026.03.24.713926
Causal effects of drug exposure on gastric cancer risk: a Mendelian randomization study involving 23 commonly used medications in the European population
Zhang G, Xia J, Zhou Y, Qian J, Yin D, Lv W.
Discov Oncol. 2026 Mar 23. doi: 10.1007/s12672-026-04672-3
Oxidative Stress-Related Genome-Wide Mendelian Randomization Identifies Causal Genes for Coronary Artery Disease
Zhang H, Feng J, Shi W, Niu G, Zheng Y, Zhao Z, Wang M, Zhou Z, Li Z, Wu Y.
Cardiovasc Ther. 2026;2026(1):e4594769. doi: 10.1155/cdr/4594769.
Genetic Evidence Supports a Potential Role of WTAP-related m6A Regulation in Vascular Dementia: Insights from Mendelian Randomization and Multi-omics Analyses
Zheng W, Qiu J, Xian D, Yang K.
J Mol Neurosci. 2026 Mar 24;76(2):48. doi: 10.1007/s12031-026-02510-3.
Caffeine intake and late dry age-related macular degeneration: tea’s protective role—insights from NHANES and Mendelian randomization
Hongli Yang, Boshi Liu, Yunxi Zhang, Zhanhe Zhang, Huang Tan & Xiaorong Li
Int J Retin Vitr 12, 43 (2026). https://doi.org/10.1186/s40942-026-00813-6
Evaluating the Role of Lipid Accumulation Product Index in Endometriosis: Findings from NHANES and Mendelian Randomization
Tang N, Luo C, Hu L, Xu F.
Int J Womens Health. 2026 Jan 22;18:553824. doi: 10.2147/IJWH.S553824
Integrating Lung Tissue-based Transcriptome-Wide Association Study with Single-cell RNA-sequencing Uncovers Susceptibility Genes and Cell Types Underlying Lung Cancer Risk
Shuai Xu, Jiajun Shi, Bingshan Li, Xiao-Ou Shu, Ran Tao, Hui Cai, Wanqing Wen, Stephen A Deppen, Maizie Xin Zhou, Lili Xu, Jifeng Wang, Jie Wu, Yaohua Yang, Xingyi Guo, Wei Zheng, Jirong Long, Qiuyin Cai
medRxiv 2026.03.19.26348840; doi: https://doi.org/10.64898/2026.03.19.26348840
Identification of potential biomarkers and therapeutic targets for liver cirrhosis based on Mendelian randomization and machine learning
Zhang K, Chen T, Jia Z, Zhao J, Huang N.
Biochem Biophys Rep. 2026 Mar 14;46:102538. doi: 10.1016/j.bbrep.2026.102538.
A two-sample Mendelian Randomization study on the causal relationship between obesity and breast cancer
Chen X, Yan X, Fu Y, Zheng H, Wu Z, Ma H, Yan A, Zhao S.
Clin Nutr ESPEN. 2026 Apr;72:102925. doi: 10.1016/j.clnesp.2026.102925.