Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

Elokuu

Causal association between inflammatory cytokines and osteonecrosis: A bidirectional 2-sample Mendelian randomization study
You W, Lin Z, Lin Y, Liu M, Ye R, Zeng R.
Medicine (Baltimore). 2025 Aug 1;104(31):e43671. doi: 10.1097/MD.0000000000043671.
Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases
Wang J-H, Dong S-S, Wang H-A, Liu S-S, Ma X, Zhu R-J, Shi W, Wu H, Yu K, Zhang T-P, Wang C-R, Guo Y, Yang T-L.
Cardiovasc Diabetol . 2025 Aug 1;24(1):312. doi: 10.1186/s12933-025-02847-w
Exploring causal relationships between brain imaging-derived phenotypes and ovarian cancer risk: a bidirectional Mendelian randomization
Liu, T., Tuo, X., Zhao, H
J Ovarian Res 18, 173 (2025). https://doi.org/10.1186/s13048-025-01733-z
Exploring causal pathways between hypertension, lipid levels, and gout: Insights from Mendelian randomization and NHANES observations
Li M, Nie Q, Lv K, Liu J, Jiang Z.
Medicine (Baltimore). 2025 Aug 1;104(31):e43638. doi: 10.1097/MD.0000000000043638.
Revealing the causal relationship between cathepsin and inflammatory disease of wrist through Mendelian randomization
Qu Y, Gong Q, Huang X, Zhao W.
Medicine (Baltimore). 2025 Aug 1;104(31):e43461. doi: 10.1097/MD.0000000000043461.
Integrative analysis reveals novel inflammatory and metabolic pathways in glioblastoma development: A large-scale mediation Mendelian randomization study
Yang X, Lin X.
Medicine (Baltimore). 2025 Aug 1;104(31):e43636. doi: 10.1097/MD.0000000000043636.

Heinäkuu

Multi-omics analysis unveiled fibroblast-mediated pathogenesis in male genital lichen sclerosus
Lin, L., Liu, Y., Wang, X.
Cell Biosci 15, 113 (2025). https://doi.org/10.1186/s13578-025-01453-3
A Proteomic Profile of the Ocular Phenome: Systemic Signatures, Predictive Value, and Causal Insights Across 131 Ocular Diseases and Traits
Liu D, Liu H, Chen X, Zhang X, Zhang J, Wu J, Chen L, Wang N.
medRxiv 2025.07.31.25332495; doi: https://doi.org/10.1101/2025.07.31.25332495
Metabolism-Mediated FGF5 Association with Stroke: Based on Mendelian Randomization and Bioinformatics Analysis
Xu C, Xu Y, Gao L, Wang M, Wang G, Wang G.
J Multidiscip Healthc. 2025 Jul 31;18:4481-4495. doi: 10.2147/JMDH.S529168.
The Palmitoyltransferases ZDHHC6 and ABHD17A Modulate Type 2 Diabetes Risk via Genetic Causality and Molecular Interactions
Jiashu Li, Taoyuan Hao, Zhenzhen He, Modan Zhu, Wanting Du, Xianbo Huang, Qiuxian Li, Xinyuan Liu, Yan Su, Weiping Teng, Zhongyan Shan
Researchsquare, 31 July 2025, doi: 10.21203/rs.3.rs-6697832/v1
Long-term cardiovascular risk in women with hypertensive disorders of pregnancy: Insights from polygenic risk scores
Kivioja A, Tyrmi J, Toivonen E, Huhtala H; FinnGen; Jääskeläinen T, Kettunen J, Saarela T, Laivuori H.
Acta Obstet Gynecol Scand. 2025 Jul 31. doi: 10.1111/aogs.70021.
Potential Causal Relationship Between Plasma and Cerebrospinal Fluid Metabolites and Meningioma: Two-Sample Mendelian Randomization Study
Du G, Xu D, Zhao H, Yan Z, Wang J.
https://www.dovepress.com/potential-causal-relationship-between-plasma-and-cerebrospinal-fluid-m-peer-reviewed-fulltext-article-JMDH
Mind the gap: characterizing bias due to population mismatch in two-sample Mendelian randomization
Li J, Morrison J.
medRxiv 2025.07.30.25332465; doi: https://doi.org/10.1101/2025.07.30.25332465
Shikonin as a therapeutic agent in renal cell carcinoma: insights from TEK-related causal association with glaucoma
Jia R, Liang Y, Zou B, Li X, Chen T, Zhang C, Bian J, Guo R.
Front Pharmacol. 2025 Jul 30;16:1580704. doi: 10.3389/fphar.2025.1580704.
Estimating effects of serum vitamin B12 levels on psychiatric disorders and cognitive impairment: a Mendelian randomization study
Lu T, Paterson AD.
Commun Med (Lond) . 2025 Jul 30;5(1):316. doi: 10.1038/s43856-025-01043-x
Exploring the liver-brain axes: insights from a bidirectional Mendelian randomization study on brain cortical structure and liver cancers
Zhu Q, Li Z, Cai C, Li D.
Discov Oncol. 2025 Jul 30;16(1):1446. doi: 10.1007/s12672-025-03276-7.
Causal relationships between gut microbiota and urothelial carcinoma mediated by inflammatory cytokines and blood cell traits identified through Mendelian randomization analysis.
Wu, X., Zou, W. & Liu, Z
Discov Onc 16, 1440 (2025). https://doi.org/10.1007/s12672-025-03219-2
Oxidative Stress Links Thyroid Autoimmunity to Cancer: Peroxiredoxin 2 Protection via Genomic and Single-Cell Insights
Kang J, Wang S, Ni X.
Cancer Biother Radiopharm. 2025 Jul 30. doi: 10.1177/10849785251360744.
Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study
Lu C, Wang M, Li J, Xian H, Huang Z, Wang Y, Xie S, Zhang W, Yu Y, Zheng H, Li D, Zheng Y, Liu H, Zhao C.
Hematology. 2025 Dec;30(1):2538327. doi: 10.1080/16078454.2025.2538327.
DLK1 downregulation serves as a potential biomarker for disease severity and a therapeutic target in bronchiectasis
Yanping Liu, Shaochu Zheng, Shihao Yang, Yuting Huang, Jinling Tang, Haizhu Huang, Kangkang Hong, Jing Luo, Jinliang Kong
Researchsquare, 29 July 2025, doi: 10.21203/rs.3.rs-7090713/v1
Identification of hub gene associated with colorectal cancer: Integrating Mendelian randomization, transcriptome analysis and experimental verification
Yu Zhang, Xu Han, Yichun Yang, Jiayan Ren, Zixi Zhang, Yanmin Zhang, Qi Su, Dake Chu
Plos Genetics, July 29, 2025 https://doi.org/10.1371/journal.pgen.1011788
Unraveling the link between inflammatory bowel disease and perianal abscess: insights from bidirectional and multivariable Mendelian randomization study
Zhu H, Pan J.
BMC Gastroenterol. 2025 Jul 29;25(1):538. doi: 10.1186/s12876-025-04137-x.
Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components
Omdahl AR, Weinstock JS, Keener R, Chhetri SB, Arvanitis M, Battle A.
Am J Hum Genet. 2025 Sep 4;112(9):2178-2197. doi: 10.1016/j.ajhg.2025.07.003. Epub 2025 Jul 28.
Causal association between non-steroidal anti-inflammatory drugs use and the risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study
Junfa Liu, Kaiyi Dong, Gang Qin, Chunyan Ye, Jinghan Wu, E. Wang, Zhitao Dong
Inflammopharmacol 33, 4615–4627 (2025). https://doi.org/10.1007/s10787-025-01866-z
Pear-shaped body types linked to lower risk of gout: genetic evidence from Mendelian randomization
Yu Qiu, Cantao Li, Ying Hua, Yan Huang, Lu Zhang, Jiaman Xu, Junna Zheng, Zhiling Fu, Xiaoxi Zhang, Fenfen Li, Daozong Xia
Int J Obes 49, 2273–2285 (2025). https://doi.org/10.1038/s41366-025-01875-6
Systemic evaluation of the effects of monomeric GLP-1R-based agonists on MASLD and its complications
Cai, Y., Xie, S., Xu, L
Diabetol Metab Syndr 17, 300 (2025). https://doi.org/10.1186/s13098-025-01870-x
Genome-wide analysis of 3' untranslated region alternative polyadenylation quantitative trait loci identified a potential novel susceptibility locus for lung cancer in cross-ancestry populations
Wang Y, Li Y, Tian T, Han R, Zeng N, Xie F, Wang Y, Fan J.
J Hum Genet. 2025 Jul 29. doi: 10.1038/s10038-025-01375-5.
The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study
Detian Jiang, Yuxin Chang, Xiaowen Zhen, Xin Zhao
Nutr Metab (Lond) 22, 86 (2025). https://doi.org/10.1186/s12986-025-00979-0
ADCY3 Ser107Pro links difficulty awakening in the morning to adiposity through circadian regulation of adipose thermogenesis
Tchio C, Maher M, Moth C, Meiler H, Lane J, Taylor H, Williams J, Saxena RR.
bioRxiv 2025.07.28.667339; doi: https://doi.org/10.1101/2025.07.28.667339
Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation
Akdeniz BC, Bahrami S, Hagen E, Fuhrer J, Fominykh V, Shadrin A, Filiz TT, Athanasiu L, Grenier-Boley B, Bellenguez C, de Rojas I, Kucukali F, Schneider A, Kleineidam L, Rujescu D, Scherbaum N, Deckert J, Riedel-Heller S, Hausner L, Molina-Porcel L, Grimmer T, Heilmann-Heimbach S, Moebus S, Scarmeas N, Garcia-Alberca JM, Franco-Macias E, Mir P, Real LM, Rodriguez-Rodriguez E, Luis Royo J, Saez ME, Carracedo A, Lopez de Munain A, Amer-Ferrer G, Calero M, Medina M, Garcia-Ribas G, Mendioroz M, Dols-Icardo O, Moreno F, Perez-Tur J, Bullido MJ, Alvarez V, Soininen H, Heikkinen S, de Mendonca A, Mehrabian S, Traykov L, Hort J, Vyhnalek M, Sandau N, Thomassen JQ, Luo J, Pijnenburg YAL, Tesi N, van Swieten J, Giedraitis V, Williams J, Nicolas G, Debette S, Amouyel P, Grunblatt E, Popp J, Bossu P, Galimberti D, Rossi G, Arosio B, Mecocci P, Squassina A, Tremolizzo L, Borroni B, Nacmias B, Seripa D, Rainero I, Daniele A, Piras F, Masullo C, Kehoe PG, Frikke-Schmidt R, Ghidoni R, Ruiz A, Fernandez V, Sanchez-Juan P, Sleegers K, Ingelsson M, Hiltunen M, Sims R, Ramirez A, Broce IJ, Haavik J, Selbaek G, Knapskog A-B, Saltvedt I, Bergh S, Aakhus E, Kirsebom B-E, Watne LO, Rongve A, Arsland D, Djurovic S, Stordal E, Toft M, Scheffler K, Fladby T, Lambert J-C, Dale A, Frei O, Andreassen O.
medRxiv 2025.07.28.25332293; doi: https://doi.org/10.1101/2025.07.28.25332293
Oral and gut microbiota in gingivitis subtypes: a causal inference study using Mendelian randomization
Lin J, Xu Q, Bi W, Yu Y, Wang Q.
BMC Oral Health. 2025 Jul 28;25(1):1270. doi: 10.1186/s12903-025-06658-z.
Air pollutants and adverse pregnancy outcomes: A multi-method integration of Mendelian randomization, meta-analysis, and animal models
Zhou W, Shao J, Huang J, Gan J, Wang Y, Chen J, Chen Y, Zi Y, Xu Q, Zhou Q, Zhao H, Li X.
Ecotoxicol Environ Saf. 2025 Jul 28;302:118699. doi: 10.1016/j.ecoenv.2025.118699.
Genetic Prediction of Causal Association Between Celiac Disease and Thyroid Function: A Two-Sample Mendelian Randomized Study
He X, Lv H, Yu W, He J, Xie Y, Zhou L, Wu H, Guo L, Yang X.
Endocr Metab Immune Disord Drug Targets. 2025 Jul 28. doi: 10.2174/0118715303364014250713045734.
Deciphering bidirectional causal links between oxidative stress and lung cancer risk through Mendelian randomization
XueLian Chen, JianRong Zeng, FengYun Cao, Jun Cai, Xin Ma, ChangYu Pu
Discov Onc 16, 1421 (2025). https://doi.org/10.1007/s12672-025-03289-2
Association of GLP1RAs with risk of chronic obstructive pulmonary disease: evidence from drug target Mendelian randomization
Lai S, Feng Y, Li L, Zhao J, Wang Z, Wang Y.
Diabetol Metab Syndr. 2025 Jul 28;17(1):295. doi: 10.1186/s13098-025-01866-7.
Obstructive sleep apnea and metabolic-associated fatty liver disease risk: Insights from National Health and Nutrition Examination Survey and Mendelian randomization analysis
Beibei C, Junhai Z, Zongbiao T, Fang P.
Nutr Metab Cardiovasc Dis . 2025 Jul 26:104265. doi: 10.1016/j.numecd.2025.104265.
Unveiling the genetic pleiotropy between anxiety disorders and autoimmune diseases: insights from large-scale genome-wide cross-trait analysis
Lin H, Xiao Y, Liu Y, Lin X, Liu X.
J Affect Disord. 2025 Jul 26:119984. doi: 10.1016/j.jad.2025.119984.
Lipidomic and transcriptomic profiling reveal alterations in the coexistence of gestational diabetes mellitus and preeclampsia impacting maternal and neonatal outcomes
Zhang C, Huang Y, Mai X, Liu L, Li Y, Zheng F, Cao J, Zou C, Wang C, Ran J, Zhang H, Wang X.
Sci Rep. 2025 Jul 25;15(1):27102. doi: 10.1038/s41598-025-12077-5.
Coronary atherosclerosis has a protective genetic causal effect against lung squamous cell carcinoma: A bidirectional two-sample Mendelian randomization study based on STROBE-MR guidelines
Liao Z, Jia P, Pang L, Chen Y, Zhang J.
Medicine (Baltimore). 2025 Jul 25;104(30):e43378. doi: 10.1097/MD.0000000000043378.
The use of statins can reduce the risk of osteoarthritis and osteoporosis
Zeng X, Luo F, Wang XD, Cao WJ, Chen YJ, Su Q.
Inflammopharmacology. 2025 Jul 25. doi: 10.1007/s10787-025-01864-1.
Association between 1400 metabolites and IgA nephropathy: A Mendelian randomization analysis
Wang C, Li Y, Zhong L, Sun N, Luo D, Xu Y, Qi A.
Medicine (Baltimore). 2025 Jul 25;104(30):e43353. doi: 10.1097/MD.0000000000043353.
Risk of remnant cholesterol and chronic obstructive pulmonary disease: a mendelian randomization study
Feng WY, Zheng JH, Xiao JQ, Wang ZX, Zheng YF, Jin XN, Xie JY, Liao WZ, Guo XG, Guan WJ.
J Thorac Dis. 2025 Jul 31;17(7):5122-5132. doi: 10.21037/jtd-24-1894.
Genetic analyses of eight complex diseases using predicted continuous representations of disease
Chen R, Rocheleau G, Petrazzini BO, Forrest IS, Park JK, Duffy Á, Vy HMT, Jordan D, Do R.
Cell Rep Methods. 2025 Jul 18:101115. doi: 10.1016/j.crmeth.2025.101115.
Exploration of potential therapeutic target genes for preeclampsia through genetic analysis
Huihui Wang, Meihong Shen, Guangtong She, Huiyan Wang, Wenbo Zhou
J Hum Hypertens 39, 643–651 (2025). https://doi.org/10.1038/s41371-025-01054-0
Sleep traits and physical activity mediate the causal association between depression and age-related diseases
Wei J, Zhang M, Qi M, He C, Ma S, Sui L, Mao Z, Zhu X, Pan X.
Eur Arch Psychiatry Clin Neurosci. 2025 Jul 25. doi: 10.1007/s00406-025-02068-y.
Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome
Zheng Z, Ma Y, Shi Y, Xu Y.
Int J Gynaecol Obstet. 2025 Jul 24. doi: 10.1002/ijgo.70411.
Proteome-wide Mendelian randomization and colocalization analyses identify novel protein targets for cardiac conduction disorders
Song ZQ, Xu YP, Chen YQ, Zeng H, Lin XS, Lu XY, Yu-Tao, Shi S, Chen YH.
J Cardiol. 2025 Jul 20:S0914-5087(25)00189-3. doi: 10.1016/j.jjcc.2025.07.005.
Genome-wide association study of pulpal and apical diseases
Salminen A, Hyvärinen K, Ritari J, Leppilahti JM, Palotie U, Vuollo V, Kambur O; FinnGen; Estonian Biobank Research Team; Reis K, Reigo A, Palta P, Perola M, Sinisalo J, Havulinna AS, Mäntylä P, Gürsoy UK, Suominen AL, Rice DP, Anttonen V, Nieminen P, Pussinen PJ.
Nat Commun. 2025 Jul 23;16(1):6774. doi: 10.1038/s41467-025-61721-1.
Unraveling the causal link between inflammatory cytokines and hypertensive renal disease: a Mendelian randomization analysis
Gong X, Xu X, He M, Zhao X, Zou W.
Int Urol Nephrol. 2025 Jul 23. doi: 10.1007/s11255-025-04674-0.
Blood metabolites, mitochondrial biofunction, and cervical cancer: a bidirectional Mendelian randomization study
Chongze Yang, Lan-hui Qin, Liwei Li, Meng-na Lan, Qiu-ying Wei, Yi Li, Jin-yuan Liao
BMC Women's Health 25, 363 (2025). https://doi.org/10.1186/s12905-025-03909-7