Publikationslista

Portas L, Talaei M, Dean C, Aung N, Hind MD, Pozarickij A, Walters RG; China Kadoorie Biobank Collaborative Group; Burney PG, Petersen S, Minelli C, Shaheen SO.

Thorax. 2025 May 30:thorax-2024-222474. doi: 10.1136/thorax-2024-222474.

Analysis of the correlation between inflammatory cytokines and glioblastoma: A Mendelian randomization study

Xuan F, Lv T, Zheng L, Yu S, Ding M.

Medicine (Baltimore). 2025 May 30;104(22):e42137. doi: 10.1097/MD.0000000000042137.

Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization study

Huang X, Zhao JV.

BMC Med. 2025 May 30;23(1):321. doi: 10.1186/s12916-025-04127-6.

From infection to tumor: genetic evidence of viral antibody immune response' role in urologic cancer development

Wang C, Zhang Q, Li Q, Wang Y, Chen X.

Discov Oncol. 2025 May 29;16(1):947. doi: 10.1007/s12672-025-02768-w.

Multi-Omics Mendelian Randomization Identifies Therapeutic Targets for Sjögren’s Disease with Clinical and Bayesian Validation

He J, Li K, Guo Z, Zhou X, Tang X.

J Inflamm Res. 2025;18:16685-16698 https://doi.org/10.2147/JIR.S543644

Unveiling the Intricate Causal Nexus Between 91 Circulating Inflammatory Proteins and Perianal Abscess Through a Comprehensive Bidirectional Two-Sample Mendelian Randomization Analysis

Wang Z, Chen T, Shi H, Zhang X, Yang W.

Health Sci Rep. 2025 May 29;8(6):e70803. doi: 10.1002/hsr2.70803.

Decoding the impact of glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist on cardiometabolic health: inflammatory mediators at the focus

Cheng F, Niu X, Wang Y, Yang F, Yang K, Li W.

Diabetol Metab Syndr. 2025 May 28;17(1):175. doi: 10.1186/s13098-025-01744-2.

Association of glucagon-like peptide-1 receptor agonists and seven common mental disorders: A drug target and mediation Mendelian randomization

Zhang Z, Li S, Dai X, Li C, Sun P, Qu J, Jiang H, Pan B.

J Affect Disord. 2025 May 28:119509. doi: 10.1016/j.jad.2025.119509.

The Mediating Role of Plasma Inflammatory Proteins in Gut Microbiota-Driven Valvular Heart Disease: A Mendelian Randomization Study

Zhao J, Wang Y, Lv C, Peng J, Lu S, Shen L.

Cell Biochem Biophys. 2025 May 28. doi: 10.1007/s12013-025-01780-9.

Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study

Wang N, Wang T, Tang M, Zu B, Chen J.

BMC Pregnancy Childbirth. 2025 May 28;25(1):622. doi: 10.1186/s12884-025-07754-2.

Sleep disturbances as risk factors for neurodegeneration later in life

Simmonds E, Levine KS, Han J, Iwaki H, Koretsky MJ, Kuznetsov N, Faghri F, Warly Solsberg C, Schuh A, Jones L, Bandres-Ciga S, Blauwendraat C, Singleton A, Escott-Price V, Leonard HL, Nalls MA.

npj Dement. 1, 6 (2025). https://doi.org/10.1038/s44400-025-00008-0

Variant-specific priors clarify colocalisation analysis

Pullin JM, Wallace C.

PLoS Genet. 2025 May 27;21(5):e1011697. doi: 10.1371/journal.pgen.1011697.

Variant-specific priors clarify colocalisation analysis

Pullin JM, Wallace C.

PLoS Genet. 2025 May 27;21(5):e1011697. doi: 10.1371/journal.pgen.1011697.

Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts

Joensuu L, Koivunen K, Tynkkynen NP, Palviainen T, Kaprio J; FinnGen Consortium; Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Sillanpää E.

Br J Sports Med. 2025 May 27;59(11):783-790. doi: 10.1136/bjsports-2024-109491.

Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability

Drouard G, Hagenbeek FA, Ollikainen M, Zheng Z, Wang X; FinnGen; Ripatti S, Pirinen M, Kaprio J.

J Proteome Res. 2025 May 27. doi: 10.1021/acs.jproteome.4c00971.

Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk

MULTI consortium; Anagnostakis F, Ko S, Saadatinia M, Wang J, Davatzikos C, Wen J.

Nat Commun. 2025 May 26;16(1):4871. doi: 10.1038/s41467-025-59964-z.

Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics

Lobato-Moreno S, Yildiz U, Claringbould A, Servaas NH, Vlachou EP, Arnold C, Bauersachs HG, Campos-Fornés V, Kim M, Berest I, Prummel KD, Noh KM, Marttinen M, Zaugg JB.

Nat Methods. 2025 Jun;22(6):1213-1225. doi: 10.1038/s41592-025-02700-8.

Metabolomics insights into the causal associations between antihypertensive drugs and myocarditis

Hu X, Hu T, Ye Y, Chen X, Abulikemu S, Yu J, Zhao Y, Wang J, Peng Y.

Int Immunopharmacol. 2025 May 26;159:114946. doi: 10.1016/j.intimp.2025.114946.

Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses

Li X, Yang CH, Zhou M, Yin MY.

Thromb J. 2025 May 26;23(1):54. doi: 10.1186/s12959-025-00733-9.

Association of lipid-lowering drugs with venous thromboembolism outcomes: a phenome-wide association study and a drug-target Mendelian randomization study

Lingyu Z, Wanting Z, Ying G, Qianqian J, Chunfang W.

J Thromb Thrombolysis. 2025 May 26. doi: 10.1007/s11239-025-03108-z.

Contextualizing molecular and structural aging across human organs

Shu J, Guo Y, Chirinos J, Fan Z, Yang Y, Li Y, Yang X, Beeche C, Su B, Horng I, Zheng R, Paschou P, Wang L-S, O’Brien JM, Gur R, Lin J, Witschey W, Rader DJ, Rosenzweig A, Zhao B.

medRxiv 2025.05.26.25328375; doi: https://doi.org/10.1101/2025.05.26.25328375

Screening of biobank SNP-array genotyping data to detect Lynch syndrome predisposing MLH1 copy number variants

Ala-Kulju K, Carpén O, Lappalainen M, Pehrsson M.

Fam Cancer. 2025 May 26;24(2):47. doi: 10.1007/s10689-025-00476-6.

Causal relationship between citrate and gestational diabetes mellitus: a two-sample Mendelian randomization analysis

He Y, Gan Y, Mao J, Shi Q.

J Matern Fetal Neonatal Med. 2025 Dec;38(1):2509160. doi: 10.1080/14767058.2025.2509160.

Causal relationships between white matter connectome and mental disorders: a large-scale genetic correlation study

Zhao Z, Zhang B, Gan R, Xie H, Shao Y, Xu K, Jia Z.

J Affect Disord. 2025 May 24;386:119469. doi: 10.1016/j.jad.2025.119469.

Unraveling drug resistance mechanisms in testicular cancer through immune cell phenotypes: a bidirectional Mendelian randomization analysis revealing novel therapeutic targets

Xiao L, Wu T.

Discov Oncol. 2025 May 24;16(1):912. doi: 10.1007/s12672-025-02757-z.

Susceptibility genes for allergic conjunctivitis revealed by cross-tissue transcriptome-wide association study

Xu Q, Li Y, Zhang X.

Exp Eye Res. 2025 May 24;257:110444. doi: 10.1016/j.exer.2025.110444.

Exploring the anti-gastric cancer mechanisms of Diosgenin through integrated network analysis, bioinformatics, single-cell sequencing, and cell experiments

Yun Z, Yang Q, Xue C, Shen Y, Lv L, Mi S, Hou L.

Front Pharmacol. 2025 May 23;16:1600960. doi: 10.3389/fphar.2025.1600960.

Endothelial selective adhesion molecule and interleukin-16 play an intermediary role in psoriasis complicated with acute myocardial infarction: A Mendelian randomization study

Kang X, Wang C, Zhong GQ, Zhang HJ.

Medicine (Baltimore). 2025 May 23;104(21):e42538. doi: 10.1097/MD.0000000000042538.

Circulating metabolic biomarkers mediated causal relationship between gut microbiota and bladder cancer: a two-step mendelian randomization study

Wei FY, He QH, Yin BT, Zhao JW, Zhao YT, Wei ZS, Li YJ, Liang HQ, Qin M, Cheng JW.

Discov Oncol. 2025 May 23;16(1):877. doi: 10.1007/s12672-025-02618-9.

The health impacts and genetic architecture of food liking in cardio-metabolic diseases

Jiang W, Wang H, Geng Y, Guo M, Zuo Y, Han S, Liu Z, Chen S, Fan S, Li S, Qiao C, Li Q, Li B, Zhang Y, Wei W, Han T.

Nat Commun. 2025 May 23;16(1):4810. doi: 10.1038/s41467-025-59945-2.

NMRAL1 as a Causal Factor in Postherpetic Neuralgia: A Proteome-Wide Mendelian Randomization Study

Ye H, Wang Y, Shi Y, Wu Y, Xu Q, Huang S.

J Pain Res. 2025 May 23;18:2623-2629. doi: 10.2147/JPR.S512034.

Immunological mediators in the causal relationship between latent autoimmune diabetes in adults and breast cancer: A Mendelian randomization analysis

Xiao F, Xie D, Zhou D, Yang L, Liu F.

Medicine (Baltimore). 2025 May 23;104(21):e42571. doi: 10.1097/MD.0000000000042571.

The impact of lipidome on intervertebral disk degeneration, low back pain, and sciatica: a Mendelian randomization study

Pang ZY, Zhu YB, Hu JX, Li XX, Gao YJ, Wang YY, Zhou Q, Li P.

Sci Rep. 2025 May 23;15(1):18045. doi: 10.1038/s41598-025-99914-9.

Causal validation of the relationship between air pollution and lung cancer: A bidirectional Mendelian randomization study and meta-analysis

Wang X, Xiao G, Xu W, Ni C.

Medicine (Baltimore). 2025 May 23;104(21):e42450. doi: 10.1097/MD.0000000000042450.

Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study

Xu J, Liu Z, Wu L, Pei F, Jiang H, Cheng C, Yang W, Yuan J, Polimanti R, Yang Y.

Cardiovasc Health 2, 17 (2025). https://doi.org/10.1038/s44325-025-00054-w

Relationship between red cell distribution width and lung cancer: evidence from Mendelian randomization and National Health and Nutrition Examination Survey

Liu Y, Qu J, Hu C, Zhao W, Zhang Y, Luo Y, Qu Y.

Discov Oncol. 2025 May 22;16(1):867. doi: 10.1007/s12672-025-02718-6.

Trans-ethnic Mendelian randomization analysis of membranous nephropathy and peripheral artery disease with mediating effects of thrombomodulin

Pan J, Huang X, Chen Y, Jiang N, Guo Y, Zhou S, Zhang Y, Hu B, Deng Q, Zhou Q.

Sci Rep. 2025 May 22;15(1):17800. doi: 10.1038/s41598-025-02626-3.

The Association between Myopia and Anxiety: A Bidirectional 2-Sample Mendelian Randomization Study

Wong W, Qin Y, Liu C, Zhang S, Jiang Y, Zeng Y, Wang D, Liang L, Han X.

Ophthalmol Sci. 2025 May 22;5(5):100832. doi: 10.1016/j.xops.2025.100832.

A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for atrial fibrillation

Yuan Y, Zheng X, Zhang W, Ren Z, Liang B.

J Arrhythm. 2025 May 22;41(3):e70097. doi: 10.1002/joa3.70097.

Deciphering the causality between micronutrients and esophageal cancer via Mendelian randomization

Diao Z, Peng G, Chen Y, Wang J, Liu J, Zhang Z, Zhang W.

Nutr Metab (Lond). 2025 May 22;22(1):49. doi: 10.1186/s12986-025-00940-1.

SGLT2 inhibition mitigates intracerebral hemorrhage risk by modulating inflammation

Huang M, Liu Y, Chen C.

Sci Rep. 2025 May 22;15(1):17770. doi: 10.1038/s41598-024-84118-4.

Integrative genome-wide association studies, proteome-wide mendelian randomization, and single-cell RNA sequencing identify interleukin-6 receptor protein as a therapeutic target in aortic aneurysm

Bai Z, An J, Han J, Zhang Y, Wang H, Yang Z, Mo X.

Int J Biol Macromol. 2025 May 21:144380. doi: 10.1016/j.ijbiomac.2025.144380.

Association of modifiable risk factors and telomere length with five neuroendocrine neoplasms: a bidirectional Mendelian randomization study

Li X, Huang L, Yan Y, Rong Y, Chen X, Gao M, Huang J.

Discov Oncol. 2025 May 21;16(1):841. doi: 10.1007/s12672-025-02678-x.