På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2025

Juni

Connection between circulating inflammatory cytokines and non-small cell lung cancer: integrated Mendelian randomization and gene function analysis
Niu K, Tang J, Zhong J, Zheng L, Zhu Y, Ling H, Liu Y, Xu Q, Qiu P, Chen L.
Discov Oncol. 2025 Jun 4;16(1):1005. doi: 10.1007/s12672-025-02817-4.
Mood instability and 22 gastrointestinal disorders: investigating the causal relationships and the mediating factors by Mendelian randomization analysis
Yan F, Huang H, Li Y.
J Affect Disord. 2025 Jun 4;388:119591. doi: 10.1016/j.jad.2025.119591.
Integrative Analysis of Plasma Proteomics and Transcriptomics Reveals Potential Therapeutic Targets for Psoriasis
Wang H, Wang C, Qin R, He J, Zhang X, Ma C, Li S, Fan L, Wang L, Cao L.
Biomedicines. 2025 Jun 4;13(6):1380. doi: 10.3390/biomedicines13061380.
Causal relationship between immune cells and osteoporosis based on genetic prediction: a bidirectional two-sample mediated Mendelian randomization analysis
Wang H, Yu Z, Chen B, Xu S, Zhou Y, Tang X, Qin Y.
Sci Rep. 2025 Jun 4;15(1):19524. doi: 10.1038/s41598-025-95740-1.
SPAG11B, a potential biomarker for rheumatoid arthritis: a two-sample bidirectional Mendelian randomization analysis
Lin K, Lin Q, Lv W, Li Y, Su R.
BMC Rheumatol. 2025 Jun 4;9(1):65. doi: 10.1186/s41927-025-00521-y.
Longitudinal change and causal relationship between gut microbiota and gestational diabetes mellitus
Wu X, Liu X, Tan H, Song J, Ma S, Tan Y.
Diabetol Metab Syndr. 2025 Jun 3;17(1):188. doi: 10.1186/s13098-025-01737-1.
Interactive Effect of Plasma Lipidome on Neuropsychiatric Disorders: A Bidirectional Mendelian Randomization Study
Xiao X, Luo X, Wang Y, Pan X, Gao L, Liu S, Zhang L.
Mol Neurobiol. 2025 Jun 3. doi: 10.1007/s12035-025-05105-y.
Identifying modifiable factors and their causal effects on osteoporosis risk
Jiang S, Xu K, Chen X.
Sci Rep. 2025 Jun 3;15(1):19472. doi: 10.1038/s41598-025-04455-w.
Identification of novel susceptibility loci for testicular germ cell tumors through multi-omics analysis
Xu Y, Shi H, Xiong J, Wu Y, Wu X, Xu Y, Wang Y, Xu S.
Discov Oncol. 2025 Jun 3;16(1):992. doi: 10.1007/s12672-025-02775-x.
Therapeutic Targets for Sepsis: Multicenter Proteome-Wide Analyses and Experimental Validation
Liu B, Jin Y, Ding Y, Gu Y, Zhou J, Luo C.
J Proteome Res. 2025 Jun 3. doi: 10.1021/acs.jproteome.5c00148.
The role of immune cells phenotype in neuroendocrine tumors development
Qiao J, Wu YW, Wang YY, Huang JJ, Shan PF.
Discov Oncol. 2025 Jun 3;16(1):993. doi: 10.1007/s12672-025-02870-z.
ENTR1 affects the progression of colon cancer by regulating energy metabolism under the influence of glycolysis
Ma A, Zhai C, He Q, Wang W, Ren H, Mao K, Lan W, Lan J.
BMC Cancer. 2025 Jun 3;25(1):992. doi: 10.1186/s12885-025-14412-5.
Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders
Gilchrist L, Mutz J, Hysi P, Legido-Quigley C, Kõks S, Lewis CM, Proitsi P.
BMC Med. 2025 Jun 2;23(1):326. doi: 10.1186/s12916-025-04129-4.
Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG
Chen J, Zhuo X, Li Y, Zhu Y, Li Z, Shen X, Zhuo Y, Tan H, Lei L.
Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):7. doi: 10.1167/iovs.66.6.7.
Atlas of Proteomic signatures of brain structure and its links to brain disorders
Ren P, Hou XH, Li Z, You J, Li Y, Zhang W, Gong W, Zhang B, Wu B, Wang L, Shen C, Zhao Y, Ma Q, Kang J, Jiang Y, Roberts N, Xu F, He Y, Yu JT, Wang M, Cheng W.
Nat Commun. 2025 Jun 2;16(1):5092. doi: 10.1038/s41467-025-60185-7.
Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study
Chen J, Zhao J, Zhang Z, Zhu X, Zuo J, Nie Z, Fu Y, Wang H, Tang M, Fu S.
Front Pharmacol. 2025 Jun 2;16:1568780. doi: 10.3389/fphar.2025.1568780.
Causal association of cholesterol metabolism-related proteins with hepatocellular carcinoma and dysfunction-associated steatotic liver disease: a mendelian randomization study
Tian D, Jiang S, Liu Y, Zheng H, Zhang L, Xu Y, Lu X.
Discov Oncol. 2025 Jun 2;16(1):987. doi: 10.1007/s12672-025-02321-9.
Whole-genome sequencing study of 488,888 individuals identifies rare variants and genes associated with glaucoma
Gao XR, Kizhatil K.
medRxiv 2025.06.02.25328820; doi: https://doi.org/10.1101/2025.06.02.25328820
Global burden of maternal hypertensive disorders (1990-2045): trends, regional disparities, and causal links to occupational exposures
Xiong J, Chen S, Wang H, Yang X, Chen X, You B, Yu R.
BMC Pregnancy Childbirth. 2025 Jun 2;25(1):641. doi: 10.1186/s12884-025-07766-y.
Refining the generation, interpretation, and application of multi-organ, multi-omics biological aging clocks
Wen J.
medRxiv 2025.02.06.25321803; doi: https://doi.org/10.1101/2025.02.06.25321803
Exploring the genetic basis between inflammatory bowel disease and venous thromboembolism
Wu Y, Shang C.
Thromb J. 2025 Jun 2;23(1):56. doi: 10.1186/s12959-025-00745-5.
NFKB1-targeted metabolites as novel therapeutic approaches for erectile dysfunction: evidence from gut microbiota network pharmacology and machine learning
Xiang B, An J, Li D.
Sex Med. 2025 Jun 2;13(3):qfaf039. doi: 10.1093/sexmed/qfaf039.
A two-sample Mendelian randomization study on the association between temporomandibular disorder and insomnia
Yuan W, Cheng Y, Cui Y, Gao D.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2025 Jun 1;43(3):354-361. Chinese. doi: 10.7518/hxkq.2025.2024255.
Association between chronic kidney disease and colorectal cancer: evidence from meta-analysis and Mendelian randomization
Qian S, Gong Y, Chen Y.
Discov Oncol. 2025 Jun 1;16(1):974. doi: 10.1007/s12672-025-02785-9.
Genetic analysis of the correlation between GLP1 action and metabolic liver disease: Insights from Mendelian randomization analysis
Ma Z, Wang B, Li D, Chen X.
J Diabetes Investig. 2025 Jun 1. doi: 10.1111/jdi.70087.

Maj

Unravelling the Shared Genetic Architecture between Suicidality and Subcortical Brain Volume: A Genome-Wide Association Study
Defo J, Ramesar R.
Acta Neuropsychiatr. 2025 Mar 31:1-31. doi: 10.1017/neu.2025.12.
Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization
Ling S, Xie D, Huang L, Huang S, Tian C, Huang L, Chen R, Qin L, Qin X.
Hereditas. 2025 May 31;162(1):92. doi: 10.1186/s41065-025-00457-w.
Unveiling the role of lipid metabolism in haemorrhagic disorders: genetic insights and therapeutic perspectives
Wei J, Yang Z, Wu X, Zheng N, Wu D.
Thromb J. 2025 May 31;23(1):55. doi: 10.1186/s12959-025-00731-x.
Lung development genes, adult lung function and cardiovascular comorbidities
Portas L, Talaei M, Dean C, Aung N, Hind MD, Pozarickij A, Walters RG; China Kadoorie Biobank Collaborative Group; Burney PG, Petersen S, Minelli C, Shaheen SO.
Thorax. 2025 May 30:thorax-2024-222474. doi: 10.1136/thorax-2024-222474.
Analysis of the correlation between inflammatory cytokines and glioblastoma: A Mendelian randomization study
Xuan F, Lv T, Zheng L, Yu S, Ding M.
Medicine (Baltimore). 2025 May 30;104(22):e42137. doi: 10.1097/MD.0000000000042137.
Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization study
Huang X, Zhao JV.
BMC Med. 2025 May 30;23(1):321. doi: 10.1186/s12916-025-04127-6.
Identifying causal genes for prostatitis through drug-targeted Mendelian randomization
Yan K, Tao Y, Chen B, Zhang D, Li Z, Li C, Zhang P.
Sci Rep. 2025 May 30;15(1):19069. doi: 10.1038/s41598-025-03510-w.
Causal association between periodontitis and oral cancer: a two-sample Mendelian randomization study
Xiao T, Hu G, Li T, Zhu X, Wang H, Zhu Z.
Discov Oncol. 2025 May 30;16(1):964. doi: 10.1007/s12672-025-02528-w.
Causal association between uterine fibroids and cardiovascular disease: A Mendelian randomization study
Yao M, Zhao S, Zhang D, Cui Y, Wang Y, Jiang L.
Medicine (Baltimore). 2025 May 30;104(22):e42627. doi: 10.1097/MD.0000000000042627.
Identification of novel therapeutic targets for atrial fibrillation through Mendelian randomization analysis of druggable genes
Ding Y, Chen R, Zheng Z, Xu S, Liu M, Hou C, Li S.
Exp Gerontol. 2025 May 30:112797. doi: 10.1016/j.exger.2025.112797.
Cross-Trait Cross-Genome Cross-Organ Analysis of Gastrointestinal Disorders and Depression
Wang C, Lv G, Chen E, Xue Y, Zhou B, Yang M, Zhong Y.
Dig Dis Sci. 2025 May 30. doi: 10.1007/s10620-025-09083-y.
Causal relationship between immune cells and post-viral fatigue syndrome: a Mendelian randomization study
Wang Z, Bai Z, Sun Y.
Virol J. 2025 May 30;22(1):171. doi: 10.1186/s12985-025-02809-4.
A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors
Chen F, Zhou Y, Mao X, Lin R, Huang H.
Discov Oncol. 2025 May 30;16(1):961. doi: 10.1007/s12672-025-02761-3.
Dietary factors and postmenopausal bleeding: A Mendelian randomization investigation
Ren J, Yang W, Tian T.
Medicine (Baltimore). 2025 May 30;104(22):e41650. doi: 10.1097/MD.0000000000041650.
Causal assessment of the relationship between diet, lifestyle, and stroke: A two-sample Mendelian randomization study
Jareebi MA.
Medicine (Baltimore). 2025 May 30;104(22):e42563. doi: 10.1097/MD.0000000000042563.
Unveiling the Intricate Causal Nexus Between 91 Circulating Inflammatory Proteins and Perianal Abscess Through a Comprehensive Bidirectional Two-Sample Mendelian Randomization Analysis
Wang Z, Chen T, Shi H, Zhang X, Yang W.
Health Sci Rep. 2025 May 29;8(6):e70803. doi: 10.1002/hsr2.70803.
From infection to tumor: genetic evidence of viral antibody immune response' role in urologic cancer development
Wang C, Zhang Q, Li Q, Wang Y, Chen X.
Discov Oncol. 2025 May 29;16(1):947. doi: 10.1007/s12672-025-02768-w.
Multi-Omics Mendelian Randomization Identifies Therapeutic Targets for Sjögren’s Disease with Clinical and Bayesian Validation
He J, Li K, Guo Z, Zhou X, Tang X.
J Inflamm Res. 2025;18:16685-16698 https://doi.org/10.2147/JIR.S543644
The Mediating Role of Plasma Inflammatory Proteins in Gut Microbiota-Driven Valvular Heart Disease: A Mendelian Randomization Study
Zhao J, Wang Y, Lv C, Peng J, Lu S, Shen L.
Cell Biochem Biophys. 2025 May 28. doi: 10.1007/s12013-025-01780-9.
Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study
Wang N, Wang T, Tang M, Zu B, Chen J.
BMC Pregnancy Childbirth. 2025 May 28;25(1):622. doi: 10.1186/s12884-025-07754-2.
Decoding the impact of glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist on cardiometabolic health: inflammatory mediators at the focus
Cheng F, Niu X, Wang Y, Yang F, Yang K, Li W.
Diabetol Metab Syndr. 2025 May 28;17(1):175. doi: 10.1186/s13098-025-01744-2.
Association of glucagon-like peptide-1 receptor agonists and seven common mental disorders: A drug target and mediation Mendelian randomization
Zhang Z, Li S, Dai X, Li C, Sun P, Qu J, Jiang H, Pan B.
J Affect Disord. 2025 May 28:119509. doi: 10.1016/j.jad.2025.119509.
Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts
Joensuu L, Koivunen K, Tynkkynen NP, Palviainen T, Kaprio J; FinnGen Consortium; Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Sillanpää E.
Br J Sports Med. 2025 May 27;59(11):783-790. doi: 10.1136/bjsports-2024-109491.
Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability
Drouard G, Hagenbeek FA, Ollikainen M, Zheng Z, Wang X; FinnGen; Ripatti S, Pirinen M, Kaprio J.
J Proteome Res. 2025 May 27. doi: 10.1021/acs.jproteome.4c00971.
Sleep disturbances as risk factors for neurodegeneration later in life
Simmonds E, Levine KS, Han J, Iwaki H, Koretsky MJ, Kuznetsov N, Faghri F, Warly Solsberg C, Schuh A, Jones L, Bandres-Ciga S, Blauwendraat C, Singleton A, Escott-Price V, Leonard HL, Nalls MA.
npj Dement. 1, 6 (2025). https://doi.org/10.1038/s44400-025-00008-0