Publication list

Erik Abner, Kanwal Batool, Nele Taba, Tiit Nikopensius, Kristi Läll, Anastasiia Alekseienko, Anders Eriksson, Joel Rämö, Hele Haapaniemi, Hanna Maria Kariis, Liis Haljasmägi, Urmo Võsa, Taavi Tillmann, Uku Vainik, Kelli Lehto, Hanna M. Ollila, Kai Kisand, Estonian Biobank Research Team, Tõnu Esko

Nat Commun 16, 8956 (2025). https://doi.org/10.1038/s41467-025-64006-9

Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial

Rodosthenous S, Viiri L E, Carson A, Cajuso T, Corbetta A, Jones S, Brenna E, FinnGen, Makkonen E, Virolainen M, Korkeala N, Widén E, Ripatti S, Ganna A.

medRxiv 2025.10.06.25337395; doi: https://doi.org/10.1101/2025.10.06.25337395

Identification of genetically-supported new drug targets for osteomyelitis based on druggable genomes

Yao R, Lu Y, Lu D, Ren H, Wang X, Lin B, Chen S, Zhu Y, Chen F, Wang Y, Gao Y, Shen J, Guo Q, Huang K.

Hum Genomics . 2025 Oct 7;19(1):117. doi: 10.1186/s40246-025-00826-6.

Sex hormones and meningiomas risk: a Mendelian randomization and immunohistochemical analysis

Chen F, Zhang J, Hou X, Li T, Xu Z, Li S, Zhou Y, Wang Y, Wang W, Liu P, Liu M

Researchsquare, 07 October 2025, doi: 10.21203/rs.3.rs-7564859/v1

Genome-wide meta-analyses of cross substance use disorders in diverse populations

Dongbing Lai, Michael Zhang, Nick Green, Marco Abreu, Tae-Hwi Schwantes-An, Clarissa C. Parker, Shanshan Zhang, Fulai Jin, Anna Sun, Pengyue Zhang, Howard J. Edenberg, Yunlong Liu, Tatiana Foroud

Mol Psychiatry (2025). https://doi.org/10.1038/s41380-025-03294-5

Using Genetics to Understand Shared Mechanisms Between Hypertension and Type 2 Diabetes Accounting for Adiposity

Voller B, Woodward R, Gu Q, Murrin O, Delgado J, Violán C, Khalid S, Türkmen D, Fox C, Lamb S, Mancini M, Farmer L, Boddy K, Dudbridge F, Bowden J, Frayling T M, Masoli J, Pilling L C, he GEMINI Consortium

medRxiv 2025.10.03.25337275; doi: https://doi.org/10.1101/2025.10.03.25337275

Genetic variants of glucose-dependent insulinotropic polypeptide (GIP) signalling as proxy for body weight reduction and cardiovascular risk

Emanuelsson F, Nordestgaard BG, Benn M.

Eur Heart J . 2025 Oct 7:ehaf779. doi: 10.1093/eurheartj/ehaf779.

Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer’s Disease Risk Prediction in Multiethnic Cohorts

Okorie M, Jonson C, Oddi A P, Castruita P A, Fulton-Howard B, Yaffe K, Yokoyama J S, Udeh-Momoh C, Andrews S J, the Alzheimer’s Disease Sequencing Project and the Healthy Aging Brain Study - Health Disparities

medRxiv 2025.10.03.25337285; doi: https://doi.org/10.1101/2025.10.03.25337285

Unveiling the therapeutic potential of senescence-related IQGAP2 in pancreatic Cancer through post-GWAS genomic and scRNA-seq analyses

Zilong Bai, Jiale Liang, Yuanhua Nie, Shilong Wang, Dongmin Chang

Discov Onc 16, 1301 (2025). https://doi.org/10.1007/s12672-025-03078-x

Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer

Zhao M, Di X, Zhao Y.

Int J Med Sci . 2025 Sep 12;22(15):4036-4048. doi: 10.7150/ijms.107109. eCollection 2025.

Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease

Daeeun Kim, Heather M. Highland, Roelof A. J. Smit, Micah R. Hysong, Victoria L. Buchanan, Kristin L. Young, Chi Zhao, Cassandra N. Spracklen, Tuomas O. Kilpeläinen, Boya Guo, Burcu F. Darst, Yanwei Cai, Zhe Wang, Jessica Lundin, Sonja I. Berndt, JoAnn E. Manson, Eirini Marouli, Leslie Lange, Ethan Lange, Myriam Fornage, Christopher R. Gignoux, Christopher A. Haiman, Stephen S. Rich, Steven Buyske, Ruth J. F. Loos, Charles Kooperberg, Ulrike Peters, Christy L. Avery, Penny Gordon-Larsen, Mariaelisa Graff, Laura M. Raffield, Kari E. North

Genome Med 17, 113 (2025). https://doi.org/10.1186/s13073-025-01522-9

Mediating Effects of Plasma Metabolites in Inflammatory Protein-Lymphoma Causality: A Mendelian Randomization Study

Ji Y, Gao X, Liu L, Wan Z, Qin W.

Curr Med Chem. 2025 Oct 2. doi: 10.2174/0109298673382735250904071151.

Identification of C4BPA as a genetically informed drug target in NSCLC: an integrative single-cell and multi-omics study based on the druggable genes

Zhihan Xiao, Xinji Liu, Wei Tang, Yan Lv, Tongyu Zhang, Xu Zhan, Qihang Sun, Willis Wasonga Omindo, Qi Wang, Ruijie Zhang, Wei Ping, Ni Zhang

Hum Genomics 19, 113 (2025). https://doi.org/10.1186/s40246-025-00829-3

Identification of Plasma Protein Biomarkers and Drug Targets for Hematologic Malignancies by Proteome-wide Mendelian Randomization

Pan T, Zhang J, Wang X, Song Y.

J Cancer . 2025 Sep 3;16(13):3917-3927. doi: 10.7150/jca.115044. eCollection 2025.

Association Between Specific Sleep Traits and Four Inflammatory Skin Diseases: A Mendelian Randomization Study

Yang P, Huang Y, He W, Chen T, Wei S, Zhao Y.

Clin Cosmet Investig Dermatol . 2025 Sep 29:18:2509-2521. doi: 10.2147/CCID.S541688. eCollection 2025.

Integrated multi-omics profiling reveals shared mechanistic pathways in asthma-allergic rhinitis comorbidity: A hybrid machine learning framework leveraging Mendelian randomization for precision diagnostics

Wang H, Tu J, Zhang J, Wang W, Yuan Z, Li C, Wang Y.

World Allergy Organ J . 2025 Sep 22;18(10):101120. doi: 10.1016/j.waojou.2025.101120. eCollection 2025 Oct.

The relationship between gut microbiota, plasma metabolites, and iron deficiency anemia in European populations: a three-sample Mendelian randomization analysis

Zheng X, Shen W, Yin J.

Hematology. 2025 Dec;30(1):2549962. doi: 10.1080/16078454.2025.2549962.

Genetic evidence for the correlation between relative nutrient intake and male reproductive health: a Mendelian randomized study

Li S, Wang S, Jing Z, Guo J, Cao X, Guo Q.

Aging Male. 2025 Dec;28(1):2568142. doi: 10.1080/13685538.2025.2568142.

Triangulation evidence for the causal effect of monocytes on pulmonary artery hypertension: a Mendelian randomization study and results from NHANES

Liu Z, Fu Q, Shao Y, Cao J.

Respir Med. 2025 Oct 1:108388. doi: 10.1016/j.rmed.2025.108388.

A genetic map of human metabolism across the allele frequency spectrum

Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg CC.

Nat Genet (2025). https://doi.org/10.1038/s41588-025-02355-3

Meta-analysis of exome-wide gene burden analysis of breast cancer susceptibility genes

Jennifer A. Collister, Karl Smith-Byrne, Joshua Atkins, Gillian Reeves, David J. Hunter

npj Breast Cancer 11, 111 (2025). https://doi.org/10.1038/s41523-025-00826-8

Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Krista Freimann, Anneke Brümmer, Robert Warmerdam, Tarran S. Rupall, Ana Laura Hernández-Ledesma, Joshua Chiou, Emily R. Holzinger, Joseph C. Maranville, Nikolina Nakic, Halit Ongen, Luca Stefanucci, Michael C. Turchin, eQTLGen Consortium, Lude Franke, Urmo Võsa, Carla P. Jones, Alejandra Medina-Rivera, Gosia Trynka, Kai Kisand, Sven Bergmann, Kaur Alasoo

Nat Commun 16, 8795 (2025). https://doi.org/10.1038/s41467-025-63856-7

Circulating vitamin D concentrations and the risk of urticaria: A bidirectional two-sample Mendelian randomization study

Chai HX, Wang F, Liu H, Xie YQ, Zhou ZH.

Asia Pac J Clin Nutr . 2025 Oct;34(5):740-749. doi: 10.6133/apjcn.202510_34(5).0004.

Limited overlap between genetic effects on disease susceptibility and disease survival

Yang Z, Pajuste FD, Zguro K, Cheng Y, Kurant DE, Eoli A, Wanner J, Jermy B, Rämö J; FinnGen; Kanoni S, van Heel DA; Genes & Health Research Team; Hayward C, Marioni RE, McCartney DL, Renieri A, Furini S; INTERVENE consortium; Mägi R, Gusev A, Drineas P, Paschou P, Heyne H, Ripatti S, Mars N, Ganna A.

Nat Genet . 2025 Sep 30. doi: 10.1038/s41588-025-02342-8.

Polygenic and developmental profiles of autism differ by age at diagnosis

Zhang X, Grove J, Gu Y, Buus CK, Nielsen LK, Neufeld SAS, Koko M, Malawsky DS, Wade EM, Verhoef E, Gui A, Hegemann L, APEX consortium, iPSYCH Autism Consortium, PGC-PTSD Consortium, Geschwind DH, Wray NR, Havdahl A, Ronald A, St Pourcain B, Robinson EB, Bourgeron T, Baron-Cohen S, Borglum AD, Martin HC, Warrier V.

Nature 646, 1146–1155 (2025). https://doi.org/10.1038/s41586-025-09542-6

Identification of MMEL1 as a novel therapeutic target for primary sclerosing cholangitis: Integrating Mendelian randomization and transcriptome landscapes

Li CL, Sun A, Liu YK, Sun RT, Hao AY, Lan YY, Cao JY, Wang ZS.

Medicine (Baltimore) . 2025 Sep 26;104(39):e44608. doi: 10.1097/MD.0000000000044608.

Measures of General Intelligence and Risk for Alcohol Use Disorder

Capusan AJ, Davis CN, Thern E, Rehm J, Gelernter J, Kranzler HR, Heilig M.

JAMA Psychiatry . 2025 Oct 1:e252689. doi: 10.1001/jamapsychiatry.2025.2689.

Two-sample Mendelian randomization investigating the causal association between endocarditis and osteomyelitis: A validation analysis using UK Biobank and FinnGen databases

Liu H, Xing H, Yu X, Wang Y, Liu H, Chang Z.

Medicine (Baltimore) . 2025 Sep 26;104(39):e44651. doi: 10.1097/MD.0000000000044651.

Polygenic and developmental profiles of autism differ by age at diagnosis

Zhang X, Grove J, Gu Y, Buus CK, Nielsen LK, Neufeld SAS, Koko M, Malawsky DS, Wade E, Verhoef E, Gui A, Hegemann L, APEX consortium, iPSYCH Autism Consortium, PGC-PTSD Consortium, Geschwind DH, NWray NR, Havdahl A, Ronald A, St. Pourcain B, Robinson EB, Bourgeron T, Baron-Cohen S, Børglum AD, Martin HC, Warrier V.

Nature 646, 1146–1155 (2025). https://doi.org/10.1038/s41586-025-09542-6

Dietary factors mediated the causal association between educational attainment and chronic periodontitis: A 2-sample Mendelian randomization study

Jiang L, Li S, Huang S, Liu B, Reissmann DR, Schmalz G, Hu X.

Medicine (Baltimore) . 2025 Sep 26;104(39):e44620. doi: 10.1097/MD.0000000000044620.

Genetic evidence informs the direction of therapeutic modulation in drug development

Robert Chen, Áine Duffy, Joshua K. Park, David Stein, Avner Schlessinger, Yuval Itan, Benjamin S. Glicksberg, Rory J. Tinker, Daniel M. Jordan, Ghislain Rocheleau, Ron Do

npj Drug Discov. 2, 24 (2025). https://doi.org/10.1038/s44386-025-00027-0

Genetic evidence for the effect of prepregnancy maternal metabolic status on the risk of congenital heart disease in offspring: A Mendelian randomization study

Sağlam E, Özler MR.

Medicine (Baltimore) . 2025 Sep 26;104(39):e44820. doi: 10.1097/MD.0000000000044820.

A Multi-Polygenic Risk Score Approach Incorporating Physical Activity Genotypes for Predicting Type 2 Diabetes and Associated Comorbidities: A FinnGen Study

Vettenterä Elina, Joensuu Laura, Waller Katja, FinnGen, Sillanpää Elina

medRxiv 2025.09.30.25336952; doi: https://doi.org/10.1101/2025.09.30.25336952

Decoding the Molecular Landscape of Inflammatory Bowel Disease: A Mendelian Randomization and Machine Learning Analysis

Zheng X, Zhang C, Zubair M, Pan J, Chen T, Yin J, Liu P, Luo P, Shen W, Chu Y.

J Gastroenterol Hepatol . 2025 Oct 1. doi: 10.1111/jgh.70085.

Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies

Maamari DJ, Biddinger KJ, Jurgens SJ, Rämö JT, Gaziano L, Zheng A, Hayes D, Gongora CA, FinnGen, Hoan Choi S, Arany Z, Thavendiranathan P, Fahed AC, Sarma AA, Neilan TG, Khera AV, Ellinor PT, Aragam KG.

JAMA Cardiol

September

Multi-ancestry genome-wide and transcriptome-wide association analyses identified new risk loci and genes for inflammatory bowel disease

Linshuoshuo Lyu, Qing Li, Chao Li, Ghadeer K Dawwas, You Chen, Ran Tao, Qi Liu, Wanqing Wen, Xiao-Ou Shu, Kay Washington, David A Schwartz, Wei Zheng, Zhijun Yin, Ken S Lau, Xingyi Guo

medRxiv 2025.09.23.25336483; doi: https://doi.org/10.1101/2025.09.23.25336483

Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis

Jun Qiao, Qian Wang, Yuhui Zhao, Minjing Chang, Shuo Sun, Pengwei Zhang, Kaixin Yao, Miaoran Chen, Leilei Zheng, Xiaolong Xing, Liuyang Cai, Anil G. Jegga, Lei Jiang, Siim Pauklin, Rongjun Zou, Yining Yang, Yuliang Feng

Nat Commun 16, 8677 (2025). https://doi.org/10.1038/s41467-025-63707-5

Genetic predisposition to high BMI and changes in BMI during adolescence modulate associations between adult BMI and plasma molecules involved in glucose metabolism

Alvaro Obeso Fernandez, Gabin Drouard, Aline Jelenkovic, Sari Aaltonen, Teemu Palviainen, Katja M. Kanninen, Jessica E. Salvatore, Danielle M. Dick, Karri Silventoinen, Jaakko Kaprio

medRxiv 2025.09.23.25336458; doi: https://doi.org/10.1101/2025.09.23.25336458

Association between mitochondrial DNA copy number and the risk of Parkinson's disease: a meta-analysis and Mendelian randomization study

Zheng H, Zhang D, Gan Y, Wu Y, Xiang W.

BMC Neurol . 2025 Sep 29;25(1):390. doi: 10.1186/s12883-025-04400-4.

Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics

The MULTI Consortium, Aleix Boquet-Pujadas, Filippos Anagnostakis, Michael R. Duggan, Cassandra M. Joynes, Arthur W. Toga, Zhijian Yang, Keenan A. Walker, Christos Davatzikos, Junhao Wen

Nat. Biomed. Eng (2025). https://doi.org/10.1038/s41551-025-01506-5

Dissecting immune cell-specific genetics in migraine: a multi-omics framework for target discovery and therapeutic prioritization

Yanggang Hong, Yuze Mi, Feng Chen, Yirong Wang, Jiajun Li, Zhendi Shu

J Headache Pain 26, 195 (2025). https://doi.org/10.1186/s10194-025-02132-x

Exploring metabolic pathways in gastrointestinal cancer: new evidence of causality

Zhiguo Wang, Chen Wang, Xiangyu Gao, Jiaming He

Discov Onc 16, 1777 (2025). https://doi.org/10.1007/s12672-025-03618-5

Genetic insights into the relationship between anti-inflammatory drug target genes and oral diseases

Zelong Hu, Yuchong Xie, Huike Wang, Shouqiang Zhu, Shijia Huang, Minzhe Xin, Haonan Ding, Yuxin Qian, Yingnan Tian, Xuwen Wang, Minxin He, Lei Jin

Inflammopharmacol 33, 6149–6163 (2025). https://doi.org/10.1007/s10787-025-01959-9

Multiomic Mendelian randomization analysis of metabolic gene methylation expression and protein levels in lung adenocarcinoma

Wang Q, Liu G, Zhang J, Zou Q, Geng J.

Discov Oncol . 2025 Sep 29;16(1):1759. doi: 10.1007/s12672-025-03600-1.

Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases

Paloma Jordà, Yiwei Lai, Amélie Jeuken, Louis-Philippe Lemieux Perreault, Elisabeth Goulet, Najim Lahrouchi, Anna Nozza, Michael W. Tanck, Peter Guerra, Julia Cadrin-Tourigny, Simon de Denus, Connie R. Bezzina, Guillaume Lettre, David Busseuil, Marie-Pierre Dubé, Jean-Claude Tardif, Rafik Tadros

npj Genom. Med. 10, 65 (2025). https://doi.org/10.1038/s41525-025-00515-2