Below you will find all the published and preprint scientific papers using FinnGen data.

2025

April

Tracing the pathways: how inflammatory cytokines and blood metabolites drive intervertebral disc degeneration
Liu Y, Lei F, Feng D, Luo J, Jin Q, Zhang H, Wang L.
Eur Spine J. 2025 Apr 26. doi: 10.1007/s00586-025-08850-9.
Sex Hormone-Related Pathogenic Genes in Multiple Sclerosis: A Multi-omics Mendelian Randomization Study
Qiu J, Zhang Y.
J Mol Neurosci. 2025 Apr 26;75(2):58. doi: 10.1007/s12031-025-02347-2.
Exploring the potential causal association of gut microbiota on panic and conduct disorder: A two-sample Mendelian randomization approach
Fatoba A, Simpson C.
J Affect Disord. 2025 Apr 26:S0165-0327(25)00718-9. doi: 10.1016/j.jad.2025.04.143.
Genetic determinants of proteomic aging
Mörseburg A, Zhao Y, Kentistou KA, Perry JRB, Ong KK, Day FR.
NPJ Aging. 2025 Apr 26;11(1):30. doi: 10.1038/s41514-025-00205-4.
Serum metabolites and risk of sudden sensorineural hearing loss: A Mendelian randomization study
Yuan W, Liu Y, Liu C, Qiu Y.
Braz J Otorhinolaryngol. 2025 Apr 26;91(4):101596. doi: 10.1016/j.bjorl.2025.101596.
Causal relationships between brain functional networks and tinnitus: A bidirectional 2-sample Mendelian randomization study
Zhong C, Zhang H, Wang L, Dong Y, Ji L, Guo Y.
Medicine (Baltimore). 2025 Apr 25;104(17):e42328. doi: 10.1097/MD.0000000000042328.
Mendelian Randomization with longitudinal exposure data: simulation study and real data application
Pott J, Palma M, Liu Y, Mack JA, Sovio U, Smith GCS, Barrett J, Burgess S.
medRxiv 2025.04.25.25326352; doi: https://doi.org/10.1101/2025.04.25.25326352
Bidirectional Mendelian randomization and potential mechanistic insights into the causal relationship between gut microbiota and malignant mesothelioma
Zhou Y, Zhu H, Zhao L, Zhao G, Sun J.
Medicine (Baltimore). 2025 Apr 25;104(17):e42245. doi: 10.1097/MD.0000000000042245.
Novel Genetic Risk Variants Associated with Oral Tongue Squamous Cell Carcinoma
Nikkilä R, Mäkitie A, Joensuu H, Markkanen S, Elenius K, Monni O, Palotie A, Saarentaus E; FinnGen; Salo T, Bizaki-Vallaskangas A.
Head Neck Pathol. 2025 Apr 25;19(1):45. doi: 10.1007/s12105-025-01784-0.
Genome-wide association studies of hospitalized influenza identify 4 risk loci and a relationship with COVID-19
Xue X, Chan P-C,So H-C.
medRxiv 2025.04.25.25325850; doi: https://doi.org/10.1101/2025.04.25.25325850
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Wang F, Liu A, Yang Z, Vartiainen P, Jukarainen S, Koskela S, Oram R, Allen L, Ritari J, Partanen J; FinnGen; Perola M, Tuomi T, Ganna A.
Cell Genom. 2025 Apr 25:100854. doi: 10.1016/j.xgen.2025.100854.
Evidence supporting the role of hypertension in the onset of migraine
Xiao G, Huang Z, Lan Q, Hu J, Shi H, Chen Y, Zhou C, Chenghua L, Zhou B.
J Transl Med. 2025 Apr 24;23(1):474. doi: 10.1186/s12967-025-06187-x.
Causal Association Between Sleep Deprivation and Glioblastoma Risk: Insights from Multi-Omics Analysis
Du R, Maierdan M, Yusufu A, Dong S, Cai X, Xu T, Sheng W, Maimaiti M.
J Mol Neurosci. 2025 Apr 24;75(2):56. doi: 10.1007/s12031-025-02354-3.
Multi-omics reveal the role of nociception-related genes TNXB, CTNND1 and CBL in depression
Wu Q, Lin D, Wang T, Lin W, Wang S, Lai L, Xie M, Wen X.
J Affect Disord. 2025 Aug 1;382:346-354. doi: 10.1016/j.jad.2025.04.067.
Association between sarcopenia and intervertebral disc degeneration: A bidirectional two-sample Mendelian randomization
Guo J, Ding Q, Sun L.
J Back Musculoskelet Rehabil. 2025 Apr 24:10538127251318926. doi: 10.1177/10538127251318926.
Causal association between endocrine diseases and lymphoid malignancies explored through two-sample Mendelian randomization analysis
Zhao C, Zhang Y, Qian L, Guo Q, Zhu N.
Sci Rep. 2025 Apr 24;15(1):14231. doi: 10.1038/s41598-025-99010-y.
Multi-ancestry sequencing-based genome-wide association study of C-reactive protein in 513,273 genomes
Li H, Zhao J, Dai J, You D, Zhao Y, Christiani DC, Chen F, Shen S.
Nat Commun. 2025 Apr 24;16(1):3892. doi: 10.1038/s41467-025-59155-w.
Integration of single-cell sequencing and mendelian randomization reveals novel causal pathways between monocytes and hepatocellular carcinoma
Yu J, Yu J, Kang Z, Peng Y.
Discov Oncol. 2025 Apr 24;16(1):604. doi: 10.1007/s12672-025-02357-x.
Nonsteroidal anti-inflammatory drugs, blood metabolites, and kidney stones: a comprehensive Mendelian randomization study
Yu H, Zeng F, Wu J, Chen H, Huang F, Zhu Z.
Urolithiasis. 2025 Apr 24;53(1):77. doi: 10.1007/s00240-025-01749-6.
The causal relationship between gastroesophageal reflux disease and constipation: a study utilizing bidirectional mendelian randomization combined with meta-analysis
Xingxing Wei, Xiangming Che
Researchsquare, 23 April 2024, doi: 10.21203/rs.3.rs-4286883/v1
Elucidating Cellular Senescence-related Genes in Benign Prostatic Hyperplasia through Mendelian Randomization and Single-cell RNA Sequencing
Wang Y, Zhou L, Liu J, Zhou Q, Xiong W, Wang L.
J Gerontol A Biol Sci Med Sci. 2025 Apr 23:glaf073. doi: 10.1093/gerona/glaf073.
Integrated multi-omics insight into the molecular networks of oxidative stress in triggering multiple sclerosis
Xu Y, Zhang X, Zhang Y, Ma H, Zhou Z, Qin H, Liu H, Han X.
Neurobiol Dis. 2025 Jun 15;210:106929. doi: 10.1016/j.nbd.2025.106929.
DNA methylation and 28 year incidence of two neuropathy phenotypes in type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications cohort study
Zhou J, Mychaleckyj JC, Onengut-Gumuscu S, Orchard TJ, Costacou T, Miller RG.
Diabetologia. 2025 Jul;68(7):1423-1439. doi: 10.1007/s00125-025-06427-1.
Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration
Yao H, Chen J, Wang Y, Li Y, Tang P, Liang M, Jiang Q.
BMC Pregnancy Childbirth. 2025 Apr 23;25(1):479. doi: 10.1186/s12884-025-07608-x.
Combining GWAS Summary Data and Proteomics Identified Potential Drug Targets in Dementia
Zhao Y, Fei L, Duan Y.
Mol Neurobiol. 2025 Apr 23. doi: 10.1007/s12035-025-04967-6.
Multiomic insight into the involvement of cell aging related genes in the pathogenesis of endometriosis
Chen L, Yi Y, Nie J.
Sci Rep. 2025 Apr 23;15(1):14103. doi: 10.1038/s41598-025-96711-2.
Causal relationship between atherosclerosis and inflammatory bowel disease risk: a two-sample Mendelian randomization study
Guo W, Peng N, Du S.
Thromb J. 2025 Apr 23;23(1):39. doi: 10.1186/s12959-025-00722-y.
Bidirectional Mendelian randomization reveals associations between telomere length and autoimmune diseases
Jiang Q, Yu C, Zhu S, Liu Y, Ye M.
Trials. 2025 Apr 23;26(1):137. doi: 10.1186/s13063-025-08831-9.
Potential association between allergic disease and risk of Alzheimer’s disease: insight from genetic analysis
Jin T, Huang W, Cheng Y, Cao Z, Guo S, Li C.
BMC Neurol. 2025 Apr 23;25(1):173. doi: 10.1186/s12883-025-04192-7.
Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobanks
Levin MG, Koyama S, Woerner J, Zhang DY, Rodriguez A, Nandi T, Truong B, Abramowitz SA, Gupta H, Kamineni H, Hornsby W, Li Z, Cohron T, Huffman JE, Ellinor P, Kim D, Liao KP, Madduri RK, Voight BF, Verma A, Damrauer SM, Natarajan P.
medRxiv [Preprint]. 2025 Apr 22:2025.04.18.25326074. doi: 10.1101/2025.04.18.25326074.
Psoriasis vulgaris and circulating metabolic biomarkers: a mendelian randomization analysis
Bi D, Shi J, Hu Y, Tey JT, Yao D, Hua S, Zhu X, Liu J, Guo S.
Arch Dermatol Res. 2025 Apr 22;317(1):733. doi: 10.1007/s00403-025-04232-9.
Exploring the effect of SGLT2 inhibitors on the risk of primary open-angle glaucoma using Mendelian randomization analysis
Guo Y, Zhao J, Hou S, Chen Z.
Sci Rep. 2025 Apr 22;15(1):13946. doi: 10.1038/s41598-025-98997-8.
The genetic associations of lipidome on bladder cancer: a Mendelian randomization study
Jin J, Wang W, Zhao K, Xu G, Peng C, Chen J, Li Y, Pan S.
Discov Oncol. 2025 Apr 22;16(1):586. doi: 10.1007/s12672-025-02389-3.
Identification of mitochondrial-related causal genes for major depression disorder via integrating multi-omics
Li H, Liu Q, Shan Q, Xu H, Wang J, Liu L, Wang Y.
J Affect Disord. 2025 Apr 22;382:540-548. doi: 10.1016/j.jad.2025.04.124.
KZFP-mediated variable DNA methylation of a primate-specific transposon is linked to type I diabetes in humans
Derakhshan M, Issarapu P, Prentice AM, Kuebel JA, Moore SE, Bernstein RM, Sesay AK, Jammeh M, Waterland RA, Hellenthal G, Imbeault M, Silver MJ.
medRxiv 2025.04.22.25326054; doi: https://doi.org/10.1101/2025.04.22.25326054
Sleep deprivation impacts the immunological milieu of epididymis leading to low sperm quality in rats
Li Z, Gong S, Yu Z, Luo Y, Zhao Y, Xue E, Lu H, Xiang D, Sun F.
Commun Biol. 2025 Apr 22;8(1):644. doi: 10.1038/s42003-025-08091-y.
Association between age at diabetes diagnosis and the development and progression of diabetic retinopathy
Li H, Wang B, Liu C.
Sci Rep. 2025 Apr 22;15(1):13827. doi: 10.1038/s41598-025-98840-0.
Elevated VRK2 expression promotes the onset and progression of bronchiectasis
Zheng S, Huang Y, Hong K, Tang J, Wu X, Qing C, Jiang Y, Lu W, Bao C, Luo J & Kong J.
The Egyptian Journal of Bronchology (2025) 19:36 https://doi.org/10.1186/s43168-025-00390-6
Exploring the comorbidity association and biological mechanisms of chronic rhinosinusitis and chronic obstructive pulmonary disease
Liu S, Yang J, Lin Y, Zhang L, Luo W.
Sci Rep. 2025 Apr 22;15(1):13855. doi: 10.1038/s41598-025-98175-w.
An expanded view of disease continuum centered on rheumatoid arthritis: from single to systemic perspectives
Zheng M.
Front Med. 2025 Apr 21. doi: 10.1007/s11684-025-1135-5.
Genetic Association Between High-Risk HPV (HPV16 and HPV18) Infection and Tumor Development: A Mendelian Randomization Analysis
Wu Y, Xia H, Du F, Zhang J, Jiang X, Tang J, Li Z.
Health Sci Rep. 2025 Apr 21;8(4):e70704. doi: 10.1002/hsr2.70704.
Exploring the role of gut microbiota in intervertebral disc degeneration: insights from bidirectional Mendelian randomization analysis
Xiao J, Zhou X, Xia T, Zhang W, Xing X, Zhang Y, Xiong L.
Eur Spine J. 2025 Jun;34(6):2092-2105. doi: 10.1007/s00586-025-08794-0.
Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study
Ohseto H, Ishikuro M, Obara T, Narita A, Takahashi I, Shinoda G, Noda A, Murakami K, Orui M, Iwama N, Kikuya M, Metoki H, Sugawara J, Tamiya G, Kuriyama S.
Sci Rep. 2025 Apr 21;15(1):13743. doi: 10.1038/s41598-025-97291-x.
Unraveling the Causal Links Between Immune Traits and Hepatocellular Carcinoma: Insights From a Bi-Directional Mendelian Randomization Study
Li J, Wang G, Xiang X, Wang J.
Turk J Gastroenterol. 2025 Apr 21. doi: 10.5152/tjg.2025.24558.
Association of the gut microbiome with diabetic nephropathy and the mediated effect of metabolites: friend or enemy?
Yu Y, Yang X, Deng J, Yin Y, Wu Y, Yu R.
Int Urol Nephrol. 2025 Apr 21. doi: 10.1007/s11255-025-04519-w.
Exploring Hepatocellular Carcinoma Etiology through Multi-omics Bioinformatics
Yimin Chen, Zhiwen Wang, Wenjie Li, Jiahui Yang, Zheyu Chen
Researchsquare, 21 April 2025, doi: 10.21203/rs.3.rs-6188338/v1
Dissecting the Genetic Architecture of Intracranial Aneurysms
Adkar SS, Lynch J, Choi RB, Roychowdhury T, Judy RL, Paruchuri K, Go DC, Bamezai S, Cabot J, Sorondo S, Levin MG, Milewicz DM, Willer CJ, Natarajan P, Pyarajan S, Chang KM, Damrauer S, Tsao P, Skirboll S, Leeper NJ, Klarin D.
Circ Genom Precis Med. 2025 Jun;18(3):e004626. doi: 10.1161/CIRCGEN.123.004626.
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer
Dai H, Yu Z, Zhao Y, Jiang K, Hang Z, Huang X, Ma H, Wang L, Li Z, Wu M, Fan J, Luo W, Qin C, Zhou W, Nie J.
Biol Direct. 2025 Apr 21;20(1):56. doi: 10.1186/s13062-025-00650-x.
COVID-19 Predisposition Inherently Increases Cardiovascular Risk Before SARS-CoV-2 Infection
Zheng M.
Cardiovasc Toxicol. 2025 Jun;25(6):821-829. doi: 10.1007/s12012-025-09996-0.
Association between gynecological cancers and female infertility: insights from bidirectional Mendelian randomization analysis
Li J, Zeng Y, Zhang D.
BMC Womens Health. 2025 Apr 18;25(1):191. doi: 10.1186/s12905-025-03729-9.