På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2025

Maj

Susceptibility genes for allergic conjunctivitis revealed by cross-tissue transcriptome-wide association study
Xu Q, Li Y, Zhang X.
Exp Eye Res. 2025 May 24;257:110444. doi: 10.1016/j.exer.2025.110444.
Unraveling drug resistance mechanisms in testicular cancer through immune cell phenotypes: a bidirectional Mendelian randomization analysis revealing novel therapeutic targets
Xiao L, Wu T.
Discov Oncol. 2025 May 24;16(1):912. doi: 10.1007/s12672-025-02757-z.
The impact of lipidome on intervertebral disk degeneration, low back pain, and sciatica: a Mendelian randomization study
Pang ZY, Zhu YB, Hu JX, Li XX, Gao YJ, Wang YY, Zhou Q, Li P.
Sci Rep. 2025 May 23;15(1):18045. doi: 10.1038/s41598-025-99914-9.
Endothelial selective adhesion molecule and interleukin-16 play an intermediary role in psoriasis complicated with acute myocardial infarction: A Mendelian randomization study
Kang X, Wang C, Zhong GQ, Zhang HJ.
Medicine (Baltimore). 2025 May 23;104(21):e42538. doi: 10.1097/MD.0000000000042538.
Circulating metabolic biomarkers mediated causal relationship between gut microbiota and bladder cancer: a two-step mendelian randomization study
Wei FY, He QH, Yin BT, Zhao JW, Zhao YT, Wei ZS, Li YJ, Liang HQ, Qin M, Cheng JW.
Discov Oncol. 2025 May 23;16(1):877. doi: 10.1007/s12672-025-02618-9.
The health impacts and genetic architecture of food liking in cardio-metabolic diseases
Jiang W, Wang H, Geng Y, Guo M, Zuo Y, Han S, Liu Z, Chen S, Fan S, Li S, Qiao C, Li Q, Li B, Zhang Y, Wei W, Han T.
Nat Commun. 2025 May 23;16(1):4810. doi: 10.1038/s41467-025-59945-2.
NMRAL1 as a Causal Factor in Postherpetic Neuralgia: A Proteome-Wide Mendelian Randomization Study
Ye H, Wang Y, Shi Y, Wu Y, Xu Q, Huang S.
J Pain Res. 2025 May 23;18:2623-2629. doi: 10.2147/JPR.S512034.
Exploring the anti-gastric cancer mechanisms of Diosgenin through integrated network analysis, bioinformatics, single-cell sequencing, and cell experiments
Yun Z, Yang Q, Xue C, Shen Y, Lv L, Mi S, Hou L.
Front Pharmacol. 2025 May 23;16:1600960. doi: 10.3389/fphar.2025.1600960.
Immunological mediators in the causal relationship between latent autoimmune diabetes in adults and breast cancer: A Mendelian randomization analysis
Xiao F, Xie D, Zhou D, Yang L, Liu F.
Medicine (Baltimore). 2025 May 23;104(21):e42571. doi: 10.1097/MD.0000000000042571.
Causal validation of the relationship between air pollution and lung cancer: A bidirectional Mendelian randomization study and meta-analysis
Wang X, Xiao G, Xu W, Ni C.
Medicine (Baltimore). 2025 May 23;104(21):e42450. doi: 10.1097/MD.0000000000042450.
Trans-ethnic Mendelian randomization analysis of membranous nephropathy and peripheral artery disease with mediating effects of thrombomodulin
Pan J, Huang X, Chen Y, Jiang N, Guo Y, Zhou S, Zhang Y, Hu B, Deng Q, Zhou Q.
Sci Rep. 2025 May 22;15(1):17800. doi: 10.1038/s41598-025-02626-3.
Deciphering the causality between micronutrients and esophageal cancer via Mendelian randomization
Diao Z, Peng G, Chen Y, Wang J, Liu J, Zhang Z, Zhang W.
Nutr Metab (Lond). 2025 May 22;22(1):49. doi: 10.1186/s12986-025-00940-1.
SGLT2 inhibition mitigates intracerebral hemorrhage risk by modulating inflammation
Huang M, Liu Y, Chen C.
Sci Rep. 2025 May 22;15(1):17770. doi: 10.1038/s41598-024-84118-4.
The Association between Myopia and Anxiety: A Bidirectional 2-Sample Mendelian Randomization Study
Wong W, Qin Y, Liu C, Zhang S, Jiang Y, Zeng Y, Wang D, Liang L, Han X.
Ophthalmol Sci. 2025 May 22;5(5):100832. doi: 10.1016/j.xops.2025.100832.
Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study
Xu J, Liu Z, Wu L, Pei F, Jiang H, Cheng C, Yang W, Yuan J, Polimanti R, Yang Y.
Cardiovasc Health 2, 17 (2025). https://doi.org/10.1038/s44325-025-00054-w
A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for atrial fibrillation
Yuan Y, Zheng X, Zhang W, Ren Z, Liang B.
J Arrhythm. 2025 May 22;41(3):e70097. doi: 10.1002/joa3.70097.
Relationship between red cell distribution width and lung cancer: evidence from Mendelian randomization and National Health and Nutrition Examination Survey
Liu Y, Qu J, Hu C, Zhao W, Zhang Y, Luo Y, Qu Y.
Discov Oncol. 2025 May 22;16(1):867. doi: 10.1007/s12672-025-02718-6.
Causal association of hypertension in family members with preeclampsia-eclampsia in pregnant women: A two-sample Mendelian randomization study
Hu R, Liang Y, He T, Zhou Y, Lv Y.
Pregnancy Hypertens. 2025 May 21;40:101223. doi: 10.1016/j.preghy.2025.101223.
Thyroid function and amyotrophic lateral sclerosis: a mendelian randomization study
Jacobs ED, Akinade AT, Marvellous Obere MC.
medRxiv 2025.05.21.25328118; doi: https://doi.org/10.1101/2025.05.21.25328118
Genome-wide association study of long COVID
Lammi V, Nakanishi T, Jones SE, Andrews SJ, Karjalainen J, Cortés B, O'Brien HE, Ochoa-Guzman A, Fulton-Howard BE, Broberg M, Haapaniemi HH, Kanai M, Pirinen M, Schmidt A, Mitchell RE, Mousas A, Mangino M, Huerta-Chagoya A, Sinnott-Armstrong N, Cirulli ET, Vaudel M, Kwong ASF, Maiti AK, Marttila MM, Posner DC, Rodriguez AA, Batini C, Minnai F, Dearman AR, Warmerdam CAR, Sequeros CB, Winkler TW, Jordan DM, Rešcenko R, Miano L, Lane JM, Chung RK, Guillen-Guio B, Leavy OC, Carvajal-Silva L, Aguilar-Valdés K, Frangione E, Guare L, Vergasova E, Marouli E, Striano P, Zainulabid UA, Kumar A, Ahmad HF, Edahiro R, Azekawa S; Long COVID Host Genetics Initiative; FinnGen; VA Million Veteran Program; MexGen-COVID Initiative; DBDS Genomic Consortium; GEN-COVID Multicenter Study; PHOSP-COVID Collaborative Group; GENCOV Study; Estonian Biobank Research Team; Luoh SW, Erikstrup C, Pedersen OBV, Lerner-Ellis J, Colombo A, Grzymski JJ, Ishii M, Okada Y, Beckmann ND, Kumari M, Wagner R, Heid IM, John C, Short PJ, Magnus P, Ansone L, Valenti LVC, Lee SA, Wain LV, Verdugo RA, Banasik K, Geller F, Franke LH, Rakitko A, Duncan EL, Renieri A, Tsilidis KK, de Cid R, Niavarani A, Abner E, Tusié-Luna T, Verma SS, Smith GD, Timpson NJ, Madduri RK, Cho K, Daly MJ, Ganna A, Schulte EC, Richards JB, Ludwig KU, Marks-Hultström M, Zeberg H, Ollila HM.
Nat Genet. 2025 May 21. doi: 10.1038/s41588-025-02100-w.
Integrative genome-wide association studies, proteome-wide mendelian randomization, and single-cell RNA sequencing identify interleukin-6 receptor protein as a therapeutic target in aortic aneurysm
Bai Z, An J, Han J, Zhang Y, Wang H, Yang Z, Mo X.
Int J Biol Macromol. 2025 May 21:144380. doi: 10.1016/j.ijbiomac.2025.144380.
Unravelling the gut-brain connection: a systematic review of migraine and the gut microbiome
Mugo CW, Church E, Horniblow RD, Mollan SP, Botfield H, Hill LJ, Sinclair AJ, Grech O.
J Headache Pain. 2025 May 21;26(1):125. doi: 10.1186/s10194-025-02039-7.
Mendelian Randomization Study Reveals That Combined Spontaneous Free Cholesterol Diffusion and Reverse Cholesterol Transport Pathways Shift from Pro-Atherogenic to Anti-Atherogenic Effects
Yan Z, Guo J.
medRxiv 2025.05.21.25327960; doi: https://doi.org/10.1101/2025.05.21.25327960
Role of the "inflammation-immunity-metabolism" network in non-small cell lung cancer: a multi-omics analysis
Zhang J, Lin L, Li W, Guo J.
Discov Oncol. 2025 May 21;16(1):847. doi: 10.1007/s12672-025-02692-z.
Association of modifiable risk factors and telomere length with five neuroendocrine neoplasms: a bidirectional Mendelian randomization study
Li X, Huang L, Yan Y, Rong Y, Chen X, Gao M, Huang J.
Discov Oncol. 2025 May 21;16(1):841. doi: 10.1007/s12672-025-02678-x.
Genetic insights support PARP1 as a mediator in the protective association of ATP-citrate lyase inhibitors with melanoma
Lu J, Li GH, Hu J, Wang Z.
Commun Biol. 2025 May 21;8(1):777. doi: 10.1038/s42003-025-07860-z.
Association between metabolic syndrome and low back pain: a two-sample Mendelian randomization study
Yan W, Kong L, He T, Guo G, Zhu Q, Xi X, Fang M.
Sci Rep. 2025 May 21;15(1):17686. doi: 10.1038/s41598-025-02630-7.
Optimization of multi-ancestry polygenic risk score disease prediction models
Lerga-Jaso J, Terpolovsky A, Novković B, Osama A, Manson C, Bohn S, De Marino A, Kunitomi M, Yazdi PG.
Sci Rep. 2025 May 20;15(1):17495. doi: 10.1038/s41598-025-02903-1.
Preliminary insights into the association between the well-being spectrum and temporomandibular disorders
Chen X, Cheng Z, Xu J, Wang Q, Zhao Z, Jiang Q.
Clin Oral Investig. 2025 May 20;29(6):304. doi: 10.1007/s00784-025-06377-3.
Genetic influence of the brain imaging phenotypes, brain and cerebrospinal fluid metabolites and brain genes on migraine subtypes: a Mendelian randomization and multi-omics study
Zhang PA, Wang JL, Dong MH, Huang XC, Li NJ, Qin RD, Li J.
J Headache Pain. 2025 May 20;26(1):124. doi: 10.1186/s10194-025-02063-7.
The causal role of homocysteine in multiple diseases: a systematic review of Mendelian randomization studies
Zhu X, Wei J, Li J, Zuo S, Wang J, Liu N.
Nutr Metab (Lond). 2025 May 20;22(1):45. doi: 10.1186/s12986-025-00933-0.
Mendelian Randomization Studies: A Metric for Quality Evaluation
Rosas-Chavez F, Merriman TR.
Gout Urate Cryst. Depos. Dis. 2025, 3(2), 8; https://doi.org/10.3390/gucdd3020008
Unraveling the causal pathway between phosphatidylinositol, metabolites, and metabolic syndrome: a Mendelian randomization study
Yang Y, Ma Y, Li M, Han Y, Liu L.
Diabetol Metab Syndr. 2025 May 20;17(1):162. doi: 10.1186/s13098-025-01731-7.
Mendelian randomization analysis reveals the causal relationship between immune cells and leukemia
Lin Y, Shi S, Song J, Liu S.
Discov Oncol. 2025 May 20;16(1):836. doi: 10.1007/s12672-025-02735-5.
A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort
Liu M, Li Z, Lu Y, Sun P, Chen Y, Yang L.
Biomedicines. 2025 May 19;13(5):1231. doi: 10.3390/biomedicines13051231.
The causal association between psoriasis and 32 types of cancer: a mendelian randomization study
Li G, Tian J, Xu J, Li K.
Discov Oncol. 2025 May 19;16(1):819. doi: 10.1007/s12672-025-02679-w.
Alcohol consumption and esophageal cancer risk: unveiling DLEU2 as a key immune modulator through Mendelian randomization and transcriptomic analysis
Qu K, Gu J, Xu Z, Hepeng Y, Ning Q, Wu X.
Discov Oncol. 2025 May 18;16(1):804. doi: 10.1007/s12672-025-02660-7.
Exploring the causal relationship between immune factors and chondrosarcoma: a Mendelian randomization study
Xu T, Xiao W, Li W, Xu X, Zhang H, Zhang X.
Discov Oncol. 2025 May 18;16(1):801. doi: 10.1007/s12672-025-02654-5.
Integrating single-cell with transcriptome-proteome Mendelian randomization reveals colorectal cancer targets
Wang S, Yao X, Li S, Wang S, Huang X, Zhou J, Li X, Wen J, Lan W, Huang Y, Li H, Sun Y, Zhao X, Chen Q, Han X, Zhu Z, Zhang X, Zhang T.
Discov Oncol. 2025 May 17;16(1):794. doi: 10.1007/s12672-025-02636-7.
The Causal Relationships between Lipids related Traits and Atrial Fibrillation/Flutter: Two-sample Mendelian Randomization Analysis
Shuo Zhang, Linghua Fan, Long Zhang, Fangfang Fan, Jia Jia, Yan Zhang, Jianping Li
Researchsquare, 16 May 2025, doi: 10.21203/rs.3.rs-6624447/v1
Characterization of genetic loci associated with allergic conjunctivitis
Koskimäki F, Ahokas O, Liinamaa J, Reis K, Reigo A, FinnGen, Estonian Biobank Research Team, Palta P, Kettunen J, Karjalainen MK, Saarela V.
medRxiv 2025.05.16.25327739; doi: https://doi.org/10.1101/2025.05.16.25327739
The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study
Zheng Q, Xu T, Luo S, Zhao J, Ying Y, Liu N, Jiang A, Pan Y, Zhang D.
Sci Rep. 2025 May 16;15(1):17062. doi: 10.1038/s41598-025-99742-x.
Association between Apolipoprotein B and diabetic nephropathy: insights from the National Health and Nutrition Examination Survey 2007-2016 and Mendelian randomization analysis
Wang H, Wu S, Pan D, Ning Y, Fu Y, Feng C, Guo J, Liu Z, Gu Y.
Nutr Diabetes. 2025 May 16;15(1):20. doi: 10.1038/s41387-025-00370-1.
Evaluating the causal effects of life-course adiposity on jaw anomalies
Chen X, Cheng Z, Wang Q, Jiang Y, Cheng Q, Jiang Q.
Prog Orthod. 2025 May 16;26(1):18. doi: 10.1186/s40510-025-00565-3.
Causal impact of genetically determined metabolites on kidney cancer and its subtypes: an integrated mendelian randomization and metabolomic study
Wang Z, Huangfu Z, Liu T, Li Y, Gao Y, Gan X, Wu X, Chen S, Li X, Wang L, Gao X.
Am J Cancer Res. 2025 May 15;15(5):2222-2242. doi: 10.62347/VUZH4644.
Genetic variants predisposing to increased risk of kidney stone disease
Lovegrove CE, Goldsworthy M, Haley J, Smelser D, Gorvin C, Hannan FM, Mahajan A, Suri M, Sadeghi-Alavijeh O, Moochhala SH, Gale DP, Carey D, Holmes MV, Furniss D, Thakker RV, Howles SA.
J Clin Invest. 2025 May 15:e186915. doi: 10.1172/JCI186915.
Genome-wide enhancer-gene regulatory maps of liver reveal novel regulatory mechanisms underlying NAFLD pathogenesis
Li R, Su K, Wu T, Xu L, Song W, Sun D, Zeng T, Chen J, Xin H, Li Y, Zang M, Hu M.
BMC Genomics. 2025 May 15;26(1):493. doi: 10.1186/s12864-025-11668-w.
Genetic drivers of etiologic heterogeneity in thyroid cancer
Jee YH, Pozdeyev N, Gignoux CR, Samantha White S, Haugen BR, Verma A, Peculis R, Rovite V, Mulford AJ, Sanders AR, Kitahara CM, Reeve MP, Kraft P, Martin AR.
medRxiv 2025.05.15.25327708; doi: https://doi.org/10.1101/2025.05.15.25327708
Chronic hepatitis B infection and pre-eclampsia/eclampsia: a Mendelian randomisation study
Pu R, Wang Z, Shang X, Lu J, Xu J, Xing Y.
J Obstet Gynaecol. 2025 Dec;45(1):2500972. doi: 10.1080/01443615.2025.2500972.
Genetic and Epigenetic Regulation of Inflammatory Genes Drives Calcific Aortic Valve Disease (CAVD)
Ding S-Y, Rehemuding R, Li X-L, Li X-M, Wei X, Yu Z-Y, Liu F, Keremu M, Cui J, Li X, Adi D, Ma Y-T.
medRxiv 2025.05.15.25327710; doi: https://doi.org/10.1101/2025.05.15.25327710