På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2025

December

1400 plasma metabolites and Sjögren’s syndrome: a Mendelian randomization analysis
Qiguo Cui, Bin Zhou, Yi Feng & Qin Huang
Clin Rheumatol (2025). https://doi.org/10.1007/s10067-025-07799-w
Mendelian Randomization Analysis of the Causal Relationship Between Micronutrients and Childhood Asthma
Liu Z, Wang C, Xie X, Chen H, Ma W, Li X, Sun L.
J Asthma. 2025 Dec 2:1-14. doi: 10.1080/02770903.2025.2596656. Online ahead of print.
Exploring the causal relationship between acute respiratory distress syndrome and gut microbiota: Unveiling the gut-lung axis through a large-scale Mendelian randomization study
Li C, Peng H, Lu F, Zhang G, Xu N, Chen X, Gao X.
Medicine (Baltimore). 2025 Nov 28;104(48):e45513. doi: 10.1097/MD.0000000000045513.
Polyunsaturated Fatty Acids and Skin Cancer: Two-Sample Mendelian Randomization Study
Kim G, Kim BR, Paik K, Jin SP, Park H, Myung W, Lee JK, Choi CW, Kim J.
Ann Dermatol. 2025 Dec;37(6):363-376. doi: 10.5021/ad.25.095.
Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors
Laura Vilar-Ribó, Mariela V Jennings, Aisha Sallah, Zeal Jinwala, Hayley HA Thorpe, Sevim B Bianchi, John Meredith, Kyra Feuer, Lydia Rader, Natasia Courchesne-Krak, Maria Niarchou, Jared Balbona, 23andMe Research Team, Sarah L Elson, Pierre Fontanillas, Emma C Johnson, Lea K Davis, Alexander S Hatoum, Travis T Mallard, Daniel E Gustavson, Hang Zhou, Abraham A Palmer, Jeanne E Savage, Rachel L Kember, Sandra Sanchez-Roige
medRxiv 2025.12.01.25341089; doi: https://doi.org/10.64898/2025.12.01.25341089
Serum urate and pancreatitis: A bidirectional Mendelian randomization study
Li Y, Liu J, Zhao X.
Medicine (Baltimore). 2025 Nov 28;104(48):e46135. doi: 10.1097/MD.0000000000046135.
Mendelian randomization study of the causal relationship between autoimmune diseases and anemia using proteomic and genetic data
Zhuang X, Pan T.
J Transl Autoimmun. 2025 Nov 12;11:100333. doi: 10.1016/j.jtauto.2025.100333. eCollection 2025 Dec.
Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus
Nick M.A. Shubert, Shuyang Yao, Maryam Kazemi Naeini, Natalia Trpchevska, Charles Bishop, Argyro Bizaki-Vallaskangas, Linda Broer, Fabio Castellana, Kaare Christensen, Jacob v. B. Hjelmborg, Maria Pina Concas, Aurora Santin, Giorgia Girotto, Giuseppe Giovanni Nardone, Licia Iacoviello, Estonian Biobank Research Team, Jonas Mengel-From, Scott Gallagher, Alexander Gudjonsson, Vilmundur Gudnason, Nancy L. Heard-Costa, Sudha Seshadri, Howard J. Hoffman, Chuan-Ming Li, Jaakko Kaprio, Joel Rämö, Elmo Saarentaus, Johannes Kettunen, Kristi Krebs, Anna K. Kähler, Lenore J. Launer, Hampton Leonard, Mike A. Nalls, Patrik K.E. Magnusson, Joyce van Meurs, Lili Milani, Antti Mäkitie, Berthe C. Oosterloo, Marianne Nygaard, Teemu Palviainen, Sheila Pratt, Nicola Quaranta, Rodolfo Sardone, Claudia L. Satizabal, John M. Schweinfurth, Eric Shiroma, Eleanor Simonsick, Lifelines Cohort Study, Christopher Spankovich, Patrick F. Sullivan, Andre Goedegebure, Andries Paul Nagtegaal, Sonja J. Pyott, Christopher R. Cederroth, Maxim B. Freidin, Frances MK Williams
medRxiv 2025.11.28.25340151; doi: https://doi.org/10.1101/2025.11.28.25340151
Novel causal associations between plasma metabolites and prostate cancer risk revealed by mendelian randomization
Chen H, Zhao H, Meng B, Liu Q.
Metabol Open. 2025 Nov 14;28:100421. doi: 10.1016/j.metop.2025.100421. eCollection 2025 Dec.

November

Does Toxoplasma gondii infection have a causal impact on human psychopathology? A Mendelian randomization analysis
Jinyong Pang, Matthew J. Valente, Kami Kim, Xiaoming Liu
medRxiv 2025.11.27.25341156; doi: https://doi.org/10.1101/2025.11.27.25341156
High-density lipoprotein cholesterol protects against delayed encephalopathy after acute carbon monoxide poisoning
Mu Y, Gao N, Wang Y, Wang S, Pang L.
Toxicol Appl Pharmacol. 2025 Nov 27:117663. doi: 10.1016/j.taap.2025.117663. Online ahead of print.
Identification of endoplasmic reticulum stress-related genes associated with Alzheimer's disease risk: A multi-omics Mendelian randomization analysis
Liang B, Li M, Zhang L.
J Affect Disord. 2025 Nov 26:120770. doi: 10.1016/j.jad.2025.120770. Online ahead of print.
Multi-omics integration identifies ASPH and PTTG1 as potential causal drivers of lung adenocarcinoma progression and immune evasion
Yang K, Chen M, Wu Y, Duan W, Huang N, Zhao X, Cheng D.
Front Immunol. 2025 Nov 12;16:1689275. doi: 10.3389/fimmu.2025.1689275. eCollection 2025.
Improving type 2 diabetes polygenic risk scores by incorporating rare, low-frequency, and population-specific variants
Katie Taylor, Alicia Huerta-Chagoya, Xiaoyu Wang, Maheak Vora, Jiang Li, Lehte Turk, Teng Hiang Heng, Joohyun Kim, Andres Moreno-Estrada, Teresa Tusie-Luna, Carlos Aguilar-Salinas, Maggie Ng, Hilary C. Martin, David A van Heel, Genes & Health Research Team, Alisa Manning, David Carey, Priit Palta, Mitja I. Kurki, Sarah Finer, Tian Ge, Uyenlinh L. Mirshahi, Haoyu Zhang, Josep M Mercader
medRxiv 2025.11.24.25340878; doi: https://doi.org/10.1101/2025.11.24.25340878
A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study
Gao Z, Wang J, Wei X, Li Y.
J Otol. 2025 Nov 13;20(4):245-252. doi: 10.26599/JOTO.2025.9540038. eCollection 2025 Oct.
iNKT cells exacerbate Sepsis-associated acute lung injury through IFN-γ-mediated promotion of macrophage apoptosis
Yang B, Tao Y, Xu X, Li C, Zou L, Zhao H, Li Y.
Int Immunopharmacol. 2025 Nov 27;168(Pt 2):115889. doi: 10.1016/j.intimp.2025.115889. Online ahead of print.
S4-Multi: enhancing polygenic score prediction in ancestrally diverse populations
Baierl J, Tyrer JP, Lai PH, Gayther SA, Hsiao YW, Jones M, Pharoah PDP, Peng PC.
HGG Adv. 2025 Nov 27:100551. doi: 10.1016/j.xhgg.2025.100551. Online ahead of print.
Mendelian Randomization Mediation Analysis Reveals the Impact of Dietary Preferences on Preeclampsia and Fetal Growth Restriction via Immune Modulation
Wang Y, Ni S, Gao X, Fang L, Li Y, Liu F, Guo L, Han C.
Food Sci Nutr. 2025 Nov 26;13(12):e71280. doi: 10.1002/fsn3.71280. eCollection 2025 Dec.
Glutamine and allergic rhinitis: A bidirectional two-sample Mendelian randomization study
Fan S, Guan Z, Ding Y, Chen W, Su S, Bai H, Li L.
Medicine (Baltimore). 2025 Nov 21;104(47):e45400. doi: 10.1097/MD.0000000000045400.
Shared Genetic Architecture and Neurobiological Pathways of Problematic Alcohol Use and Anxiety Disorders
Mingjian Shi, Tommy Gunawan, Samantha G. Malone, Michael Setzer, Zachary Piserchia, Christal N. Davis, Christopher T. Rentsch, Eleni Friligkou, Hang Zhou, Renato Polimanti, Lu Wang, Nataraja Sarma Vaitinadin, Henry R. Kranzler, Joshua C. Gray
medRxiv 2025.11.24.25339061; doi: https://doi.org/10.1101/2025.11.24.25339061
The Impact of Complement Factor H-Related Protein Gene Deletions on Kidney Transplantation
Markkinen S, Lokki A. I, Helanterä I, Ritari J, Partanen J, Meri S, Hyvärinen K
Scand J Immunol. 2025 Dec;102(6):e70073. doi: 10.1111/sji.70073.
Potential Causal Effects of Cystatin C on Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study
Lee Y, Seo JH.
Biomedicines. 2025 Nov 20;13(11):2827. doi: 10.3390/biomedicines13112827.
The Effect of Epigenetic Age Acceleration on Atopic Dermatitis: A Mendelian Randomization Study
Xin Y, Dai B, Wang J.
Clin Cosmet Investig Dermatol. 2025 Nov 21;18:3139-3146. doi: 10.2147/CCID.S540501. eCollection 2025.
Personal history of irradiation and risk of osteomyelitis: A Mendelian randomization study
Yun X, Fan Z, Fu Y, Guo H.
Medicine (Baltimore). 2025 Nov 21;104(47):e46034. doi: 10.1097/MD.0000000000046034.
Genetic crossroads of cardiovascular disease and its comorbidities: Toward holistic therapeutic strategies
Mishra BH, Mishra PP.
BMC Med Genomics. 2025 Nov 26. doi: 10.1186/s12920-025-02279-1. Online ahead of print.
Bioavailable testosterone and thyroid cancer: A 2-sample Mendelian randomization study
Xu Q, Jiang H, Li Y, Zhang J, He Q.
Medicine (Baltimore). 2025 Nov 21;104(47):e45528. doi: 10.1097/MD.0000000000045528.
Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study
Luo L, Zhou D, Su Q.
Medicine (Baltimore). 2025 Nov 21;104(47):e46075. doi: 10.1097/MD.0000000000046075.
Causal associations between 1400 circulating metabolites and spontaneous abortion: A bidirectional 2-sample Mendelian randomization study
Zhou X, Fang YX, Zhang DW, Ma LY, Yao MM.
Medicine (Baltimore). 2025 Nov 21;104(47):e45981. doi: 10.1097/MD.0000000000045981.
Population-scale multiome immune cell atlas reveals complex disease drivers
Masahiro Kanai, Toni M Delorey, Jarno Honkanen, Rodosthenis S Rodosthenous, Julianna Juvila, Shane Murphy, Isabella Teixeira-Soldano, Hee Seung Hwang, Juha Karjalainen, Jussi Halonen, Georgia Panagiotaropoulou, Yuanxiang Zhang, Cristin McCabe, Eric Chen, Kosaku Nanki, Toshimi Yoshida, Kai Liu, Marla Glean, Nitya Mehrotra, Emily P Finan, Daniel Chafamo, Yixiao Zhu, Mikko Arvas, Sanni Ruotsalainen, Zhili Zheng, FinnGen, Mary P Reeve, Mitja Kurki, Caroline BM Porter, Orr Ashenberg, Wei Zhou, Kimmo Pitkänen, Jukka Partanen, Aarno Palotie, Daniel B Graham, Mark J Daly, Ramnik J Xavier
medRxiv 2025.11.25.25340489; doi: https://doi.org/10.1101/2025.11.25.25340489
An Integrated Multi-Omics Analysis Identifies Oxeiptosis-Related Biomarkers in Diabetic Retinopathy
Deng J, Ge P, Gao Y, Li HY, Lin Y, Lu Y, Xie H, Xu D, Xie P, Hu Z.
Biomedicines. 2025 Nov 15;13(11):2789. doi: 10.3390/biomedicines13112789.
Intertwined and unequal causality of type 1 diabetes and autoimmune thyroid disease: Insights from Mendelian randomization
Wu J, Yu Y, Shangguan X, Yang X, Yu R, Zhou C.
Medicine (Baltimore). 2025 Nov 21;104(47):e45891. doi: 10.1097/MD.0000000000045891.
Waist-to-hip ratio and female infertility: An observational study and Mendelian randomization analysis
Wu S, Jiang H, Wang X, Meng Y, Lai S, Wan J.
Medicine (Baltimore). 2025 Nov 21;104(47):e45815. doi: 10.1097/MD.0000000000045815.
Identification of potential bladder cancer drug targets through Mendelian randomization and molecular docking
Chengwei Bi, Kexun Li, Yong Yang, Yuanlong Shi, Guoying Zhang, Bing Zhao, Yuanpeng Duan, Yapeng Xing, Wei Luo, Libo Yang, Yu Zhang & Yunchao Huang
Discov Onc 16, 2172 (2025). https://doi.org/10.1007/s12672-025-03929-7
Association of human plasma and cerebrospinal fluid metabolomes with vascular dementia and its subtypes: A Mendelian randomization study
Zhang X, Dong Y, Zou Z, Chen L, Li W, Wang L, Li K, He J, Shi Q.
Brain Res. 2025 Nov 24:150060. doi: 10.1016/j.brainres.2025.150060. Online ahead of print.
Causal effect of education on low back pain, intervertebral disc degeneration and sciatica: Mendelian randomization study
Wu Z, Gong Y, Long H, Deng R, He J, Su M, Wang J, Gong K.
Future Sci OA. 2025 Dec;11(1):2590373. doi: 10.1080/20565623.2025.2590373. Epub 2025 Nov 26.
Unique association of COVID-19 with increased risk of aplastic anemia among various viruses: insights from a two-sample Mendelian randomization study
Jixuan Zou, Yi Chen, Mingjing Wang, Weiyi Liu & Xiaomei Hu
J Transl Med 23, 1353 (2025). https://doi.org/10.1186/s12967-025-07374-6
Statins Regulate Stem Cell Growth Factor-β to Balance Osteogenesis and Adipogenesis in Mesenchymal Stem Cells, Endowing Anti-Osteonecrosis Effects
Fan F, Chen Y, Peng W, Yan W, Tan H, Zhang C, Tan S, Xiao Q, Gao Y, Zhang J, Liu L, Lian C.
J Cell Mol Med. 2025 Nov;29(22):e70967. doi: 10.1111/jcmm.70967.
Global impact of air pollution on cancer: causal evidence and health inequities across regions from 1990 to 2021
Zhou J, Liu L, He W.
BMC Cancer. 2025 Nov 25;25(1):1818. doi: 10.1186/s12885-025-15234-1.
Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization
Jia Q, Xiao J, Zhang W, Yu C, Song S, Li Y, Wang T.
BMC Pulm Med. 2025 Nov 24;25(1):542. doi: 10.1186/s12890-025-04006-z.
A genome-wide CRISPR screen identifies the TNRC18 gene locus as a regulator of inflammatory signaling
Rahimov F, Ghosh S, Petiwala S, Schmidt M, Nyamugenda E, Shi M, Tam J, Verduzco D, Singh S, Avram V, Modi A, Espinoza CA, Lu C, Wang J, Keller A, Macoritto M, Mahi NA, Anton T, Chung N, Flister MJ, Katlinski KV, Biswas A, den Hollander AI, Waring JF, Stender JD.
Nat Commun. 2025 Nov 24;16(1):10346. doi: 10.1038/s41467-025-65277-y.
Causal Effects Between Retinal Characteristics and Cardiovascular Diseases: Insights from Genetic Correlation, Mendelian Randomization, and Cross-Sectional Study
Cui X, Sun C, Wen D, Xiao J, Li X.
Glob Heart. 2025 Nov 21;20(1):104. doi: 10.5334/gh.1493. eCollection 2025.
Uncovering novel biomarkers and drug targets for androgenetic alopecia via metabolite regulation and multi-tissue validation
Yi S, Liu A, Zhang X, Deng Y, Chen Y, Huoshen W.
Free Radic Biol Med. 2025 Nov 22;243:220-230. doi: 10.1016/j.freeradbiomed.2025.11.053. Online ahead of print.
Dissecting the genetic and proteomic risk factors for delirium
Vasilis Raptis, Youngjune Bhak, Timothy I. Cannings, Alasdair M. J. MacLullich, Albert Tenesa
Nat Aging (2025). https://doi.org/10.1038/s43587-025-01018-6
Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade
Wanner JS, Krafft M, Niiranen T, Zimmerman DS, Ellinor PT, Nadkarni G, Jurgens SJ, Rämö J, Heyne HO.
Circulation. 2025 Nov 24. doi: 10.1161/CIRCULATIONAHA.125.075057. Online ahead of print.
CXCL10 promotes non-small cell lung cancer (NSCLC) progression by modulating the phosphate to urate ratio (PUR)
Zhang Y, Li Q.
Discov Oncol. 2025 Nov 24. doi: 10.1007/s12672-025-04151-1. Online ahead of print.
Lipidome's Role in Diabetic Retinopathy Subtypes via Inflammation: Mendelian Randomization and Mediation Analysis
Xu X, Liu N, Dong K, Ouyang S, Yu W.
Ophthalmol Sci. 2025 Sep 30;6(1):100951. doi: 10.1016/j.xops.2025.100951. eCollection 2026 Jan.
Causal Effects of Endometriosis Stages on Adverse Pregnancy and Perinatal Outcomes: A Mendelian Randomization Study
Zhao W, Li Z, Ou J.
Int J Womens Health. 2025 Nov 18;17:4601-4613. doi: 10.2147/IJWH.S540774. eCollection 2025.
Causal relationships of Janus kinase 2 with chronic kidney diseases: a two-sample Mendelian randomisation study
Wang Y, Ding Y, Zhang J, Wuren T.
Clin Exp Nephrol. 2025 Nov 24. doi: 10.1007/s10157-025-02791-9. Online ahead of print.
The Role of Metabolites in CSF on NAFLD Development: A Mendelian Randomisation Analysis
Liang F, Xiao T, Wang B.
Endocrinol Diabetes Metab. 2025 Nov;8(6):e70088. doi: 10.1002/edm2.70088.
B2M regulates ELANE in pyroptosis to affect pancreatic cancer progression
Xie H, Hu X, Cai Y, Zhu S, Deng Z.
Transl Oncol. 2025 Nov 21;63:102613. doi: 10.1016/j.tranon.2025.102613. Online ahead of print.