Publikationslista

Ma S, Ge Y, Lu Z, Zhang J, Zhang Q, Peng Y, Xi Z, Peng H, Xu MY, Xiong Z, Gao Y, Wang Y, Li L, Zhang C, Chao Z, Li T, Zhang R, Zhang Q, Horne DA, Wang B, Gao X, Zhang X, Tian J, Li J, Jin M, Wei GH, Wang Z.

Cancer Res. 2025 Aug 4. doi: 10.1158/0008-5472.CAN-24-5018.

Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling

Foote IF, Flint JP, Fürtjes AE, Mullin DS, Fisk JD, Karakach TK, Rutenberg A, Martin NG, Lupton MK, Llewellyn DJ, Ranson JM, Cox SR, Luciano M, Rockwood K, Grotzinger AD.

Nat Genet . 2025 Aug;57(8):1848-1859. doi: 10.1038/s41588-025-02269-0

Exploring the Causal Relationship Between Inflammatory Bowel Disease and Bell's Palsy Based on Inflammatory Proteins: A Mendelian Randomization Study

Fan D, Wu W, Dai J, Chen Y, Lian Q, Zhao C, Que B, Qiu R.

Brain Behav. 2025 Aug;15(8):e70715. doi: 10.1002/brb3.70715.

Exploring the causal relationship between 16 eye diseases and stroke and their subtypes from a genome-wide perspective

Su B, Sun Y, Yu W, Wang C, Xia Q, Zhu Y.

Sci Rep. 2025 Aug 4;15(1):28357. doi: 10.1038/s41598-025-98225-3.

Causal relationship between white matter structural connectivity and epilepsy

Zhang N, Huang R, Dong X.

Epilepsy Behav. 2025 Aug 2;171:110642. doi: 10.1016/j.yebeh.2025.110642.

Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas

Li, Y., Lin, L., Zhang, W.

Discov Onc 16, 1457 (2025). https://doi.org/10.1007/s12672-025-03318-0

ZDHHC4 Influences Obsessive-Compulsive Disorder Risk Through Imaging-Derived Phenotypes: A Mendelian Randomization Study

Huang Y, Luo H, Huang J, Hou X.

J Mol Neurosci. 2025 Aug 2;75(3):98. doi: 10.1007/s12031-025-02391-y.

Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases

Wang J-H, Dong S-S, Wang H-A, Liu S-S, Ma X, Zhu R-J, Shi W, Wu H, Yu K, Zhang T-P, Wang C-R, Guo Y, Yang T-L.

Cardiovasc Diabetol . 2025 Aug 1;24(1):312. doi: 10.1186/s12933-025-02847-w

Revealing the causal relationship between cathepsin and inflammatory disease of wrist through Mendelian randomization

Qu Y, Gong Q, Huang X, Zhao W.

Medicine (Baltimore). 2025 Aug 1;104(31):e43461. doi: 10.1097/MD.0000000000043461.

Integrative analysis reveals novel inflammatory and metabolic pathways in glioblastoma development: A large-scale mediation Mendelian randomization study

Yang X, Lin X.

Medicine (Baltimore). 2025 Aug 1;104(31):e43636. doi: 10.1097/MD.0000000000043636.

Exploring causal relationships between brain imaging-derived phenotypes and ovarian cancer risk: a bidirectional Mendelian randomization

Liu, T., Tuo, X., Zhao, H

J Ovarian Res 18, 173 (2025). https://doi.org/10.1186/s13048-025-01733-z

Exploring the impact of physical activity and micronutrients on diabetic nephropathy: a subtype-specific genetic correlation and Mendelian randomization study

Li F, Dang L, Wang Y, Cao J.

Nutr Metab (Lond). 2025 Aug 1;22(1):87. doi: 10.1186/s12986-025-00980-7.

Causal association between inflammatory cytokines and osteonecrosis: A bidirectional 2-sample Mendelian randomization study

You W, Lin Z, Lin Y, Liu M, Ye R, Zeng R.

Medicine (Baltimore). 2025 Aug 1;104(31):e43671. doi: 10.1097/MD.0000000000043671.

Exploring causal pathways between hypertension, lipid levels, and gout: Insights from Mendelian randomization and NHANES observations

Li M, Nie Q, Lv K, Liu J, Jiang Z.

Medicine (Baltimore). 2025 Aug 1;104(31):e43638. doi: 10.1097/MD.0000000000043638.

Juli

Long-term cardiovascular risk in women with hypertensive disorders of pregnancy: Insights from polygenic risk scores

Kivioja A, Tyrmi J, Toivonen E, Huhtala H; FinnGen; Jääskeläinen T, Kettunen J, Saarela T, Laivuori H.

Acta Obstet Gynecol Scand. 2025 Jul 31. doi: 10.1111/aogs.70021.

Multi-omics analysis unveiled fibroblast-mediated pathogenesis in male genital lichen sclerosus

Lin, L., Liu, Y., Wang, X.

Cell Biosci 15, 113 (2025). https://doi.org/10.1186/s13578-025-01453-3

Potential Causal Relationship Between Plasma and Cerebrospinal Fluid Metabolites and Meningioma: Two-Sample Mendelian Randomization Study

Du G, Xu D, Zhao H, Yan Z, Wang J.

https://www.dovepress.com/potential-causal-relationship-between-plasma-and-cerebrospinal-fluid-m-peer-reviewed-fulltext-article-JMDH

A Proteomic Profile of the Ocular Phenome: Systemic Signatures, Predictive Value, and Causal Insights Across 131 Ocular Diseases and Traits

Liu D, Liu H, Chen X, Zhang X, Zhang J, Wu J, Chen L, Wang N.

medRxiv 2025.07.31.25332495; doi: https://doi.org/10.1101/2025.07.31.25332495

Metabolism-Mediated FGF5 Association with Stroke: Based on Mendelian Randomization and Bioinformatics Analysis

Xu C, Xu Y, Gao L, Wang M, Wang G, Wang G.

J Multidiscip Healthc. 2025 Jul 31;18:4481-4495. doi: 10.2147/JMDH.S529168.

The Palmitoyltransferases ZDHHC6 and ABHD17A Modulate Type 2 Diabetes Risk via Genetic Causality and Molecular Interactions

Jiashu Li, Taoyuan Hao, Zhenzhen He, Modan Zhu, Wanting Du, Xianbo Huang, Qiuxian Li, Xinyuan Liu, Yan Su, Weiping Teng, Zhongyan Shan

Researchsquare, 31 July 2025, doi: 10.21203/rs.3.rs-6697832/v1

Oxidative Stress Links Thyroid Autoimmunity to Cancer: Peroxiredoxin 2 Protection via Genomic and Single-Cell Insights

Kang J, Wang S, Ni X.

Cancer Biother Radiopharm. 2025 Jul 30. doi: 10.1177/10849785251360744.

Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study

Lu C, Wang M, Li J, Xian H, Huang Z, Wang Y, Xie S, Zhang W, Yu Y, Zheng H, Li D, Zheng Y, Liu H, Zhao C.

Hematology. 2025 Dec;30(1):2538327. doi: 10.1080/16078454.2025.2538327.

Causal relationships between gut microbiota and urothelial carcinoma mediated by inflammatory cytokines and blood cell traits identified through Mendelian randomization analysis.

Wu, X., Zou, W. & Liu, Z

Discov Onc 16, 1440 (2025). https://doi.org/10.1007/s12672-025-03219-2

Estimating effects of serum vitamin B12 levels on psychiatric disorders and cognitive impairment: a Mendelian randomization study

Lu T, Paterson AD.

Commun Med (Lond) . 2025 Jul 30;5(1):316. doi: 10.1038/s43856-025-01043-x

Mind the gap: characterizing bias due to population mismatch in two-sample Mendelian randomization

Li J, Morrison J.

medRxiv 2025.07.30.25332465; doi: https://doi.org/10.1101/2025.07.30.25332465

Shikonin as a therapeutic agent in renal cell carcinoma: insights from TEK-related causal association with glaucoma

Jia R, Liang Y, Zou B, Li X, Chen T, Zhang C, Bian J, Guo R.

Front Pharmacol. 2025 Jul 30;16:1580704. doi: 10.3389/fphar.2025.1580704.

Exploring the liver-brain axes: insights from a bidirectional Mendelian randomization study on brain cortical structure and liver cancers

Zhu Q, Li Z, Cai C, Li D.

Discov Oncol. 2025 Jul 30;16(1):1446. doi: 10.1007/s12672-025-03276-7.

The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study

Detian Jiang, Yuxin Chang, Xiaowen Zhen, Xin Zhao

Nutr Metab (Lond) 22, 86 (2025). https://doi.org/10.1186/s12986-025-00979-0

Identification of hub gene associated with colorectal cancer: Integrating Mendelian randomization, transcriptome analysis and experimental verification

Yu Zhang, Xu Han, Yichun Yang, Jiayan Ren, Zixi Zhang, Yanmin Zhang, Qi Su, Dake Chu

Plos Genetics, July 29, 2025 https://doi.org/10.1371/journal.pgen.1011788

Genome-wide analysis of 3' untranslated region alternative polyadenylation quantitative trait loci identified a potential novel susceptibility locus for lung cancer in cross-ancestry populations

Wang Y, Li Y, Tian T, Han R, Zeng N, Xie F, Wang Y, Fan J.

J Hum Genet. 2025 Jul 29. doi: 10.1038/s10038-025-01375-5.

Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components

Omdahl AR, Weinstock JS, Keener R, Chhetri SB, Arvanitis M, Battle A.

Am J Hum Genet. 2025 Sep 4;112(9):2178-2197. doi: 10.1016/j.ajhg.2025.07.003. Epub 2025 Jul 28.

Pear-shaped body types linked to lower risk of gout: genetic evidence from Mendelian randomization

Yu Qiu, Cantao Li, Ying Hua, Yan Huang, Lu Zhang, Jiaman Xu, Junna Zheng, Zhiling Fu, Xiaoxi Zhang, Fenfen Li, Daozong Xia

Int J Obes 49, 2273–2285 (2025). https://doi.org/10.1038/s41366-025-01875-6

DLK1 downregulation serves as a potential biomarker for disease severity and a therapeutic target in bronchiectasis

Yanping Liu, Shaochu Zheng, Shihao Yang, Yuting Huang, Jinling Tang, Haizhu Huang, Kangkang Hong, Jing Luo, Jinliang Kong

Researchsquare, 29 July 2025, doi: 10.21203/rs.3.rs-7090713/v1

Causal association between non-steroidal anti-inflammatory drugs use and the risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study

Junfa Liu, Kaiyi Dong, Gang Qin, Chunyan Ye, Jinghan Wu, E. Wang, Zhitao Dong

Inflammopharmacol 33, 4615–4627 (2025). https://doi.org/10.1007/s10787-025-01866-z

Unraveling the link between inflammatory bowel disease and perianal abscess: insights from bidirectional and multivariable Mendelian randomization study

Zhu H, Pan J.

BMC Gastroenterol. 2025 Jul 29;25(1):538. doi: 10.1186/s12876-025-04137-x.

Systemic evaluation of the effects of monomeric GLP-1R-based agonists on MASLD and its complications

Cai, Y., Xie, S., Xu, L

Diabetol Metab Syndr 17, 300 (2025). https://doi.org/10.1186/s13098-025-01870-x

Oral and gut microbiota in gingivitis subtypes: a causal inference study using Mendelian randomization

Lin J, Xu Q, Bi W, Yu Y, Wang Q.

BMC Oral Health. 2025 Jul 28;25(1):1270. doi: 10.1186/s12903-025-06658-z.

Air pollutants and adverse pregnancy outcomes: A multi-method integration of Mendelian randomization, meta-analysis, and animal models

Zhou W, Shao J, Huang J, Gan J, Wang Y, Chen J, Chen Y, Zi Y, Xu Q, Zhou Q, Zhao H, Li X.

Ecotoxicol Environ Saf. 2025 Jul 28;302:118699. doi: 10.1016/j.ecoenv.2025.118699.

Genetic Prediction of Causal Association Between Celiac Disease and Thyroid Function: A Two-Sample Mendelian Randomized Study

He X, Lv H, Yu W, He J, Xie Y, Zhou L, Wu H, Guo L, Yang X.

Endocr Metab Immune Disord Drug Targets. 2025 Jul 28. doi: 10.2174/0118715303364014250713045734.

Association of GLP1RAs with risk of chronic obstructive pulmonary disease: evidence from drug target Mendelian randomization

Lai S, Feng Y, Li L, Zhao J, Wang Z, Wang Y.

Diabetol Metab Syndr. 2025 Jul 28;17(1):295. doi: 10.1186/s13098-025-01866-7.

ADCY3 Ser107Pro links difficulty awakening in the morning to adiposity through circadian regulation of adipose thermogenesis

Tchio C, Maher M, Moth C, Meiler H, Lane J, Taylor H, Williams J, Saxena RR.

bioRxiv 2025.07.28.667339; doi: https://doi.org/10.1101/2025.07.28.667339

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation

Akdeniz BC, Bahrami S, Hagen E, Fuhrer J, Fominykh V, Shadrin A, Filiz TT, Athanasiu L, Grenier-Boley B, Bellenguez C, de Rojas I, Kucukali F, Schneider A, Kleineidam L, Rujescu D, Scherbaum N, Deckert J, Riedel-Heller S, Hausner L, Molina-Porcel L, Grimmer T, Heilmann-Heimbach S, Moebus S, Scarmeas N, Garcia-Alberca JM, Franco-Macias E, Mir P, Real LM, Rodriguez-Rodriguez E, Luis Royo J, Saez ME, Carracedo A, Lopez de Munain A, Amer-Ferrer G, Calero M, Medina M, Garcia-Ribas G, Mendioroz M, Dols-Icardo O, Moreno F, Perez-Tur J, Bullido MJ, Alvarez V, Soininen H, Heikkinen S, de Mendonca A, Mehrabian S, Traykov L, Hort J, Vyhnalek M, Sandau N, Thomassen JQ, Luo J, Pijnenburg YAL, Tesi N, van Swieten J, Giedraitis V, Williams J, Nicolas G, Debette S, Amouyel P, Grunblatt E, Popp J, Bossu P, Galimberti D, Rossi G, Arosio B, Mecocci P, Squassina A, Tremolizzo L, Borroni B, Nacmias B, Seripa D, Rainero I, Daniele A, Piras F, Masullo C, Kehoe PG, Frikke-Schmidt R, Ghidoni R, Ruiz A, Fernandez V, Sanchez-Juan P, Sleegers K, Ingelsson M, Hiltunen M, Sims R, Ramirez A, Broce IJ, Haavik J, Selbaek G, Knapskog A-B, Saltvedt I, Bergh S, Aakhus E, Kirsebom B-E, Watne LO, Rongve A, Arsland D, Djurovic S, Stordal E, Toft M, Scheffler K, Fladby T, Lambert J-C, Dale A, Frei O, Andreassen O.

medRxiv 2025.07.28.25332293; doi: https://doi.org/10.1101/2025.07.28.25332293

Deciphering bidirectional causal links between oxidative stress and lung cancer risk through Mendelian randomization

XueLian Chen, JianRong Zeng, FengYun Cao, Jun Cai, Xin Ma, ChangYu Pu

Discov Onc 16, 1421 (2025). https://doi.org/10.1007/s12672-025-03289-2