På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2025

November

Exploring the causal relationship between gut microbiota and thromboembolism: A Mendelian randomization study
Wang Z, Zheng Z.
Medicine (Baltimore). 2025 Nov 14;104(46):e45790. doi: 10.1097/MD.0000000000045790.
Causal Relationship Between Plasma Protein-to-Protein Ratios and Rheumatoid Arthritis: A Proteome-wide Mendelian Randomization Study
Yan M, Hou K, Wang T, Zhang Y.
Curr Mol Med. 2025 Nov 14. doi: 10.2174/0115665240448559251025102228. Online ahead of print.
Cross-tissue transcriptome-wide association and Mendelian randomization identify RALB as a susceptibility gene for breast hypertrophy
Gu J, Chen J, Hu Z, Luo H.
Medicine (Baltimore). 2025 Nov 14;104(46):e45872. doi: 10.1097/MD.0000000000045872.
Causal validation of the relationship between air pollution and ovarian cancer: A bidirectional Mendelian randomization study and meta-analysis
Yi W, Feng X, Yang J.
Medicine (Baltimore). 2025 Nov 14;104(46):e45841. doi: 10.1097/MD.0000000000045841.
Multi-omics evidence supports PROC as a potential predictor of VTE risk: A Mendelian randomization study
Wan B, Zhang C, Yu Z, Zhang Y, Liu Y, Luo S, Liu G.
Medicine (Baltimore). 2025 Nov 14;104(46):e45921. doi: 10.1097/MD.0000000000045921.
Causal relationship between plasma homocysteine levels and colorectal cancer: A Mendelian randomization study
Ru X, Wu L, Guo Y, Shen Y.
Medicine (Baltimore). 2025 Nov 14;104(46):e45773. doi: 10.1097/MD.0000000000045773.
Education, socioeconomic status, leisure sedentary behaviors and female infertility: mendelian randomization study
Qu Y, Huang X, Mi J, Chen X, Wu B, Xu J.
BMC Womens Health. 2025 Nov 14;25(1):557. doi: 10.1186/s12905-025-03849-2.
Rheumatoid arthritis increases risk of atherosclerosis: A Mendelian randomization study
Liu QP, Zhang LX, Gao HZ, Luo JH, Chai ST
Medicine (Baltimore). 2025 Nov 14;104(46):e45590. doi: 10.1097/MD.0000000000045590
Bioinformatics analysis identifies ULK3 as a novel prognostic and immune-related biomarker in esophageal cancer
Cui K, He J, Zhao N, Ma R, Wang Y.
Transl Cancer Res. 2025 Oct 31;14(10):6588-6604. doi: 10.21037/tcr-2025-989. Epub 2025 Oct 29.
GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology
Robert N. Luben, Mahantesh I. Biradar, Kelsey V. Stuart, Ruiqi Hu, Zihan Sun, Zheng Li, Ningli Wang, Tan Do, Chi Pui Pang, Masakazu Nakano, Kei Tashiro, Yoko Ikeda, Yuichi Tokuda, Masami Tanaka, Natsue Omi, Morio Ueno, Chie Sotozono, Shigeru Kinoshita, Kazuhiko Mori, Naris Kitnarong, Antonio Fea, Mônica B. Melo, José Paulo C. Vasconcellos, Vital P. Costa, Monisha E. Nongpiur, Ching Lin Ho, Shamira A. Perera, Jamie E. Craig, Antonia Kolovos, Ahmad Tajudin Liza-Sharmini, Edgar U. Leuenberger, Ki Ho Park, Lingam Vijaya, Ronnie George, Tin Aung, C. C. Khor, Paul J. Foster, Pirro Hysi & Anthony P. Khawaja
Nat Commun 16, 10003 (2025). https://doi.org/10.1038/s41467-025-64949-z
MICA protein as a plasma biomarker for dermatomyositis with malignancy: a proteome-wide Mendelian randomization and ELISA study
He K, Ye J, Shao X, Teng J, Ye M, Zheng J, Cao H.
Clin Rheumatol. 2025 Nov 14. doi: 10.1007/s10067-025-07751-y. Online ahead of print.
Unraveling the causal association of epigenetic age acceleration with common oral diseases and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis
Peng L, Nie S, Sun Y, Wang S, Wang Y, Liu Z.
Clin Epigenetics. 2025 Nov 14;17(1):189. doi: 10.1186/s13148-025-02005-9.
Causal links between congenital malformations, birth weight, and neuroblastoma: insights from Mendelian randomization
Ailikamu Aierken, Falide Atabieke, Yierzhati Aizezi, Munire Aierken, Shui-Xue Li & Ling Zhou
BMC Pediatr 25, 935 (2025). https://doi.org/10.1186/s12887-025-06295-z
Causal Associations of Smoking, Alcohol, Obesity, Sedentary Behavior, Hypertension, and Hyperglycemia With Retinal Vein Occlusion: A Mendelian Randomization Study
Li D, Liu D, Li Y, Lai Z, Cao W.
Curr Genomics. 2025;26(4):290-301. doi: 10.2174/0113892029320896241218055907. Epub 2025 Jan 17.
Integrative Mendelian randomization and spatial transcriptomics analysis reveals causal links between plasma lipidome and non-small cell lung cancer
Zhang B, Liu J, Guo Q, Wang H, Miao L, Zhou L.
Discov Oncol. 2025 Nov 14;16(1):2107. doi: 10.1007/s12672-025-03823-2.
Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women
Lindsay A Guare, Jagyashila Das, Lannawill Caruth, Ananya Rajagopalan, Alexis T. Akerele, Ben M Brumpton, Tzu-Ting Chen, Leah Kottyan, Yen-Feng Lin, Elisa Moreno, Ashley J Mulford, Marija Simona Dombrovska, Yuan Luo, Vita Rovite, Alan R Sanders, Craig Teerlink, Danielle Candelieri, Noemie Elhadad, Andrew Hill, Gail P. Jarvik, James Jaworski, Julie Lynch, Shinichi Namba, Yukinori Okada, Yue Shi, Yuya Shirai, Jonathan Shortt, Wei-Qi Wei, Chunhua Weng, Yuji Yamamoto, Penn Medicine Biobank, Regeneron Genetics Center, Global Biobank Meta-analysis Initiative, Sinead Chapman, Wei Zhou, Todd Edwards, Suneeta Senapati, Digna R. Velez Edwards, Shefali Setia-Verma
medRxiv 2024.11.26.24316723; doi: https://doi.org/10.1101/2024.11.26.24316723
Genome-wide association study and polygenic risk prediction of hypothyroidism
Søren A. Rand, Gustav Ahlberg, Vinicius Tragante, Laia M. Monfort, Chaoqun Zheng, Ulla Feldt-Rasmussen, Marianne C. Klose, Maris Teder-Laving, Andres Metspalu, Henrik E. Poulsen, Christina Ellervik, Birte Nygaard, Christian Erikstrup, Mie T. Bruun, Bitten A. Jensen, Henrik Ullum, Søren Brunak, DBDS Genomic Consortium, Estonian Biobank Research Team, 23andMe Research Team, Michael Schwinn, Sisse R. Ostrowski, Ole B. Pedersen, Erik Sørensen, Ingileif Jonsdottir, Daniel F. Gudbjartsson, Gudmar Thorleifsson, Hilma Holm, Saedis Saevarsdottir, Kari Stefansson, Morten Salling Olesen, Henning Bundgaard & Jonas Ghouse
Nat Genet 57, 3007–3015 (2025). https://doi.org/10.1038/s41588-025-02410-z
Childhood Obesity and Age-Related Diseases: A Systematic Review and Meta-Analysis of Mendelian Randomization Evidence
Zhu H, Yi X, He M, Wu S, Li M, Gao S.
Pediatr Obes. 2025 Nov 14:e70071. doi: 10.1111/ijpo.70071. Online ahead of print.
Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study
Wang Q, Kuang Q, Chen C, Wang B, Xiang W, Li X, Mou J.
PM R. 2025 Nov 13. doi: 10.1002/pmrj.70029. Online ahead of print.
Multi-ancestry proteogenomic analysis identifies risk proteins for intracranial aneurysms
Chen-Yang Su, Juliano Malizia, Masashi Hasebe, Thomas Zheng, Alejandro-Mejia Garcia, Hsuan Megan Tsao, Zhaohe Lin, Ta-Yu Yang, Fumihiko Matsuda, Patrick A. Dion, Vincent Mooser, Guy Rouleau, Guillaume Butler-Laporte, Tianyuan Lu, Satoshi Yoshiji, Sirui Zhou
medRxiv 2025.11.11.25339992; doi: https://doi.org/10.1101/2025.11.11.25339992
Dissecting the effect of blood colony-stimulating factors and receptors on Alzheimer's disease: the role of myeloid traits and inflammation
Guo X, Tang P, He J, Li R.
Cytokine. 2025 Nov 12;197:157072. doi: 10.1016/j.cyto.2025.157072. Online ahead of print.
Polygenic prediction of coronary heart disease among 130,000 Mexican adults
Liu T, Berumen J, Torres J, Alegre-Díaz J, Baca P, González-Carballo C, Ramirez-Reyes R, Rivas F, Aguilar-Ramirez D, Bragg F, Herrington W, Hill M, Trichia E, Vergara A, Wade R, Collins R, Kuri-Morales P, Emberson JR, Tapia-Conyer R, Gnatiuc Friedrichs L.
Eur J Prev Cardiol. 2025 Nov 13:zwaf728. doi: 10.1093/eurjpc/zwaf728. Online ahead of print.
Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression
Shorter JR, Pasman JA, Kurvits S, Jangmo A, Naamanka J, Harder A, Hagen E, Kowalec K, Frilander N, Zetterberg R, Meijsen JJ, Gådin JR, Bergstedt J, Xiong Y, Hägg S, Landén M, Rück C, Wallert J, Skalkidou A, Koch E, Akdeniz BC, Frei O; FinnGen; Hovatta I, Reichborn-Kjennerud T, Werge TM, Sullivan PF, Andreassen OA, Tesli M, Lehto K, Buil A, Lu Y.
Nat Genet. 2025 Nov 13. doi: 10.1038/s41588-025-02396-8. Online ahead of print.
Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity
Xiuzhi Wang, Jinyu Liu, Xichen Wang, Jin Yang, Yipeng Le, Yingchao Song, Qian Su, Xiaoxiao Xiao, Yifan Li, Wen Qin, Chunshui Yu, Ping Wang & Meng Liang
Nat Commun 16, 9958 (2025). https://doi.org/10.1038/s41467-025-64904-y
Genome-wide analysis in over 1.6 million participants uncovers 147 loci associated with obstructive sleep apnoea
Garcia-Marin L M, Ceja Z, Parasuraman A, Xu J, Diaz-Torres S, Flores-Ocampo V, Aman A, Maya-Martinez M, Huang X, Pasquali C, Aguilar-Roldan A, Uckac B, Cao F, Ogonowski N S, Martin N, MacGregor S, Dong X, Lewis S J, Saviiri M, Wang J, Renteria M
medRxiv 2025.11.08.25339824; doi: https://doi.org/10.1101/2025.11.08.25339824
TLR1-Regulated Ferroptosis Gene Decreases the Occurrence of Restless Legs Syndrome
Chen Q, Men X.
Brain Behav. 2025 Nov;15(11):e71038. doi: 10.1002/brb3.71038.
Bidirectional Causal Associations Between Plasma Metabolites and Parkinson’s Disease
Mengjie Zhao, Taiping Li, Hong Shen, Ancha Baranova, Vikas Chandhoke & Fuquan Zhang
Mol Neurobiol 63, 30 (2026). https://doi.org/10.1007/s12035-025-05306-5
The associations between diet-induced inflammation and health outcomes: a population-based phenome-wide association study
Weiwei Chen, Ke Liu, Xinzhe Jing, Yu Qian, Bin Liu, Ying Chen, Jiayu Li, Xiaohui Sun, Yingying Mao & Ding Ye
npj Sci Food 9, 223 (2025). https://doi.org/10.1038/s41538-025-00583-9
The role and prognostic value of mitochondria-related gene PARK7 in breast cancer
Yu S, Zhou Y, Zhang S, He F, Jiang L, Lv X, Gu X, Xie X.
Breast Cancer Res. 2025 Nov 11;27(1):200. doi: 10.1186/s13058-025-02153-z.
Exploring the causal associations between obesity indicators and male reproductive diseases: new evidence from Mendelian randomization
Huijuan Wei, Haoting Chen, Yifei Lin & Haibin Lu
Basic Clin. Androl. 35, 43 (2025). https://doi.org/10.1186/s12610-024-00242-1
Plasma proteins and osteosarcoma risk: causal evidence from Mendelian randomization
Ma H, Liao J, He Z, Liu M, Wei F, Wei Q, Luo Q.
Discov Oncol. 2025 Nov 11;16(1):2090. doi: 10.1007/s12672-025-03932-y.
Molecular mechanisms and genetic predisposition to osteoarthritis and osteosarcoma through Mendelian inheritance patterns
Hao Fei, Wen Huang, Yueyuan Chen & Shuo Yang
Discov Onc 16, 2093 (2025). https://doi.org/10.1007/s12672-025-03917-x
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
Olav B. Smeland, Gleda Kutrolli, Shahram Bahrami, Vera Fominykh, Nadine Parker, Julian Fuhrer, Guy F. L. Hindley, Linn Rødevand, Piotr Jaholkowski, Markos Tesfaye, Pravesh Parekh, Torbjørn Elvsåshagen, Andrew D. Grotzinger, Nils Eiel Steen, Dennis van der Meer, Kevin S. O’Connell, Srdjan Djurovic, Anders M. Dale, Alexey A. Shadrin, Oleksandr Frei & Ole A. Andreassen
Nat Neurosci 28, 2439–2450 (2025). https://doi.org/10.1038/s41593-025-02090-2
Plasma proteins and osteosarcoma risk: causal evidence from Mendelian randomization
Ma H, Liao J, He Z, Liu M, Wei F, Wei Q, Luo Q.
Discov Oncol. 2025 Nov 11;16(1):2090. doi: 10.1007/s12672-025-03932-y.
Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease
Albarrán-Juárez J, Markov A, Jensen AL, Møller PL, Uryga AK, Djordjevic D, Hansen J, Jensen LF, Sharysh D, Pyke C, Moreno J, Borghetti G, Bachmann J, Herum K, Røge LM, Traylor M, Nyberg M, Nyegaard M, Bentzon JF.
iScience. 2025 Oct 4;28(11):113698. doi: 10.1016/j.isci.2025.113698. eCollection 2025 Nov 21.
Elucidation and application of the neuroimmune axis between depression and autoimmune diseases: A genome wide and cohort study
Fu Sun , Shirong Hui , Bin Gong, Jinhua Gu , Peng Huang
PLOS ONE 20(11): e0336109. https://doi.org/10.1371/journal.pone.0336109
Bidirectional causal association between cathepsins and neuropsychiatric disorders: univariate and multivariate Mendelian randomization study
Zeyang Li, Lei Jia & Shengnan Huai
Eur Arch Psychiatry Clin Neurosci (2025). https://doi.org/10.1007/s00406-025-02150-5
131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma
Saarentaus EC, Fischer-Rasmussen K, Sliz E, Bizaki-Vallaskangas A; FinnGen; Laitinen T, Toppila-Salmi S, Kankaanranta H, Kettunen J, Bønnelykke K, Palotie A, Mäkitie A.
Nat Commun. 2025 Nov 10;16(1):9879. doi: 10.1038/s41467-025-64847-4.
Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for gout
Wei-quan Liao, Hui-ying Chen, Yu-ying Li, Li-juan Xiao, Zai-xing Qiu, Sha-sha Hu, Si-hui He, Lan Luo, Jing-jing Xie & Jian-yong Zhang
Naunyn-Schmiedeberg's Arch Pharmacol (2025). https://doi.org/10.1007/s00210-025-04787-4
Causal Influences of Micronutrients on Anxiety: Insights From an Observational and Mendelian Randomization Analysis
Fang X, Zhao Q, Liu P, Baranova A, Cao H, Zhang X, Zhang F.
Food Sci Nutr. 2025 Nov 5;13(11):e71166. doi: 10.1002/fsn3.71166. eCollection 2025 Nov.
Impact of Immune Cells on IgA Vasculitis via Metabolites and Inflammatory Cytokines
Ming Xie, Nian Zhou, Qian Liang, Zhong Lin & Yanbing Yao
J Clin Immunol 45, 157 (2025). https://doi.org/10.1007/s10875-025-01946-3
Causal relationship between multiple modifiable risk factors and gestational diabetes mellitus: a two-sample Mendelian randomization study
Liao CC, Lee CI, Li JM.
Can J Diabetes. 2025 Nov 8:S1499-2671(25)00394-6. doi: 10.1016/j.jcjd.2025.10.178. Online ahead of print.
Mitochondrial-related pathogenic genes in varicose veins: A multi-omics Mendelian randomization study
Tan X, Liu Z, Chen K, Li D, Xia J, Niu C, Li H, Huang J.
Phlebology. 2025 Nov 10:2683555251398726. doi: 10.1177/02683555251398726. Online ahead of print.
FINEMAP-miss: Fine-mapping genome-wide association studies with missing genotype information
Kartau J, Pirinen M.
Bioinformatics. 2025 Dec 1;41(12):btaf616. doi: 10.1093/bioinformatics/btaf616.
Role of Transitional %B cells in Mediating the Effect of Phosphatidylinositol (16:0_18:1) on Aortic Dissection
Ma L, Tang L, Jin L, Li J, Li H, Chen L, Qiu Z.
Am J Hypertens. 2025 Nov 6:hpaf223. doi: 10.1093/ajh/hpaf223. Online ahead of print.
The influence of mitochondrial biological function on sudden sensorineural hearing loss: Exploring potential mechanisms and associations through Mendelian randomization analysis
Chen J, Hao C, Tang X, Yao H, Su S.
Medicine (Baltimore). 2025 Nov 7;104(45):e45151. doi: 10.1097/MD.0000000000045151.
Causal association between 3 adiposity indices and 5 infectious diseases: A Mendelian randomization study
Chen X, Yin J, Chen C, Xiang T.
Medicine (Baltimore). 2025 Nov 7;104(45):e45775. doi: 10.1097/MD.0000000000045775.
Causal association between sepsis and acute respiratory distress syndrome: Evidence from a 2-sample Mendelian randomization study
Zhang P, Tian W, Tian Y, Yu N, Liu C, Ma S, Li X, Zhou X, Lu H.
Medicine (Baltimore). 2025 Nov 7;104(45):e45574. doi: 10.1097/MD.0000000000045574.
Mendelian randomization analysis of gut microbiota and chronic kidney disease: Implications for herbal interventions
Hu X, Wang L, Lin C, Zhu Z, Yang S, Wang S, Wang Y, Jin H, Lv Y, Wang D, Zhang X, Ren K.
Medicine (Baltimore). 2025 Nov 7;104(45):e45730. doi: 10.1097/MD.0000000000045730.
Rotator cuff injury and myocardial infarction: Findings of NHANES 2011 to 2018 and Mendelian randomization study
Wang Z, Dang J, Xu L, Yang X, Jia C.
Medicine (Baltimore). 2025 Nov 7;104(45):e45840. doi: 10.1097/MD.0000000000045840.