Below you will find all the published and preprint scientific papers using FinnGen data.

2025

September

Bidirectional Mendelian randomization analysis of the causal relationship between fibromyalgia and insomnia
Jin Gao, Liangke Pan, Zhenglun Pan
Researchsquare, 12 September 2025, doi:10.21203/rs.3.rs-7169915/v1
Deciphering diabetic neuropathy: immune cell causality revealed
Yu Y, Yang X, Yin Y, Deng J, Chen C, Yu R.
Neurol Res . 2025 Sep;47(9):782-790. doi: 10.1080/01616412.2025.2503456.
Genes and environment profoundly affect the human virome
Kamitaki N, Tang D, McCarroll S, Loh, P-R.
bioRxiv 2025.09.08.674901; doi: https://doi.org/10.1101/2025.09.08.674901
Perturbations in lipid metabolism mediate the relationship between cholecystectomy and dementia: A mediation Mendelian randomization study
Gu H, Yu K, Zhou J, Chu B, Zhang W, Dong J, He J.
J Alzheimers Dis . 2025 Sep 11:13872877251376316. doi: 10.1177/13872877251376316.
Deciphering the Genetic Association Between the FODMAP Diet and Recurring Oral Aphthae-The Mediating Role of Ferroptosis
Jia B, Wu X, Wang Q, Ren J, Li G, Zheng X, Yang S.
Food Sci Nutr . 2025 Sep 9;13(9):e70949. doi: 10.1002/fsn3.70949. eCollection 2025 Sep.
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study
Joshua Reitz, Daniel B. Rosoff, Tyler Perlstein, Alexandra Wagner, Jeesun Jung, Josephin Wagner, Benjamin C. Reiner, Falk W. Lohoff
Mol Psychiatry 30, 6119–6133 (2025). https://doi.org/10.1038/s41380-025-03199-3
The Role of Plasma Metabolites in Mediating the Effect of Gut Microbiota on Obstructive Sleep Apnea: A Two-Step, Two-Sample Mendelian Randomization Study
Wang X, Zhao R, Guo J, Yang K, Xu B.
Nat Sci Sleep . 2025 Sep 3:17:2119-2130. doi: 10.2147/NSS.S527778. eCollection 2025.
Genetic Association of Lipids and Lipid-Lowering Drug Target Genes With Atopic Dermatitis: A Drug Target Mendelian Randomization Study
Luo M, Lin J, Zhuo Q, Lin L, Han Y.
Health Sci Rep . 2025 Sep 7;8(9):e71040. doi: 10.1002/hsr2.71040. eCollection 2025 Sep.
Association between copper exposure and renal fibrosis in patients with chronic kidney disease: evidence from Mendelian randomization and a retrospective study
Liu K, Yu M, He Y, Wang T, Hu H, Wan Z, Shuai P, Chen S, Li G, Wang L, Zhong X.
Front Public Health . 2025 Aug 25:13:1657180. doi: 10.3389/fpubh.2025.1657180. eCollection 2025.
Vitamin A and vitamin B12 levels and coronary artery atherosclerosis: Univariate and multivariate Mendelian randomization analysis
Huang L, Shi J, Li H, Lin Q.
Medicine (Baltimore) . 2025 Sep 5;104(36):e44244. doi: 10.1097/MD.0000000000044244.
MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites
Ahmed A, Cule M, Naz A, Thanaj M, Sorokin EP, Odoemelam CS, Whitcher B, Sattar N, Bell JD, Thomas EL, Yaghootkar H.
J Obes . 2025 Aug 31:2025:7792701. doi: 10.1155/jobe/7792701. eCollection 2025.
Exploration of causal relationship between transplant rejection and immune cells: A two-sample Mendelian randomization study
Xue F, Wu X, Ni M, Jiang T, Wang H, Ma Y, Wu Q.
Transpl Immunol . 2025 Sep:92:102278. doi: 10.1016/j.trim.2025.102278.
The Relationship Between Human Cerebrospinal Fluid Proteins and the Risk of Delirium: A Study Based on Genetic Data
Xu Z, Ye F, Yuan Z, Liu C, Zhu S, Li B, Wu Q.
Brain Behav . 2025 Sep;15(9):e70836. doi: 10.1002/brb3.70836.
Potential Causal Relationships Between Circulating Micronutrient Levels and Multiple Neuroimmune Diseases: A Genetic Association Analysis
Chen L, Wu X, Wang K, Zhou X, Mou Y, Liu Z, Shen Z, Lv Z, Lv L.
Brain Behav . 2025 Sep;15(9):e70848. doi: 10.1002/brb3.70848.
Bidirectional Mendelian randomization study reveals causal relationships between polymyalgia rheumatica and serum metabolites
Song A, Kang L, Cao S, Wang Y, Li H.
Medicine (Baltimore) . 2025 Sep 5;104(36):e44304. doi: 10.1097/MD.0000000000044304.
A Cross-Tissue Transcriptome-Wide Association Study Identified Susceptibility Genes for Intervertebral Disc Degeneration
Zhang L, Zhao W, Yang H, Deng T, Li Y.
JOR Spine . 2025 Sep 7;8(3):e70109. doi: 10.1002/jsp2.70109. eCollection 2025 Sep.
The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study
Xin X, Guan L, Li J, Zhang J, Wu H.
Int J Womens Health . 2025 Sep 2:17:2833-2844. doi: 10.2147/IJWH.S534178. eCollection 2025.
Identifying potential therapeutic targets in periodontitis: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization
Zhou H, Chen R, Deng Z, Li S.
Naunyn Schmiedebergs Arch Pharmacol . 2025 Sep 9. doi: 10.1007/s00210-025-04580-3.
Multi-omic insights into mitochondrial dysfunction and prostatic disease: evidence from transcriptomics, proteomics, and methylomics
Gong B, Yang F, Zhang N, Wu Z, Liu T, Wang K, Zhang X, Zhang Y, Song Z, Liang C.
Front Genet . 2025 Aug 22:16:1609933. doi: 10.3389/fgene.2025.1609933. eCollection 2025.
Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study
Wang Z, Hu Y, Wei Y, Xue C, Hu Y, Wang Y, Wu C, Jiang F, Wang F.
Endocr Res . 2025 Sep 8:1-10. doi: 10.1080/07435800.2025.2557991.
Circulating inflammatory proteins predict dementia risk, are linked to structural brain changes and reveal risk mediation pathways
Dorsa Abdolkarimi, Yue Liu, Lachlan Gilchrist, Sara Calhas, Sheena Waters, Charles R Marshall, Petroula Proitsi
medRxiv 2025.08.29.25334731; doi: https://doi.org/10.1101/2025.08.29.25334731
Hidradenitis suppurativa is an HLA-associated autoimmune disease
Zierer J, Cojean C, Osinga R, Läuchli S, Wieczorek G, Roth L, Roediger B.
J Invest Dermatol . 2025 Sep 4:S0022-202X(25)02412-1. doi: 10.1016/j.jid.2025.08.035.
Unlocking New Treatment Horizons for Celiac Disease: PRKCD Revealed as a Promising Target through Mendelian Randomization
Zhou J, Xu Y, Wang H, Wang K, Chen C.
Endocr Metab Immune Disord Drug Targets . 2025 Aug 29. doi: 10.2174/0118715303410531250815124524.
Causal effects of lung function and COPD on functional outcome following ischemic stroke: a univariable and multivariable Mendelian randomization study
Wan-ting Sun, Juan Wang, Zhuo-ya Yao, Fang Pan, Zhao-dan Gan, Yun Yang, Jun Lu, Long-yun Zhou, Guang-xu Xu
medRxiv 2025.09.03.25335062; doi: https://doi.org/10.1101/2025.09.03.25335062
Dietary antioxidants: a challenge or an opportunity for asthma? Genetic insights from a Two-sample mendelian randomization study
Zhou X, Zhou Y, Chen J, Chen C, Chen R, Zheng S, Wang Z, Zhou L.
J Asthma . 2025 Sep 8:1-11. doi: 10.1080/02770903.2025.2555297.
Association Between Socioeconomic Status and Major Congenital Anomalies: A Two-Sample Mendelian Randomization Study
Linares D, Miao Q, Luna B.
Birth Defects Res . 2025 Sep;117(9):e2524. doi: 10.1002/bdr2.2524.
Multi-ancestry genome-wide association study of endometriosis and its clinical manifestations in ∼1.4 million women: translating gene discovery into pathogenic mechanisms and therapeutic targets
Dora Koller, Jun He, Solveig Løkhammer, Selena Aranda, Dan Qiu, David Davtian, Qianyu Chen, Ziang Xu, Zhongzheng Mao, Eleni Friligkou, Sefayet Karaca, Bru Cormand, Idhaliz Flores, Signe Altmäe, Marina Mitjans, Brenda Cabrera-Mendoza, Renato Polimanti
medRxiv 2025.09.03.25335012; doi: https://doi.org/10.1101/2025.09.03.25335012
Causal Associations Between Oral Microbiota and Gestational Diabetes Mellitus: A Two-Sample Mendelian Randomization Study
Jin H, Wang Y, Li H, Cheng Y, Ma Y.
Int J Womens Health . 2025 Aug 30:17:2777-2791. doi: 10.2147/IJWH.S531088. eCollection 2025.
Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study
Zhang Y, Lin Z, He X, Lu J, Tan P, Huang Q, Zhang K.
Am J Hypertens . 2025 Aug 16:hpaf154. doi: 10.1093/ajh/hpaf154.
Association Between Platelet Indices and Risk of Chronic Obstructive Pulmonary Disease: A Bidirectional Mendelian Randomization Study
Liao W, Lin X, Liu K, Yang Y, Du L, Pan J, Chen F, Ye W, Chen B, Chen R, Chen W, Yao W.
Int J Chron Obstruct Pulmon Dis . 2025 Aug 27:20:2967-2977. doi: 10.2147/COPD.S531797. eCollection 2025.
The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases
Fiona A. Hagenbeek, Anne Richmond, Max Tamlander, Kira Detrois, Zhiyu Yang, Tuomo Hartonen, Daniel L. McCartney, FinnGen, Riccardo E. Marioni, Pekka Martikainen, Nina Mars, Andrea Ganna, Samuli Ripatti
medRxiv 2025.09.02.25334913; doi: https://doi.org/10.1101/2025.09.02.25334913
Trajectory and genetic correlation mapping of cross-disease risks following incident type 2 inflammatory diseases
Yask Gupta, Henning Olbrich, Diamant Thaci, Philip Curman, Ralf J. Ludwig
medRxiv 2025.09.02.25334921; doi: https://doi.org/10.1101/2025.09.02.25334921
Unlocking the Secrets: Causal Associations Between Blood Metabolites and Aspergillosis
Youzhen Ma, Wenlong Du
Curr Microbiol 82, 490 (2025). https://doi.org/10.1007/s00284-025-04465-x
Causal relationship between vitamin D and adult height: A bidirectional Mendelian randomization study
Chen L, Wu M, Zeng Z, Hu X, Wang Y.
Medicine (Baltimore) . 2025 Aug 29;104(35):e44123. doi: 10.1097/MD.0000000000044123.
Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study
Taageby Nielsen S, Luo J, Tybjærg-Hansen A, Iversen K, Bundgaard H, Qvist Thomassen J, Frikke-Schmidt R.
Eur Heart J . 2025 Sep 3:ehaf565. doi: 10.1093/eurheartj/ehaf565.
Genome-wide association study of neuropathic pain phenotypes implicates loci involved in neural cell adhesion, channels, collagen matrix formation, and immune regulation
Packer R, Coley K, Williams AT, Shrine N, Izquierdo AG, Chen J, Batini C, Marttila M, Rao BS, Bratty R, Dudbridge F, Hennah W, Tobin MD.
Pain. 2025 Sep 3. doi: 10.1097/j.pain.0000000000003785. Online ahead of print.
Association between diabetes mellitus and adhesive capsulitis of shoulder: A 2-sample Mendelian randomization study
Li W, Lou J, Huangfu W, Han D.
Medicine (Baltimore) . 2025 Aug 29;104(35):e44119. doi: 10.1097/MD.0000000000044119.
The Causal Relationship Between Circulating Inflammatory Proteins and Tinnitus: A Mendelian Randomization Study Mediated by Blood Metabolites
Chen K, Cai Y.
Brain Behav . 2025 Sep;15(9):e70699. doi: 10.1002/brb3.70699.
Multiple Sclerosis Drives Gastric Cancer via Shared Inflammatory Pathways: A Mendelian Randomization Study
Hengyi Liao, Xuhao Wang, Yiji Zhang, Zhiya Zhang, Yin Liao
medRxiv 2025.09.01.25334880; doi: https://doi.org/10.1101/2025.09.01.25334880
Exploring the causal relationship between 25-hydroxyvitamin D and asthma: A bidirectional Mendelian randomization study
Wu X, Zhan X, Ouyang C.
Medicine (Baltimore) . 2025 Aug 29;104(35):e44249. doi: 10.1097/MD.0000000000044249.
Causal relationship between five autoimmune diseases and intervertebral disc degeneration:a bidirectional Mendelian analysis]
Zhang BF, Yin XL, Huang ZL, Pei S, Li YW.
Zhongguo Gu Shang . 2025 Aug 25;38(8):856-66. doi: 10.12200/j.issn.1003-0034.20240413.
Predicting Alzheimer’s Disease Phenotypes With Aging Clocks: An Exploratory Analysis
Cindy David Sarmento, Gabin Drouard, Toni T Saari, Aino Aaltonen, Aino Heikkinen, Teemu Palviainen, Sanna-Kaisa Herukka, Tarja Kokkola, Sari Kärkkäinen, FinnGen, Aarno Palotie, Valtteri Julkunen, Heiko Runz, Jaakko Kaprio, Miina Ollikainen, Eero Vuoksimaa
medRxiv 2025.09.01.25334848; doi: https://doi.org/10.1101/2025.09.01.25334848
Metabolome-Wide Mendelian Randomization Identifies Valine as a Potential Mediator of the Effect of Obesity on Pancreatic Cancer Risk
Li K, Zhang C, Yan C.
FASEB J . 2025 Sep 15;39(17):e70995. doi: 10.1096/fj.202501757R.
The genetic architecture of postoperative delirium after major surgery and its relationship with non-postoperative neurocognitive conditions
Richard A. Armstrong, Paul Yousefi, Ben Gibbison, Golam M Khandaker, Tom R Gaunt
medRxiv 2025.09.01.25334224; doi: https://doi.org/10.1101/2025.09.01.25334224
Identification of ATG4B and NLRP1 as M1 Macrophage-Activating Related Plasma Proteins in Systemic Lupus Erythematosus via Multi-Omics Approaches
He M, Chen L, Zuo Y, Du J, Tang W.
Int Arch Allergy Immunol . 2025 Sep 2:1-25. doi: 10.1159/000548167.
Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk
Thomas Yates, Molly Went, Charlie Mills, Philip Law, Ines Gockel, Carlo Maj, Johannes Schumacher, Claire Palles, Richard Houlston
Br J Cancer 133, 1344–1353 (2025). https://doi.org/10.1038/s41416-025-03170-7
Association between metabolites and hepatocellular carcinoma: findings from a two-sample Mendelian randomization study
Hoang T, Truong VM, Tran TTA, Tran BLT, Cao NH.
J Liver Cancer. 2025 Sep 2. doi: 10.17998/jlc.2025.08.26.
Multi-omics analysis of immunologically relevant genes in multiple sclerosis to identify potential drug target
Li W, Chai S, Zhang N, Zeng F, Tang X, Zhang F, Yang F, Chen Q, Wang C, Li B, Zheng F.
J Affect Disord . 2025 Aug 31:392:120174. doi: 10.1016/j.jad.2025.120174.
Adverse events during pregnancy, circulating metabolites, and congenital malformations: a Mendelian randomization study
Cheng J, Dong X, Yang Y, Qin X, Zhou X, Fu Y, Wang J, Wang Y, Zhang D.
BMC Pregnancy Childbirth . 2025 Sep 1;25(1):915. doi: 10.1186/s12884-025-07860-1.

August

Shared genetics between metabolic traits and sensorineural hearing loss: a large-scale genome-wide cross-trait analysis
Xiaoyu Wang, Xiaoxu Xia, Ke Qiu, Tao Shu, Wendu Pang, Jianjun Ren, Yu Zhao
Mol Genet Genomics 300, 80 (2025). https://doi.org/10.1007/s00438-025-02281-3