På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2025

April

Genetic correlations and causal associations between BMI, HDL-C, and postoperative infections: a two-sample Mendelian randomization study
Yang T, Chen Z, Cao D, Song W, Jiang J, Ma X, Mao Z, Guan X, Wu J, Shi R, Si X.
Sci Rep. 2025 Apr 7;15(1):11834. doi: 10.1038/s41598-025-95812-2.
Revealing the mediating mechanisms between BMI and osteoarthritis: a Mendelian randomization and mediation analysis
Yu H, Wang J, Xu X, Li H, Guo J.
Aging Clin Exp Res. 2025 Apr 7;37(1):119. doi: 10.1007/s40520-025-03035-2.
Causal relationship between rosacea and psychiatric disorders: a bidirectional two-sample Mendelian randomization study
Li Y, Hu T, Jiang L, Ge L.
Arch Dermatol Res. 2025 Apr 7;317(1):683. doi: 10.1007/s00403-025-04142-w.
Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study
Wang S, Fang Z, Xiao W, Xie Y, Zhang Y, Liu Z.
Discov Oncol. 2025 Apr 7;16(1):481. doi: 10.1007/s12672-025-02249-0.
Elucidating Causal Relationships Among Gut Microbiota, Human Blood Metabolites, and Knee Osteoarthritis: Evidence from a Two-Stage Mendelian Randomization Analysis
Wang Z, Zhao C, Wang Z, Li M, Zhang L, Diao J, Chen J, Zhang L, Wang Y, Li M, Zhou Y, Xu H.
Rejuvenation Res. 2025 Apr 7. doi: 10.1089/rej.2024.0079.
Ulcerative colitis increases the risk of atrioventricular block: evidence from a Mendelian randomized analysis
Shu W, Huang G.
Sci Rep. 2025 Apr 7;15(1):11873. doi: 10.1038/s41598-025-96111-6.
No Associations Between Genetically Predicted Chronotype, Insomnia, Daytime Sleepiness, or Physical Activity and Acne Vulgaris: A Two-Sample Mendelian Randomization Study
Tian C.
Clin Cosmet Investig Dermatol. 2025 Apr 6;18:827-835. doi: 10.2147/CCID.S510739.
Warfarin use and vestibular dysfunction insights from NHANES data, network pharmacology, Mendelian randomization, and molecular docking
Liu S, Zhang L, Luo W.
Sci Rep. 2025 Apr 6;15(1):11748. doi: 10.1038/s41598-025-96681-5.
Uncovering leading compounds for alzheimer’s disease treatment: mendelian randomization and virtual screening insights into plasma protein modulation
Sun X, Hu X, Wei J, An H.
Biol Res. 2025 Apr 5;58(1):19. doi: 10.1186/s40659-025-00598-2.
Causal relationship between mitochondrial proteins and risks of aortic aneurysms and aortic dissection: a Mendelian randomization study
Wang L, Lin Y, Lin Z, Wu Q, Zhong G, Chen L.
J Cardiothorac Surg. 2025 Apr 5;20(1):181. doi: 10.1186/s13019-025-03389-8.
Assessing the genetic estimates of the association between plasma caffeine and cancer risk through Mendelian randomization
Wang H, Ma K, Shan M, Zhang G.
Eur J Nutr. 2025 Apr 5;64(4):145. doi: 10.1007/s00394-025-03663-4.
Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study
Yang X, Lin T, Luo L, Chen H, Dai Y, Li D, Zhu L.
Gynecol Endocrinol. 2025 Dec;41(1):2487498. doi: 10.1080/09513590.2025.2487498.
Identification of biomarkers for endometriosis based on summary-data-based Mendelian randomization and machine learning
Xie Z, Feng Y, He Y, Lin Y, Wang X.
Medicine (Baltimore). 2025 Apr 4;104(14):e41804. doi: 10.1097/MD.0000000000041804.
Mendelian-based urolithiasis risk concerning fish consumption and fish oil supplement
Zhu J, Nie J.
Medicine (Baltimore). 2025 Apr 4;104(14):e41760. doi: 10.1097/MD.0000000000041760.
Mendelian randomization analysis of the causal relationship between plasma proteins and childhood asthma
Wang C, Fan H, Sun Y, Sun L.
Medicine (Baltimore). 2025 Apr 4;104(14):e42050. doi: 10.1097/MD.0000000000042050.
Causal relationship between gut microbiota, metabolites, and short stature: a Mendelian randomization study
Zheng Z, Sun H, Zhang P, Cao F, Xiao X, Zhao T.
Pediatr Res. 2025 Apr 3. doi: 10.1038/s41390-025-03985-3.
Decoding the genetic links between substance use disorder and cancer vulnerability
Su X, Mo X, Kan J, Yang F, Zhang B, Huang Y.
Psychopharmacology (Berl). 2025 Apr 3. doi: 10.1007/s00213-025-06781-3.
Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis
Liu L, Liao M, Liu B, Huang Q, Wu H, Li M.
Obstet Gynecol Sci. 2025 Apr 3. doi: 10.5468/ogs.24254.
A mendelian randomization study on the association between 731 types of immune cells and 91 types of blood cells with venous thromboembolism
Zhang Y, Wang R.
Thromb J. 2025 Apr 3;23(1):28. doi: 10.1186/s12959-025-00714-y.
Health implications associated with fat-free mass: phenome-wide Mendelian randomization study
Ying Y, Zhang C, Wu S, Wang S, Lian J, Lin Y, Guan H, Cai D.
Cardiorenal Med. 2025 Apr 3:1-20. doi: 10.1159/000545641.
Causal relationship between graves' disease and mental disorders: A bidirectional Mendelian randomization study
Deng Y, Hao Z, Chen W, Zhang J, Zou Y, Zhang J, Xi Y, Xu J.
J Psychosom Res. 2025 Apr 3;192:112124. doi: 10.1016/j.jpsychores.2025.112124.
Dissecting causal relationships between gut microbiota, inflammatory factors, and acute kidney injury: A Mendelian randomization study
Huai J, Ye X.
Clin Nephrol. 2025 Apr 3. doi: 10.5414/CN111632.
Plasma cytokine levels and PCOS risk: Mendelian randomization analysis reveals IL6R as a preventive factor
Li X, Li Y, Zhang B, Wang J, Yang Y, Du Y.
J Ovarian Res. 2025 Apr 3;18(1):69. doi: 10.1186/s13048-025-01647-w.
Identifying blood mitochondrial DNA copy number as a biomarker for development of neurodegenerative diseases: Evidence from Mendelian randomization analysis
Lei S, Liu Y.
Neuroscience. 2025 Apr 2;573:421-429. doi: 10.1016/j.neuroscience.2025.04.003.
Mendelian Randomization Unveils a Causal Relationship Between Inflammation, Metabolism, and Systemic Sclerosis
Zeng Y, Zeng W, Li Z, Yang X, Pan J, Lei L.
medRxiv 2025.04.02.25325153; doi: https://doi.org/10.1101/2025.04.02.25325153
Metabolic Factors Mediate the Causal Effect of Physical Activity and Sedentary Behavior on Stroke and Its Subtypes: Evidence from Mendelian Randomization Study
Wei J, Zhao J, Yang K, Ma S, Zhang M, Sun Y, He C, Pan X, Zhu X.
Mol Neurobiol. 2025 Apr 2. doi: 10.1007/s12035-025-04881-x.
Association between sleep apnoea and arrhythmia: A multivariable Mendelian randomization study
He W, Wang J, Nie J, Wang DW, Ni L, Li D.
medRxiv 2025.04.02.25325145; doi: https://doi.org/10.1101/2025.04.02.25325145
Dissecting shared genetic architecture between hypothyroidism and immune-related diseases
Li S, Gong M.
medRxiv 2024.04.02.24305135; doi: https://doi.org/10.1101/2024.04.02.24305135
Exploring the Relationship Between Antipsychotic Drug Target Genes and Epilepsy: Evidence From Food and Drug Administration Adverse Event Reporting System Database and Mendelian Randomization
Yin Z, Zhan Z, Qiu Y, Wang M, Li J, Song B, Chen Z, Wu J, Wang Z.
Brain Behav. 2025 Apr;15(4):e70467. doi: 10.1002/brb3.70467.
Researching the causal relationship between immune cells and frontotemporal Dementia: A Mendelian Randomization analysis
Cheng Y, He X, Huang X, Mao F, Qin F, Wang Y.
Brain Res. 2025 Apr 2;1857:149608. doi: 10.1016/j.brainres.2025.149608.
Thyroid function and hepatic fibrosis/cirrhosis: a two-sample Mendelian randomization study
Wang Y, Zhang X, Li Q, Zhang Q, Liu J.
Front Genet. 2025 Apr 2;16:1399353. doi: 10.3389/fgene.2025.1399353.
Exploring glucagon-like peptide-1 receptor agonists as potential disease-modifying agents in autoimmune diseases
Yang Y, Liu W, Zhang Z, Zhang Y, Wang X, Wang J, Cai H, Liu Y, Meng R, Fu Y, Luo H, Yang L, Liu W.
J Autoimmun. 2025 Apr 1;153:103414. doi: 10.1016/j.jaut.2025.103414.
Cross-ancestry genome-wide association study identifies new susceptibility genes for preeclampsia
Shan Y, Hu H, Chu Y.
BMC Pregnancy Childbirth. 2025 Apr 1;25(1):379. doi: 10.1186/s12884-025-07534-y.
BMI matters: understanding the link between weight and severe psoriasis
Wang H, Hou S, Kang X, Yu C, Yang B, Shi Y, Li F, Li W, Gu J, Lei M, Lin Y, Wang G, Jin H, Liu X.
Sci Rep. 2025 Apr 1;15(1):11158. doi: 10.1038/s41598-025-94505-0.
Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis
Oliva M, Sarkar MK, March ME, Saeidian AH, Mentch FD, Hsieh CL, Tang F, Uppala R, Patrick MT, Li Q, Bogle R, Kahlenberg JM, Watson D, Glessner JT, Youssefian L, Vahidnezhad H, Tsoi LC, Hakonarson H, Gudjonsson JE, Smith KM, Riley-Gillis B.
Nat Commun. 2025 Apr 1;16(1):3101. doi: 10.1038/s41467-025-58310-7.
Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake
Sun L, Leng R, Liu M, Su M, He Q, Zhang Z, Liu Z, Wang Z, Jiang H, Wang L, Guo S, Xu Y, Huo Y, Miller CL, Banach M, Huang Y, Evans PC, Pelisek J, Camici GG, Berk BC, Offermanns S, Ge J, Xu S, Weng J.
J Clin Invest. 2025 Apr 1;135(7):e181928. doi: 10.1172/JCI181928.
Effect of the plasma metabolites, biomarkers, and inflammatory proteins on urolithiasis: insights from Mendelian randomization and mediation analysis
Huang H, Wen Z, Li H, Wang C, Chen C, Liu Y, Qin J, Cao S, Yang X.
Urolithiasis. 2025 Apr 1;53(1):65. doi: 10.1007/s00240-025-01738-9.
Causal Characteristics of Immune Cells Associated with Aortic Dissection: A Mendelian Randomisation Analysis
Li TL, Fu ML, Wang LH, Wang JL, Liu YW, Huang L.
Eur Cardiol. 2025 Apr 1;20:e07. doi: 10.15420/ecr.2024.44.

Mars

Assessing the effect of modifiable risk factors on hepatocellular carcinoma: evidence from a bidirectional Mendelian randomization analysis
Wei L, Ding E, Lu D, Rui Z, Shen J, Fan G.
Discov Oncol. 2025 Mar 31;16(1):437. doi: 10.1007/s12672-025-02177-z.
Dissecting Causal Relationships Between Gut Microbiota, 1400 Blood Metabolites, and Intervertebral Disc Degeneration
Liu Y, Feng D, Zhang H, Wang L.
Neurospine. 2025 Mar;22(1):211-221. doi: 10.14245/ns.2449172.586.
Severe traumatic brain injury and risk for osteoporosis: a Mendelian randomization study
Wang G, Wang J, Yang D, Liu L, Xu P.
BMC Med Genomics. 2025 Mar 31;18(1):61. doi: 10.1186/s12920-025-02127-2.
Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations
Malone SG, Davis CN, Piserchia Z, Setzer MR, Toikumo S, Zhou H, Winterlind EL, Gelernter J, Justice A, Leggio L, Rentsch CT, Kranzler HR, Gray JC.
Nat Hum Behav. 2025 May;9(5):1056-1066. doi: 10.1038/s41562-025-02148-y.
Exploring the association between 91 circulating inflammatory proteins and the risk of carcinoid syndrome: a Mendelian randomization analysis
Wang J, Peng S.
Discov Oncol. 2025 Mar 31;16(1):434. doi: 10.1007/s12672-025-02147-5.
Causal association between non-steroidal anti-inflammatory drugs use and the risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study
Peng ZH, Li MR, He MX, Liu J, Dou JH, Wang YW, Dong Y, Yan C, Li ZH, Chong T, Li ZL.
BMC Med Genomics. 2025 Mar 31;18(1):60. doi: 10.1186/s12920-025-02128-1.
Appraising the causal role of cathepsins in genitourinary carcinoma: a two-sample mendelian randomization and prospective study based on 36,225 individuals
Zhu Q, Liu D, Liu H, Pan X, Shi Y, Guo J, Tong N, Chen J, Zeng H.
Discov Oncol. 2025 Mar 31;16(1):435. doi: 10.1007/s12672-025-02219-6.
Exploring the causal relationship between vitiligo and psoriasis: a bidirectional Mendelian randomization analysis
Xu Z, Yang C, Gan X, Yan P, Xiao C, Ye Y, Jiang X.
Arch Dermatol Res. 2025 Mar 29;317(1):648. doi: 10.1007/s00403-025-04102-4.
Uncovering somatic genetic drivers in prostate cancer through comprehensive genome-wide analysis
Lin L, Li Z, Chen K, Shao Y, Li X.
Geroscience. 2025 Mar 29. doi: 10.1007/s11357-025-01623-8.
Examining the link between 179 lipid species and 7 diseases using genetic predictors
Ottensmann L, Tabassum R, Ruotsalainen SE, Gerl MJ, Klose C, McCartney DL, Widén E; FinnGen; Simons K, Ripatti S, Vitart V, Hayward C, Pirinen M.
EBioMedicine. 2025 Apr;114:105671. doi: 10.1016/j.ebiom.2025.105671.
A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases
You D, Wu Y, Lu M, Shao F, Tang Y, Liu S, Liu L, Zhou Z, Zhang R, Shen S, Lange T, Xu H, Ma H, Yin Y, Shen H, Chen F, Christiani DC, Jin G, Zhao Y.
Nat Commun. 2025 Mar 28;16(1):3032. doi: 10.1038/s41467-025-58248-w.
Genetically predicted amino acids related to neural regulation mediate the association between diabetes mellitus and postherpetic neuralgia: a Mendelian randomization study
Lan H, Ai Z, Xu S, Li H, Feng Z, Guo R, Wang Y.
Diabetol Metab Syndr. 2025 Mar 28;17(1):104. doi: 10.1186/s13098-025-01672-1.