Below you will find all the published and preprint scientific papers using FinnGen data.

2024

September

GNN4DM: a graph neural network-based method to identify overlapping functional disease modules
Gézsi A, Antal P.
Bioinformatics. 2024 Oct 1;40(10):btae573. doi: 10.1093/bioinformatics/btae573.
Causal associations of air pollution with rheumatoid arthritis: A transethnic Mendelian randomization study
He A, Li H, Ouyang S, He J, Gong Z, Zhou Q, Wang S, Zhao X.
PLoS One. 2024 Sep 24;19(9):e0307514. doi: 10.1371/journal.pone.0307514.
Assessing the causal association of sleep abnormalities with preeclampsia and eclampsia: a Mendelian randomization analysis
Li J, Kong Y, Shi G, Dong S, Wang X, Feng L, Guo Q, Lu C.
Hypertens Pregnancy. 2024 Dec;43(1):2405857. doi: 10.1080/10641955.2024.2405857.
Life-course obesity and heart failure: a two-sample Mendelian randomization study
Wang H, Min J, Zhong L, Zhang J, Ye L, Chen C.
Intern Emerg Med. 2024 Sep 24. doi: 10.1007/s11739-024-03772-8.
Genetic correlation between chronic sinusitis and autoimmune diseases
Wang E, Sun Y, Zhao H, Wang M, Cao Z.
Front Allergy. 2024 Sep 24;5:1387774. doi: 10.3389/falgy.2024.1387774.
Tea intake and non-alcoholic fatty liver disease risk: A two-sample Mendelian randomization study
Lu C, Ke L, Mentis AA, Zhang Q, Wang Z, Wang Z.
Metabol Open. 2024 Sep 24;24:100322. doi: 10.1016/j.metop.2024.100322.
Causal relationships between obesity-related anthropometric indicators and sepsis risk: a Mendelian-randomization study
Zhang C, Ren J, Xu X, Lei H, Deng G, Liu J, Gao X, Li J, Wang X, Wang G.
Front Nutr. 2024 Sep 23;11:1433754. doi: 10.3389/fnut.2024.1433754.
Bayesian-based analysis of the causality between 731 immune cells and erectile dysfunction: a two-sample, bidirectional, and multivariable Mendelian randomization study
Chen J, Liu Y, Zhan P, Gao T, Zuo J, Li X, Zhang F, Wang H, Fu S.
Sex Med. 2024 Sep 21;12(4):qfae062. doi: 10.1093/sexmed/qfae062.
Bidirectional Mendelian randomization explores the causal relationship between dietary habits and rheumatoid arthritis
Xu W, Ouyang M, Peng D, Jiang Z.
Medicine (Baltimore). 2024 Sep 20;103(38):e39779. doi: 10.1097/MD.0000000000039779.
Polymyalgia rheumatica and giant cell arteritis: A bidirectional Mendelian randomization study
Teng L, Li L, Cui D, An R, Jin J.
Medicine (Baltimore). 2024 Sep 20;103(38):e39723. doi: 10.1097/MD.0000000000039723.
Causal effects of post-traumatic stress disorder on autoimmune thyroid disease: insights from mendelian randomization
Chen Z, Yu Y, Yao J, Guo Z, Cui Y, Li F, Li C.
Front Psychiatry. 2024 Sep 20;15:1417302. doi: 10.3389/fpsyt.2024.1417302.
Dissecting causal relationships between gut microbiome, immune cells, and brain injury: A Mendelian randomization study
Xian L, Xu X, Mai Y, Guo T, Chen Z, Deng X.
Medicine (Baltimore). 2024 Sep 20;103(38):e39740. doi: 10.1097/MD.0000000000039740.
The potential protective effect of 3-Hydroxybutyrate against aortic dissection: a mendelian randomization analysis
Qiu S, Liu Z, Wang CT, Sun XD, Liu ZQ, Liu W.
Nutr Metab (Lond). 2024 Sep 20;21(1):75. doi: 10.1186/s12986-024-00853-5.
Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders
Tesfaye M, Jaholkowski P, Shadrin AA, van der Meer D, Hindley GFL, Holen B, Parker N, Parekh P, Birkenæs V, Rahman Z, Bahrami S, Kutrolli G, Frei O, Djurovic S, Dale AM, Smeland OB, O'Connell KS, Andreassen OA.
Psychiatry Clin Neurosci. 2024 Dec;78(12):783-791. doi: 10.1111/pcn.13742.
Genetic susceptibility to acute viral bronchiolitis
Pasanen A, Karjalainen MK, Korppi M, Hallman M, Rämet M; Research Project FinnGen.
J Infect Dis. 2024 Sep 20:jiae467. doi: 10.1093/infdis/jiae467.
Sedentary and 21 gastrointestinal disorders: A Mendelian randomization study
Lin Y, He J, Ding Z.
Medicine (Baltimore). 2024 Sep 20;103(38):e39813. doi: 10.1097/MD.0000000000039813.
Unveiling genetic links between gut microbiota and asthma: a Mendelian randomization
Zheng X, Chen M, Zhuang Y, Zhao L, Qian Y, Shi C.
Front Microbiol. 2024 Sep 20;15:1448629. doi: 10.3389/fmicb.2024.1448629.
Genetically predicted frailty index and risk of chronic kidney disease
Chen HJ, Qiu J, Guo Y, Chen F.
Sci Rep. 2024 Sep 19;14(1):21862. doi: 10.1038/s41598-024-71881-7.
Causal Relationship Between Mood Swing and Gynecological Disorders: A Mendelian Randomization Study
Bian J, Li H, Shang Y, Zhang F, Tang L.
Int J Womens Health. 2024 Sep 19;16:1541-1549. doi: 10.2147/IJWH.S468624.
No genetic causal relationship between acne and prostate cancer through Mendelian randomization combined with meta-analysis
He M, Wang X, Wang D, Wang Y, Qi J, Jia J, Zhang M, Meng Q, Yan B, Guo H, Qu C.
Front Oncol. 2024 Sep 19;14:1460467. doi: 10.3389/fonc.2024.1460467.
Unraveling the causative connection between urticaria, inflammatory cytokines, and mental disorders: Perspectives from genetic evidence
Liu Z, Wang Y, Wang S, Wu J, Jia C, Tan X, Liu X, Huang X, Zhang L.
Skin Res Technol. 2024 Sep;30(9):e13906. doi: 10.1111/srt.13906.
Associations between human blood metabolome and vascular dementia
Jia Y, Guo D, Liu Y, Sun L, Chang X, He Y, Shi M, Chen GC, Zhang Y, Hui L, Zhu Z.
Prog Neuropsychopharmacol Biol Psychiatry. 2024 Sep 19;136:111150. doi: 10.1016/j.pnpbp.2024.111150.
Allium Vegetables Intake and Digestive System Cancer Risk: A Study Based on Mendelian Randomization, Network Pharmacology and Molecular Docking
Li S, Lou J, Mulatihan Y, Xiong Y, Li Y, Xu Q.
medRxiv 2024.09.18.24313801; doi: https://doi.org/10.1101/2024.09.18.24313801
Improving on polygenic scores across complex traits using select and shrink with summary statistics (S4) and LDpred2
Tyrer JP, Peng PC, DeVries AA, Gayther SA, Jones MR, Pharoah PD.
BMC Genomics. 2024 Sep 18;25(1):878. doi: 10.1186/s12864-024-10706-3.
Integrative multi-omics summary-based mendelian randomization identifies key oxidative stress-related genes as therapeutic targets for atrial fibrillation and flutter
Chen S, Sun J, Wen W, Chen Z, Yu Z.
Front Genet. 2024 Sep 18;15:1447872. doi: 10.3389/fgene.2024.1447872.
Causal Relationships of Circulating Inflammatory Proteins and Portal Vein Thrombosis: A Mendelian Randomization Study
Zhang B, Yao Z, Li P, Niu G, Yan Z, She K, Cheng G, Yang M.
Semin Thromb Hemost. 2024 Sep 18. doi: 10.1055/s-0044-1790259.
Landscape of stroke comorbidities: A disease-wide association study
Zheng M, Lavie CJ.
Prog Cardiovasc Dis. 2024 Sep-Oct;86:96-99. doi: 10.1016/j.pcad.2024.09.005.
Genetic Distinctions Between Reticular Pseudodrusen and Drusen: Insights from a Genome-Wide Association Study
Schwartz R, Warwick AN, Khawaja AP, Luben R, Khalid H, Phatak S, Jhingan M, de Vente C, Valmaggia P, Liakopoulos S, Olvera-Barrios A, Sánchez CI, Egan C, Bonelli R, Tufail A.
medRxiv 2024.09.18.24313862; doi: https://doi.org/10.1101/2024.09.18.24313862
Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study
Friligkou E, Løkhammer S, Cabrera-Mendoza B, Shen J, He J, Deiana G, Zanoaga MD, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee DS, Pathak GA, Polimanti R.
Nat Genet. 2024 Oct;56(10):2036-2045. doi: 10.1038/s41588-024-01908-2.
Investigating the causal link between gut microbiota and dry age-related macular degeneration: a bidirectional Mendelian randomization study
Huang HY, Wang J, Qin B, Tan Y.
Int J Ophthalmol. 2024 Sep 18;17(9):1723-1730. doi: 10.18240/ijo.2024.09.21.
Leveraging cell death patterns to predict metastasis in prostate adenocarcinoma and targeting PTGDS for tumor suppression
Chen B, Guo L, Wang L, Wu P, Zheng X, Tan C, Xie N, Sun X, Zhou M, Huang H, Hao N, Lei Y, Yan K, Wu D, Du Y.
Sci Rep. 2024 Sep 17;14(1):21680. doi: 10.1038/s41598-024-72985-w.
A Two-step Bayesian Mendelian Randomization Study on Cholecystitis and Dermatitis
Zhao C, Cen C, Zhang R, He W, Jiao Y, Chen Z, Wu Z, Luan T.
medRxiv 2024.09.17.24313850; doi: https://doi.org/10.1101/2024.09.17.24313850
Variant scoring performance across selection regimes depends on variant-to-gene and gene-to-disease components
Finucane HK, Parsa S, Guez J, Kanai M, Satterstrom FK, Nkambule LL, Daly MJ, Seed C, Karczewski KJ.
bioRxiv 2024.09.17.613327; doi: https://doi.org/10.1101/2024.09.17.613327
Causal effects of gut microbiota, metabolites, immune cells, liposomes, and inflammatory proteins on anorexia nervosa: A mediation joint multi-omics Mendelian randomization analysis
Li Z, Bi T.
J Affect Disord. 2024 Sep 17;368:343-358. doi: 10.1016/j.jad.2024.09.115.
Association of Obstructive Sleep Apnea on Heart Failure and Its Risk Factors: A Two-Step Mendelian Randomization Study
Liu J, Chen Z, Cai D.
Cardiology. 2024 Sep 17:1-10. doi: 10.1159/000541360.
Genetically defined causal effects of natural killer cells related traits in risk of infection: a Mendelian randomization study
Lin Y, Zhang S, Wang X, Wang J, Huang L.
BMC Infect Dis. 2024 Sep 17;24(1):986. doi: 10.1186/s12879-024-09890-0.
Circulating immune cells and apolipoprotein A mediation: a Mendelian randomization study on hypertensive disorder of pregnancy
Liu J, Zhou Y, Dong Y, Wang W, Li Y, Pei J.
Front Immunol. 2024 Sep 17;15:1438680. doi: 10.3389/fimmu.2024.1438680.
Accurate multi-population imputation of MICA, MICB, HLA-E, HLA-F and HLA-G alleles from genome SNP data
Tammi S, Koskela S; Blood Service Biobank; Hyvärinen K, Partanen J, Ritari J.
PLoS Comput Biol. 2024 Sep 16;20(9):e1011718. doi: 10.1371/journal.pcbi.1011718.
Causal pathways in lymphoid leukemia: the gut microbiota, immune cells, and serum metabolites
Zhuang X, Yin Q, Yang R, Man X, Wang R, Geng H, Shi Y.
Front Immunol. 2024 Sep 16;15:1437869. doi: 10.3389/fimmu.2024.1437869.
Analysis of Genetic Risk Factors Associated with Charcot Foot Based on the FinnGen Study R9 Data: A Wide-angle Mendelian Randomization Study
Jiang S, Wang S.
Int J Low Extrem Wounds. 2024 Sep 16:15347346241283260. doi: 10.1177/15347346241283260.
Relationship between type 1 diabetes and autoimmune diseases in european populations: A two-sample Mendelian randomization study
Xie W, Jiang H, Chen Y, Yu Z, Song Y, Zhang H, Li S, Han S, Liu N.
Front Genet. 2024 Sep 16;15:1335839. doi: 10.3389/fgene.2024.1335839.
Restriction of salt, alcohol and coffee intake and Ménière's disease: insight from Mendelian randomization study
Gao W, Ma P, Wang Z, Guo J, Lun Y, Wang W, Yuan H, Li S, Liang R, Lu L.
Front Nutr. 2024 Sep 16;11:1460864. doi: 10.3389/fnut.2024.1460864.
Causal Relationship of Skin Microbiota on Psoriasis: A Mendelian Randomization Study
Chen Y, Zhuang Z, Rao Z.
Clin Cosmet Investig Dermatol. 2024 Sep 16;17:2089-2096. doi: 10.2147/CCID.S484366.
Effect of inflammatory cytokines and plasma metabolome on OSA: a bidirectional two- sample Mendelian randomization study and mediation analysis
Sun X, Wang C, He Y, Chen K, Miao Y.
Front Immunol. 2024 Sep 16;15:1416870. doi: 10.3389/fimmu.2024.1416870.
Lipid levels and multiple myeloma risk: insights from Meta-analysis and mendelian randomization
Zhu W, Charwudzi A, Li Q, Zhai Z, Hu L, Pu L.
Lipids Health Dis. 2024 Sep 16;23(1):299. doi: 10.1186/s12944-024-02289-5.
Utilize proteomic analysis to identify potential therapeutic targets for combating sepsis and sepsis-related death
Zhang T, Shi Y, Li J, Huang P, Chen K, Yao J.
Front Endocrinol (Lausanne). 2024 Sep 16;15:1448314. doi: 10.3389/fendo.2024.1448314.
A metabolomic profile of biological aging in 250,341 individuals from the UK Biobank
Zhang S, Wang Z, Wang Y, Zhu Y, Zhou Q, Jian X, Zhao G, Qiu J, Xia K, Tang B, Mutz J, Li J, Li B.
Nat Commun. 2024 Sep 15;15(1):8081. doi: 10.1038/s41467-024-52310-9.
PM2.5 is linked to Alzheimer's syndrome and delirium: a mendelian randomization analysis
Sun X, Yuan X, Chen H, Li W.
Int J Clin Exp Pathol. 2024 Sep 15;17(9):308-315. doi: 10.62347/FMUC9744.
A multi-omics bidirectional mendelian randomization study and meta-analysis on the causal relationship between gut microbiota, inflammatory proteins, and fibromyalgia
Niu M, Li J, Sarafian V, Maes M.
medRxiv 2024.09.13.24313599; doi: https://doi.org/10.1101/2024.09.13.24313599
Comprehensive analysis of molecular, physiological, and functional biomarkers of aging with neurological diseases using Mendelian randomization
Imahori Y, Qin C, Tang B, Hägg S.
Geroscience. 2024 Sep 13. doi: 10.1007/s11357-024-01334-6.