Below you will find all the published and preprint scientific papers using FinnGen data.

2023

November

Reassessment of casual association between body mass index and site-specific solid cancers: A comprehensive Mendelian randomization study
Jianxiong Lai, Yuanhui Xu, Jian Li
Researchsquare, 07 November 2023, doi:10.21203/rs.3.rs-3552788/v1
Effects of gut microbiota on prostatic cancer: a two-sample Mendelian randomization study
Xie Q, Hu B
Front Microbiol. 2023 Nov 6;14:1250369. doi: 10.3389/fmicb.2023.1250369
Causal associations between modifiable risk factors and intervertebral disc degeneration
Guo W, Li BL, Zhao JY, Li XM, Wang LF
Spine J. 2023 Nov 6:S1529-9430(23)03487-3. doi: 10.1016/j.spinee.2023.10.021
Circadian Rhythm and the Risk of Cardiovascular Diseases: Genetic Evidence
Yan L, Chen J, Li F, Chen Y, Mei Z, Chen L
Aging Dis. 2023 Nov 5. doi: 10.14336/AD.2023.1018
Therapeutic targets for endometriosis: genome-wide Mendelian randomization and colocalization analyses
Zeng P, Lu L, Zhang H, Li Y, Tan S, Yu T, Zhou H
Gene. 2023 Nov 4:147970. doi: 10.1016/j.gene.2023.147970
Impact of blood pressure and antihypertensive drug classes on intracranial aneurysm: a Mendelian randomization study
Zeng Y, Guo R, Cao S, Yang H
J Stroke Cerebrovasc Dis. 2023 Nov;32(11):107355. doi: 10.1016/j.jstrokecerebrovasdis.2023.107355
Causal relationship between sleep apnea and non-alcoholic fatty liver disease: A Mendelian randomization study
Zhang Z, Li M, Ji G, Zhang L
Eur J Clin Invest. 2023 Nov 2:e14116. doi: 10.1111/eci.14116
Investigation on the association between serum lipid levels and periodontitis: a bidirectional Mendelian randomization analysis
Chen Z, Song J, Tang L
BMC Oral Health. 2023 Nov 2;23(1):827. doi: 10.1186/s12903-023-03575-x
Causal Relationship Study Between Basal Metabolic Rate and the Risk of Dental Caries: Evidence from Genome-Wide Association Analysis
Chengxi Li, Xue Wang
Researchsquare, 02 November 2023, doi:10.21203/rs.3.rs-3512528/v1
Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study
Fu Q, Shen T, Yu Q, Jiang L, Yang R
Sci Rep. 2023 Nov 1;13(1):18807. doi: 10.1038/s41598-023-46117-9
Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk
Triozzi JL, Hsi RS, Wang G, Akwo EA, Wheless L, Chen HC, Tao R, Ikizler TA, Robinson-Cohen C, Hung AM; VA Million Veteran Program
JAMA Netw Open. 2023 Nov 1;6(11):e2343290. doi: 10.1001/jamanetworkopen.2023.43290
Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals
Liuska PJ, Rämö JT, Lemmelä S, Kaarniranta K, Uusitalo H, Lahtela E, Daly MJ, Harju M, Palotie A, Turunen JA; FinnGen Study†
Invest Ophthalmol Vis Sci. 2023 Nov 1;64(14):33. doi: 10.1167/iovs.64.14.33
Causal relationships between circulating inflammatory cytokines and diffuse large B cell lymphoma: a bidirectional Mendelian randomization study
Yu J, Fu L, Zhang Z, Ding L, Hong L, Gao F, Jin J, Feng W, Fu J, Hong P, Xu C.
Clin Exp Med. 2023 Nov 1. doi: 10.1007/s10238-023-01221-y
Correlation between diabetic retinopathy and diabetic nephropathy: a two-sample Mendelian randomization study
Fang J, Luo C, Zhang D, He Q, Liu L
Front Endocrinol (Lausanne). 2023 Nov 1;14:1265711. doi: 10.3389/fendo.2023.1265711

October

Genetic causal relationship between gut microbiome and psoriatic arthritis: a bidirectional two-sample Mendelian randomization study
Qian X, Fu Z, Diao C, Zhang W, Tao W, Hu J, Zhang S, Zhao D
Front Microbiol. 2023 Oct 31;14:1265786. doi: 10.3389/fmicb.2023.1265786
Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk
Xia T, Du M, Li H, Wang Y, Zha J, Wu T, Ju S
Radiology. 2023 Oct;309(1):e231007. doi: 10.1148/radiol.231007
No evident causal association between Helicobacter pylori infection and colorectal cancer: a bidirectional mendelian randomization study
Luo F, Zhou P, Ran X, Gu M, Zhou S
Sci Rep. 2023 Oct 29;13(1):18544. doi: 10.1038/s41598-023-45545-x
Increased risk of dementia differs across cardiovascular diseases and types of dementia - Data from a nationwide study
Kauko A, Engler D, Niiranen T, Ortega-Alonso A, Schnabel RB
J Intern Med. 2023 Oct 29. doi: 10.1111/joim.13733
A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss
He Y, Karhunen V, Pulakka A, Kantomaa M, Sebert S
Sci Rep. 2023 Oct 27;13(1):18434. doi: 10.1038/s41598-023-44735-x
A Mendelian randomization study revealed a causal link between napping and deep vein thrombosis (DVT)
Yan D, Liu G, Yin Y, Zhang Q, Shi D, Zhang J, Li Y
Sleep Breath. 2023 Oct 26. doi: 10.1007/s11325-023-02940-y
Causality Investigation between Gut Microbiota, Derived Metabolites, and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study
Yan W, Jiang M, Hu W, Zhan X, Liu Y, Zhou J, Ji J, Wang S, Tai J
Nutrients. 2023 Oct 26;15(21):4544. doi: 10.3390/nu15214544
Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model
Vartiainen P, Jukarainen S, Rhedin SA, Prinz A, Hartonen T, Vabalas A, Viippola E, Rodosthenous RS, Koskelainen S, Liu A, Lundholm C, Smew AI, Osvald EC, Helle E, Perola M, Almqvist C, Heinonen S, Ganna A.
Lancet Digit Health. 2023 Nov;5(11):e821-e830. doi: 10.1016/S2589-7500(23)00175-9.
The association between thyroid and breast cancers: a bidirectional mendelian randomization study
Liu J, Liang L
Front Endocrinol (Lausanne). 2023 Oct 25;14:1185497. doi: 10.3389/fendo.2023.1185497
Relationship between gut microbiota and intussusception: an analysis based on Mendelian randomization
Feng Cheng, Chun Luo, KeLei Shang, XiaoGuang Tan
Researchsquare, 24 October 2023, doi: 10.21203/rs.3.rs-3420042/v1
Causal association between uric acid levels and the risk of aortic aneurysm and aortic dissection: A two-sample Mendelian randomization study.
Chen J, Zhang X, Yao H, Pang J
Nutr Metab Cardiovasc Dis. 2023 Oct 24:S0939-4753(23)00427-1. doi: 10.1016/j.numecd.2023.10.020
Bidirectional Mendelian Randomization Study of Personality Traits Reveals a Positive Feedback Loop Between Neuroticism and Back Pain
Elgaeva EE, Williams FMK, Zaytseva OO, Freidin MB, Aulchenko YS, Suri P, Tsepilov YA
J Pain. 2023 Oct;24(10):1875-1885. doi: 10.1016/j.jpain.2023.05.012
Genome-wide association study of traumatic brain injury in U.S. military veterans enrolled in the VA million veteran program
Merritt VC, Maihofer AX, Gasperi M, Chanfreau-Coffinier C, Stein MB, Panizzon MS, Hauger RL, Logue MW, Delano-Wood L, Nievergelt CM.
Mol Psychiatry. 2023 Oct 24. doi: 10.1038/s41380-023-02304-8.
Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci
Pasanen A, Karjalainen MK; FinnGen; Zhang G, Tiensuu H, Haapalainen AM, Ojaniemi M, Feenstra B, Jacobsson B, Palotie A, Laivuori H, Muglia LJ, Rämet M, Hallman M.
PLoS Genet. 2023 Oct 23;19(10):e1010982. doi: 10.1371/journal.pgen.1010982.
Association of plasma branched-chain amino acid with multiple cancers: A mendelian randomization analysis
Xu H, Wang X, Xu X, Liu L, Zhang Y, Yan X, Zhang Y, Dang K, Li Y
Clin Nutr. 2023 Oct 23;42(12):2493-2502. doi: 10.1016/j.clnu.2023.10.019
Causal effects of gut microbiota on scoliosis: A bidirectional two-sample mendelian randomization study
Lai B, Jiang H, Gao Y, Zhou X
Heliyon. 2023 Oct 27;9(11):e21654. doi: 10.1016/j.heliyon.2023.e21654
The causal relationship between C-reactive protein and idiopathic pulmonary fibrosis: A univariate and multivariate Mendelian randomization study
Qiuping Yang, Xuefen Chen, Yuhhua Zhang, Qi Wu
Researchsquare, 17 October 2023, doi:10.21203/rs.3.rs-3433170/v1
Vitamin D and hyperemesis gravidarum: A Mendelian randomization study
Hu F
J Gynecol Obstet Hum Reprod. 2023 Oct 20:102678. doi: 10.1016/j.jogoh.2023.102678
Determining the targets of of licorice against postmenopausal osteoporosis: A drug target mendelian randomization study followed network pharmacology analysis
Shan Shan, Yijie Chen, Zhifen Zhang
Researchsquare, 19 October 2023, doi: 10.21203/rs.3.rs-3452254/v1
The associations of alcoholic liver disease and nonalcoholic fatty liver disease with bone mineral density and the mediation of serum 25-Hydroxyvitamin D: A bidirectional and two-step Mendelian randomization
Huang Q, Guo J, Zhao H, Zheng Y, Zhang Y
PLoS One. 2023 Oct 19;18(10):e0292881. doi: 10.1371/journal.pone.0292881
The relationship between COVID-19, depressive disorder, and anxiety: a bidirectional Mendelian randomization study
Zihao L, Jinyun S, Shuanglin G, Xiuzhen C, Yonglin L, Hongyu Z
Front Psychiatry. 2023 Oct 19;14:1257553. doi: 10.3389/fpsyt.2023.1257553
The causality between gut microbiome and liver cirrhosis: a bi-directional two-sample Mendelian randomization analysis
Xiao QA, Yang YF, Chen L, Xie YC, Li HT, Fu ZG, Han Q, Qin J, Tian J, Zhao WJ, Cai F, Hu YT, Ai LF, Li C, Chen XY, Wang D, Tan YY, Xia X, Zhang XL
Front Microbiol. 2023 Oct 18;14:1256874. doi: 10.3389/fmicb.2023.1256874
Interaction between Genetic Risks and Socioeconomic Factors on Thyroid Cancer: Evidence from 0.5 Million UK Biobank Participants
Li Y, Zhan Y, Mao W, Wang B, Dong P, Na R
Cancers (Basel). 2023 Oct 18;15(20):5028. doi: 10.3390/cancers15205028
Causal Relationships Between Myasthenia Gravis and Gut Microbiota by Mendelian Randomization Analysis
Jiahui Wang, Jing Wang, Xihao Wang, Qifeng Yao, Jianghua Ying, Yueyu Huang, Weiming Mao, An Zhao
Researchsquare, 17 October 2023, doi: 10.21203/rs.3.rs-3440195/v1
Understanding and Predicting Polycystic Ovary Syndrome through Shared Genetics with Testosterone, SHBG, and Chronic Inflammation
Kay Petersen L, Brixi G, Li J, Hu J, Wang Z, Han X, Yaskolka Meir A, Tyrmi J, MahKalingaiah S, Piltonen T, Liang L
medRxiv 2023.10.17.23297115; doi: https://doi.org/10.1101/2023.10.17.23297115
Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study
Yin Q, Shi G, Zhu L
Front Microbiol. 2023 Oct 17;14:1230125. doi: 10.3389/fmicb.2023.1230125
Association between gut microbiota and influenza: a bidirectional two-sample mendelian randomization study
Xu F, Gan X, Tao Y, Li D, Xie P, Liu F, Yang F, Ma Y
BMC Infect Dis. 2023 Oct 17;23(1):692. doi: 10.1186/s12879-023-08706-x
Major depressive disorder and chronic gastritis: A bidirectional two-sample Mendelian randomization study
Li J, Chen X, Yin M, Lan X, Xie L, Huang W, Luo M, Ai Y, He J
J Psychosom Res. 2023 Oct;173:111458. doi: 10.1016/j.jpsychores.2023.111458
Causal relationship between coffee intake and neurological diseases: a Mendelian randomization study
Zhang J, Liu Y, Xu G, Cao X, Wang W, Zhang D, Zhu M
Eur J Clin Nutr. 2023 Oct 16. doi: 10.1038/s41430-023-01355-y
Relationship Between Helicobacter Pylori Infection and Chronic Respiratory Disease: A Two-sample Mendelian Randomization Study
Guobing Jia, Tao Guo, Chengshi He
Researchsquare, 16 October 2023, doi:10.21203/rs.3.rs-3420975/v1
Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits
Mocci E, Ward K, Perry JA, Starkweather A, Stone LS, Schabrun SM, Renn C, Dorsey SG, Ament SA
PLoS Genet. 2023 Oct 16;19(10):e1010977. doi: 10.1371/journal.pgen.1010977
Associations of non-alcoholic fatty liver disease and cirrhosis with liver cancer in European and East Asian populations: A Mendelian randomization study
Deng Y, Huang J, Wong MCS
Cancer Rep (Hoboken). 2023 Oct 16:e1913. doi: 10.1002/cnr2.1913
Causality of occupational exposure on rheumatoid arthritis and ankylosing spondylitis: a two-sample mendelian randomization study
Du K, Zhang CY, Li A, Hu JZ, Guo R, Li SM
Front Immunol. 2023 Oct 2;14:1223810. doi: 10.3389/fimmu.2023.1223810
Causal Associations Between Gut Microbiota and Psoriasis: A Mendelian Randomization Study
Zang C, Liu J, Mao M, Zhu W, Chen W, Wei B
Dermatol Ther (Heidelb). 2023 Oct;13(10):2331-2343. doi: 10.1007/s13555-023-01007-w
Novel Finnish-enriched variants causing severe hypercholesterolemia and their clinical impact on coronary artery disease
Junna N, Ruotsalainen S, Ripatti P, FinnGen, Ripatti S, Widén E
Atherosclerosis. 2023 Oct 12:117327. doi: 10.1016/j.atherosclerosis.2023.117327
Causal effects of inflammatory bowel diseases on the risk of kidney stone disease: a two-sample bidirectional mendelian randomization
Zhang H, Huang Y, Zhang J, Su H, Ge C
BMC Urol. 2023 Oct 12;23(1):162. doi: 10.1186/s12894-023-01332-4