Below you will find all the published and preprint scientific papers using FinnGen data.

2024

April

A Mendelian randomization study of the effect of selenium on autoimmune thyroid disease
Hu C, Yu YF, Tong KK, Hu G, Wu JY, Yang XY, Bai SY, Yu R, Li YY.
Eur Rev Med Pharmacol Sci. 2024 Apr;28(8):2988-2995. doi: 10.26355/eurrev_202404_36011.
Genetic associations of protein-coding variants in venous thromboembolism
He XY, Wu BS, Yang L, Guo Y, Deng YT, Li ZY, Fei CJ, Liu WS, Ge YJ, Kang J, Feng J, Cheng W, Dong Q, Yu JT.
Nat Commun. 2024 Apr 1;15(1):2819. doi: 10.1038/s41467-024-47178-8.

March

The Impact of Non-alcohol Fatty Liver Disease on Bone Mineral Density is Mediated by Sclerostin by Mendelian Randomization Study
Liu Y, Yuan M, He J, Cai L, Leng A.
Calcif Tissue Int. 2024 May;114(5):502-512. doi: 10.1007/s00223-024-01204-5.
Genetically determined metabolites in allergic conjunctivitis: A Mendelian randomization study
Zou X, Huang H, Tan Y.
World Allergy Organ J. 2024 Mar 31;17(4):100894. doi: 10.1016/j.waojou.2024.100894.
Osteoporosis and Primary Biliary Cholangitis: A Trans-ethnic Mendelian Randomization Analysis
Wu Y, Qian Q, Liu Q, Wang R, Pu X, Li Y, Zhang H, You Z, Miao Q, Xiao X, Lian M, Wang Q, Nakamura M, Gershwin ME, Li Z, Ma X, Tang R.
Clin Rev Allergy Immunol. 2024 Mar 30. doi: 10.1007/s12016-024-08986-4.
The role of genetically-influenced phospholipid transfer protein activity in lipoprotein metabolism and coronary artery disease
Ao L, Noordam R, Rensen PCN, van Heemst D, Willems van Dijk K.
J Clin Lipidol. 2024 Jul-Aug;18(4):e579-e587. doi: 10.1016/j.jacl.2024.03.007.
Assessment of bidirectional relationships between autoimmune diseases and primary ovarian insufficiency: insights from a bidirectional two-sample Mendelian randomization analysis
Luo R, Wang J, Liu Y.
Arch Gynecol Obstet. 2024 Mar 29. doi: 10.1007/s00404-024-07482-6.
Pharmaceutical Repurposing Strategies for Metabolic Disorders: Insights from Mendelian Randomization Studies
Zhang S, Hu X, Hou D, Sun X, Sun D.
medRxiv 2024.03.29.24305070; doi: https://doi.org/10.1101/2024.03.29.24305070
Association of circulating inflammatory proteins with type 2 diabetes mellitus and its complications: a bidirectional Mendelian randomization study
Liang YC, Jia MJ, Li L, Liu DL, Chu SF, Li HL.
Front Endocrinol (Lausanne). 2024 Mar 28;15:1358311. doi: 10.3389/fendo.2024.1358311.
Causal Relationship between the Gut Microbiota and Haematological Malignancies: A Two-Sample Mendelian Randomization Analysis
Biyu Xiang, Qianyuan Li, Hongfei Zhang, Shuqi JI, Yuzhen Peng, Chenjiao Yao
Researchsquare, 28 March 2024, doi: 10.21203/rs.3.rs-4124452/v1
The causal effect of iron status on risk of anxiety disorders: A two-sample Mendelian randomization study
Yin R, Gao Q, Fu G, Zhao Q.
PLoS One. 2024 Mar 28;19(3):e0300143. doi: 10.1371/journal.pone.0300143.
Association between asthma and melanoma: Results from the NHANES 2009-2016 and Mendelian randomization study
Jun Tan, Xuanran Huang, Yan Dong, Jianjun Li
Researchsquare, 28 March 2024, doi: 10.21203/rs.3.rs-4144117/v1
Mendelian Randomization Highlights Gut Microbiota of Short-chain Fatty Acids' Producer as Protective Factor of Cerebrovascular Disease
Luo S, Mao R, Li Y.
Curr Neurovasc Res. 2024 Mar 28. doi: 10.2174/0115672026299307240321090030.
Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease
Sharma P, Klarin D, Voight BF, Tsao PS, Levin MG, Damrauer SM.
Arterioscler Thromb Vasc Biol. 2024 Mar 28. doi: 10.1161/ATVBAHA.124.320674.
Association between asthma and melanoma: Results from the NHANES 2009-2016 and Mendelian randomization study
Jun Tan, Xuanran Huang, Yan Dong, Jianjun Li
Researchsquare, 28 March 2024, doi: 10.21203/rs.3.rs-4144117/v1
Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-Analysis
Liang YJ, Wang YY, Rong SS, Chen ZJ, Chen SY, Tham JA, Chan PP, Yam JC, Wiggs JL, Pang CP, Tham CC, Chen LJ.
JAMA Ophthalmol. 2024 Mar 28:e240363. doi: 10.1001/jamaophthalmol.2024.0363.
Causal relationship between immune cells and Osteonecrosis: a bidirectional Mendelian randomization study
Chen meng, Baochuang Qi, Huan Luo, Zhifang Tang, Junxiao Ren, Hongxin Shi, Chuan Li, Yongqing Xu
Researchsquare, 27 March 2024, doi:10.21203/rs.3.rs-4137998/v1
Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study
Li Z, Wu X, Li H, Bi C, Zhang C, Sun Y, Yan Z.
BMC Psychiatry. 2024 Mar 27;24(1):232. doi: 10.1186/s12888-024-05693-4.
Association of lipids and lipid-lowering drug target genes with Osteomyelitis : A mendelian randomization analysis
Zhi-Yi Zhou, Zhe-Han Yang, Jun-Pan Chen, Ming-Hao Wen, Jia-Yuan Lei, Wan-Zhe Liao, Ya-Han Li, Ling-Hui Liu, Zi-Yuan Lu
Researchsquare, 27 March 2024, doi: 10.21203/rs.3.rs-4028881/v1
Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care
Ye X, Bai Y, Li M, Ye Y, Chen Y, Liu B, Dai Y, Wang S, Pan W, Wang Z, Mao Y, Chen Q.
Elife. 2024 Mar 27;12:RP92895. doi: 10.7554/eLife.92895.
Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study
Cai Y, Jun G, Zhuang X.
Osteoporos Int. 2024 Jun;35(6):1089-1098. doi: 10.1007/s00198-023-07013-0.
Association between 91 inflammatory factors combined with 1400 metabolites and ankylosing spondylitis: a two-sample Mendelian randomization study
Yi-fa Rong, Xue-Zhen LIANG, Kai JIANG, Hai-Feng JIA, Han-Zheng LI, Bo-Wen LU, Gang Li
Researchsquare, 27 March 2024, doi: 10.21203/rs.3.rs-4139990/v1
Genetic risk, adherence to healthy lifestyle behaviors, and risk of cholelithiasis: A population-based cohort study
Mi N, Liang Z, Yang M, Zhao J, Tian L, Huang C, Xie P, Wu S, He Q, Sun Y, Lin Y, Yue P, Xia B, Yuan J, Meng W.
Prev Med. 2024 Mar 27;182:107942. doi: 10.1016/j.ypmed.2024.107942.
Association between gut microbiota and autoimmune cholestatic liver disease, a Mendelian randomization study
Cui Y, Guo Y, Kong Y, Zhang G.
Front Microbiol. 2024 Mar 27;15:1348027. doi: 10.3389/fmicb.2024.1348027.
Causal relationship between gestational diabetes and preeclampsia: A bidirectional mendelian randomization analysis
Yang X, QimeiZhong, Huang M, Li L, Tang C, Luo S, Wang L, Qi H.
Diabetes Res Clin Pract. 2024 Mar 26;210:111643. doi: 10.1016/j.diabres.2024.111643.
Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study
Tissink EP, Shadrin AA, van der Meer D, Parker N, Hindley G, Roelfs D, Frei O, Fan CC, Nagel M, Nærland T, Budisteanu M, Djurovic S, Westlye LT, van den Heuvel MP, Posthuma D, Kaufmann T, Dale AM, Andreassen OA.
Nat Commun. 2024 Mar 26;15(1):2655. doi: 10.1038/s41467-024-46817-4.
Association between gut microbiota and onset of type 2 diabetes mellitus: a two-sample Mendelian randomization study
Zhang H, Ma L, Peng W, Wang B, Sun Y.
Front Cell Infect Microbiol. 2024 Mar 26;14:1327032. doi: 10.3389/fcimb.2024.1327032.
Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss
Jung SH, Lee YC, Shivakumar M, Kim J, Yun JS, Park WY, Won HH; Penn Medicine Biobank; Kim D.
BMC Med. 2024 Mar 26;22(1):141. doi: 10.1186/s12916-024-03364-5.
Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis
Hong S, Chen L, Zhou X, Huang Y, Tian Y, Hu H, Yu B, Wu H, Yang C, Lv Z, Lv L.
Front Microbiol. 2024 Mar 25;15:1357303. doi: 10.3389/fmicb.2024.1357303.
Unveiling the Causal Association between Non-Infectious Respiratory Disorders and Sepsis through Mendelian Randomization Analysis
Liu C, He L, Zheng X.
Shock. 2024 Mar 25. doi: 10.1097/SHK.0000000000002358.
Periodontitis and Sjogren's syndrome: a bidirectional two-sample mendelian randomization study
Liu Y, Liu N, Sun P, Liu Y, Hua W.
BMC Oral Health. 2024 Mar 25;24(1):380. doi: 10.1186/s12903-024-04151-7.
Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis
Li J, Wang F, Li Z, Feng J, Men Y, Han J, Xia J, Zhang C, Han Y, Chen T, Zhao Y, Zhou S, Da Y, Chai G, Hao J.
J Transl Med. 2024 Mar 24;22(1):302. doi: 10.1186/s12967-024-04994-2.
Causal relationship between gut microbiota and rosacea: a two-sample Mendelian randomization study
Li J, Yang F, Liu Y, Jiang X.
Front Med (Lausanne). 2024 Mar 22;11:1322685. doi: 10.3389/fmed.2024.1322685.
Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study
Yuan W, Li X, Wang G, Qu B, Zhao F.
Front Immunol. 2024 Mar 22;15:1325868. doi: 10.3389/fimmu.2024.1325868.
Inflammatory cytokines mediating the effect of oral lichen planus on oral cavity cancer risk: a univariable and multivariable mendelian randomization study
Zheng T, Liu C, Wang Y, Zhou H, Zhou R, Zhu X, Zhu Z, Tan Y, Li Z, Huang X, Tan J, Zhu K.
BMC Oral Health. 2024 Mar 22;24(1):375. doi: 10.1186/s12903-024-04104-0.
Causal association of TSH with ischemic heart diseases and heart failure: A 2-sample Mendelian randomization study
Gao Y, Zhan T, Xu Y, Zhu K, Shi Y, Jin L, Meng L.
Medicine (Baltimore). 2024 Mar 22;103(12):e37539. doi: 10.1097/MD.0000000000037539.
A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders
Yan W, Zhuang Z, Gao Y, Wang Y, He D.
Front Microbiol. 2024 Mar 22;15:1372827. doi: 10.3389/fmicb.2024.1372827.
Statins as a risk factor for diabetic retinopathy: a Mendelian randomization and cross-sectional observational study
Chen C, Zhang H, Lan Y, Yan W, Liu S, Chen Y, Xie T, Ning J, Yan X, Shang L, Han J.
J Transl Med. 2024 Mar 22;22(1):298. doi: 10.1186/s12967-024-05097-8.
Causal Relationship of Obstructive Sleep Apnea with Bone Mineral Density and the Role of BMI
Xu F, Zhang X, Zhang Y, Chen W, Liao Z.
Nat Sci Sleep. 2024 Mar 22;16:325-333. doi: 10.2147/NSS.S443557.
Investigation of the Association between Air Pollution and Non-Alcoholic Fatty Liver Disease in the European Population: A Mendelian Randomization Study
Yang J, Zhang Y, Yuan Y, Xie Z, Li L.
Toxics. 2024 Mar 21;12(3):228. doi: 10.3390/toxics12030228.
Genetic correlation between circulating metabolites and chalazion: a two-sample Mendelian randomization study
Zhang X, Cai Y, Jiang Y, Du W, An W, Fu Q, Chen Y.
Front Mol Biosci. 2024 Mar 21;11:1368669. doi: 10.3389/fmolb.2024.1368669.
A machine-learning method for biobank-scale genetic prediction of blood group antigens
Hyvärinen K, Haimila K, Moslemi C, Biobank BS, Olsson ML, Ostrowski SR, Pedersen OB, Erikstrup C, Partanen J, Ritari J.
PLoS Comput Biol. 2024 Mar 21;20(3):e1011977. doi: 10.1371/journal.pcbi.1011977.
Hemorrhoidal disease and its genetic association with depression, bipolar disorder, anxiety disorders, and schizophrenia: a bidirectional mendelian randomization study
Huang Z, Huang J, Leung CK, Zhang CJ, Akinwunmi B, Ming WK.
Hum Genomics. 2024 Mar 21;18(1):27. doi: 10.1186/s40246-024-00588-7.
Causal relationships between Sjögren's syndrome and Parkinson's disease: A Mendelian randomization study
Wang J, Li Y, Zhang J, Jiang H, Qi J, Gu Q, Sun Q, Chen L, Jiang Z, Liu A, Ying Z.
Int J Rheum Dis. 2024 Mar;27(3):e15128. doi: 10.1111/1756-185X.15128.
Genetically predicted mood swings increased risk of cardiovascular disease: Evidence from a Mendelian randomization analysis
Liu Z, Wang H, Yang Z, Lu Y, Wang J, Zou C.
J Affect Disord. 2024 Mar 20;354:463-472. doi: 10.1016/j.jad.2024.03.076.
Genetic evidence for T-wave area from 12-lead electrocardiograms to monitor cardiovascular diseases in patients taking diabetes medications
Qi M, Zhang H, Xiu X, He D, Cooper DN, Yang Y, Zhao H.
Hum Genet. 2024 Mar 20. doi: 10.1007/s00439-024-02661-6.
Mendelian randomization analysis reveals a causal effect of Streptococcus salivarius on diabetic retinopathy through regulating host fasting glucose
Li J, Zheng G, Jiang D, Deng C, Zhang Y, Ma Y, Su J.
J Cell Mol Med. 2024 Apr;28(7):e18200. doi: 10.1111/jcmm.18200.
Diabetes mellitus and idiopathic pulmonary fibrosis: a Mendelian randomization study
Kang Q, Ren J, Cong J, Yu W.
BMC Pulm Med. 2024 Mar 20;24(1):142. doi: 10.1186/s12890-024-02961-7.
Genetically predicted mood swings increased risk of cardiovascular disease: Evidence from a Mendelian randomization analysis
Liu Z, Wang H, Yang Z, Lu Y, Wang J, Zou C.
J Affect Disord. 2024 Mar 20;354:463-472. doi: 10.1016/j.jad.2024.03.076.
Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis
Yao Z, Guo F, Tan Y, Zhang Y, Geng Y, Yang G, Wang S.
Front Immunol. 2024 Mar 20;15:1334772. doi: 10.3389/fimmu.2024.1334772