Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2024

April

Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma
Zhang L, Xiong Y, Zhang J, Feng Y, Xu A.
J Transl Med. 2024 Apr 4;22(1):330. doi: 10.1186/s12967-024-04919-z.
Genetic predisposition to childhood obesity does not influence the risk of developing skin cancer in adulthood
Keatley J, Law MH, Seviiri M, Olsen CM, Pandeya N, Ong JS, MacGregor S, Whiteman DC, Dusingize JC.
Sci Rep. 2024 Apr 3;14(1):7854. doi: 10.1038/s41598-024-58418-8.
Potential benefits of statin therapy in reducing osteoarthritis risk: a Mendelian randomization study
Zhang L, Sui L, Li J, Zhang R, Pan W, Lv T.
Arthritis Care Res (Hoboken). 2024 Apr 3. doi: 10.1002/acr.25343.
Ancestral allele of DNA polymerase gamma modifies antiviral tolerance
Kang Y, Hepojoki J, Maldonado RS, Mito T, Terzioglu M, Manninen T, Kant R, Singh S, Othman A, Verma R, Uusimaa J, Wartiovaara K, Kareinen L, Zamboni N, Nyman TA, Paetau A, Kipar A, Vapalahti O, Suomalainen A.
Nature. 2024 Apr;628(8009):844-853. doi: 10.1038/s41586-024-07260-z.
Dual effects of serum urate on stroke risk and prognosis: insights from Mendelian randomization
Chen S, Chen Z, Xu Q, Jiang X, Lin C, Ji J.
Front Neurol. 2024 Apr 2;15:1359292. doi: 10.3389/fneur.2024.1359292.
Genetic determinants of plasma protein levels in the Estonian population
Kalnapenkis A, Jõeloo M, Lepik K, Kukuškina V, Kals M, Alasoo K; Estonian Biobank Research Team; Mägi R, Esko T, Võsa U.
Sci Rep. 2024 Apr 2;14(1):7694. doi: 10.1038/s41598-024-57966-3.
Role of CD64 on CD14+ CD16+ Monocytes in Mediating the Effect of genus Collinsella on Nonalcoholic Fatty Liver Disease
Ru yi Yu, Guoyong Chen, dong xia
Researchsquare, 02 April 2024, doi: 10.21203/rs.3.rs-4146688/v1
Exploring Potential Drug Targets for Pancreatic Cancer Based on Mendelian Randomization
Peishan Yao, junming huang, yi dang, Ya Wang
Researchsquare, 02 April 2024, doi: 10.21203/rs.3.rs-4183057/v1
Shared genetic etiology between hypothyroidism and complex diseases: a large-scale genome-wide cross-trait analysis
Li S, Gong M.
medRxiv 2024.04.02.24305135; doi: https://doi.org/10.1101/2024.04.02.24305135
Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis
Fu H, Xu T, Zhao W, Jiang L, Shan S.
Front Microbiol. 2024 Apr 2;15:1360445. doi: 10.3389/fmicb.2024.1360445.
Diet-derived circulating antioxidants, periodontitis and dental caries: A Mendelian randomization study
Gao Y, Huang D, Liu Y, Qiu Y, Lu S.
J Periodontal Res. 2024 Apr 2. doi: 10.1111/jre.13260.
A Mendelian randomization study of the effect of selenium on autoimmune thyroid disease
Hu C, Yu YF, Tong KK, Hu G, Wu JY, Yang XY, Bai SY, Yu R, Li YY.
Eur Rev Med Pharmacol Sci. 2024 Apr;28(8):2988-2995. doi: 10.26355/eurrev_202404_36011.
Genetic associations of protein-coding variants in venous thromboembolism
He XY, Wu BS, Yang L, Guo Y, Deng YT, Li ZY, Fei CJ, Liu WS, Ge YJ, Kang J, Feng J, Cheng W, Dong Q, Yu JT.
Nat Commun. 2024 Apr 1;15(1):2819. doi: 10.1038/s41467-024-47178-8.
The causal relationship between COVID-19 and ten esophageal diseases: a study utilizing Mendelian randomization
He X, Li Y, Liu J, Yan G, Gao X, Li G, Wei L, Feng G, Li J, Zhou H.
Front Med (Lausanne). 2024 May 1;11:1346888. doi: 10.3389/fmed.2024.1346888.

March

Genetically determined metabolites in allergic conjunctivitis: A Mendelian randomization study
Zou X, Huang H, Tan Y.
World Allergy Organ J. 2024 Mar 31;17(4):100894. doi: 10.1016/j.waojou.2024.100894.
The Impact of Non-alcohol Fatty Liver Disease on Bone Mineral Density is Mediated by Sclerostin by Mendelian Randomization Study
Liu Y, Yuan M, He J, Cai L, Leng A.
Calcif Tissue Int. 2024 May;114(5):502-512. doi: 10.1007/s00223-024-01204-5.
Osteoporosis and Primary Biliary Cholangitis: A Trans-ethnic Mendelian Randomization Analysis
Wu Y, Qian Q, Liu Q, Wang R, Pu X, Li Y, Zhang H, You Z, Miao Q, Xiao X, Lian M, Wang Q, Nakamura M, Gershwin ME, Li Z, Ma X, Tang R.
Clin Rev Allergy Immunol. 2024 Mar 30. doi: 10.1007/s12016-024-08986-4.
The role of genetically-influenced phospholipid transfer protein activity in lipoprotein metabolism and coronary artery disease
Ao L, Noordam R, Rensen PCN, van Heemst D, Willems van Dijk K.
J Clin Lipidol. 2024 Jul-Aug;18(4):e579-e587. doi: 10.1016/j.jacl.2024.03.007.
Assessment of bidirectional relationships between autoimmune diseases and primary ovarian insufficiency: insights from a bidirectional two-sample Mendelian randomization analysis
Luo R, Wang J, Liu Y.
Arch Gynecol Obstet. 2024 Mar 29. doi: 10.1007/s00404-024-07482-6.
Pharmaceutical Repurposing Strategies for Metabolic Disorders: Insights from Mendelian Randomization Studies
Zhang S, Hu X, Hou D, Sun X, Sun D.
medRxiv 2024.03.29.24305070; doi: https://doi.org/10.1101/2024.03.29.24305070
Mendelian Randomization Highlights Gut Microbiota of Short-chain Fatty Acids' Producer as Protective Factor of Cerebrovascular Disease
Luo S, Mao R, Li Y.
Curr Neurovasc Res. 2024 Mar 28. doi: 10.2174/0115672026299307240321090030.
Association between asthma and melanoma: Results from the NHANES 2009-2016 and Mendelian randomization study
Jun Tan, Xuanran Huang, Yan Dong, Jianjun Li
Researchsquare, 28 March 2024, doi: 10.21203/rs.3.rs-4144117/v1
Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease
Sharma P, Klarin D, Voight BF, Tsao PS, Levin MG, Damrauer SM.
Arterioscler Thromb Vasc Biol. 2024 Mar 28. doi: 10.1161/ATVBAHA.124.320674.
Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-Analysis
Liang YJ, Wang YY, Rong SS, Chen ZJ, Chen SY, Tham JA, Chan PP, Yam JC, Wiggs JL, Pang CP, Tham CC, Chen LJ.
JAMA Ophthalmol. 2024 Mar 28:e240363. doi: 10.1001/jamaophthalmol.2024.0363.
Association between asthma and melanoma: Results from the NHANES 2009-2016 and Mendelian randomization study
Jun Tan, Xuanran Huang, Yan Dong, Jianjun Li
Researchsquare, 28 March 2024, doi: 10.21203/rs.3.rs-4144117/v1
The causal effect of iron status on risk of anxiety disorders: A two-sample Mendelian randomization study
Yin R, Gao Q, Fu G, Zhao Q.
PLoS One. 2024 Mar 28;19(3):e0300143. doi: 10.1371/journal.pone.0300143.
Association of circulating inflammatory proteins with type 2 diabetes mellitus and its complications: a bidirectional Mendelian randomization study
Liang YC, Jia MJ, Li L, Liu DL, Chu SF, Li HL.
Front Endocrinol (Lausanne). 2024 Mar 28;15:1358311. doi: 10.3389/fendo.2024.1358311.
Causal Relationship between the Gut Microbiota and Haematological Malignancies: A Two-Sample Mendelian Randomization Analysis
Biyu Xiang, Qianyuan Li, Hongfei Zhang, Shuqi JI, Yuzhen Peng, Chenjiao Yao
Researchsquare, 28 March 2024, doi: 10.21203/rs.3.rs-4124452/v1
Causal relationship between immune cells and Osteonecrosis: a bidirectional Mendelian randomization study
Chen meng, Baochuang Qi, Huan Luo, Zhifang Tang, Junxiao Ren, Hongxin Shi, Chuan Li, Yongqing Xu
Researchsquare, 27 March 2024, doi:10.21203/rs.3.rs-4137998/v1
Association between 91 inflammatory factors combined with 1400 metabolites and ankylosing spondylitis: a two-sample Mendelian randomization study
Yi-fa Rong, Xue-Zhen LIANG, Kai JIANG, Hai-Feng JIA, Han-Zheng LI, Bo-Wen LU, Gang Li
Researchsquare, 27 March 2024, doi: 10.21203/rs.3.rs-4139990/v1
Genetic risk, adherence to healthy lifestyle behaviors, and risk of cholelithiasis: A population-based cohort study
Mi N, Liang Z, Yang M, Zhao J, Tian L, Huang C, Xie P, Wu S, He Q, Sun Y, Lin Y, Yue P, Xia B, Yuan J, Meng W.
Prev Med. 2024 Mar 27;182:107942. doi: 10.1016/j.ypmed.2024.107942.
Association between gut microbiota and autoimmune cholestatic liver disease, a Mendelian randomization study
Cui Y, Guo Y, Kong Y, Zhang G.
Front Microbiol. 2024 Mar 27;15:1348027. doi: 10.3389/fmicb.2024.1348027.
Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study
Li Z, Wu X, Li H, Bi C, Zhang C, Sun Y, Yan Z.
BMC Psychiatry. 2024 Mar 27;24(1):232. doi: 10.1186/s12888-024-05693-4.
Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care
Ye X, Bai Y, Li M, Ye Y, Chen Y, Liu B, Dai Y, Wang S, Pan W, Wang Z, Mao Y, Chen Q.
Elife. 2024 Mar 27;12:RP92895. doi: 10.7554/eLife.92895.
Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study
Cai Y, Jun G, Zhuang X.
Osteoporos Int. 2024 Jun;35(6):1089-1098. doi: 10.1007/s00198-023-07013-0.
Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss
Jung SH, Lee YC, Shivakumar M, Kim J, Yun JS, Park WY, Won HH; Penn Medicine Biobank; Kim D.
BMC Med. 2024 Mar 26;22(1):141. doi: 10.1186/s12916-024-03364-5.
Association between gut microbiota and onset of type 2 diabetes mellitus: a two-sample Mendelian randomization study
Zhang H, Ma L, Peng W, Wang B, Sun Y.
Front Cell Infect Microbiol. 2024 Mar 26;14:1327032. doi: 10.3389/fcimb.2024.1327032.
Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study
Tissink EP, Shadrin AA, van der Meer D, Parker N, Hindley G, Roelfs D, Frei O, Fan CC, Nagel M, Nærland T, Budisteanu M, Djurovic S, Westlye LT, van den Heuvel MP, Posthuma D, Kaufmann T, Dale AM, Andreassen OA.
Nat Commun. 2024 Mar 26;15(1):2655. doi: 10.1038/s41467-024-46817-4.
Causal relationship between gestational diabetes and preeclampsia: A bidirectional mendelian randomization analysis
Yang X, QimeiZhong, Huang M, Li L, Tang C, Luo S, Wang L, Qi H.
Diabetes Res Clin Pract. 2024 Mar 26;210:111643. doi: 10.1016/j.diabres.2024.111643.
Unveiling the Causal Association between Non-Infectious Respiratory Disorders and Sepsis through Mendelian Randomization Analysis
Liu C, He L, Zheng X.
Shock. 2024 Mar 25. doi: 10.1097/SHK.0000000000002358.
Periodontitis and Sjogren's syndrome: a bidirectional two-sample mendelian randomization study
Liu Y, Liu N, Sun P, Liu Y, Hua W.
BMC Oral Health. 2024 Mar 25;24(1):380. doi: 10.1186/s12903-024-04151-7.
Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis
Hong S, Chen L, Zhou X, Huang Y, Tian Y, Hu H, Yu B, Wu H, Yang C, Lv Z, Lv L.
Front Microbiol. 2024 Mar 25;15:1357303. doi: 10.3389/fmicb.2024.1357303.
Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis
Li J, Wang F, Li Z, Feng J, Men Y, Han J, Xia J, Zhang C, Han Y, Chen T, Zhao Y, Zhou S, Da Y, Chai G, Hao J.
J Transl Med. 2024 Mar 24;22(1):302. doi: 10.1186/s12967-024-04994-2.
Association of autoimmune and allergic diseases with senile cataract: a bidirectional two-sample Mendelian randomization study
Yuan W, Li X, Wang G, Qu B, Zhao F.
Front Immunol. 2024 Mar 22;15:1325868. doi: 10.3389/fimmu.2024.1325868.
Inflammatory cytokines mediating the effect of oral lichen planus on oral cavity cancer risk: a univariable and multivariable mendelian randomization study
Zheng T, Liu C, Wang Y, Zhou H, Zhou R, Zhu X, Zhu Z, Tan Y, Li Z, Huang X, Tan J, Zhu K.
BMC Oral Health. 2024 Mar 22;24(1):375. doi: 10.1186/s12903-024-04104-0.
Causal association of TSH with ischemic heart diseases and heart failure: A 2-sample Mendelian randomization study
Gao Y, Zhan T, Xu Y, Zhu K, Shi Y, Jin L, Meng L.
Medicine (Baltimore). 2024 Mar 22;103(12):e37539. doi: 10.1097/MD.0000000000037539.
Causal Relationship of Obstructive Sleep Apnea with Bone Mineral Density and the Role of BMI
Xu F, Zhang X, Zhang Y, Chen W, Liao Z.
Nat Sci Sleep. 2024 Mar 22;16:325-333. doi: 10.2147/NSS.S443557.
A Mendelian randomization investigation of the causal association between the gut microbiota and sleep disorders
Yan W, Zhuang Z, Gao Y, Wang Y, He D.
Front Microbiol. 2024 Mar 22;15:1372827. doi: 10.3389/fmicb.2024.1372827.
Statins as a risk factor for diabetic retinopathy: a Mendelian randomization and cross-sectional observational study
Chen C, Zhang H, Lan Y, Yan W, Liu S, Chen Y, Xie T, Ning J, Yan X, Shang L, Han J.
J Transl Med. 2024 Mar 22;22(1):298. doi: 10.1186/s12967-024-05097-8.
Causal relationship between gut microbiota and rosacea: a two-sample Mendelian randomization study
Li J, Yang F, Liu Y, Jiang X.
Front Med (Lausanne). 2024 Mar 22;11:1322685. doi: 10.3389/fmed.2024.1322685.