Below you will find all the published and preprint scientific papers using FinnGen data.

2026

May

Dissecting Immune Mechanisms Underlying Sarcopenia Using Multi-omics Approaches
Kaixi Ding, Wei Jiang, Ming Lei & Yongxiang Gao
Calcif Tissue Int 117, 74 (2026). https://doi.org/10.1007/s00223-026-01524-8
Identifying THBS3 as a potentially viable therapeutic target for gastric cancer: Intergration of Mendelian randomization and cell experiments validation study
Wang YY, Xing YT, Guo KY, Zhu ZT.
Int J Biol Macromol. 2026 Apr 29;364:152278. doi: 10.1016/j.ijbiomac.2026.152278.
Social isolation and 59 common health conditions: insights from observational and genetics analyses
Sizhi Ai, Qiqi Wu, Yu Nie, Yiliang Ou, Yu He, Puiyin Li, Qi Yong H. Ai, Hongliang Feng, Yaping Liu, Tong Luo, Jihui Zhang & Yannis Yan Liang
BMC Med 24, 282 (2026). https://doi.org/10.1186/s12916-026-04784-1
The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications
Yakov A. Tsepilov, Daniel Suveges, Daniel Considine, Szymon Szyszkowski, Xiangyu Jack Ge, Irene Lopez Santiago, Polina Rusina, Tobi Alegbe, Vivien W. Ho, Kirill Tsukanov, Juan Maria Roldan-Romero, Ines A. Smit, Helena Cornu, Laura Harris, Kaur Alasoo, Alexander Predeus, Samuel Lessard, Clement Chatelain, Shameer Khader, Stephanie Yang, Anna O'Carroll, Yury S. Aulchenko, Daniel Seaton, Annalisa Buniello, Ewan Birney, Eric B. Fauman, Mark I. McCarthy, David G. Hulcoop, Gosia Trynka, Ellen M. McDonagh, David Ochoa
bioRxiv 2026.04.28.721048; doi: https://doi.org/10.64898/2026.04.28.721048
Focus on M2-TAMs and gastric cancer: a Mendelian randomization and bioinformatics analysis
Min G, Tang H, Min G, Li Y.
Mol Genet Genomics. 2026 May 2;301(1):105. doi: 10.1007/s00438-026-02422-2.

April

The causal relationship in hypertensive encephalopathy: mechanistic analysis of five specific circulating cytokines
Zhang P, Huang Y, Li H, Zhang C, Chen Z.
Open Med (Wars). 2026 Apr 24;21(1):20261412. doi: 10.1515/med-2026-1412.
Genetic Evidence Links Gestational Diabetes Mellitus to Increased ER-Negative Breast Cancer Risk Through a Mendelian Randomization Analysis
Peng W, Huang Z, Zhang M.
Int J Endocrinol. 2026 Apr 28;2026:7371037. doi: 10.1155/ije/7371037
Exploring the causal effect of genetically predicted blood and cerebrospinal fluid metabolites and metabolic pathways on intracranial aneurysm
Ding L, Cao W, Zhou Z, Mei Z, Chen B, Lu X, Chen W.
J Int Med Res. 2026 Apr;54(4):3000605261442755. doi: 10.1177/03000605261442755
Causal associations between plasma metabolites and head and neck cancer: a bidirectional Mendelian randomization study
Pan Z, Wang X, Xu Z, Lu M, Zhang X, Xiao L.
Braz J Otorhinolaryngol. 2026 Apr 28;92(4):101812. doi: 10.1016/j.bjorl.2026.101812
A shared MHC immunogenetic signal links aging, rheumatoid arthritis, and herpes zoster through high inflammatory burden–compensatory immune tolerance dysregulation
Xin Yao, Manli Wan
medRxiv 2026.04.28.26351835; doi: https://doi.org/10.64898/2026.04.28.26351835
Exploring Risk Drugs and Mechanisms in Dystonia: Insights from Pharmacovigilance and Proteogenomics
Chen Z, Yao J, Lin J, Sun H, Li J, Zhang W, Meng H, Hou S.
Curr Neuropharmacol. 2026 Apr 13. doi: 10.2174/011570159X448484260107125041
Causal role of EPA on ischemic heart disease, triglyceride rich lipoproteins and related traits: A two-sample Mendelian randomization analysis
Rehana Rasul, Mary Schooling, Ghada Soliman, Joy Shi, Zach Shahn
medRxiv 2026.04.27.26351885; doi: https://doi.org/10.64898/2026.04.27.26351885
Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations
Dora Koller, Jun He, Solveig Løkhammer, Selena Aranda, Dan Qiu, David Davtian, Qianyu Chen, Ziang Xu, Zhongzheng Mao, Eleni Friligkou, Sefayet Karaca, Bru Cormand, Idhaliz Flores, Signe Altmäe, Marina Mitjans, Brenda Cabrera-Mendoza & Renato Polimanti
Nat Genet 58, 1051–1061 (2026). https://doi.org/10.1038/s41588-026-02582-2
Identification of key biomarkers for myocardial infarction by multi-omics analysis and machine learning
Wu J, Yang Y, Huang J, Li X, Ma Q, Chen H, Wang Y, Lama E, Qiu Z, Zhou Z.
Front Immunol. 2026 Apr 13;17:1711521. doi: 10.3389/fimmu.2026.1711521
preSCRIPT: Large-scale prescription search and annotation engine for pharmacogenomic studies
Maria Pieczarka, Paweł Pieńkowski, Paula Konowalska, Sylwia Grubarek, Jacek Hajto, Dzesika Hoinkis, Marcin Piechota, Małgorzata Borczyk, Michał Korostyński
medRxiv 2026.04.28.26351989; doi: https://doi.org/10.64898/2026.04.28.26351989
Computational multi-omics integration suggests an association between LAMA3 expression, immune suppression, and metabolic programs in pancreatic ductal adenocarcinoma
Ruixiang Li, Yuheng Gu, Hua Yang & Shangke Huang
Discov Onc 17, 650 (2026). https://doi.org/10.1007/s12672-026-04804-9
The causality between gut microbiota and ectopic pregnancy based on genome-wide association: A Mendelian randomization study
Zhang N, Wang Z, Yang F, Liu T, Ji D.
Afr J Reprod Health. 2026 Apr 28;30(8):66-75. doi: 10.29063/ajrh2026/v30i8.7
Transcriptomics and Mendelian randomization studies reveal the critical role of Stanniocalcin-2 in linking perfluorinated compound-exposure to colorectal cancer
Bingxin Li, Qianqian Yang, Jianghui Wu, Jiahui Zheng, Na Zhao, Zhaoyu Gao, Yang Luo, Rui Zhang, Shunjiang Xu
Front. Public Health, 28 April 2026 Sec. Environmental Health and Exposome Volume 14 - 2026 | https://doi.org/10.3389/fpubh.2026.1768633
The effects of micronutrients on the risk of upper gastrointestinal diseases: a two-sample Mendelian randomization study
Zhang X, Cheng Y, Ding R, Gu J.
Eur J Nutr. 2026 Apr 28;65(4):122. doi: 10.1007/s00394-026-03966-0.
Mapping the genetic landscape of eight common cardiovascular diseases
Cato Romero, Douglas P Wightman, Sean Jurgens, Eva van Walree, Marre Corver, Poeya Haydarlou, Marijn Schipper, Connie Bezzina, Danielle Posthuma, Sophie van der Sluis
medRxiv 2026.04.26.26351760; doi: https://doi.org/10.64898/2026.04.26.26351760
Genome-wide association study identifies protective genetic factors in active blood donors against multiple diseases
Clancy J, Toivonen J, Lauronen J, Partanen J; Blood Service Biobank; FinnGen; Arvas M, Ritari J.
Eur J Hum Genet. 2026 Apr 27. doi: 10.1038/s41431-026-02100-2.
Identification of key genes as diagnostic biomarkers for lung adenocarcinoma using bioinformatics and machine learning
Liu Z, Luo C, Zhao H, Li L, Ma X, Wang J, Qiu S, Wang T, Li M, Li G, Li H, Li G.
Discov Oncol. 2026 Apr 27. doi: 10.1007/s12672-026-05031-y
Unveiling the Gut-Brain Axis: Fusobacteriaceae Promotes Parkinson’s Disease Development via CA9 Suppression-Induced Ferroptosis
Ren Zihan, Li Pengfei & Cao Jingsi
J Mol Neurosci 76, 68 (2026). https://doi.org/10.1007/s12031-026-02530-z
Causal relationships of inflammatory cytokines and serum metabolites with colorectal carcinoma: A Mendelian randomization study
Feng S, Xiao X, Zhou M, Huang Z, Zhong B.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2026 Jan 28;51(1):118-128. doi: 10.11817/j.issn.1672-7347.2026.250494.
Causal association between systemic diseases and periodontitis: a twoway two-sample Mendelian randomization study
Sun L, Zheng Q, Hou Y, Lou H.
Quintessence Int. 2026 Apr 24;0(0):0. doi: 10.3290/j.qi.b6990697
SNPic: SNP Topic Modeling for Interpretable Clustering of Complex phenotypes
Zhang Leyi, Christof Seiler, Doug Speed, Raphael Micheroli, Caroline Ospelt
bioRxiv 2026.04.22.720106; doi: https://doi.org/10.64898/2026.04.22.720106
Narcolepsy is associated with cardiovascular burden
Reyhane Eghtedarian, Hele Haapaniemi, Markus Ramste, FinnGen, Hanna M. Ollila
medRxiv 2026.04.22.26351468; doi: https://doi.org/10.64898/2026.04.22.26351468
Cross-sectional assessment of telephone- and computer-administered instruments in detection of cognitive impairment
Aaltonen A, Saari TT, Urjansson M, Palviainen T, Paajanen TI, FinnGen, Palotie A, Runz H, Kaprio J, Julkunen V, Vuoksimaa E.
J Clin Exp Neuropsychol. 2026 Apr 24:1-12. doi: 10.1080/13803395.2026.2661625.
Shared Risk Genes and Casual Relationships across Sex Hormone Related Traits and Alzheimer’s Disease
Chenyu Yang, Noah Cook, Youjie Zeng, Sathesh K. Sivasankaran, FinnGen, Alex DeCasien, Shea J Andrews, Michael E. Belloy
medRxiv 2026.04.23.26351626; doi: https://doi.org/10.64898/2026.04.23.26351626
DNA Methylation Regulates CDK5R1 and NRBP1 to Exert Effects on Alcohol Dependence: Insights From Mendelian Randomization
Deng F, Peng J, Lai S, Zhang G, Li M, Huang Y, Yuan M, Yao G, Zhang P, Lu L.
Addict Biol. 2026 May;31(5):e70162. doi: 10.1111/adb.70162.
Multi-ancestral GWAS with the VA Million Veteran Program enables functional interpretation of rheumatoid arthritis alleles
Saori Sakaue, Doris Yang, Harrison Zhang, Daniel Posner, Zachary Rodriguez, Zoe Love, Jing Cui, Ashley Budu-Aggrey, Yuk-Lam Ho, Lauren Costa, Paul Monach, Sicong Huang, Kazuyoshi Ishigaki, Connor Melley, Vidisha Tanukonda, Rahul Sangar, Monika Maripuri, Sara Morini Sweet, Vidul Panickan, Gregory McDermott, Jennifer S. Hanberg, Thomas Riley, Vincent Laufer, Yukinori Okada, Ian Scott, S. Louis Bridges, Joshua Baker, VA Million Veteran Program, Peter W. Wilson, J. Michael Gaziano, Chuan Hong, Anurag Verma, Kelly Cho, Jennifer E. Huffman, Tianxi Cai, Soumya Raychaudhuri, Katherine P. Liao
medRxiv 2026.04.22.26351423; doi: https://doi.org/10.64898/2026.04.22.26351423
Interpretable Machine Learning for Sepsis Risk Prediction in Elderly ICU Patients With Heart Failure: Integrating Genetic Evidence and Clinical Data
Lin Wang, Yiping Hu, Yu Xiong, Yang Yu, Chunxiang Zhang
Research Square, 23 April 2026, [https://doi.org/10.21203/rs.3.rs-9185668/v1]
Identification of LRP8 as a potential therapeutic target for irritable bowel syndrome from the proteomes of plasma and cerebrospinal fluid in a Mendelian randomization study
Zhuo Y, Zhao L, Li D, Ding Y, Liu N, Wang Y, Liu J, Shen C, Zhang S.
Rev Esp Enferm Dig. 2026 Apr 23. doi: 10.17235/reed.2026.11686/2025.
Systematic elucidation of the cross-omics regulatory network in chronic rhinosinusitis: the LAT-IL23R metabolic axis
Ou Z, Gao C.
Braz J Otorhinolaryngol. 2026 Apr 22;92(4):101819. doi: 10.1016/j.bjorl.2026.101819
Pan-cancer polygenic risk score associates with cancer susceptibility following kidney transplantation
Ritari J, Hyvärinen K, Jahnukainen K, Partanen J, Helanterä I, Jahnukainen T.
JCI Insight. 2026 Apr 23:e198098. doi: 10.1172/jci.insight.198098.
Causal association between sleep disorders and nephrolithiasis: a two-sample Mendelian randomization study
Lewei Huang, Lianhui Fan, Shudong Wang, Hongtao Liu, Qingwei Zeng & Gang Sun
Int Urol Nephrol (2026). https://doi.org/10.1007/s11255-026-05130-3
Exploring the regulatory mechanisms of antidiabetic drugs on osteoporosis and Bone mineral density
Jing YL, Zhu XY, Gong SA, Sun T, Lin XY.
Exp Gerontol. 2026 Apr 21:113142. doi: 10.1016/j.exger.2026.113142
Proteomic Insights into Lp(a) Cardiovascular Mechanisms: A Mendelian Randomization Study
Julia Tomasi, Huilei Xu, Luqing Zhang, Caitlin E Carey, Matthias Schoenberger, Denise P. Yates, JP Casas
medRxiv 2026.04.20.26351299; doi: https://doi.org/10.64898/2026.04.20.26351299
Inhibition of Adenosine Kinase Alleviates Hypertrophic Cardiomyopathy by Ameliorating Coronary Microvascular Dysfunction
Wan F, Ma B, Han Z, Zheng Y, Lu M, Chen J, Wang J, Song L.
ESC Heart Fail. 2026 Apr 22:xvag118. doi: 10.1093/eschf/xvag118
Meta-Analysis of Rare Cancers Leveraging Clinically Ascertained Cohorts Reveals Novel Germline Susceptibility Loci
Shaye Carver, Tomin Perea-Chamblee, Kodi Taraszka, Intae Moon, Xinran Yu, Yi Ding, Jian Carrot-Zhang, Alexander Gusev
medRxiv 2026.04.16.26350975; doi: https://doi.org/10.64898/2026.04.16.26350975
Causal Statistical Association between Remnant Cholesterol and Coronary Heart Disease: Genetic Insights into the PSRC1-CELSR2-SORT1 Gene Cluster
Han G, Lei CL, Shi Y, Gao J, Liu X, Peng K, Cai Y, Hoi PM, Li Y.
J Lipid Res. 2026 Apr 20:101047. doi: 10.1016/j.jlr.2026.101047.
Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy
Vähämäki IT, Immonen AT, Rämö JT, Jaakkola AM, Krootila K, Kaukonen M; FinnGen; Palotie A, Lohi H, Kivelä TT, Turunen JA.
Acta Ophthalmol. 2026 Apr 20. doi: 10.1111/aos.70144.
Multi-Scale Genetic and Transcriptomic Analyses Identify Druggable Targets for Epilepsy
Zhong GY, Liu C, Wang HL, Liang M, Liu ZL.
Curr Med Sci. 2026 Apr 21. doi: 10.1007/s11596-026-00194-9.
The Role of Vitamin B6 and Folate-Related Pathways Involved in Gut Microbial Composition in the Development of Preeclampsia: Metabolome-Wide Mendelian Randomization Analysis
Shen Q, Tian H, Gao X, Wei M, Yu J, Wang J.
Health Sci Rep. 2026 Apr 19;9(4):e72314. doi: 10.1002/hsr2.72314.
Causal relationship between autoimmune diseases and iron deficiency anemia: a two-sample mendelian randomization study
Wen Chen, Yinuo Wang, Haojun Long, Yongyu Yang, Yingliang Liu, Jie Xiao, Qiyu Lu, Yixiong Shu, Daoming Liang & Li Zhai
Sci Rep 16, 12935 (2026). https://doi.org/10.1038/s41598-026-42356-8
Higher body mass index is a causal risk factor for skin infections: a Mendelian randomisation study using UK Biobank and FinnGen
Hopkins R, de Villiers E, Weedon MN, Shields BM, Dennis JM, McGovern AP, Green HD.
Diabetes Obes Metab. 2026 Apr 20. doi: 10.1111/dom.70797.
Impact of gut microbiome, plasma metabolites, peripheral immune cells, and circulating inflammatory protein on chronic spontaneous urticaria: Bidirectional 2-sample Mendelian randomization study and mediation analysis
Deng L, Yao Y, Wang Q, Lu Z, Li E, Hu Y, Chen J, Wang G, Yu T, Ji J, Jiao Q.
J Allergy Clin Immunol Glob. 2026 Mar 24;5(3):100686. doi: 10.1016/j.jacig.2026.100686.
Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization
Taylor-Bateman V, Bothongo P, Walker V, Kehoe PG, Tybjærg Nordestgaard L, Ben-Shlomo Y, Davies NM, Williams DM, Anderson EL.
Nat Aging 6, 905–915 (2026). https://doi.org/10.1038/s43587-026-01106-1
Obstructive Sleep Apnea and Female Reproductive Endocrine Diseases: A Mendelian Randomization and Mediation Analysis
Wang Z, Qin J, Wang J, Chen Z, Qiao Z, Yan M, Wu D.
Int J Endocrinol. 2026 Apr 16;2026:3604933. doi: 10.1155/ije/3604933
Vestibular migraine as a vestibulo-trigeminal interface phenotype: a triangulation study across genetics, peripheral multiomics and human cell atlases
Hanchen Rui, Guimei Fan, Guangcong Li, Lan Zhu, Chaoping Yang
Research Square , 20 April 2026, [https://doi.org/10.21203/rs.3.rs-9347560/v1]