Below you will find all the published and preprint scientific papers using FinnGen data.

2025

July

Genetic susceptibility to cerebral palsy involves complement system-mediated neuronal development and plasticity pathway
Huang Kun, Qi Zhou, Hao Wu, Dejiang Yang, Chongyu Xiong, Xiaowei Zhang
Sci Rep 15, 23088 (2025). https://doi.org/10.1038/s41598-025-07178-0
Real-world data and Mendelian randomization analysis in assessing adverse reactions of rilonacept
Lihong Liu, Zhenfei Chi, Zhe Zhang
Int J Clin Pharm 47, 1365–1374 (2025). https://doi.org/10.1007/s11096-025-01932-0
Exploring the Causal Relationship Between Antidepressant Use and Lung Cancer Risk: A Mendelian Randomization Analysis
Yang C, Xu W.
Clin Respir J. 2025 Jul;19(7):e70102. doi: 10.1111/crj.70102.
Functional determinants and evolutionary consequences of pleiotropy in complex and Mendelian traits
Guanglei Chen, Yaxian Jin, Cancan Chu, Yuhao Zheng, Changfu Yang, Yunzhi Chen, Xing Zhu
Sci Rep 15, 21633 (2025). https://doi.org/10.1038/s41598-025-05290-9
Autism spectrum disorders and childhood caries: a comprehensive Mendelian randomization study
Qiufang Jin, Zexiu He, Dongfang Xu, Ruihua Lin, Tongtong Zhang, Bingjian Lv, Yuliang Zhao
BMC Pediatr 25, 484 (2025). https://doi.org/10.1186/s12887-025-05839-7
Investigating the potential role of EIF2S2 in OSCC progression through comprehensive bioinformatics analysis and experimental validation
Zhiwen Shao, Tao Dong, Ke Yun, Zhaohui Wang, Yu Wen, Zongli Zhang, Tao Jia
Eur J Med Res 30, 562 (2025). https://doi.org/10.1186/s40001-025-02830-x
Mendelian Randomization Analysis Reveals Causal Associations Between Autoimmune Diseases and Female Infertility Risk
Wang J, Long H, Su M, Cao Y, Zhou R, Li X, Li J, Tang Y, Tang J, Wang S, Tang L, Chen R, Deng D, Tang L.
Reprod Toxicol. 2025 Jul 2:108984. doi: 10.1016/j.reprotox.2025.108984.
Linking obstructive sleep apnea with pulmonary hypertension via pooled prevalence and causal association: A systematic review, meta-analysis and Mendelian randomization
Du D, Qin J, Hu X, Xu D, Gao L, Wu Y, Chen M, Chen Z, Luo F, Shen Y.
Heart Lung. 2025 Jul 2;74:82-89. doi: 10.1016/j.hrtlng.2025.06.009.
Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis
Nan Li, Chuan He
Sci Rep 15, 23618 (2025). https://doi.org/10.1038/s41598-025-07962-y
Frailty and the Risk of Delirium: A Mendelian Randomization Study
Yu M, Li B.
Crit Care Nurs Q. 2025 Jul-Sep 01;48(3):316-324. doi: 10.1097/CNQ.0000000000000565.
Causal association of antibody-mediated immune responses to infectious disease agents with lung cancer: a Mendelian randomization study
Guicai Liang, Lyubo Wang, Zhiqiang Wang, Tao Li, Lei Jiang, Yuncheng Bai, Lei Yang, Yi Feng, Yan Li, Meng Yang, Jiling Chang, Haiyue Yang, Xilong Zhou, Lincan Duan, Chunlei Ge
Discov Onc 16, 1234 (2025). https://doi.org/10.1007/s12672-025-02997-z
Genetic prediction of immune cells, inflammatory proteins, and metabolite-mediated association between gut microbiota and COPD: a Mendelian randomization study
Guanglei Chen, Yaxian Jin, Cancan Chu, Yuhao Zheng, Changfu Yang, Yunzhi Chen, Xing Zhu
Sci Rep 15, 21633 (2025). https://doi.org/10.1038/s41598-025-05290-9
Association of air pollution, lifestyle factors, and metabolic syndrome: a Mendelian randomization study
Sijie Gu, Fulei Chen, Teng Li, Huanyu Hu, Mulatibieke Keerman, Qiang Niu, Heng Guo, Shuxia Guo, Jia He
Researchsquare, 01 July 2025, doi: 10.21203/rs.3.rs-6966151/v1
Investigating the potential of oxidative stress-related gene as predictive markers in idiopathic pulmonary fibrosis
Wang Y, Zhang Z, Zhang H, Xu L, Huang S, Wen Y, Zhuang Z, Li X, Lu J, Li X.
Sci Rep. 2025 Jul 1;15(1):21228. doi: 10.1038/s41598-025-02579-7.
Loss of CFHR5 function reduces the risk for age-related macular degeneration
Reeve MP, Loomis S, Nissilä E, Soare TW, Rausch T, Zheng Z, Della Briotta Parolo P, Ben-Isvy D, Aho E, Cesetti E, Okunuki Y, McLaughlin H, Mäkelä J; FinnGen; Kurki M, Talkowski ME, Korbel JO, Connor K, Meri S, Daly MJ, Runz H.
Nat Commun. 2025 Jul 1;16(1):5766. doi: 10.1038/s41467-025-61193-3.
The role of immune cells in cirrhosis: evidence from a two-sample Mendelian randomization study
Chen Y, Wang K, Liu Y, Zeng H, Long H, Kang J, Wang S, He J.
Sci Rep. 2025 Jul 1;15(1):20737. doi: 10.1038/s41598-025-07325-7.
Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for stroke
Xueling Zhao, Menghao He, Desheng Zhou, Zhong Li, Lijuan Liu, Renyi Yang, Xinhua Zhu, Cuilan Gong, Siyang Yan
BMC Neurol 25, 255 (2025). https://doi.org/10.1186/s12883-025-04239-9
Gut microbiota constituents may affect hypertrophic scarring risk through interaction with specific immune cells in a two-step, two-sample Mendelian randomization study
Jiaqi Lou, Ziyi Xiang, Xiaoyu Zhu, Jiliang Li, Guoying Jin, Shengyong Cui, Neng Huang, Pei Xu, Sida Xu, Youfen Fan, Xin Le
Sci Rep 15, 20656 (2025). https://doi.org/10.1038/s41598-025-07455-y
Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study
Kuang X, Wu B, Hu D, Matsika J, Cheng C, Xiao J, Cai Z, Li M, Chen J, Zhou W, Liu B.
Discov Oncol. 2025 Jul 1;16(1):1226. doi: 10.1007/s12672-025-03010-3.
Exploring the role of immune cell traits and circulating inflammatory cytokines in the development of diabetic neuropathy
Guo N, Li Q, Wang H, Li P.
Cytokine. 2025 Jul 1;194:156985. doi: 10.1016/j.cyto.2025.156985.
Genetic evidence suggests a causal relationship linking thyroid function to prospective memory and dementia and Parkinson’s disease
Yang Wang, Yanying Liu,Huimin Yang, Zhuang Mo, Haiyan Liu, Qi Yu
Sci Rep 15, 21633 (2025). https://doi.org/10.1038/s41598-025-05290-9
Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis
Li Y, Wang Y, Chen S, Liu L.
Sci Rep. 2025 Jul 1;15(1):21499. doi: 10.1038/s41598-025-08633-8.
Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants
Franz Förster, David Emmert, Katrin Horn, Janne Pott, Johannes Frasnelli, Mohammed Aslam Imtiaz, Konstantinos Melas, Valentina Talevi, Honglei Chen, Christoph Engel, Michele Filosi, Myriam Fornage, Martin Gögele, Markus Löffler, Cristian Pattaro, Peter Pramstaller, Srishti Shrestha, N. Ahmad Aziz, Monique M. B. Breteler, Kerstin Wirkner, Markus Scholz, Christian Fuchsberger
Nat Commun 16, 5434 (2025). https://doi.org/10.1038/s41467-025-61330-y
The mediating factors between systemic lupus erythematosus and prostate cancer risk: a two-step Mendelian randomization and transcriptome analysis
Siwen Zhong, Wei Li, Xingliang Yang, Jun Qiao, Quliang Zhong, Yuan Tian, Peng Chen, Yuewei Tao, Fa Sun, Tao Li
Discov Onc 16, 1199 (2025). https://doi.org/10.1007/s12672-025-03046-5
Mendelian randomization study reveals causal association between skin microbiome and skin cancers
Yong He, Liming Li, Yuancheng Li, Xiaoke Wang, Leqi Qian, Jiajia Yang, Mingjun Jiang
Sci Rep 15, 21590 (2025). https://doi.org/10.1038/s41598-025-07265-2

June

Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signatures
Kim MS, Song M, Kim H, Park S, Shim I, Lim S, Kim B, Chen X, Sui Y, Cho SMJ, Koyama S, Yun J-S, Natarajan P, Ellinor PT, Fahed AC, Won H-H.
medRxiv 2025.06.30.25330607; doi: https://doi.org/10.1101/2025.06.30.25330607
Investigation of potential toxicity associated with long-term amitriptyline exposure: Evidence from genomics
Liu J, Li Z, Deng Z, Wang Y, Deng F.
Ecotoxicol Environ Saf. 2025 Jun 30;302:118587. doi: 10.1016/j.ecoenv.2025.118587.
The causal and mediated relationships between major depressive disorder (MDD), post-traumatic stress disorder (PTSD), anxiety disorders and premature mortality: Evidence from genome-wide association study
Wu C, Tong S, You Y, Li Y, Cai R, Fang J, Fang X, Zhang X.
J Affect Disord. 2025 Jun 30:119781. doi: 10.1016/j.jad.2025.119781.
Single-cell multi-omic integration analysis prioritizes druggable genes and reveals cell-type-specific causal effects in glioblastomagenesis
Huang Y-F, Huang K-L.
medRxiv 2025.06.28.25330486; doi: https://doi.org/10.1101/2025.06.28.25330486
Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves' Ophthalmopathy: A Mendelian Randomization Study
Li Y, Chen L, Lin S, An W, Miao L, Wan M, Zhang B.
Transl Vis Sci Technol. 2025 Jun 2;14(6):34. doi: 10.1167/tvst.14.6.34.
Uncovering the Molecular Landscape of Physical Activity: Proteomic Insights from the UK Biobank
Qian H, Wu C, Yang Y, Li B, Rosenzweig A, Wang M.
medRxiv 2025.06.27.25330418; doi: https://doi.org/10.1101/2025.06.27.25330418
Association between gut microbiota and disorders of lipoprotein metabolism: a two sample Mendelian randomization study
Du Q, Chen Y, Kou C, Wei J, Xu R, Cao Y, Yu L, Kou X.
Nutr Metab Cardiovasc Dis. 2025 Jun 27:104212. doi: 10.1016/j.numecd.2025.104212.
Glatiramer Acetate Reduces Risk of Cardiovascular Disease and Myocardial Infarction
Lehrer S, Rheinstein PH.
In Vivo. 2025 Jul-Aug;39(4):2066-2072. doi: 10.21873/invivo.14001.
Genome-wide Cross-multi-trait Analysis into Shared Genetic Architecture of Coronary Artery Disease and Aortic Aneurysms
Virkkala J, FINNGEN, Kettunen J, Kaikkonen MU.
medRxiv 2025.06.27.25330395; doi: https://doi.org/10.1101/2025.06.27.25330395
Identification of Potential Therapeutic Targets for Coronary Atherosclerosis from an Inflammatory Perspective Through Integrated Proteomics and Single-Cell Omics
Wang H, Xie F, Wang M, Ji J, Song Y, Dai Y, Wang L, Kang Z, Cao L.
Int J Mol Sci. 2025 Jun 27;26(13):6201. doi: 10.3390/ijms26136201.
Genetic associations between Serotonin Receptor 1F (HTR1F) regulatory variation and sleep apnea in non-obese individuals: Insights from GWAS and eQTL analyses
Strausz S, Broberg M, Jones SE, Koskela J, Kiiskinen T, FinnGen; Estonian Biobank Research Team; Palotie A, Palotie T, Bachour A, Saxena R, Ripatti S, Abner E, Ollila HM.
Eur Respir J. 2025 Jun 26:2401778. doi: 10.1183/13993003.01778-2024.
Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization
Li H, Yue F, Gu X, Guan H, Chen K, Zhang J, Ji H, He J.
Eur Arch Psychiatry Clin Neurosci. 2025 Jun 26. doi: 10.1007/s00406-025-02048-2.
Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression
Xiong Y, Krebs K, Jermy B, Karlsson R, Pasman JA, Nguyen TD, Gong T, Kowalec K, Rück C, Sigström R, Jonsson L, Clements CC, Hörbeck E, Andersson E, Bäckman J; FinnGen; Estonian Biobank Research Team; Ganna A, German J, Sullivan PF, Landén M, Lehto K, Lu Y.
Mol Psychiatry. 2025 Jun 26. doi: 10.1038/s41380-025-03084-z.
Genetic mapping of lifespan and mitochondrial stress response in C. elegans
Li X, Li W, Gao AW, Zhu Y, Katsyuba E, Overmyer KA, Li TY, Wang Z, Legon L, Plantade L, Mouchiroud L, Cornaglia M, Li H, Houtkooper RH, Coon JJ, Auwerx J.
bioRxiv 2025.06.26.661693; doi: https://doi.org/10.1101/2025.06.26.661693
Genetic associations between serotonin receptor 1F (HTR1F) regulatory variation and sleep apnoea in non-obese individuals: insights from GWAS and eQTL analyses
Strausz S, Broberg M, Jones SE, Koskela J, Kiiskinen T; FinnGen; Estonian Biobank Research Team; Palotie A, Palotie T, Bachour A, Saxena R, Ripatti S, Abner E, Ollila HM.
Eur Respir J. 2025 Sep 17;66(3):2401778. doi: 10.1183/13993003.01778-2024. Print 2025 Sep.
The influence of 179 lipid metabolism on head and neck cancer is mediated by 91 inflammatory factors
Hua S, Lang T, Liu R.
Community Dent Health. 2025 Jun;42(2):17-26. doi: 10.1177/0265539X251343832
Causal relationship between varicose veins and hydrocele: A bidirectional two-sample Mendelian randomization study
Guo C, Qu Y, Liu H.
SAGE Open Med. 2025 Jun 25;13:20503121251338670. doi: 10.1177/20503121251338670.
Bayesian-weighted Mendelian randomization reveals sleep apnea syndrome mediates the BMI-chronic pain link
Shi W, Luo J, Yang L, Chen D, Zhang Y, Peng J, Ruetzler K, Sun M, Jin H.
J Thorac Dis. 2025 Jun 30;17(6):4091-4103. doi: 10.21037/jtd-2025-827.
Homocysteine and risk of interstitial lung disease: A mendelian randomization approach to causal inference
Li S, Hu X, Hu X, Liu H, Meng S.
Sarcoidosis Vasc Diffuse Lung Dis. 2025 Jun 25;42(2):16386.
The Casual Associations Between Brain Functional Networks and Fibromyalgia: A Large-Scale Genetic Correlation and Mendelian Randomization Study
Hu Y, Yang G, Deng Z, Yang S, Li Y, Xiao W, Lu B, Zhu X.
Bioengineering (Basel). 2025 Jun 25;12(7):692. doi: 10.3390/bioengineering12070692.
Uncovering Putative Causal Non-Coding RNAs in Acute and Chronic Myeloid Leukemia: A Genome-Wide Mendelian Randomization Study
Jung S, Kim JW, Han B.
Cancer Res Treat. 2025 Jun 25. doi: 10.4143/crt.2025.377.
Assessing the Causal Effect of Pulse Pressure on Migraine Risk: A Mendelian Randomization Study
Xu H, Qin X, Feng Z, You S.
J Pain Res. 2025 Jun 25;18:3159-3170. doi: 10.2147/JPR.S512795.
Genetic Contribution of Cardiorespiratory Fitness in Morbidity and Mortality: A Prospective FinnGen and HUNT study
Joensuu L, Lukander V, Herranen P, Tynkkynen NP, Kujala U, Lopéz-Bueno R, Nordeidet AN, Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Ollikainen M, FinnGen, Sillanpää E.
medRxiv 2025.06.25.25330268; doi: https://doi.org/10.1101/2025.06.25.25330268
Identification of novel therapeutic targets for cognitive performance and associations with brain health
Lu-Yang Zhang, Yu-Xin Liu, Yun-Hui Chu, Yun-Fan You, Luo-Qi Zhou, Sheng Yang, Ming-Hao Dong, Hang Zhang, Xiao-Wei Pang, Lian Chen, Li-Fang Zhu, Jun Xiao, Ke Shang, Wei Wang, Chuan Qin, Dai-Shi Tian
Transl Psychiatry 15, 214 (2025). https://doi.org/10.1038/s41398-025-03437-w
Causal Associations Between Socioeconomic Status, Intelligence, Cognition and Atrial Fibrillation: Evidence From Mendelian Randomization
Kaisaier W, Ye M, Wu Z, Liu C, He J, Lip GYH, Chen Y, Zhu W.
JACC Asia. 2025 Jun 2:S2772-3747(25)00265-0. doi: 10.1016/j.jacasi.2025.04.008.