Below you will find all the published and preprint scientific papers using FinnGen data.

2025

October

Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study
Lin W, Chen X, Wei Y, Yang L, Li H, Zhu T.
Brain Behav . 2025 Oct;15(10):e70870. doi: 10.1002/brb3.70870.
Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer’s Disease Risk Prediction in Multiethnic Cohorts
Okorie M, Jonson C, Oddi A P, Castruita P A, Fulton-Howard B, Yaffe K, Yokoyama J S, Udeh-Momoh C, Andrews S J, the Alzheimer’s Disease Sequencing Project and the Healthy Aging Brain Study - Health Disparities
medRxiv 2025.10.03.25337285; doi: https://doi.org/10.1101/2025.10.03.25337285
Genetic variants of glucose-dependent insulinotropic polypeptide (GIP) signalling as proxy for body weight reduction and cardiovascular risk
Emanuelsson F, Nordestgaard BG, Benn M.
Eur Heart J . 2025 Oct 7:ehaf779. doi: 10.1093/eurheartj/ehaf779.
Unveiling the therapeutic potential of senescence-related IQGAP2 in pancreatic Cancer through post-GWAS genomic and scRNA-seq analyses
Zilong Bai, Jiale Liang, Yuanhua Nie, Shilong Wang, Dongmin Chang
Discov Onc 16, 1301 (2025). https://doi.org/10.1007/s12672-025-03078-x
Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial
Rodosthenous S, Viiri L E, Carson A, Cajuso T, Corbetta A, Jones S, Brenna E, FinnGen, Makkonen E, Virolainen M, Korkeala N, Widén E, Ripatti S, Ganna A.
medRxiv 2025.10.06.25337395; doi: https://doi.org/10.1101/2025.10.06.25337395
Sex hormones and meningiomas risk: a Mendelian randomization and immunohistochemical analysis
Chen F, Zhang J, Hou X, Li T, Xu Z, Li S, Zhou Y, Wang Y, Wang W, Liu P, Liu M
Researchsquare, 07 October 2025, doi: 10.21203/rs.3.rs-7564859/v1
Genome-wide meta-analyses of cross substance use disorders in diverse populations
Dongbing Lai, Michael Zhang, Nick Green, Marco Abreu, Tae-Hwi Schwantes-An, Clarissa C. Parker, Shanshan Zhang, Fulai Jin, Anna Sun, Pengyue Zhang, Howard J. Edenberg, Yunlong Liu, Tatiana Foroud
Mol Psychiatry (2025). https://doi.org/10.1038/s41380-025-03294-5
Identification of genetically-supported new drug targets for osteomyelitis based on druggable genomes
Yao R, Lu Y, Lu D, Ren H, Wang X, Lin B, Chen S, Zhu Y, Chen F, Wang Y, Gao Y, Shen J, Guo Q, Huang K.
Hum Genomics . 2025 Oct 7;19(1):117. doi: 10.1186/s40246-025-00826-6.
Using Genetics to Understand Shared Mechanisms Between Hypertension and Type 2 Diabetes Accounting for Adiposity
Voller B, Woodward R, Gu Q, Murrin O, Delgado J, Violán C, Khalid S, Türkmen D, Fox C, Lamb S, Mancini M, Farmer L, Boddy K, Dudbridge F, Bowden J, Frayling T M, Masoli J, Pilling L C, he GEMINI Consortium
medRxiv 2025.10.03.25337275; doi: https://doi.org/10.1101/2025.10.03.25337275
Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease
Daeeun Kim, Heather M. Highland, Roelof A. J. Smit, Micah R. Hysong, Victoria L. Buchanan, Kristin L. Young, Chi Zhao, Cassandra N. Spracklen, Tuomas O. Kilpeläinen, Boya Guo, Burcu F. Darst, Yanwei Cai, Zhe Wang, Jessica Lundin, Sonja I. Berndt, JoAnn E. Manson, Eirini Marouli, Leslie Lange, Ethan Lange, Myriam Fornage, Christopher R. Gignoux, Christopher A. Haiman, Stephen S. Rich, Steven Buyske, Ruth J. F. Loos, Charles Kooperberg, Ulrike Peters, Christy L. Avery, Penny Gordon-Larsen, Mariaelisa Graff, Laura M. Raffield, Kari E. North
Genome Med 17, 113 (2025). https://doi.org/10.1186/s13073-025-01522-9
Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer
Zhao M, Di X, Zhao Y.
Int J Med Sci . 2025 Sep 12;22(15):4036-4048. doi: 10.7150/ijms.107109. eCollection 2025.
Identification of C4BPA as a genetically informed drug target in NSCLC: an integrative single-cell and multi-omics study based on the druggable genes
Zhihan Xiao, Xinji Liu, Wei Tang, Yan Lv, Tongyu Zhang, Xu Zhan, Qihang Sun, Willis Wasonga Omindo, Qi Wang, Ruijie Zhang, Wei Ping, Ni Zhang
Hum Genomics 19, 113 (2025). https://doi.org/10.1186/s40246-025-00829-3
Mediating Effects of Plasma Metabolites in Inflammatory Protein-Lymphoma Causality: A Mendelian Randomization Study
Ji Y, Gao X, Liu L, Wan Z, Qin W.
Curr Med Chem. 2025 Oct 2. doi: 10.2174/0109298673382735250904071151.
Identification of Plasma Protein Biomarkers and Drug Targets for Hematologic Malignancies by Proteome-wide Mendelian Randomization
Pan T, Zhang J, Wang X, Song Y.
J Cancer . 2025 Sep 3;16(13):3917-3927. doi: 10.7150/jca.115044. eCollection 2025.
Association Between Specific Sleep Traits and Four Inflammatory Skin Diseases: A Mendelian Randomization Study
Yang P, Huang Y, He W, Chen T, Wei S, Zhao Y.
Clin Cosmet Investig Dermatol . 2025 Sep 29:18:2509-2521. doi: 10.2147/CCID.S541688. eCollection 2025.
Integrated multi-omics profiling reveals shared mechanistic pathways in asthma-allergic rhinitis comorbidity: A hybrid machine learning framework leveraging Mendelian randomization for precision diagnostics
Wang H, Tu J, Zhang J, Wang W, Yuan Z, Li C, Wang Y.
World Allergy Organ J . 2025 Sep 22;18(10):101120. doi: 10.1016/j.waojou.2025.101120. eCollection 2025 Oct.
Genetic evidence for the correlation between relative nutrient intake and male reproductive health: a Mendelian randomized study
Li S, Wang S, Jing Z, Guo J, Cao X, Guo Q.
Aging Male. 2025 Dec;28(1):2568142. doi: 10.1080/13685538.2025.2568142.
The relationship between gut microbiota, plasma metabolites, and iron deficiency anemia in European populations: a three-sample Mendelian randomization analysis
Zheng X, Shen W, Yin J.
Hematology. 2025 Dec;30(1):2549962. doi: 10.1080/16078454.2025.2549962.
Meta-analysis of exome-wide gene burden analysis of breast cancer susceptibility genes
Jennifer A. Collister, Karl Smith-Byrne, Joshua Atkins, Gillian Reeves, David J. Hunter
npj Breast Cancer 11, 111 (2025). https://doi.org/10.1038/s41523-025-00826-8
A genetic map of human metabolism across the allele frequency spectrum
Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg CC.
Nat Genet (2025). https://doi.org/10.1038/s41588-025-02355-3
Triangulation evidence for the causal effect of monocytes on pulmonary artery hypertension: a Mendelian randomization study and results from NHANES
Liu Z, Fu Q, Shao Y, Cao J.
Respir Med. 2025 Oct 1:108388. doi: 10.1016/j.rmed.2025.108388.
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus
Krista Freimann, Anneke Brümmer, Robert Warmerdam, Tarran S. Rupall, Ana Laura Hernández-Ledesma, Joshua Chiou, Emily R. Holzinger, Joseph C. Maranville, Nikolina Nakic, Halit Ongen, Luca Stefanucci, Michael C. Turchin, eQTLGen Consortium, Lude Franke, Urmo Võsa, Carla P. Jones, Alejandra Medina-Rivera, Gosia Trynka, Kai Kisand, Sven Bergmann, Kaur Alasoo
Nat Commun 16, 8795 (2025). https://doi.org/10.1038/s41467-025-63856-7
Circulating vitamin D concentrations and the risk of urticaria: A bidirectional two-sample Mendelian randomization study
Chai HX, Wang F, Liu H, Xie YQ, Zhou ZH.
Asia Pac J Clin Nutr . 2025 Oct;34(5):740-749. doi: 10.6133/apjcn.202510_34(5).0004.
Genetic evidence for the effect of prepregnancy maternal metabolic status on the risk of congenital heart disease in offspring: A Mendelian randomization study
Sağlam E, Özler MR.
Medicine (Baltimore) . 2025 Sep 26;104(39):e44820. doi: 10.1097/MD.0000000000044820.
Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies
Maamari DJ, Biddinger KJ, Jurgens SJ, Rämö JT, Gaziano L, Zheng A, Hayes D, Gongora CA, FinnGen, Hoan Choi S, Arany Z, Thavendiranathan P, Fahed AC, Sarma AA, Neilan TG, Khera AV, Ellinor PT, Aragam KG.
JAMA Cardiol
A Multi-Polygenic Risk Score Approach Incorporating Physical Activity Genotypes for Predicting Type 2 Diabetes and Associated Comorbidities: A FinnGen Study
Vettenterä Elina, Joensuu Laura, Waller Katja, FinnGen, Sillanpää Elina
medRxiv 2025.09.30.25336952; doi: https://doi.org/10.1101/2025.09.30.25336952
Decoding the Molecular Landscape of Inflammatory Bowel Disease: A Mendelian Randomization and Machine Learning Analysis
Zheng X, Zhang C, Zubair M, Pan J, Chen T, Yin J, Liu P, Luo P, Shen W, Chu Y.
J Gastroenterol Hepatol . 2025 Oct 1. doi: 10.1111/jgh.70085.
Polygenic and developmental profiles of autism differ by age at diagnosis
Zhang X, Grove J, Gu Y, Buus CK, Nielsen LK, Neufeld SAS, Koko M, Malawsky DS, Wade EM, Verhoef E, Gui A, Hegemann L, APEX consortium, iPSYCH Autism Consortium, PGC-PTSD Consortium, Geschwind DH, Wray NR, Havdahl A, Ronald A, St Pourcain B, Robinson EB, Bourgeron T, Baron-Cohen S, Borglum AD, Martin HC, Warrier V.
Nature 646, 1146–1155 (2025). https://doi.org/10.1038/s41586-025-09542-6
Limited overlap between genetic effects on disease susceptibility and disease survival
Yang Z, Pajuste FD, Zguro K, Cheng Y, Kurant DE, Eoli A, Wanner J, Jermy B, Rämö J; FinnGen; Kanoni S, van Heel DA; Genes & Health Research Team; Hayward C, Marioni RE, McCartney DL, Renieri A, Furini S; INTERVENE consortium; Mägi R, Gusev A, Drineas P, Paschou P, Heyne H, Ripatti S, Mars N, Ganna A.
Nat Genet . 2025 Sep 30. doi: 10.1038/s41588-025-02342-8.
Identification of MMEL1 as a novel therapeutic target for primary sclerosing cholangitis: Integrating Mendelian randomization and transcriptome landscapes
Li CL, Sun A, Liu YK, Sun RT, Hao AY, Lan YY, Cao JY, Wang ZS.
Medicine (Baltimore) . 2025 Sep 26;104(39):e44608. doi: 10.1097/MD.0000000000044608.
Measures of General Intelligence and Risk for Alcohol Use Disorder
Capusan AJ, Davis CN, Thern E, Rehm J, Gelernter J, Kranzler HR, Heilig M.
JAMA Psychiatry . 2025 Oct 1:e252689. doi: 10.1001/jamapsychiatry.2025.2689.
Polygenic and developmental profiles of autism differ by age at diagnosis
Zhang X, Grove J, Gu Y, Buus CK, Nielsen LK, Neufeld SAS, Koko M, Malawsky DS, Wade E, Verhoef E, Gui A, Hegemann L, APEX consortium, iPSYCH Autism Consortium, PGC-PTSD Consortium, Geschwind DH, NWray NR, Havdahl A, Ronald A, St. Pourcain B, Robinson EB, Bourgeron T, Baron-Cohen S, Børglum AD, Martin HC, Warrier V.
Nature 646, 1146–1155 (2025). https://doi.org/10.1038/s41586-025-09542-6
Two-sample Mendelian randomization investigating the causal association between endocarditis and osteomyelitis: A validation analysis using UK Biobank and FinnGen databases
Liu H, Xing H, Yu X, Wang Y, Liu H, Chang Z.
Medicine (Baltimore) . 2025 Sep 26;104(39):e44651. doi: 10.1097/MD.0000000000044651.
Dietary factors mediated the causal association between educational attainment and chronic periodontitis: A 2-sample Mendelian randomization study
Jiang L, Li S, Huang S, Liu B, Reissmann DR, Schmalz G, Hu X.
Medicine (Baltimore) . 2025 Sep 26;104(39):e44620. doi: 10.1097/MD.0000000000044620.
Genetic evidence informs the direction of therapeutic modulation in drug development
Robert Chen, Áine Duffy, Joshua K. Park, David Stein, Avner Schlessinger, Yuval Itan, Benjamin S. Glicksberg, Rory J. Tinker, Daniel M. Jordan, Ghislain Rocheleau, Ron Do
npj Drug Discov. 2, 24 (2025). https://doi.org/10.1038/s44386-025-00027-0

September

Dissecting immune cell-specific genetics in migraine: a multi-omics framework for target discovery and therapeutic prioritization
Yanggang Hong, Yuze Mi, Feng Chen, Yirong Wang, Jiajun Li, Zhendi Shu
J Headache Pain 26, 195 (2025). https://doi.org/10.1186/s10194-025-02132-x
Multi-ancestry genome-wide and transcriptome-wide association analyses identified new risk loci and genes for inflammatory bowel disease
Linshuoshuo Lyu, Qing Li, Chao Li, Ghadeer K Dawwas, You Chen, Ran Tao, Qi Liu, Wanqing Wen, Xiao-Ou Shu, Kay Washington, David A Schwartz, Wei Zheng, Zhijun Yin, Ken S Lau, Xingyi Guo
medRxiv 2025.09.23.25336483; doi: https://doi.org/10.1101/2025.09.23.25336483
Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis
Jun Qiao, Qian Wang, Yuhui Zhao, Minjing Chang, Shuo Sun, Pengwei Zhang, Kaixin Yao, Miaoran Chen, Leilei Zheng, Xiaolong Xing, Liuyang Cai, Anil G. Jegga, Lei Jiang, Siim Pauklin, Rongjun Zou, Yining Yang, Yuliang Feng
Nat Commun 16, 8677 (2025). https://doi.org/10.1038/s41467-025-63707-5
Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics
The MULTI Consortium, Aleix Boquet-Pujadas, Filippos Anagnostakis, Michael R. Duggan, Cassandra M. Joynes, Arthur W. Toga, Zhijian Yang, Keenan A. Walker, Christos Davatzikos, Junhao Wen
Nat. Biomed. Eng (2025). https://doi.org/10.1038/s41551-025-01506-5
Genetic predisposition to high BMI and changes in BMI during adolescence modulate associations between adult BMI and plasma molecules involved in glucose metabolism
Alvaro Obeso Fernandez, Gabin Drouard, Aline Jelenkovic, Sari Aaltonen, Teemu Palviainen, Katja M. Kanninen, Jessica E. Salvatore, Danielle M. Dick, Karri Silventoinen, Jaakko Kaprio
medRxiv 2025.09.23.25336458; doi: https://doi.org/10.1101/2025.09.23.25336458
Association between mitochondrial DNA copy number and the risk of Parkinson's disease: a meta-analysis and Mendelian randomization study
Zheng H, Zhang D, Gan Y, Wu Y, Xiang W.
BMC Neurol . 2025 Sep 29;25(1):390. doi: 10.1186/s12883-025-04400-4.
Association between brain connectivity and renal pathophysiology: a multi-trait Mendelian randomization analysis
Xu Z, Ma M, An R, Wang Y.
Brain Struct Funct . 2025 Sep 29;230(8):151. doi: 10.1007/s00429-025-03014-3.
Exploring metabolic pathways in gastrointestinal cancer: new evidence of causality
Zhiguo Wang, Chen Wang, Xiangyu Gao, Jiaming He
Discov Onc 16, 1777 (2025). https://doi.org/10.1007/s12672-025-03618-5
Genetic insights into the relationship between anti-inflammatory drug target genes and oral diseases
Zelong Hu, Yuchong Xie, Huike Wang, Shouqiang Zhu, Shijia Huang, Minzhe Xin, Haonan Ding, Yuxin Qian, Yingnan Tian, Xuwen Wang, Minxin He, Lei Jin
Inflammopharmacol 33, 6149–6163 (2025). https://doi.org/10.1007/s10787-025-01959-9
Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases
Paloma Jordà, Yiwei Lai, Amélie Jeuken, Louis-Philippe Lemieux Perreault, Elisabeth Goulet, Najim Lahrouchi, Anna Nozza, Michael W. Tanck, Peter Guerra, Julia Cadrin-Tourigny, Simon de Denus, Connie R. Bezzina, Guillaume Lettre, David Busseuil, Marie-Pierre Dubé, Jean-Claude Tardif, Rafik Tadros
npj Genom. Med. 10, 65 (2025). https://doi.org/10.1038/s41525-025-00515-2
Multiomic Mendelian randomization analysis of metabolic gene methylation expression and protein levels in lung adenocarcinoma
Wang Q, Liu G, Zhang J, Zou Q, Geng J.
Discov Oncol . 2025 Sep 29;16(1):1759. doi: 10.1007/s12672-025-03600-1.
Benign prostatic hyperplasia and risk of urological cancers: a prospective cohort study based on the UK biobank
Jinjing Guo, Liang Zhou, Jiaming He, Xinkai Pan, Dingwen Liu, Jiaren Li, Qing Zhou & Long Wang
Discov Onc 16, 1771 (2025). https://doi.org/10.1007/s12672-025-03564-2
Exploring Causal Relationships Between Kidney Function and the Risk of Senile Cataract and Primary Open-Angle Glaucoma: A Mendelian Randomization Study and Bioinformatics Analyses
Li P, Qiu T, Xu L, Wu L, Zhao S, Liu X, Yang Y, Wang J.
J Multidiscip Healthc . 2025 Sep 23:18:6051-6061. doi: 10.2147/JMDH.S539951. eCollection 2025.
Mendelian randomization to inform a clinical trial of chitotriosidase inhibition for pulmonary sarcoidosis
Daniel A. Culver, Marco F. Schmidt, Marlies S. Wijsenbeek-Lourens, Michael Kreuter, Vincent Cottin, Jolanta Kunikowska, Natalia V. Rivera, Marcel Veltkamp, Hannes A. Baukmann, Justin L. Cope, Charles N. J. Ravarani, Zbigniew Zasłona, Theodoros Charitos, Piotr S. Iwanowski
medRxiv 2025.09.25.25336344; doi: https://doi.org/10.1101/2025.09.25.25336344
Selenoprotein S and the Causal Risk of Hypertension in Pregnancy: A Mendelian Randomization Study
Cai M, Lv W, He Y, Liu W, Gao Y.
Healthcare (Basel) . 2025 Sep 22;13(18):2383. doi: 10.3390/healthcare13182383.