Below you will find all the published and preprint scientific papers using FinnGen data.

2026

March

Role of lipid metabolites in mediating causal effects of gut microbiota on type 2 diabetes mellitus
Li L, Tang S, Liu F, Yang M.
Comput Biol Chem. 2026 Feb 28;123:108955. doi: 10.1016/j.compbiolchem.2026.108955.
Single-cell transcriptome-wide Mendelian randomization and colocalization analyses reveal immune-cell-specific mechanisms and actionable drug targets in prostate cancer
Yanggang Hong, Yi Wang, Yirong Wang, Feng Chen, Jiajun Li
medRxiv 2026.03.10.26348013; doi: https://doi.org/10.64898/2026.03.10.26348013
Atopic dermatitis and chronic sinusitis: a two-sample Mendelian randomized study
Luo J, Zhu Y, Zhang Y, Zhang K.
Braz J Otorhinolaryngol. 2026 Mar 9;92(3):101789. doi: 10.1016/j.bjorl.2026.101789.
XMR: A cross-population Mendelian randomization method for causal inference using genome-wide summary statistics
Xinrui Huang, Zitong Chao, Zhiwei Wang, Xianghong Hu, Can Yang
medRxiv 2026.03.10.26348003; doi: https://doi.org/10.64898/2026.03.10.26348003
Comprehensive Analysis of Bulk RNA-seq, Machine Learning, Mendelian Randomization, and Single-Cell Sequencing Unravels SLC22A3 as a Solute Carrier Superfamily-Associated Biomarker in Atherosclerosis
Yongchao Yu, Lan Wang, Tianhui Wang, Ya Zhang, Xiaomeng Su, Xingyang Dai & Xiangang Mo
J. Cardiovasc. Transl. Res. 19, 39 (2026). https://doi.org/10.1007/s12265-026-10757-9
The impact of combined spinal-epidural analgesia (CSEA) on postpartum depression: A Mendelian randomization study
Zhang M, Liu S.
Can J Pain. 2026 Mar 2;10(1):2617362. doi: 10.1080/24740527.2026.2617362.
Identification of circadian rhythm-related genes in colorectal cancer by integrating bioinformatics and multi-omics mendelian randomization
Shen Z, Tao M, Qin Y, Tang W, Yuan Y, Gu W.
Naunyn Schmiedebergs Arch Pharmacol. 2026 Mar 9. doi: 10.1007/s00210-026-05187-y
Investigating the causal association between plasma lipids and the risk of squamous cervical cancer: A two-sample mendelian randomization study
Cui Y, Li Y, Na J, Lu J, Wang X, Hanv S, Wang J.
J Med Biochem. 2025 Nov 5;44(8):1843-1849. doi: 10.5937/jomb0-58020.
Genetically proxied inhibition of angiotensinogen synthesis is associated with lower cardiovascular risk
Panagiotis Zangas, Murad Omarov, Lanyue Zhang, Marios K Georgakis
medRxiv 2026.03.08.26347887; doi: https://doi.org/10.64898/2026.03.08.26347887
Causal relationship between renin-angiotensin system inhibitors and cancer: a two-sample, two-step Mendelian randomization study
Zeng C, Zhu J, Zhen X, Mao Y, Wei Z, Zhen Z.
Chin Clin Oncol. 2026 Feb;15(1):4. doi: 10.21037/cco-2025-aw-131.
Evaluation of Potential Therapeutic Targets for Bacterial Infectious Skin Diseases: A Proteome-Wide Mendelian Randomization Study
Yan Z, Shi Z, Wang Y, Yin H.
Clin Cosmet Investig Dermatol. 2026 Mar 2;19:576669. doi: 10.2147/CCID.S576669.
POLK and KCNK17 as novel candidate genes for type 2 diabetes via stress response and ion channel regulation
Qu Y, Wang Y, Zhang Y, Wu H, Yao Y.
J Endocrinol Invest. 2026 Mar 7. doi: 10.1007/s40618-026-02825-3.
Genomic and proteomic insights into hidradenitis suppurativa
Argyropoulou M, Stylianakis E, Ricaño-Ponce I, Keur N, Kanni T, Stergianou D, Netea MG, Kumar V, Giamarellos-Bourboulis EJ.
J Eur Acad Dermatol Venereol. 2026 Mar 7. doi: 10.1111/jdv.70390.
Association Between Unsaturated Fatty Acid Levels and Chronic Obstructive Pulmonary Disease: A Bidirectional Mendelian Randomization Study
Jiang S, Lu L, Wang X, Zhu X, Chen X, Chang HC, Gu X, Yang F, Liu X, Zhang X, Shen X.
Clin Respir J. 2026 Mar;20(3):e70179. doi: 10.1111/crj.70179.
Mendelian randomization study finds no causal link between inflammatory bowel disease and cirrhosis
An J, Zhu M, Fu Y, Gao K, Xie H, Ding H, Guo C, Zeng F, Xiong Y.
Medicine (Baltimore). 2026 Mar 6;105(10):e47823. doi: 10.1097/MD.0000000000047823.
Finnish-Enriched SLC26A7 Variant in Congenital Hypothyroidism: Clinical Spectrum, Thyroid Histopathology, and Expression Analysis
Niuro L, Ojala J, Ravi R, Melnyk V, Linnossuo V, Palmu S, Jännäri M, Tyystjärvi S, Löf C, Patyra K, Makkonen K, Jääskeläinen J, Danner E, Huopio H, Niinikoski H, Viikari L, Kero A, Miettinen P, Schoenmakers N, FinnGen F, Reeve MP, Kero J.
Thyroid. 2026 Feb;36(2):141-152. doi: 10.1177/10507256251411983.
From lipid profiles to disease onset: Triglycerides as predictive biomarkers in endometriosis
Wu Q, Zhang Q, Tie Y, Cheng G.
Medicine (Baltimore). 2026 Mar 6;105(10):e47910. doi: 10.1097/MD.0000000000047910.
Bidirectional Mendelian randomization analysis of the causal association between obesity and hepatocellular carcinoma in a European population
Ding X, Zhou X, Tang N, Wang X, Jin X, Ma X, Wu B, Wu C, Yang X, Yang J, Wu T, Liang Q, Yin L.
Medicine (Baltimore). 2026 Mar 6;105(10):e48000. doi: 10.1097/MD.0000000000048000.
Psychological distress and oral lichen planus: A bidirectional Mendelian randomization study
Yuan W, Gao Y.
Community Dent Health. 2026 Mar 6:265539X261429989. doi: 10.1177/0265539X261429989.
The genetic basis of dermatophytosis skin infection susceptibility
Haapaniemi H, Eghtedarian R, Tervi A, Valliere J; Estonian Biobank Research Team; FinnGen; Abner E, Ollila HM.
Nat Commun. 2026 Mar 6. doi: 10.1038/s41467-026-69670-z.
Shared genetic structure between COVID-19 and migraine: insights from large-scale genome-wide cross-trait analysis
Wang X, Guo J, Liu J, Jiang J, Long Y, Sun R.
Virus Res. 2026 Mar 3:199708. doi: 10.1016/j.virusres.2026.199708.
Genome-Wide Association Study of Creatinine Clearance Identifies New Loci for Kidney Function
Anna D. Argoty-Pantoja, Peter J. van der Most, Zoha Kamali, Mahboube Ganji-Arjenaki, Amarens van der Vaart, Ahmad Vaez, Study Lifelines Cohort, Stephan J.L. Bakker, Harold Snieder, Martin H. de Borst
medRxiv 2026.03.04.26347652; doi: https://doi.org/10.64898/2026.03.04.26347652
Neutrophil extracellular traps-associated candidate genes in IgA vasculitis: an exploratory multi-omics analysis integrating transcriptomics and Mendelian randomization
Liyu Lin, Zilun Wu, Jiaqiang Wu & Wen Luo
Pediatr Rheumatol (2026). https://doi.org/10.1186/s12969-026-01197-5
Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis: A Mendelian Randomization Study
Daghlas I, Perez-Alcantara M, Gill D.
Neurology. 2026 Apr 14;106(7):e214759. doi: 10.1212/WNL.0000000000214759.
Genetic variation in reproductive life-history traits is not correlated with estrogen-receptor positive breast cancer risk
Euan A Young, E Yagmur Erten, Erik Postma, Virpi Lummaa, Bert van der Vegt, Geertruida H de Bock, Hannah L Dugdale
bioRxiv 2025.06.26.661731; doi: https://doi.org/10.1101/2025.06.26.661731
Corrigendum to "Genetic risk factors for pneumonia differ by patient subgroup" [eBioMedicine 124 (2026) 106136] DOI: 10.1016/j.ebiom.2026.106136
Heikkilä A, Sliz E, Väyrynen S, Reis K, Elnahas AG, Reigo A, Esko T; FinnGen; Estonian Biobank Research Team; Kettunen J, Hautala T.
EBioMedicine. 2026 Mar 3;125:106195. doi: 10.1016/j.ebiom.2026.106195.
Contactin-2 protects against aortic valve calcification via osteogenic differentiation inhibition
Zhongxing Zhou, Ruming Shen, Shuaijie Chen, Hailin Zhang, Longqing Chen, Xiuzhu Weng, Xiaoyan Lin & Dajun Chai
Sci Rep (2026). https://doi.org/10.1038/s41598-026-42767-7
Unraveling the link between early sexual initiation and endometriosis: evidence from population-based analyses and genetic causal inference
Mengying Li & Yimei Ma
Reprod Biol Endocrinol (2026). https://doi.org/10.1186/s12958-026-01539-8
Structural variants contribute substantially to complex trait heritability
Dat Thanh Nguyen, Alexey A Shadrin, Nadine Parker, Julian Fuhrer, Nam Sy Vo, Anders Dale, Ole Andreassen, Oleksandr Frei
bioRxiv 2026.02.28.708732; doi: https://doi.org/10.64898/2026.02.28.708732
Genetic insights into immunothrombosis: from shared loci to repurposed drugs for autoimmune and thrombotic diseases
Yichen Long, Yang Ou, Guangxiang Huang, Xin Tan, Shengyan Zhao, Lang Min, Chunyan Sun, Zeyu Luo, Hui Pan
medRxiv 2026.02.28.26346627; doi: https://doi.org/10.64898/2026.02.28.26346627
The vitamin K oxidoreductase VKORC1L1 prevents oxidative stress in hepatocytes and protects from MASLD and hepatocellular carcinoma
Shan Gao, Shiyang Wu, Fengzhen Liu, Ping Zhu, Yijie He, Shuyuan Hu, Ruibai Wang, Jin Yang, Lu Zhao, Xuman Liu, Zhifa Han, Tao Wang, Yan Zhang, Kun Wang, Yan Chen, Keshen Li, Guiyou Liu
bioRxiv 2026.02.25.707953; doi: https://doi.org/10.64898/2026.02.25.707953
Causal relationships between 41 inflammatory cytokines and myopia: a Mendelian randomization study
Wu XF, Yu L, Zhang Y, Li S, Li R, Sun LY.
Int J Ophthalmol. 2026 Mar 18;19(3):575-581. doi: 10.18240/ijo.2026.03.19.
The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study
Richard A. Armstrong, Paul Yousefi, Ben Gibbison, Golam M Khandaker, Tom R Gaunt
PLoS Med 23(3): e1004963. https://doi.org/10.1371/journal.pmed.1004963
Genome-wide cross-trait analysis of vascular dementia and Alzheimer’s disease highlights novel loci and lung-brain axis
Shan Gao, Shiyang Wu, Fengzhen Liu, Ping Zhu, Yijie He, Shuyuan Hu, Ruibai Wang, Jin Yang, Lu Zhao, Xuman Liu, Zhifa Han, Tao Wang, Yan Zhang, Kun Wang, Yan Chen, Keshen Li, Guiyou Liu
medRxiv 2026.02.27.26345967; doi: https://doi.org/10.64898/2026.02.27.26345967

February

Genetic Susceptibility to Helicobacter pylori Infection and Pancreatic Cancer Risk: A Two-Sample Mendelian Randomisation Study
Yang NY, Ke TM, Huang Y, Lophatananon A, Muir KR.
Life (Basel). 2026 Feb 7;16(2):284. doi: 10.3390/life16020284.
Immune cells mediated the causal relationship between gut microbiota and carpal tunnel syndrome: A Mendelian randomization study
Li JA, Zhou CH, Shen R, Xiao HD, Guo HB, Liang JY, Zhang Y.
Medicine (Baltimore). 2026 Feb 27;105(9):e47825. doi: 10.1097/MD.0000000000047825.
Causal links between gut microbiota, plasma metabolites, and insomnia: Insights from Mendelian randomization
Zheng X, Xu J, Yin J, Fan J, Gong Y, Yang J.
Dialogues Clin Neurosci. 2026 Dec;28(1):85-94. doi: 10.1080/19585969.2026.2636470.
Genetic evidence that FGF21 signaling reduces problematic alcohol use and alcohol-related liver disease
Rosoff DB, Wagner J, Perlstein T, Reitz J, Jung J, Blaney H, Gharib AM, Hsu C, Heller T, Koh C, Pacher P, Schwantes-An TH, Morgan T, Seth D, Christodoulides C, Davey Smith G, Ray D, Lohoff FW.
J Hepatol. 2026 Feb 24:S0168-8278(26)00077-2. doi: 10.1016/j.jhep.2026.01.025.
Circulating Metabolic Factors Mediating the Effect of Obesity-Related Indicators on Meniscal Injuries: A Mendelian Randomization Study
Ye D, Zhang Z, Zhang J.
Int J Genomics. 2026 Feb 23;2026:8056288. doi: 10.1155/ijog/8056288.
Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk
Reeve MP, Kanai M, Graham DB, Karjalainen J, Luo S, Kolosov N, Adams C, Ritari J, Karczewski KJ, Kiiskinen T, Jiang Y, Fuller Z, Mehtonen J, Kurki MI, Khan Z; FinnGen; Partanen J, McCarthy MI, Artomov M, Palotie A, Tuomi T, Pirinen M, Kero J, Xavier RJ, Daly MJ, Ripatti S.
Nat Genet. 2026 Feb 26. doi: 10.1038/s41588-026-02521-1.
Single-cell transcriptomic mendelian randomization and co-localization reveal immune-mediated regulatory mechanisms and drug targets in atopic dermatitis
Zhou K, Li W, Zou Y, Cai L, Xu Q, Tong Z, Zhao X, Gong T, Ji C, Cheng B, Xiang N.
Int Immunopharmacol. 2026 Feb 25;175:116330. doi: 10.1016/j.intimp.2026.116330.
Defining and Modeling Human Interleukin-34 Deficiency
Francisco Hernandez-Rasco, Rocío Ruiz, Itziar de Rojas, Raquel Puerta, Ana María Espinosa-Oliva, Juan García-Revilla, Paula Bayon, Alberto Rivera-Ramos, Sebastián Jiménez, Maria Eugenia Saez, Rocío M. de Pablos, Feiyang Zhao, Claudia Olive, Pilar Sanz, Xavier Montalbán, Sergi Valero, Amanda Cano, María Victoria Fernández, Jose Enrique Cavazos, Sudha Seshadri, Merce Boada, Santos Mañes, Michael T. Heneka, Francisco Javier Vitorica, Alfredo Ramirez, José Luis Venero, Agustín Ruiz
medRxiv 2026.02.21.26346696; doi: https://doi.org/10.64898/2026.02.21.26346696
Exploring the molecular mechanisms and optimizing treatment of hypertrophic scar by integrating genome-wide association studies and multi-omics data
Zhang Z, Lian J, Zhang Z, Geng Y, Li M, Lian X, Li C, Zheng C, Shao Y.
Burns. 2026 Feb 16;52(4):107919. doi: 10.1016/j.burns.2026.107919.
The Impact of Brain Morphometry on Low Back Pain Risk: A Mendelian Randomization Study
Liu Z, Li Y, Dai Y, Jiang B, Ma H, Tu Z, Wang B.
J Pain Res. 2026 Feb 19;19:565590. doi: 10.2147/JPR.S565590.
Quantifying new threats to health and biomedical literature integrity from rapidly scaled publications and problematic research
Spick M, Onoja A, Harrison C, Stender S, Byrne J, Geifman N.
J Clin Epidemiol. 2026 Feb 23:112203. doi: 10.1016/j.jclinepi.2026.112203.
Impact of proteogenomic evidence on clinical success
Mohd Anisul Karim, Abhay Hukku, Bruno Ariano, Emily Holzinger, Yakov Tsepilov, James Hayhurst, Annalisa Buniello, Ellen M. McDonagh, Stephane E Castel, Matthew R. Nelson, Joseph Maranville, Laura Yerges-Armstrong, Maya Ghoussaini
medRxiv 2026.02.23.26346731; doi: https://doi.org/10.64898/2026.02.23.26346731
Sex-Specific Basal Metabolic Rate and NAFLD Risk: The Multi-Population Observational and Mendelian Randomization Study
Hu C, Tao Y, Zhang L, Cheng Z, Sun L, Chen Z.
Diabetes Metab Syndr Obes. 2026 Feb 18;19:583771. doi: 10.2147/DMSO.S583771.
A genome-wide association study identifies EYA2 as a contributing gene for diabetic retinopathy in type 2 diabetes
Cai T, Pan Q, Tao Y, Yang L, Nangia C, Rajendrakumar AL, Shao Y, Ye Y, Dottorini T, Haque M, Palmer CNA, Meng W.
Commun Med (2026). https://doi.org/10.1038/s43856-026-01465-1
Lifestyle behaviors and immune cell characteristics in type 2 diabetes risk: a Mendelian randomization study
Fanjing Wang, Yixuan Lin, Chuqiao Shen, Guoming Shen & Zhaohui Fang
J Diabetes Metab Disord 25, 84 (2026). https://doi.org/10.1007/s40200-026-01922-7
Causal relationship between mental illness and venous thromboembolism: a Mendelian randomization study
Jin D, Yu C, Jiang Y, Zhou Y, Zheng H, Yang X, Chen Y, Bi P, Yu D, Zeng J.
Eur Arch Psychiatry Clin Neurosci. 2026 Feb 24. doi: 10.1007/s00406-025-02180-z.