Below you will find all the published and preprint scientific papers using FinnGen data.

2023

August

Genetic Evidence Strongly Supports Managing Weight and Blood Pressure in Addition to Glycemic Control in Preventing Vascular Complications in People With Type 2 Diabetes
Ahmed A, Amin H, Drenos F, Sattar N, Yaghootkar H.
Diabetes Care. 2023 Aug 9:dc230855. doi: 10.2337/dc23-0855.
Machine learning reveals genetic modifiers of the immune microenvironment of cancer
Riley-Gillis B, Tsaih S-W, King E, Wollenhaupt S, Reeb J, Peck AR, Wackman K, Lemke A, Rui H, Dezso Z, Flister MJ.
iScience, Volume 26, Issue 9, 2023, 107576, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2023.107576.
A common variant that alters SUN1 degradation associates with hepatic steatosis and metabolic traits in multiple cohorts
Upadhyay KK, Du X, Chen Y, Buscher B, Chen VL, Oliveri A, Zhao R, Speliotes EK, Brady GF.
J Hepatol. 2023 Nov;79(5):1226-1235. doi: 10.1016/j.jhep.2023.07.036.
Association between periodontitis and temporomandibular joint disorders
Wang S, Jiang H, Qi H, Luo D, Qiu T, Hu M.
Arthritis Res Ther. 2023 Aug 8;25(1):143. doi: 10.1186/s13075-023-03129-0.
Rheumatoid arthritis and heart failure: A bidirectional two-sample Mendelian randomization study
Yan Yang, Fenfang Cui, Min xu, Qin He, Ying Liu, Ying Lan, Xiqian Zhang, yaxian zheng, Xu Zhang
Researchsquare, 08 August 2023, doi: 10.21203/rs.3.rs-3227239/v1
Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization
Woolf B, Cronjé HT, Zagkos L, Burgess S, Gill D, Larsson SC.
BMC Med. 2023 Aug 8;21(1):296. doi: 10.1186/s12916-023-03008-0.
Causal Roles of Lifestyle, Psychosocial Characteristics and Sleep Status in Sarcopenia: A Mendelian Randomization Study
Liu M, Yu D, Pan Y, Ji S, Han N, Yang C, Sun G.
J Gerontol A Biol Sci Med Sci. 2023 Aug 7:glad191. doi: 10.1093/gerona/glad191.
Genetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study
Wu D, Zhou J, Huang Y, Zheng Q, Wang T, Liu L.
Cancer Med. 2023 Aug 7. doi: 10.1002/cam4.6406.
Genetic Evidence for Causal Association Between Atrial Fibrillation and Dementia: A Mendelian Randomization Study
Li M, Jiang C, Lai Y, Wang Y, Zhao M, Li S, Peng X, He L, Guo X, Li S, Liu N, Jiang C, Tang R, Sang C, Long D, Du X, Dong J, Ma C.
J Am Heart Assoc. 2023 Aug 7:e029623. doi: 10.1161/JAHA.123.029623
Genetically predicted thyroid function and risk of colorectal cancer: a bidirectional Mendelian randomization study
Du Q, Zheng Z, Wang Y, Yang L, Zhou Z.
J Cancer Res Clin Oncol. 2023 Aug 6. doi: 10.1007/s00432-023-05233-9.
Causal relationship between gut microbiome and risk of AMD: a two-sample Mendelian Randomization study
Gai-yun Li, Pei-sen Yao
Researchsquare, 04 August 2023, doi: 10.21203/rs.3.rs-3097550/v1
The relationship between antidepressants and breast cancer: evidence from Mendelian randomization
Niu D, Li C, Yan X, Qu H, Zheng Y.
Cancer Causes Control. 2023 Aug 4. doi: 10.1007/s10552-023-01766-z.
A common genetic factor underlies genetic risk for gynaecological and reproductive disorders and is correlated with risk to depression
Kiewa J, Mortlock S, Meltzer-Brody S, Middeldorp C, Wray NR, Byrne EM.
Neuroendocrinology. 2023 Aug 4. doi: 10.1159/000533413.
The relationship of fatty acids to ischaemic heart disease and lifespan in men and women using Mendelian randomization
Schooling CM, Kwok MK, Zhao JV.
Int J Epidemiol. 2023 Aug 3:dyad108. doi: 10.1093/ije/dyad108.
Univariable and multivariable Mendelian randomization investigating the effects of telomere length on the risk of adverse pregnancy outcomes.
Han X, Wu T, Liu CY.
Front Endocrinol (Lausanne). 2023 Aug 3;14:1225600. doi: 10.3389/fendo.2023.1225600.
Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression
Tian Y, Dong D, Wang Z, Wu L, Park JY, Wei GH, Wang L; PRACTICAL/ELLIPSE consortium.
The American Journal of Human Genetics, Volume 110, Issue 8, 2023, https://doi.org/10.1016/j.ajhg.2023.07.003.
A FinnGen pilot clinical recall study for Alzheimer's disease
Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen; Perola M, Palotie A, Vuoksimaa E, Runz H.
Sci Rep. 2023 Aug 3;13(1):12641. doi: 10.1038/s41598-023-39835-7.
Tea Intake Increases Risk of Glaucoma: A Multivariable Mendelian Randomization Study
Changzhong Xu, Lusi Zhang, Guangshuang Tan, Datong Xu, Qian Jiang, Bing Jiang
Researchsquare, 02 August 2023, doi: 10.21203/rs.3.rs-3208832/v1
Two-sample Mendelian randomization study does not reveal a significant relationship between cytomegalovirus (CMV) infection and autism spectrum disorder
Zhang M, Ming Y, Du Y, Xin Z.
BMC Psychiatry. 2023 Aug 2;23(1):559. doi: 10.1186/s12888-023-05035-w.
Rheumatoid arthritis and hypothyroidism: a bidirectional Mendelian randomization study.
Duan L, Chen D, Shi Y, Ye S, Dou S, Feng Y.
Front Immunol. 2023 Aug 2;14:1146261. doi: 10.3389/fimmu.2023.1146261
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
Tesfaye M, Jaholkowski P, Hindley GFL, Shadrin AA, Rahman Z, Bahrami S, Lin A, Holen B, Parker N, Cheng W, Rødevand L, Frei O, Djurovic S, Dale AM, Smeland OB, O'Connell KS, Andreassen OA.
Genome Med. 2023 Aug 1;15(1):60. doi: 10.1186/s13073-023-01212-4.
Genetic insights into the risk of metabolic syndrome and its components on psoriasis: A bidirectional Mendelian randomization
Liu L, Wang W, Si Y, Li X.
J Dermatol. 2023 Aug 1. doi: 10.1111/1346-8138.16910.
Causal association between basal metabolic rate and risk of cardiovascular diseases: a univariable and multivariable Mendelian randomization study
Li Y, Zhai H, Kang L, Chu Q, Zhao X, Li R.
Sci Rep. 2023 Aug 1;13(1):12487. doi: 10.1038/s41598-023-39551-2.
Association between coffee consumption and diabetic complications: A two- sample Mendelian randomization study
Yingchao Liang, Xinyu Hu, Mingjie Jia, Deliang Liu, Shufang Chu, Huilin Li
Researchsquare, 01 August 2023, doi: 10.21203/rs.3.rs-3188194/v1

July

Genetically predicted osteoprotegerin levels and the risk of cardiovascular diseases: A Mendelian randomization study
Zhu Y, Wang Y, Wang Y, Cui Z, Liu F, Hu J.
Int J Cardiol. 2023 Jul 31:131233. doi: 10.1016/j.ijcard.2023.131233.
Causal relationship between osteoarthritis with atrial fibrillation and coronary atherosclerosis: a bidirectional Mendelian randomization study of European ancestry
Yin M, Xu W, Pang J, Xie S, Xiang M, Shi B, Fan H, Yu G.
Front Cardiovasc Med. 2023 Jul 31;10:1213672. doi: 10.3389/fcvm.2023.1213672.
Genetic variation in SLC5A2 mimicking SGLT2-inhibition and risk of cardiovascular disease and all-cause mortality: reduced risk not explained by lower plasma glucose
Bechmann LE, Emanuelsson F, Nordestgaard BG, Benn M.
Cardiovasc Res. 2023 Jul 30:cvad122. doi: 10.1093/cvr/cvad122.
Mendelian Randomisation Analysis Suggests that Hypothyroidism Reduces Endometrial Cancer Risk
Glubb DM, Wang X, O'Mara TA
medRxiv 2023.07.30.23293405; doi: https://doi.org/10.1101/2023.07.30.23293405
Association between the use of lipid-lowering drugs and the risk of inflammatory bowel disease
Liu X, Lv Z, Xie Z, Wang Q, Yao W, Yu J, Jing Q, Meng X, Ma B, Xue D, Hao C.
Eur J Clin Invest. 2023 Jul 28:e14067. doi: 10.1111/eci.14067.
Immune-mediated inflammatory diseases and the risk of valvular heart disease: a Mendelian randomization study
Cai D, Zheng Z, Hu J, Fu Y, Song Y, Lian J.
Clin Rheumatol. 2023 Jul 28. doi: 10.1007/s10067-023-06693-7.
Modifiable factors for benign salivary gland neoplasms: A Mendelian randomization study
Gao Y, Chen H, Liu Y, Zhang X, Qiu Y, Huang D.
Oral Dis. 2023 Jul 27. doi: 10.1111/odi.14682.
Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study
Qu Y, Chen L, Guo S, Liu Y, Wu H.
Front Endocrinol (Lausanne). 2023 Jul 27;14:1133260. doi: 10.3389/fendo.2023.1133260.
Genetic Variants Associated With Hidradenitis Suppurativa
Sun Q, Broadaway KA, Edmiston SN, Fajgenbaum K, Miller-Fleming T, Westerkam LL, Melendez-Gonzalez M, Bui H, Blum FR, Levitt B, Lin L, Hao H, Harris KM, Liu Z, Thomas NE, Cox NJ, Li Y, Mohlke KL, Sayed CJ.
JAMA Dermatol. 2023 Jul 26. doi: 10.1001/jamadermatol.2023.2217.
Body mass index and risk of inflammatory breast disease: a Mendelian randomization study
Wei C, Wang X, Zeng J, Zhang G.
Nutr Hosp. 2023 Jul 26. English. doi: 10.20960/nh.04746.
No evidence of genetic causal association between sex hormone-related traits and systemic lupus erythematosus: A two-sample Mendelian randomization study
Yuan G, Yang M, Xie J, Xu K, Zhang F.
Clin Rheumatol. 2023 Jul 26. doi: 10.1007/s10067-023-06700-x.
Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes
Maina JG, Balkhiyarova Z, Nouwen A, Pupko I, Ulrich A, Boissel M, Bonnefond A, Froguel P, Khamis A, Prokopenko I, Kaakinen M.
Diabetes Care 2023; dc222373. https://doi.org/10.2337/dc22-2373
Causal Effects of Plasma Haptoglobin Levels on Alzheimer's Disease: A Two-Sample Mendelian Randomization Study
Lin Y, Hu T, Cheng L, Chen Y, Li W, Guo Q, Miao Y.
J Alzheimers Dis. 2023 Jul 26. doi: 10.3233/JAD-230159.
The UK BiLEVE and Mendelian randomisation: using multivariable instrumental variables to address "damned if you, damned if you don't" adjustment problems
Woolf B, Gill D, Sallis H, Munafò MR.
BMC Res Notes. 2023 Jul 25;16(1):157. doi: 10.1186/s13104-023-06434-8.
The long-term mediation role of cytokines on the causal pathway from maternal gestational age to offspring eye diseases: Lifecourse-Network Mendelian randomization
Hou L, Li Y, Kang L, Li X, Li H, Xue F.
Int Immunopharmacol. 2023 Jul 22;122:110667. doi: 10.1016/j.intimp.2023.110667.
Kidney damage on fertility and pregnancy: A Mendelian randomization
Ren J, Huang Q, Lie X, Tong X, Yao Q, Zhou G.
PLoS One. 2023 Jul 21;18(7):e0288788. doi: 10.1371/journal.pone.0288788.
Atopic dermatitis and risk of 14 site-specific cancers: a Mendelian Randomization study
Liu Q, Chen L, Wang Y, Wang X, Lewis SJ, Wang J.
J Eur Acad Dermatol Venereol. 2023 Jul 21. doi: 10.1111/jdv.19380.
The genetic architecture and evolution of the human skeletal form
Kun E, Javan EM, Smith O, Gulamali F, de la Fuente J, Flynn BI, Vajrala K, Trutner Z, Jayakumar P, Tucker-Drob EM, Sohail M, Singh T, Narasimhan VM.
Science381,eadf8009(2023).DOI:10.1126/science.adf8009
isGWAS: ultra-high-throughput, scalable and equitable inference of genetic associations with disease
Foley CN, Kuncheva Z, Marioni R, Runz H, Sun B.
bioRxiv 2023.07.21.550074; doi: https://doi.org/10.1101/2023.07.21.550074
The causal relationship of depression, anxiety, and neuroticism with main indicators of sarcopenia: A Mendelian randomization study
Zhang Y, Song Y, Miao Y, Liu Y, Han D.
Int J Geriatr Psychiatry. 2023 Jul;38(7):e5980. doi: 10.1002/gps.5980.
Associations between obesity, smoking behaviors, reproductive traits and spontaneous abortion: a univariable and multivariable Mendelian randomization study
Wang Q, Liu F, Tuo Y, Ma L, Feng X.
Front Endocrinol (Lausanne). 2023 Jul 20;14:1193995. doi: 10.3389/fendo.2023.1193995.
Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent
De Lillo A, Wendt FR, Pathak GA, Polimanti R.
Hum Genomics. 2023 Jul 20;17(1):67. doi: 10.1186/s40246-023-00514-3.
A Mendelian randomization study of serum uric acid with the risk of venous thromboembolism
Ji L, Shu P.
Arthritis Res Ther. 2023 Jul 19;25(1):122. doi: 10.1186/s13075-023-03115-6.
Physical activity, sedentary behavior and pancreatitis risk: Mendelian randomization study
Ling R, Liang J, Mo S, Qi J, Fu X, Tian Y.
PLoS One. 2023 Jul 19;18(7):e0287810. doi: 10.1371/journal.pone.0287810.
Leisure sedentary behaviour increases the risk of venous thromboembolism: a Mendelian randomisation study
Chen L, You G, Yang Z, Shen R, Zhang R, Zhu D, Wang L, Lin S, Lv L, Huang K.
BMC Cardiovasc Disord. 2023 Jul 18;23(1):362. doi: 10.1186/s12872-023-03395-5.
Causal association between body mass index and temporomandibular disorders: a bidirectional two-sample Mendelian randomization analysis
Chen X, Cheng Z, Xu J, Zhao Z, Jiang Q.
BMC Oral Health. 2023 Jul 18;23(1):499. doi: 10.1186/s12903-023-03179-5.