Below you will find all the published and preprint scientific papers using FinnGen data.

2025

September

Multiomic Mendelian randomization analysis of metabolic gene methylation expression and protein levels in lung adenocarcinoma
Wang Q, Liu G, Zhang J, Zou Q, Geng J.
Discov Oncol . 2025 Sep 29;16(1):1759. doi: 10.1007/s12672-025-03600-1.
Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases
Paloma Jordà, Yiwei Lai, Amélie Jeuken, Louis-Philippe Lemieux Perreault, Elisabeth Goulet, Najim Lahrouchi, Anna Nozza, Michael W. Tanck, Peter Guerra, Julia Cadrin-Tourigny, Simon de Denus, Connie R. Bezzina, Guillaume Lettre, David Busseuil, Marie-Pierre Dubé, Jean-Claude Tardif, Rafik Tadros
npj Genom. Med. 10, 65 (2025). https://doi.org/10.1038/s41525-025-00515-2
Benign prostatic hyperplasia and risk of urological cancers: a prospective cohort study based on the UK biobank
Jinjing Guo, Liang Zhou, Jiaming He, Xinkai Pan, Dingwen Liu, Jiaren Li, Qing Zhou & Long Wang
Discov Onc 16, 1771 (2025). https://doi.org/10.1007/s12672-025-03564-2
Binge drinking trajectories across adolescence and early adulthood: Associations with genetic influences for dual-systems impulsive personality traits, alcohol consumption, and alcohol use disorder
Miller AP, Spychala KM, Slutske WS, Fromme K, Gizer IR.
Journal of Psychopathology and Clinical Science, 134(7), 775–789. https://doi.org/10.1037/abn0001049
Mendelian randomization to inform a clinical trial of chitotriosidase inhibition for pulmonary sarcoidosis
Daniel A. Culver, Marco F. Schmidt, Marlies S. Wijsenbeek-Lourens, Michael Kreuter, Vincent Cottin, Jolanta Kunikowska, Natalia V. Rivera, Marcel Veltkamp, Hannes A. Baukmann, Justin L. Cope, Charles N. J. Ravarani, Zbigniew Zasłona, Theodoros Charitos, Piotr S. Iwanowski
medRxiv 2025.09.25.25336344; doi: https://doi.org/10.1101/2025.09.25.25336344
Selenoprotein S and the Causal Risk of Hypertension in Pregnancy: A Mendelian Randomization Study
Cai M, Lv W, He Y, Liu W, Gao Y.
Healthcare (Basel) . 2025 Sep 22;13(18):2383. doi: 10.3390/healthcare13182383.
Mendelian randomization and FinnGen analysis of the causal relationship between 473 gut microbiota species and chronic sinusitis
Zhang C, Wang Y, Hu C, Guo B, Jiang H, Zhao C, Wang Y.
Braz J Otorhinolaryngol . 2025 Sep 25;92(1):101711. doi: 10.1016/j.bjorl.2025.101711.
Mendelian randomisation with proxy exposures: challenges and opportunities
Rahu I, Tambets R, Fauman EB, Alasoo K.
Genetics 2025 Sep 26:iyaf210. doi: 10.1093/genetics/iyaf210.
Multiomics Mendelian randomization integrating pQTL, eQTL and mQTL data revealed BTN3A2 as a potential drug target for nephrolithiasis
Shanshan Sun, Yutao Wang, Qingzhuo Dong, Jianbin Bi, Yang Fu
Sci Rep 15, 32990 (2025). https://doi.org/10.1038/s41598-025-17664-0
Integrating multi-omic Mendelian randomization, microarray, single-cell RNA sequencing, and spatial RNA sequencing to identify potential therapeutic targets for vitiligo
Huang J, Hu Y, Zhang Y, Jiang L, Fu C, Zhang K, Wen Y, Zhou S, Huang J, Chen J, Zeng Q.
J Invest Dermatol . 2025 Sep 24:S0022-202X(25)02444-3. doi: 10.1016/j.jid.2025.09.015.
Causal relationship between gut microbiota and pituitary neuroendocrine tumors: a bidirectional Mendelian randomization
Wencai Wang, Menghao Liu, Zun Wang, Wei Ye, Xianfeng Li
Discov Onc 16, 1713 (2025). https://doi.org/10.1007/s12672-025-02958-6
Genetic Insights Into Depression Induced by Tuberculosis via Mediating Roles of Interleukins: Evidence From Mendelian Randomization
Qiu X, Li H, Huang W, Liu X.
Trop Med Int Health . 2025 Sep 25. doi: 10.1111/tmi.70039.
Decoding the genetic architecture of women reproductive aging: multi-omic integration identifies novel loci and mechanistic pathways for precision intervention
Yi-fan Kang, Jian-rong Liu
BMC Genomics 26, 854 (2025). https://doi.org/10.1186/s12864-025-12016-8
Investigating Potential Causal Relationships Between Plasma Protein Ratios and Alopecia Areata: A Bidirectional Mendelian Randomization Study
Tan X, Yin Z, Zhu S, Deng L.
Br J Hosp Med (Lond) . 2025 Sep 25;86(9):1-15. doi: 10.12968/hmed.2025.0405. Epub 2025 Sep 15.
Study on the Gene Regulatory Effects in Leukemia Based on Multi-omics Mendelian Randomization, Network Pharmacology, and Functional Validation
Guanjun Chen, Yulan Li, Zhenyu Song, Tianjun Huang, Zumiao Liu, Chunjiang Zhu
Researchsquare, 07 August 2025, doi: 10.21203/rs.3.rs-7510513/v1
Genetic liability to meniscus degeneration and its comorbidity patterns: a phenome-wide association study in the UK Biobank
Dong-gi Lee, Yonghyun Nam, Jaehyun Joo, Se-Hwan Lee, Jaeun Jung, Su Chin Heo, Dokyoon Kim
medRxiv 2025.09.23.25336468; doi: https://doi.org/10.1101/2025.09.23.25336468
MRdb: a comprehensive database of univariate and multivariate Mendelian randomization with large-scale GWAS summary data
Liu Q, Zhang Y, Li H, Li J, Xin M, Sun R, Dai Y, Shan X, He Y, Xu B, Ning S, Wang P, Guo Q.
Database (Oxford) . 2025 Jan 18:2025:baaf054. doi: 10.1093/database/baaf054.
Assessment of causality between circulating inflammatory proteins and subtypes of diabetic retinopathy
Dong M, Zhang NZ, Cao WY, Deng XX, Zhang WX, Xing YQ, Yang N.
Int J Ophthalmol . 2025 Oct 18;18(10):1971-1979. doi: 10.18240/ijo.2025.10.22. eCollection 2025.
Genetic liability to meniscus degeneration and its comorbidity patterns: a phenome-wide association study in the UK Biobank
Dong-gi Lee, Yonghyun Nam, Jaehyun Joo, Se-Hwan Lee, Jaeun Jung, Su Chin Heo, Dokyoon Kim
medRxiv [Preprint]. 2025 Sep 25:2025.09.23.25336468. doi: 10.1101/2025.09.23.25336468.
The relationship between insomnia and multiple gastrointestinal disorders: a Mendelian randomization study
Jin Yu, Yongyao Shen, Zeping Wang, Wanying Shen, Bo Chen, Yongjin Guo, Liying Jiang
BMC Gastroenterol 25, 643 (2025). https://doi.org/10.1186/s12876-025-04228-9
Exploration of potential novel drug targets for rheumatoid arthritis by plasma proteome screening
Ma Z, Chen R, Feng Z.
PLoS Comput Biol . 2025 Sep 25;21(9):e1013333. doi: 10.1371/journal.pcbi.1013333. eCollection 2025 Sep.
Genetic evidence for repurposing GLP-1 receptor agonists in chronic kidney disease and IgA nephropathy: Metabolic and anti-inflammatory pathways beyond glycaemic control
Yang X, Tang W, Chan H, Wang M, Yang H, Li Q.
Diabetes Obes Metab . 2025 Sep 24. doi: 10.1111/dom.70144.
Multifaceted dietary exposures and atrial fibrillation: Bidirectional causal evidence from two-sample Mendelian randomization study
Li H, Xu J.
Medicine (Baltimore) . 2025 Sep 19;104(38):e44722. doi: 10.1097/MD.0000000000044722.
Inhibition of lactylation by LRP1 expression increases the risk of intervertebral disc degeneration: A multi-omics summary-based Mendelian randomization analysis
Yang Y, Ai Z, Liu D, Gao X
Medicine (Baltimore) . 2025 Sep 19;104(38):e44795. doi: 10.1097/MD.0000000000044795.
Shared genetic architecture contributes to risk of major cardiovascular diseases
Jun Qiao, Lei Jiang, Liuyang Cai, Minjing Chang, Can Wang, Rong Zhao, Shan Song, Yuhui Zhao, Miaoran Chen, Shifang Ding, Ning Tan, Pengcheng He, Sakthivel Sadayappan, Jinguo Xu, Siim Pauklin, Zhengbing Liu, Yuliang Feng
Nat Commun 16, 8368 (2025). https://doi.org/10.1038/s41467-025-62419-0
Exploring the causal effects of epilepsy and its subtypes on anthropometric traits: A 2-sample Mendelian randomization study
Chen L, Hu X, Wu M, Zeng Z, Wang Y
Medicine (Baltimore) . 2025 Sep 19;104(38):e44619. doi: 10.1097/MD.0000000000044619.
Associations between dietary intake and pancreatic disease: a mendelian randomization study
Zhang Q, Yu S, Gao D, Gong J.
Int J Surg . 2025 Sep 24. doi: 10.1097/JS9.0000000000003527.
Analyzing the causal relationship between gut microbiota, metabolites, and constipation: A Mendelian randomization study
He M, Wang S, Zhang J, Zheng Y
Medicine (Baltimore) . 2025 Sep 19;104(38):e44542. doi: 10.1097/MD.0000000000044542.
Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis
Hazelwood E, Goudswaard LJ, Lee MA, Vabistsevits M, Pournaras DJ, Brenner H, Buchanan DD, Gruber SB, Gsur A, Li L, Vodickova L, Grant RC, Samadder NJ, Timpson NJ, Gunter MJ, Schuster-Böckler B, Yarmolinsky J, Richardson TG, Freisling H, Murphy N, Vincent EE.
J Natl Cancer Inst . 2025 Sep 24:djaf201. doi: 10.1093/jnci/djaf201
The role of phosphatidylinositol (18:1_18:1) in benign prostatic hyperplasia: an integrated study of Mendelian randomization and network pharmacology
Chen B, He Z, Peng S, Li B, Ou Y, Zhuang R, Xie R, Huang H.
World J Urol . 2025 Sep 23;43(1):569. doi: 10.1007/s00345-025-05870-4.
Association between clonal hematopoiesis and autoimmune diseases: a bidirectional Mendelian randomization study
Xin-Yang He, Zhuo-Nan Jia, Jian-Zhao Wu, Jie Lv, Zi-Wen Liu, Li-Han Liu, Ri-Lang Liu, Kun Yuan, Kai-Li Yang, Can-Can Li, Yu-Tian Liu, Qian Xu
Discov Med 2, 246 (2025). https://doi.org/10.1007/s44337-025-00281-1
Breakfast Skipping Increases the Risk of Coronary Heart Disease and Myocardial Infarction: Evidence From the Mendelian Randomization Study
Cao S, Zeng Y, Chen G.
Food Sci Nutr . 2025 Sep 18;13(9):e70998. doi: 10.1002/fsn3.70998. eCollection 2025 Sep.
Investigating the causal role of the gut microbiome in Kawasaki disease: mediating effects of immune cells
Youfei Fan, Shuo Zhang, Feng Guo
Clin Rheumatol 44, 4615–4627 (2025). https://doi.org/10.1007/s10067-025-07687-3
Labor Epidural Anesthesia and Postpartum Depression Risk: Prospective Observation Study and Mendelian Randomization Analysis
Zheng W, Gan P, Wan X, Wang X, Gong J, Min J.
Drug Des Devel Ther . 2025 Sep 15:19:8327-8338. doi: 10.2147/DDDT.S533306. eCollection 2025.
Triangulating cross-carcinoma GWAS delineates shared programs and disease-specific drivers
Yu-Feng Huang, Kun-Long Huang
medRxiv 2025.09.21.25336284; doi: https://doi.org/10.1101/2025.09.21.25336284
Prioritization of potential drug targets for diabetic kidney disease using integrative omics data mining and causal inference
Zhang J, Peng J, Yu C, Ning Y, Lin W, Ni M, Xie Q, Yang C, Liang H, Lin M.
J Pharm Anal . 2025 Aug;15(8):101265. doi: 10.1016/j.jpha.2025.101265.
Gut microbiota-mediated targeting of EHMT2 in individuals of European ancestry: A novel therapeutic approach for Alzheimer's disease
Yan Y, Pan Y, Lu S, Kou J, Chen X, Zeng W, Luo D, Qiu L, Zhang H, Chen D.
J Alzheimers Dis . 2025 Sep 22:13872877251372945. doi: 10.1177/13872877251372945.
Alterations of gut microbiome in chronic rhinosinusitis: insights from a mendelian randomization study
Wang KS, Tu JH, Wang QX, Zhou SZ, Wu JR, Qiu QH.
Braz J Otorhinolaryngol . 2025 Sep 20;92(1):101698. doi: 10.1016/j.bjorl.2025.101698.
The Genetic Associations Between Kidney Stones, Obesity, Type 2 Diabetes, and Hypertension
Zhou LT, Stark IW, Ali AE, Jayachandran M, Haskic Z, Harris PC, Koo K, McDonnell SK, Larson NB, Lieske JC.
Mayo Clin Proc . 2025 Sep 19:S0025-6196(25)00243-5. doi: 10.1016/j.mayocp.2025.04.030.
Uncovering genetic architecture of the heart via genetic association studies of unsupervised deep learning derived endophenotypes
You L, Zhao X, Xie Z, Patel K, Cheng Chen C, Kitkungvan D, Mohammed KK, Narula N, Arbustini E, Cassidy C, Narula J, Zhi D.
bioRxiv 2025.09.17.676827; doi: https://doi.org/10.1101/2025.09.17.676827
Functional determinants and evolutionary consequences of pleiotropy in complex and Mendelian traits
Barbitoff YA, Bogaichuk PM, Pavlova NS, Malysheva PV, Predeus AV.
Mol Biol Evol . 2025 Sep 17:msaf232. doi: 10.1093/molbev/msaf232.
The Genetics of Fibromyalgia and its Relationships to Psychiatric and Medical Traits
Uri Bright, Sarah Beck, Daniel F. Levey, Joseph D. Deak, The VA Million Veteran Program, J. Michael Gaziano, Murray B. Stein, Joel Gelernter
medRxiv 2025.09.18.25335991; doi: https://doi.org/10.1101/2025.09.18.25335991
Genetic architecture of plasma metabolome in 254,825 individuals
Yi-Xuan Qiang, Yi-Xuan Wang, Xiao-Yu He, Yue-Ting Deng, Yi-Jun Ge, Bang-Sheng Wu, You Jia, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Nat Commun 16, 8272 (2025). https://doi.org/10.1038/s41467-025-62126-w
Prospective evidence for the gut-bone axis in osteoporotic fractures: Insights from genetic prediction and metabolite mediators
Zhu B, Yu X, Lu H, Su M, Li X, Jin J, Yan Y, Jin Y.
Bone . 2025 Sep 17:201:117651. doi: 10.1016/j.bone.2025.117651.
The Causal Relationship Between Multiple Modifiable Risk Factors and Hallux Valgus: A Two-Sample Mendelian Randomization Study
Liu S, Zheng W, Chen H, Tu M, Zhong Y, Lou Y, Wen Y, Chen L.
Food Sci Nutr . 2025 Sep 17;13(9):e70965. doi: 10.1002/fsn3.70965. eCollection 2025 Sep.
No Association of Polycystic Ovary Syndrome with Pancreatic Cancer: A Mendelian Randomization Study
Gao X, Wang Y, Wang Y, Yang Z, Yan X, Li S, Jiang Y, Li Y, Zhao S, Zhao H, Chen ZJ.
Phenomics. 2024 Sep 19;4(5):522-524. doi: 10.1007/s43657-024-00156-y.
Mapping the plasma metabolome to human health and disease in 274,241 adults
Jia You, Xi-Han Cui, Yi-Lin Chen, Yi-Xuan Wang, Hai-Yun Li, Yi-Xuan Qiang, Ji-Yun Cheng, Yue-Ting Deng, Yu Guo, Peng Ren, Yi Zhang, Yu He, Xiao-Yu He, Shi-Dong Chen, Ya-Ru Zhang, Yu-Yuan Huang, Ying Mao, Jian-Feng Feng, Wei Cheng, Jin-Tai YuNat
Nat Metab (2025). https://doi.org/10.1038/s42255-025-01371-1
Genetic Variants Related to TGF-β Signaling Pathway Modulate Risk of Meniscus Injury: A Multiancestry Genome-wide Association Study
Umesh A, Cordogan S, Simpson SK, Bram JT, Jones RH, Schairer WW, Sboner A, Elemento O, Green DW, Fabricant PD.
Clin Orthop Relat Res . 2025 Sep 17. doi: 10.1097/CORR.0000000000003679.
The genetic architecture of fibromyalgia across 2.5 million individuals
Isabel Kerrebijn, Gyda Bjornsdottir, Keon Arbabi, Lea Urpa, Hele Haapaniemi, Gudmar Thorleifsson, Lilja Stefansdottir, Stephan Frangakis, Jesse Valliere, Lovemore Kunorozva, Erik Abner, Caleb Ji, Bitten Aagaard, Henning Bliddal, Søren Brunak, Mie T Bruun, Maria Didriksen, Christian Erikstrup, Arni J Geirsson, Daniel F Gudbjartsson, Thomas F Hansen, Ingileif Jonsdottir, Stacey Knight, Kirk U Knowlton, Christina Mikkelsen, Lincoln D Nadauld, Thorunn A Olafsdottir, Sisse R Ostrowski, Ole BV Pedersen, Saedis Saevarsdottir, Astros T Skuladottir, Erik Sørensen, Hreinn Stefansson, Patrick Sulem, Olafur A Sveinsson, Gudny E Thorlacius, Unnur Thorsteinsdottir, Henrik Ullum, Arnor Vikingsson, Thomas M Werge, Chronic Pain Genomics Consortium, FinnGen, DBDS Genomic Consortium, Estonian Biobank Research Team, Genes & Health Research Team, Richa Saxena, Kari Stefansson, Chad M Brummett, Bente Glintborg, Daniel J Clauw, Thorgeir E Thorgeirsson, Frances MK Williams, Nasa Sinnott-Armstrong, Hanna M Ollila, Michael Wainberg
medRxiv 2025.09.18.25335914; doi: https://doi.org/10.1101/2025.09.18.25335914
No Causal Relationship Between Helicobacter Pylori Infection and Rosacea: A 2-Sample Mendelian Randomization Study
Qiu Y, Shen S, Zhang Y.
Clin Cosmet Investig Dermatol . 2025 Sep 12:18:2359-2365. doi: 10.2147/CCID.S543236.