Below you will find all the published and preprint scientific papers using FinnGen data.

2025

January

Potential Therapeutic drug Targets for Hypertension Identified using Proteomics and Mendelian Randomization
Pan W, Huang D, Lin C, Huang H, Chen Q, Wang L, Li M, Yu H.
Am J Hypertens. 2025 Jan 23:hpaf011. doi: 10.1093/ajh/hpaf011.
Investigating the dual causative pathways linking immune cells and venous thromboembolism via Mendelian randomization analysis
Qi N, Lyu Z, Huang L, Zhao Y, Zhang W, Zhou X, Zhang Y, Cui J.
Thromb J. 2025 Jan 23;23(1):8. doi: 10.1186/s12959-025-00692-1.
The causal association between lipid-lowering strategies and risk of intracranial aneurysms: A drug-target Mendelian randomization study
Zhou D, Song J, Han G, Zhang X, Ji X, Meng R.
J Clin Lipidol. 2025 Jan 22:S1933-2874(25)00003-0. doi: 10.1016/j.jacl.2025.01.003.
Lipid-Lowering Drugs and Pulmonary Vascular Disease: A Mendelian Randomization Study
Yuan X, Hong P, Zhou J.
Pulm Circ. 2025 Jan 22;15(1):e70043. doi: 10.1002/pul2.70043.
Whole Transcriptome-Wide Analysis Combined with Summarydata-Based Mendelian Randomization Identifies High-Riskgenes for Cholelithiasis Incidence
Liu X, Wang H, Xie Z, Li L, He Y, Meng Z, Li J, Yu J, Du Z, Zheng Y, Liu T, Hao C, Xue D, Wang L, Gao E.
Clin Transl Gastroenterol. 2025 Jan 22. doi: 10.14309/ctg.0000000000000800.
Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomization
Zhao X, Li J, Yan S, Tan Y, Chen R, Li N, Zhou J, Liu C, Zhou P, Chen Y, Yan H, Zhao H, Song L.
Cardiovasc Diabetol. 2025 Jan 22;24(1):28. doi: 10.1186/s12933-025-02588-w.
A two-sample bidirectional Mendelian randomization analysis between telomere length and hyperthyroidism
Zhu S, Hao Z, Chen Q, Liu X, Wu W, Zhang F.
Front Endocrinol (Lausanne). 2025 Jan 22;15:1369800. doi: 10.3389/fendo.2024.1369800.
Evaluating the Impact of Folate on Male Infertility Using Mendelian Randomization: A Comprehensive Analysis
Wang W, Chen K, Yu Y, Chen M, Wang L, Pang Y, Ren M, Zhang H, Fu K.
World J Mens Health. 2025 Jan 22. doi: 10.5534/wjmh.240252.
A genome-wide association study identifies genetic variants associated with hip pain in the UK Biobank cohort (N = 221,127)
Pan Q, Tao Y, Cai T, Veluchamy A, Hebert HL, Zhu P, Haque M, Dottorini T, Colvin LA, Smith BH, Meng W.
Sci Rep. 2025 Jan 22;15(1):2812. doi: 10.1038/s41598-025-85871-w.
Insomnia in relation to 10 urological and reproductive conditions: a two-sample Mendelian randomization study
Wu Y, Wang Y, Wang W, Xia J, Gu Y, Qian Q, Sun G.
Transl Androl Urol. 2025 Jan 31;14(1):8-14. doi: 10.21037/tau-24-444.
Maternal Smoking Around Birth Is a Risk Factor for Gastrointestinal Diseases in Offspring: A Mendelian Randomization Study
Wang S, Zhang T, Li D, Cao X.
Dig Dis Sci. 2025 Jan 22. doi: 10.1007/s10620-025-08854-x.
Genetic susceptibility and potential therapeutic targets of unruptured intracranial aneurysms: A genome-wide study based on Mendelian randomization
Liu S, Guan H, Wang F.
Clin Neurol Neurosurg. 2025 Jan 21;249:108749. doi: 10.1016/j.clineuro.2025.108749.
Association between epigenetic aging and atrioventricular block: a two-sample Mendelian randomization study
Pan W, Zhang C, Du X, Su X, Lin J, Jiang T, Chen W.
Epigenomics. 2025 Jan 20:1-12. doi: 10.1080/17501911.2025.2454894.
Increased risk of hypertrophic scarring in estrogen receptor-positive breast cancer: a bidirectional mendelian randomization study
Cao Y, Liu C.
Arch Dermatol Res. 2025 Jan 20;317(1):299. doi: 10.1007/s00403-024-03737-z.
Roles of cerebrospinal fluid metabolites in mediating the relationship between cathepsins and narcolepsy type 1: A comprehensive Mendelian randomization analysis
Wu Y, Gan Q, Su X, Ding Y, Liu Q, Wang J, Zhang Y, Zhang N, Wu K.
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 20;137:111263. doi: 10.1016/j.pnpbp.2025.111263.
Unveiling circulating targets in pancreatic cancer: Insights from proteogenomic evidence and clinical cohorts
Feng H, Chen Z, Li J, Feng J, Yang F, Meng F, Yin H, Guo Y, Xu H, Liu Y, Liu R, Lou W, Liu L, Han X, Su H, Zhang L.
iScience. 2025 Jan 20;28(3):111693. doi: 10.1016/j.isci.2024.111693.
Potential therapeutic targets for colorectal cancer and its subsites: evidence from the proteome-wide Mendelian randomization analyses
Li J, Liu Y, Liu C, Xiao P.
Transl Cancer Res. 2025 Jan 31;14(1):486-496. doi: 10.21037/tcr-24-1503.
Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis
Xue Q, Pan JP, Qian D, Ji J, Fei LY, Yao S, Tan X, Fan WG.
Clin Cosmet Investig Dermatol. 2025 Jan 20;18:191-200. doi: 10.2147/CCID.S495773.
Effect of trace elements and nutrients on 21 autoimmune diseases: a Mendelian randomization study
Jia MJ, Yin HF, Liang YC, Jiang F, Li HL.
Front Immunol. 2025 Jan 20;15:1462815. doi: 10.3389/fimmu.2024.1462815.
Unraveling the impact of blood RANKL and OPG levels on Alzheimer's disease: Independent of bone mineral density and inflammation
Guo X, Shi W, Lu J, Tang P, Li R.
Alzheimers Dement (N Y). 2025 Jan 20;11(1):e70044. doi: 10.1002/trc2.70044.
Systematic druggable genome-wide Mendelian randomization identifies therapeutic target genes for chronic periodontitis
Cheng Z, Wang F, Ran M, Liang S, Song Q.
medRxiv 2025.01.19.25320804; doi: https://doi.org/10.1101/2025.01.19.25320804
Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease
Qi Z, Li Q, Yang S, Fu C, Hu B.
Biomedicines. 2025 Jan 19;13(1):231. doi: 10.3390/biomedicines13010231.
Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk
Khouri-Farah N, Wentworth Winchester E, Schilder BM, Robinson K, Curtis SW, Skene NG, Leslie-Clarkson EJ, Cotney J.
bioRxiv 2025.01.18.633396; doi: https://doi.org/10.1101/2025.01.18.633396
Bidirectional Mendelian Randomization Analysis to Study the Relationship Between Human Skin Microbiota and Radiation-Induced Skin Toxicity
Chen H, Xia X, Shi K, Xie T, Sun X, Xu Z, Ge X.
Microorganisms. 2025 Jan 17;13(1):194. doi: 10.3390/microorganisms13010194.
Proteome-wide mendelian randomization identifies causal plasma proteins in interstitial lung disease
Yu K, Li W, Long W, Li Y, Li Y, Liao H, Liu J.
Sci Rep. 2025 Jan 17;15(1):2293. doi: 10.1038/s41598-025-85338-y.
Integrative genetics and multiomics analysis reveal mechanisms and therapeutic targets in vitiligo highlighting JAK STAT pathway regulation of CTSS
Dong ZY, He MJ, Yu YK, Wang F, Zhao PY, Ran DL, Fu DS, He Q, Yang RP, Zhang JA.
Sci Rep. 2025 Jan 17;15(1):2245. doi: 10.1038/s41598-025-86134-4.
Association between different obesity metrics and risk of inguinal hernia
Shi H, Peng X, Lin Y, Song H, Liu L, Zeng Y, He B, Gu Y.
Updates Surg. 2025 Jan 16. doi: 10.1007/s13304-025-02062-y.
No Causal Association between Angiotensin-Converting Enzyme Inhibitors and Skin Fibrosis Risk: Evidence from Mendelian Randomization
Wei Y, Wan Z, Jiang Y, Liu Z, Yang M, Tang J.
J Invest Dermatol. 2025 Jul;145(7):1808-1810.e3. doi: 10.1016/j.jid.2024.12.020. Epub 2025 Jan 13.
Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population
Wang Z, Chen H, Liu Y, Zou L, Zhang Z, Yin Z, Mao S, Guo C, Yang B, Wu P, Yao X.
Front Oncol. 2025 Jan 15;14:1466190. doi: 10.3389/fonc.2024.1466190.
Genetically predicted causal link between the plasma lipidome and pancreatic diseases: a bidirectional Mendelian randomization study
Lin L, Huang Y, Qian S, Chen L, Sun H.
Front Nutr. 2025 Jan 15;11:1466509. doi: 10.3389/fnut.2024.1466509.
Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome
Xu J, Si S, Han Y, Zeng L, Zhao J.
J Transl Med. 2025 Jan 13;23(1):56. doi: 10.1186/s12967-024-05993-z.
Adverse Pregnancy Outcomes and Coronary Artery Disease Risk: A Negative Control Mendelian Randomization Study
Rogne T, Gill D.
Circulation. 2025 Jan 14;151(2):193-195. doi: 10.1161/CIRCULATIONAHA.124.070509.
Separating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study
Li X, Zhao W, Pan H, Wang D.
J Obes Metab Syndr. 2025 Jan 13. doi: 10.7570/jomes24018.
Potential drug targets for asthma identified through mendelian randomization analysis
Chen X, Shang Y, Shen D, Shi S, Wen Z, Li L, Chen H.
Respir Res. 2025 Jan 13;26(1):16. doi: 10.1186/s12931-024-03086-5.
Evidence for a causal link between lipoprotein (a) and mental disorders: A retrospective and Mendelian randomization study
Pan G, Fu Q, Xu Y, Jiang L.
J Affect Disord. 2025 Jan 12:S0165-0327(25)00050-3. doi: 10.1016/j.jad.2025.01.038.
Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis
Fang LH, Zhang JQ, Huang JK, Tang XD.
BMC Gastroenterol. 2025 Jan 11;25(1):13. doi: 10.1186/s12876-024-03571-7.
Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study
Yang M, Xie J, Su Y, Xu K, Wen P, Wan X, Yu H, Yang Z, Liu L, Xu P.
Exp Gerontol. 2025 Jan 10:112682. doi: 10.1016/j.exger.2025.112682.
Immune Cells and Intracerebral Hemorrhage: A Causal Investigation Through Mendelian Randomization
Mo L, Pan W, Cao W, Wang K, Huang L.
Brain Behav. 2025 Jan;15(1):e70263. doi: 10.1002/brb3.70263.
Association of antihypertensive drug target genes with alzheimer's disease: a mendelian randomization study
Zheng H, Chen C, Feng Y.
Alzheimers Res Ther. 2025 Jan 10;17(1):18. doi: 10.1186/s13195-025-01671-4.
Causal relationship between immune cells and heart failure: A Mendelian randomization study
Lu S, Yu Y, Zhu Z, Wang M, Liu R, Liu J.
Medicine (Baltimore). 2025 Jan 10;104(2):e41247. doi: 10.1097/MD.0000000000041247.
Chronic overlapping pain conditions and nociplastic pain
Johnston KJA, Signer R, Huckins LM.
HGG Adv. 2025 Jan 9;6(1):100381. doi: 10.1016/j.xhgg.2024.100381.
Genetic association between human skin microbiota with vaginitis: a two-sample Mendelian randomization study
Zhang Y, Chen H, Shi Y, Jiang L, Hong S.
Arch Dermatol Res. 2025 Jan 7;317(1):191. doi: 10.1007/s00403-024-03703-9.
Metformin and the risk of malignant tumors of digestive system: a mendelian randomization study
Liu P, Xiao J, Xiao J, Zhou J.
Diabetol Metab Syndr. 2025 Jan 7;17(1):6. doi: 10.1186/s13098-024-01573-9.
Exploring the relationship between MGAT2 and glioblastoma: A Mendelian Randomization and bioinformatics approach
Qiu Z, Guo C, Liu X, Gao S, Xiao W, Cheng H, Yin L.
Brain Res. 2025 Jan 7;1850:149449. doi: 10.1016/j.brainres.2025.149449.
Assessing the Causal Effect of Circulating Protein-To-Protein Ratio on the Risk of Morbidity of Hepatocellular Carcinoma
Yue Q, Li X, Wan X, Lin X, Li Y, Zhang M, Xu S.
Cancer Med. 2025 Jan;14(1):e70570. doi: 10.1002/cam4.70570.
Causal associations between dietary factors with head and neck cancer: A two-sample Mendelian randomization study
Xu Y, Chen G, Mao M, Jiang M, Chen J, Ma Z.
Laryngoscope Investig Otolaryngol. 2025 Jan 7;10(1):e70070. doi: 10.1002/lio2.70070.
Investigating the causal relationship between skin microbiota and hypertrophic scar using bidirectional mendelian randomization
Hou K, Tan Y, Zhang Q.
Burns. 2025 Jan 6;51(2):107376. doi: 10.1016/j.burns.2025.107376.
Effects of immune cells in mediating the relationship between inflammatory bowel disease and pyoderma gangrenosum: a two-sample, two-step mendelian randomization study
Zhu H, Pan J.
Arch Dermatol Res. 2025 Jan 6;317(1):176. doi: 10.1007/s00403-024-03736-0.
Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis
Fang C, Liu X, Yu C, Li S, Liu X, Qiu S, Liang H, Ou C, Xiu J.
J Transl Med. 2025 Jan 6;23(1):14. doi: 10.1186/s12967-024-06027-4.
Causal associations between circulating protein ratios and drug resistance in papillary thyroid cancer: a Mendelian randomization study
Deng J, Yu M, Gu Y, Lai Y, Qiu L.
Discov Oncol. 2025 Jan 4;16(1):4. doi: 10.1007/s12672-025-01758-2.