Below you will find all the published and preprint scientific papers using FinnGen data.

2025

April

Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis
Liu L, Liao M, Liu B, Huang Q, Wu H, Li M.
Obstet Gynecol Sci. 2025 Apr 3. doi: 10.5468/ogs.24254.
A mendelian randomization study on the association between 731 types of immune cells and 91 types of blood cells with venous thromboembolism
Zhang Y, Wang R.
Thromb J. 2025 Apr 3;23(1):28. doi: 10.1186/s12959-025-00714-y.
Health implications associated with fat-free mass: phenome-wide Mendelian randomization study
Ying Y, Zhang C, Wu S, Wang S, Lian J, Lin Y, Guan H, Cai D.
Cardiorenal Med. 2025 Apr 3:1-20. doi: 10.1159/000545641.
Causal relationship between graves' disease and mental disorders: A bidirectional Mendelian randomization study
Deng Y, Hao Z, Chen W, Zhang J, Zou Y, Zhang J, Xi Y, Xu J.
J Psychosom Res. 2025 Apr 3;192:112124. doi: 10.1016/j.jpsychores.2025.112124.
Dissecting causal relationships between gut microbiota, inflammatory factors, and acute kidney injury: A Mendelian randomization study
Huai J, Ye X.
Clin Nephrol. 2025 Apr 3. doi: 10.5414/CN111632.
Plasma cytokine levels and PCOS risk: Mendelian randomization analysis reveals IL6R as a preventive factor
Li X, Li Y, Zhang B, Wang J, Yang Y, Du Y.
J Ovarian Res. 2025 Apr 3;18(1):69. doi: 10.1186/s13048-025-01647-w.
Identifying blood mitochondrial DNA copy number as a biomarker for development of neurodegenerative diseases: Evidence from Mendelian randomization analysis
Lei S, Liu Y.
Neuroscience. 2025 Apr 2;573:421-429. doi: 10.1016/j.neuroscience.2025.04.003.
Mendelian Randomization Unveils a Causal Relationship Between Inflammation, Metabolism, and Systemic Sclerosis
Zeng Y, Zeng W, Li Z, Yang X, Pan J, Lei L.
medRxiv 2025.04.02.25325153; doi: https://doi.org/10.1101/2025.04.02.25325153
Metabolic Factors Mediate the Causal Effect of Physical Activity and Sedentary Behavior on Stroke and Its Subtypes: Evidence from Mendelian Randomization Study
Wei J, Zhao J, Yang K, Ma S, Zhang M, Sun Y, He C, Pan X, Zhu X.
Mol Neurobiol. 2025 Apr 2. doi: 10.1007/s12035-025-04881-x.
Association between sleep apnoea and arrhythmia: A multivariable Mendelian randomization study
He W, Wang J, Nie J, Wang DW, Ni L, Li D.
medRxiv 2025.04.02.25325145; doi: https://doi.org/10.1101/2025.04.02.25325145
Dissecting shared genetic architecture between hypothyroidism and immune-related diseases
Li S, Gong M.
medRxiv 2024.04.02.24305135; doi: https://doi.org/10.1101/2024.04.02.24305135
Exploring the Relationship Between Antipsychotic Drug Target Genes and Epilepsy: Evidence From Food and Drug Administration Adverse Event Reporting System Database and Mendelian Randomization
Yin Z, Zhan Z, Qiu Y, Wang M, Li J, Song B, Chen Z, Wu J, Wang Z.
Brain Behav. 2025 Apr;15(4):e70467. doi: 10.1002/brb3.70467.
Researching the causal relationship between immune cells and frontotemporal Dementia: A Mendelian Randomization analysis
Cheng Y, He X, Huang X, Mao F, Qin F, Wang Y.
Brain Res. 2025 Apr 2;1857:149608. doi: 10.1016/j.brainres.2025.149608.
Thyroid function and hepatic fibrosis/cirrhosis: a two-sample Mendelian randomization study
Wang Y, Zhang X, Li Q, Zhang Q, Liu J.
Front Genet. 2025 Apr 2;16:1399353. doi: 10.3389/fgene.2025.1399353.
Exploring glucagon-like peptide-1 receptor agonists as potential disease-modifying agents in autoimmune diseases
Yang Y, Liu W, Zhang Z, Zhang Y, Wang X, Wang J, Cai H, Liu Y, Meng R, Fu Y, Luo H, Yang L, Liu W.
J Autoimmun. 2025 Apr 1;153:103414. doi: 10.1016/j.jaut.2025.103414.
Cross-ancestry genome-wide association study identifies new susceptibility genes for preeclampsia
Shan Y, Hu H, Chu Y.
BMC Pregnancy Childbirth. 2025 Apr 1;25(1):379. doi: 10.1186/s12884-025-07534-y.
BMI matters: understanding the link between weight and severe psoriasis
Wang H, Hou S, Kang X, Yu C, Yang B, Shi Y, Li F, Li W, Gu J, Lei M, Lin Y, Wang G, Jin H, Liu X.
Sci Rep. 2025 Apr 1;15(1):11158. doi: 10.1038/s41598-025-94505-0.
Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis
Oliva M, Sarkar MK, March ME, Saeidian AH, Mentch FD, Hsieh CL, Tang F, Uppala R, Patrick MT, Li Q, Bogle R, Kahlenberg JM, Watson D, Glessner JT, Youssefian L, Vahidnezhad H, Tsoi LC, Hakonarson H, Gudjonsson JE, Smith KM, Riley-Gillis B.
Nat Commun. 2025 Apr 1;16(1):3101. doi: 10.1038/s41467-025-58310-7.
Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake
Sun L, Leng R, Liu M, Su M, He Q, Zhang Z, Liu Z, Wang Z, Jiang H, Wang L, Guo S, Xu Y, Huo Y, Miller CL, Banach M, Huang Y, Evans PC, Pelisek J, Camici GG, Berk BC, Offermanns S, Ge J, Xu S, Weng J.
J Clin Invest. 2025 Apr 1;135(7):e181928. doi: 10.1172/JCI181928.
Effect of the plasma metabolites, biomarkers, and inflammatory proteins on urolithiasis: insights from Mendelian randomization and mediation analysis
Huang H, Wen Z, Li H, Wang C, Chen C, Liu Y, Qin J, Cao S, Yang X.
Urolithiasis. 2025 Apr 1;53(1):65. doi: 10.1007/s00240-025-01738-9.
Causal Characteristics of Immune Cells Associated with Aortic Dissection: A Mendelian Randomisation Analysis
Li TL, Fu ML, Wang LH, Wang JL, Liu YW, Huang L.
Eur Cardiol. 2025 Apr 1;20:e07. doi: 10.15420/ecr.2024.44.

March

Causal association between non-steroidal anti-inflammatory drugs use and the risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study
Peng ZH, Li MR, He MX, Liu J, Dou JH, Wang YW, Dong Y, Yan C, Li ZH, Chong T, Li ZL.
BMC Med Genomics. 2025 Mar 31;18(1):60. doi: 10.1186/s12920-025-02128-1.
Appraising the causal role of cathepsins in genitourinary carcinoma: a two-sample mendelian randomization and prospective study based on 36,225 individuals
Zhu Q, Liu D, Liu H, Pan X, Shi Y, Guo J, Tong N, Chen J, Zeng H.
Discov Oncol. 2025 Mar 31;16(1):435. doi: 10.1007/s12672-025-02219-6.
Assessing the effect of modifiable risk factors on hepatocellular carcinoma: evidence from a bidirectional Mendelian randomization analysis
Wei L, Ding E, Lu D, Rui Z, Shen J, Fan G.
Discov Oncol. 2025 Mar 31;16(1):437. doi: 10.1007/s12672-025-02177-z.
Dissecting Causal Relationships Between Gut Microbiota, 1400 Blood Metabolites, and Intervertebral Disc Degeneration
Liu Y, Feng D, Zhang H, Wang L.
Neurospine. 2025 Mar;22(1):211-221. doi: 10.14245/ns.2449172.586.
Severe traumatic brain injury and risk for osteoporosis: a Mendelian randomization study
Wang G, Wang J, Yang D, Liu L, Xu P.
BMC Med Genomics. 2025 Mar 31;18(1):61. doi: 10.1186/s12920-025-02127-2.
Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations
Malone SG, Davis CN, Piserchia Z, Setzer MR, Toikumo S, Zhou H, Winterlind EL, Gelernter J, Justice A, Leggio L, Rentsch CT, Kranzler HR, Gray JC.
Nat Hum Behav. 2025 May;9(5):1056-1066. doi: 10.1038/s41562-025-02148-y.
Exploring the association between 91 circulating inflammatory proteins and the risk of carcinoid syndrome: a Mendelian randomization analysis
Wang J, Peng S.
Discov Oncol. 2025 Mar 31;16(1):434. doi: 10.1007/s12672-025-02147-5.
Exploring the causal relationship between vitiligo and psoriasis: a bidirectional Mendelian randomization analysis
Xu Z, Yang C, Gan X, Yan P, Xiao C, Ye Y, Jiang X.
Arch Dermatol Res. 2025 Mar 29;317(1):648. doi: 10.1007/s00403-025-04102-4.
Uncovering somatic genetic drivers in prostate cancer through comprehensive genome-wide analysis
Lin L, Li Z, Chen K, Shao Y, Li X.
Geroscience. 2025 Mar 29. doi: 10.1007/s11357-025-01623-8.
Exploring blood immune cells in the protective effects of gut microbiota on rheumatic heart disease based on Mendelian randomization analysis
Lu J, Huang Y, Yin Y, Tang B.
Sci Rep. 2025 Mar 28;15(1):10745. doi: 10.1038/s41598-025-92356-3.
Exploring causal relationships between circulating micronutrients and age-related eye diseases: a Mendelian randomization study
Cao X, Xu Z, Zhang B, Jiang Z, Yuan X.
Genes Nutr. 2025 Mar 28;20(1):8. doi: 10.1186/s12263-025-00767-8.
Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints
Yin X, Li J, Bose D, Okamoto J, Kwon A, Jackson AU, Fernandes Silva L, Oravilahti A, Chu X, Stringham HM, Liu L, Peng R, Xia Z, Ripatti S, Daly M, Palotie A, Scott LJ, Burant CF, Fauman EB, Wen X, Boehnke M, Laakso M, Morrison J.
Nat Commun. 2025 Mar 28;16(1):3039. doi: 10.1038/s41467-025-58129-2.
Examining the link between 179 lipid species and 7 diseases using genetic predictors
Ottensmann L, Tabassum R, Ruotsalainen SE, Gerl MJ, Klose C, McCartney DL, Widén E; FinnGen; Simons K, Ripatti S, Vitart V, Hayward C, Pirinen M.
EBioMedicine. 2025 Apr;114:105671. doi: 10.1016/j.ebiom.2025.105671.
A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases
You D, Wu Y, Lu M, Shao F, Tang Y, Liu S, Liu L, Zhou Z, Zhang R, Shen S, Lange T, Xu H, Ma H, Yin Y, Shen H, Chen F, Christiani DC, Jin G, Zhao Y.
Nat Commun. 2025 Mar 28;16(1):3032. doi: 10.1038/s41467-025-58248-w.
Genetically predicted amino acids related to neural regulation mediate the association between diabetes mellitus and postherpetic neuralgia: a Mendelian randomization study
Lan H, Ai Z, Xu S, Li H, Feng Z, Guo R, Wang Y.
Diabetol Metab Syndr. 2025 Mar 28;17(1):104. doi: 10.1186/s13098-025-01672-1.
Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genes
Liang RS, Su JQ, Wu XQ, Wang Q, Cai YM, Su HY, Tang JX, Yao CW.
Sci Rep. 2025 Mar 28;15(1):10779. doi: 10.1038/s41598-025-94761-0.
The Causal Relationship Between Opioid Use and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study
Shan G, Ma Y, Jin Y.
Pain Physician. 2025 Mar;28(2):E147-E156. PMID: 40168564.
The hidden pathway: biological aging as a mediator between diabetes and breast cancer risk: a Mendelian randomized study
Zhao Y, Zhang J, Chen D, Xing S, Zhang S, Zhang Q.
Discov Oncol. 2025 Mar 28;16(1):416. doi: 10.1007/s12672-025-02204-z.
Monocyte CCL2 signaling possibly contributes to increased asthma susceptibility in type 2 diabetes
Luo T, Guo W, Ji W, Du W, Lv Y, Feng Z.
Sci Rep. 2025 Mar 28;15(1):10768. doi: 10.1038/s41598-025-95039-1.
Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints
Yin X, Li J, Bose D, Okamoto J, Kwon A, Jackson AU, Fernandes Silva L, Oravilahti A, Chu X, Stringham HM, Liu L, Peng R, Xia Z, Ripatti S, Daly M, Palotie A, Scott LJ, Burant CF, Fauman EB, Wen X, Boehnke M, Laakso M, Morrison J.
Nat Commun. 2025 Mar 28;16(1):3039. doi: 10.1038/s41467-025-58129-2.
Integration of metabolomics and genomics implicates a causality between 1398 blood metabolites and gout
Fan M, Yun Z, Yuan J, Lu D, Xie H, Yuan H, Gao H.
Clin Rheumatol. 2025 Mar 28. doi: 10.1007/s10067-025-07402-2.
Genetic effects of circulating hormone and proteome on amyotrophic lateral sclerosis identified by Mendelian randomization
Fan X, Zeng Y, Zhang F, Xu Y, Duan Q, Long S, Lin Y, Wang K, Jiang L.
Sci Rep. 2025 Mar 28;15(1):10782. doi: 10.1038/s41598-025-95151-2.
Exploring new drug treatment targets for immune related bone diseases using a multi omics joint analysis strategy
Yang W, Liu C, Li Z, Cui M.
Sci Rep. 2025 Mar 27;15(1):10618. doi: 10.1038/s41598-025-94053-7.
Bidirectional two-sample mendelian randomization analysis identifies a causal relationship between major depressive disorder and allergic diseases
Zhang Q, Mou YK, Yun JJ, Yang T, Song XY, Wang Z, Geng DQ, Song XC, Ren C.
Health Psychol. 2025 Mar 27. doi: 10.1037/hea0001487.
Complex interplay between type 2 diabetes mellitus and pancreatic cancer: insights from observational and mendelian randomization analyses
Wang Y, Xie L, Gu Y, Jin H, Yang J, Liu Q, Zhang X.
BMC Cancer. 2025 Mar 27;25(1):556. doi: 10.1186/s12885-025-13976-6.
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis
Liu J, Zeng D, Wang Y, Deng F, Wu S, Deng Z.
Biol Direct. 2025 Mar 27;20(1):38. doi: 10.1186/s13062-025-00631-0.
Sleep factors and risk of thyroid cancer, nodules and dysfunction: Mendelian randomization study
Fan Y, Zheng X, Xu T, Li P, Zhang Y, Ran Y, Wei T.
Gland Surg. 2025 Mar 31;14(3):368-379. doi: 10.21037/gs-24-435.
Sarcopenia-related traits and risk of falls in older adults: results from meta-analysis of cohort studies and Mendelian randomization analyses
Yang H, Jiang Y, Liang D, Yang C, Qin K, Xie Y, Zhang L, Tang P, Cui X, Lyu H.
Aging Clin Exp Res. 2025 Mar 26;37(1):106. doi: 10.1007/s40520-025-02997-7.
Biomakers for acute appendicitis: a two-sample Mendelian randomization study
Zhang K, OuYang H.
medRxiv 2025.03.26.25324673; doi: https://doi.org/10.1101/2025.03.26.25324673