Below you will find all the published and preprint scientific papers using FinnGen data.

2023

August

Proteome-Wide Mendelian Randomization Analysis Identified Potential Drug Targets for Atrial Fibrillation
Wang X, Huang T, Jia J.
J Am Heart Assoc. 2023 Aug 15;12(16):e029003. doi: 10.1161/JAHA.122.029003.
Inflammatory biomarkers and delirium: a Mendelian randomization study.
Yu M, Li Y, Li B, Ge Q.
Front Aging Neurosci. 2023 Aug 15;15:1221272. doi: 10.3389/fnagi.2023.1221272.
Association between alcohol and urolithiasis: a mendelian randomization study
Yang S, Tan W, Wei B, Gu C, Li S, Wang S.
Urolithiasis. 2023 Aug 15;51(1):103. doi: 10.1007/s00240-023-01472-0.
The causal effects of leisure screen time on irritable bowel syndrome risk from a Mendelian randomization study
Lu L, Liu C, Liu K, Shi C, Liu Z, Jiang X, Wang F
Sci Rep. 2023 Aug 14;13(1):13216. doi: 10.1038/s41598-023-40153-1
Effect of genetically determined BCAA levels on cardiovascular diseases and their risk factors: A Mendelian randomization study
Zuo Z, Tong Y, Li M, Wang Z, Wang X, Guo X, Sun Y, Zhang Z.
Nutr Metab Cardiovasc Dis. 2023 Aug 14:S0939-4753(23)00326-5. doi: 10.1016/j.numecd.2023.08.003.
Gut microbiota and intervertebral disc degeneration: a bidirectional two-sample Mendelian randomization study
Geng Z, Wang J, Chen G, Liu J, Lan J, Zhang Z, Miao J.
J Orthop Surg Res. 2023 Aug 14;18(1):601. doi: 10.1186/s13018-023-04081-0.
Causal effects between atrial fibrillation and heart failure: evidence from a bidirectional Mendelian randomization study
Zhang Z, Li L, Hu Z, Zhou L, Zhang Z, Xiong Y, Yao Y
BMC Med Genomics. 2023 Aug 14;16(1):187. doi: 10.1186/s12920-023-01606-8
Diabetes mellitus and ankylosing spondylitis: A bidirectional Mendelian randomization study
hongsheng Luo, bingcheng Pan, shuanghua Liu, weidong Huang, yimei Tan, zhenyu Gan, zhenhua Pan, menghe Huang1, dayuan Zhong, shuan Wu
Researchsquare, 14 August 2023, doi: 10.21203/rs.3.rs-3237241/v1
Visceral adipose tissue and risk of nonalcoholic fatty liver disease: A Mendelian randomization study
Tao M, Zhou G, Liu J, He M, Wang C, Luo X, Zhang L.
Clin Endocrinol (Oxf). 2023 Aug 10. doi: 10.1111/cen.14953
The Causal Relationship Between Autoimmune Diseases and Sepsis:A Two-Sample Bidirectional Mendelian Randomization Study
Liwei Li, Fuqing Cai, Guang Xiong, Jiamin Qin, Yan Geng, Jie-an Huang
Researchsquare, 11 August 2023, doi:10.21203/rs.3.rs-3228738/v1
Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis
Guan B, Wang A, Xu H.
Cardiovasc Diabetol. 2023 Aug 10;22(1):207. doi: 10.1186/s12933-023-01927-z.
Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal
Kudtarkar P, Costanzo MC, Sun Y, Jang D, Koesterer R, Mychaleckyj JC, Nayak U, Onengut-Gumuscu S, Rich SS, Flannick JA, Gaulton KJ, Burtt NP.
PLoS Biol. 2023 Aug 10;21(8):e3002233. doi: 10.1371/journal.pbio.3002233
Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization
Xiang Y, Zhang C, Wang J, Cheng Y, Wang L, Tong Y, Yan D.
J Transl Med. 2023 Aug 10;21(1):535. doi: 10.1186/s12967-023-04335-9.
The Causal Relationship between Gut Microbiota and Non-alcoholic Fatty Liver Disease: A Mendelian Randomization Study
Liwei Li, Fuqing Cai, Guang Xiong, Jiamin Qin, Yan Geng, Jie-an Huang
Researchsquare, 10 August 2023, doi:10.21203/rs.3.rs-3228738/v1
Machine learning reveals genetic modifiers of the immune microenvironment of cancer
Riley-Gillis B, Tsaih S-W, King E, Wollenhaupt S, Reeb J, Peck AR, Wackman K, Lemke A, Rui H, Dezso Z, Flister MJ.
iScience, Volume 26, Issue 9, 2023, 107576, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2023.107576.
Genetically Proxied Sarcopenia-Related Muscle Traits and Depression: Evidence from the FinnGen Cohort
Lv Z, Zhao Y, Cui J, Zhang J.
Am J Geriatr Psychiatry. 2023 Aug 9:S1064-7481(23)00375-5. doi: 10.1016/j.jagp.2023.08.001
Genetic Evidence Strongly Supports Managing Weight and Blood Pressure in Addition to Glycemic Control in Preventing Vascular Complications in People With Type 2 Diabetes
Ahmed A, Amin H, Drenos F, Sattar N, Yaghootkar H.
Diabetes Care. 2023 Aug 9:dc230855. doi: 10.2337/dc23-0855.
A common variant that alters SUN1 degradation associates with hepatic steatosis and metabolic traits in multiple cohorts
Upadhyay KK, Du X, Chen Y, Buscher B, Chen VL, Oliveri A, Zhao R, Speliotes EK, Brady GF.
J Hepatol. 2023 Nov;79(5):1226-1235. doi: 10.1016/j.jhep.2023.07.036.
Association between periodontitis and temporomandibular joint disorders
Wang S, Jiang H, Qi H, Luo D, Qiu T, Hu M.
Arthritis Res Ther. 2023 Aug 8;25(1):143. doi: 10.1186/s13075-023-03129-0.
Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization
Woolf B, Cronjé HT, Zagkos L, Burgess S, Gill D, Larsson SC.
BMC Med. 2023 Aug 8;21(1):296. doi: 10.1186/s12916-023-03008-0.
Rheumatoid arthritis and heart failure: A bidirectional two-sample Mendelian randomization study
Yan Yang, Fenfang Cui, Min xu, Qin He, Ying Liu, Ying Lan, Xiqian Zhang, yaxian zheng, Xu Zhang
Researchsquare, 08 August 2023, doi: 10.21203/rs.3.rs-3227239/v1
Genetic Evidence for Causal Association Between Atrial Fibrillation and Dementia: A Mendelian Randomization Study
Li M, Jiang C, Lai Y, Wang Y, Zhao M, Li S, Peng X, He L, Guo X, Li S, Liu N, Jiang C, Tang R, Sang C, Long D, Du X, Dong J, Ma C.
J Am Heart Assoc. 2023 Aug 7:e029623. doi: 10.1161/JAHA.123.029623
Causal Roles of Lifestyle, Psychosocial Characteristics and Sleep Status in Sarcopenia: A Mendelian Randomization Study
Liu M, Yu D, Pan Y, Ji S, Han N, Yang C, Sun G.
J Gerontol A Biol Sci Med Sci. 2023 Aug 7:glad191. doi: 10.1093/gerona/glad191.
Genetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study
Wu D, Zhou J, Huang Y, Zheng Q, Wang T, Liu L.
Cancer Med. 2023 Aug 7. doi: 10.1002/cam4.6406.
Genetically predicted thyroid function and risk of colorectal cancer: a bidirectional Mendelian randomization study
Du Q, Zheng Z, Wang Y, Yang L, Zhou Z.
J Cancer Res Clin Oncol. 2023 Aug 6. doi: 10.1007/s00432-023-05233-9.
The relationship between antidepressants and breast cancer: evidence from Mendelian randomization
Niu D, Li C, Yan X, Qu H, Zheng Y.
Cancer Causes Control. 2023 Aug 4. doi: 10.1007/s10552-023-01766-z.
Causal relationship between gut microbiome and risk of AMD: a two-sample Mendelian Randomization study
Gai-yun Li, Pei-sen Yao
Researchsquare, 04 August 2023, doi: 10.21203/rs.3.rs-3097550/v1
A common genetic factor underlies genetic risk for gynaecological and reproductive disorders and is correlated with risk to depression
Kiewa J, Mortlock S, Meltzer-Brody S, Middeldorp C, Wray NR, Byrne EM.
Neuroendocrinology. 2023 Aug 4. doi: 10.1159/000533413.
The relationship of fatty acids to ischaemic heart disease and lifespan in men and women using Mendelian randomization
Schooling CM, Kwok MK, Zhao JV.
Int J Epidemiol. 2023 Aug 3:dyad108. doi: 10.1093/ije/dyad108.
Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression
Tian Y, Dong D, Wang Z, Wu L, Park JY, Wei GH, Wang L; PRACTICAL/ELLIPSE consortium.
The American Journal of Human Genetics, Volume 110, Issue 8, 2023, https://doi.org/10.1016/j.ajhg.2023.07.003.
Univariable and multivariable Mendelian randomization investigating the effects of telomere length on the risk of adverse pregnancy outcomes.
Han X, Wu T, Liu CY.
Front Endocrinol (Lausanne). 2023 Aug 3;14:1225600. doi: 10.3389/fendo.2023.1225600.
A FinnGen pilot clinical recall study for Alzheimer's disease
Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen; Perola M, Palotie A, Vuoksimaa E, Runz H.
Sci Rep. 2023 Aug 3;13(1):12641. doi: 10.1038/s41598-023-39835-7.
Rheumatoid arthritis and hypothyroidism: a bidirectional Mendelian randomization study.
Duan L, Chen D, Shi Y, Ye S, Dou S, Feng Y.
Front Immunol. 2023 Aug 2;14:1146261. doi: 10.3389/fimmu.2023.1146261
Tea Intake Increases Risk of Glaucoma: A Multivariable Mendelian Randomization Study
Changzhong Xu, Lusi Zhang, Guangshuang Tan, Datong Xu, Qian Jiang, Bing Jiang
Researchsquare, 02 August 2023, doi: 10.21203/rs.3.rs-3208832/v1
Two-sample Mendelian randomization study does not reveal a significant relationship between cytomegalovirus (CMV) infection and autism spectrum disorder
Zhang M, Ming Y, Du Y, Xin Z.
BMC Psychiatry. 2023 Aug 2;23(1):559. doi: 10.1186/s12888-023-05035-w.
Association between coffee consumption and diabetic complications: A two- sample Mendelian randomization study
Yingchao Liang, Xinyu Hu, Mingjie Jia, Deliang Liu, Shufang Chu, Huilin Li
Researchsquare, 01 August 2023, doi: 10.21203/rs.3.rs-3188194/v1
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
Tesfaye M, Jaholkowski P, Hindley GFL, Shadrin AA, Rahman Z, Bahrami S, Lin A, Holen B, Parker N, Cheng W, Rødevand L, Frei O, Djurovic S, Dale AM, Smeland OB, O'Connell KS, Andreassen OA.
Genome Med. 2023 Aug 1;15(1):60. doi: 10.1186/s13073-023-01212-4.
Genetic insights into the risk of metabolic syndrome and its components on psoriasis: A bidirectional Mendelian randomization
Liu L, Wang W, Si Y, Li X.
J Dermatol. 2023 Aug 1. doi: 10.1111/1346-8138.16910.
Causal association between basal metabolic rate and risk of cardiovascular diseases: a univariable and multivariable Mendelian randomization study
Li Y, Zhai H, Kang L, Chu Q, Zhao X, Li R.
Sci Rep. 2023 Aug 1;13(1):12487. doi: 10.1038/s41598-023-39551-2.

July

Genetically predicted osteoprotegerin levels and the risk of cardiovascular diseases: A Mendelian randomization study
Zhu Y, Wang Y, Wang Y, Cui Z, Liu F, Hu J.
Int J Cardiol. 2023 Jul 31:131233. doi: 10.1016/j.ijcard.2023.131233.
Causal relationship between osteoarthritis with atrial fibrillation and coronary atherosclerosis: a bidirectional Mendelian randomization study of European ancestry
Yin M, Xu W, Pang J, Xie S, Xiang M, Shi B, Fan H, Yu G.
Front Cardiovasc Med. 2023 Jul 31;10:1213672. doi: 10.3389/fcvm.2023.1213672.
Mendelian Randomisation Analysis Suggests that Hypothyroidism Reduces Endometrial Cancer Risk
Glubb DM, Wang X, O'Mara TA
medRxiv 2023.07.30.23293405; doi: https://doi.org/10.1101/2023.07.30.23293405
Genetic variation in SLC5A2 mimicking SGLT2-inhibition and risk of cardiovascular disease and all-cause mortality: reduced risk not explained by lower plasma glucose
Bechmann LE, Emanuelsson F, Nordestgaard BG, Benn M.
Cardiovasc Res. 2023 Jul 30:cvad122. doi: 10.1093/cvr/cvad122.
Immune-mediated inflammatory diseases and the risk of valvular heart disease: a Mendelian randomization study
Cai D, Zheng Z, Hu J, Fu Y, Song Y, Lian J.
Clin Rheumatol. 2023 Jul 28. doi: 10.1007/s10067-023-06693-7.
Association between the use of lipid-lowering drugs and the risk of inflammatory bowel disease
Liu X, Lv Z, Xie Z, Wang Q, Yao W, Yu J, Jing Q, Meng X, Ma B, Xue D, Hao C.
Eur J Clin Invest. 2023 Jul 28:e14067. doi: 10.1111/eci.14067.
Modifiable factors for benign salivary gland neoplasms: A Mendelian randomization study
Gao Y, Chen H, Liu Y, Zhang X, Qiu Y, Huang D.
Oral Dis. 2023 Jul 27. doi: 10.1111/odi.14682.
Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study
Qu Y, Chen L, Guo S, Liu Y, Wu H.
Front Endocrinol (Lausanne). 2023 Jul 27;14:1133260. doi: 10.3389/fendo.2023.1133260.
Genetic Variants Associated With Hidradenitis Suppurativa
Sun Q, Broadaway KA, Edmiston SN, Fajgenbaum K, Miller-Fleming T, Westerkam LL, Melendez-Gonzalez M, Bui H, Blum FR, Levitt B, Lin L, Hao H, Harris KM, Liu Z, Thomas NE, Cox NJ, Li Y, Mohlke KL, Sayed CJ.
JAMA Dermatol. 2023 Jul 26. doi: 10.1001/jamadermatol.2023.2217.
Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes
Maina JG, Balkhiyarova Z, Nouwen A, Pupko I, Ulrich A, Boissel M, Bonnefond A, Froguel P, Khamis A, Prokopenko I, Kaakinen M.
Diabetes Care 2023; dc222373. https://doi.org/10.2337/dc22-2373
Body mass index and risk of inflammatory breast disease: a Mendelian randomization study
Wei C, Wang X, Zeng J, Zhang G.
Nutr Hosp. 2023 Jul 26. English. doi: 10.20960/nh.04746.