Integrated metabolomics and genetic analyses reveal loss of protective docosahexaenoic acid as a key driver linking ultra-processed food to Crohn's disease risk

Sidan Wang, Lintao Dan, Xixian Ruan, Judith Wellens, Yuhao Sun, Jialu Yao, Li Tian, Rahul Kalla, Evropi Theodoratou, Shuai Yuan, Susanna C Larsson, Jonas F Ludvigsson, Laurent Peyrin-Biroulet, Jack Satsangi, Fernando Magro, Xue Li, Xiaoyan Wang, Jie Chen

medRxiv 2026.02.20.26346727; doi: https://doi.org/10.64898/2026.02.20.26346727

https://doi.org/10.64898/2026.02.20.26346727

Preprint

Feb 22, 2026

Consortium publication