Improving type 2 diabetes polygenic risk scores by incorporating rare, low-frequency, and population-specific variants

Katie Taylor, Alicia Huerta-Chagoya, Xiaoyu Wang, Maheak Vora, Jiang Li, Lehte Turk, Teng Hiang Heng, Joohyun Kim, Andres Moreno-Estrada, Teresa Tusie-Luna, Carlos Aguilar-Salinas, Maggie Ng, Hilary C. Martin, David A van Heel, Genes & Health Research Team, Alisa Manning, David Carey, Priit Palta, Mitja I. Kurki, Sarah Finer, Tian Ge, Uyenlinh L. Mirshahi, Haoyu Zhang, Josep M Mercader
medRxiv 2025.11.24.25340878; doi: https://doi.org/10.1101/2025.11.24.25340878
Preprint
Nov 28, 2025