Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation

Akdeniz BC, Bahrami S, Hagen E, Fuhrer J, Fominykh V, Shadrin A, Filiz TT, Athanasiu L, Grenier-Boley B, Bellenguez C, de Rojas I, Kucukali F, Schneider A, Kleineidam L, Rujescu D, Scherbaum N, Deckert J, Riedel-Heller S, Hausner L, Molina-Porcel L, Grimmer T, Heilmann-Heimbach S, Moebus S, Scarmeas N, Garcia-Alberca JM, Franco-Macias E, Mir P, Real LM, Rodriguez-Rodriguez E, Luis Royo J, Saez ME, Carracedo A, Lopez de Munain A, Amer-Ferrer G, Calero M, Medina M, Garcia-Ribas G, Mendioroz M, Dols-Icardo O, Moreno F, Perez-Tur J, Bullido MJ, Alvarez V, Soininen H, Heikkinen S, de Mendonca A, Mehrabian S, Traykov L, Hort J, Vyhnalek M, Sandau N, Thomassen JQ, Luo J, Pijnenburg YAL, Tesi N, van Swieten J, Giedraitis V, Williams J, Nicolas G, Debette S, Amouyel P, Grunblatt E, Popp J, Bossu P, Galimberti D, Rossi G, Arosio B, Mecocci P, Squassina A, Tremolizzo L, Borroni B, Nacmias B, Seripa D, Rainero I, Daniele A, Piras F, Masullo C, Kehoe PG, Frikke-Schmidt R, Ghidoni R, Ruiz A, Fernandez V, Sanchez-Juan P, Sleegers K, Ingelsson M, Hiltunen M, Sims R, Ramirez A, Broce IJ, Haavik J, Selbaek G, Knapskog A-B, Saltvedt I, Bergh S, Aakhus E, Kirsebom B-E, Watne LO, Rongve A, Arsland D, Djurovic S, Stordal E, Toft M, Scheffler K, Fladby T, Lambert J-C, Dale A, Frei O, Andreassen O.
medRxiv 2025.07.28.25332293; doi: https://doi.org/10.1101/2025.07.28.25332293
Preprint
Jul 28, 2025